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8FQF
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BU of 8fqf by Molmil
GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 150mM NaCl, 330uM CTZ, and 100mM glutamate (Open-Na260)
Descriptor: CHLORIDE ION, Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit
Authors:Nakagawa, T.
Deposit date:2023-01-06
Release date:2024-02-28
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (2.29 Å)
Cite:The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport.
Nat.Struct.Mol.Biol., 2024
8FPG
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BU of 8fpg by Molmil
GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100uM CNQX (Closed-CaNaMg)
Descriptor: CHLORIDE ION, Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit
Authors:Nakagawa, T.
Deposit date:2023-01-04
Release date:2024-02-28
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (2.32 Å)
Cite:The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport.
Nat.Struct.Mol.Biol., 2024
8FQ5
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BU of 8fq5 by Molmil
GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 140mM NMDG, 330uM CTZ, and 100mM L-glutamate (Open-Na110)
Descriptor: CHLORIDE ION, Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit
Authors:Nakagawa, T.
Deposit date:2023-01-05
Release date:2024-02-28
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (2.34 Å)
Cite:The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport.
Nat.Struct.Mol.Biol., 2024
8FQB
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BU of 8fqb by Molmil
GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 10mM CaCl2, 140mM NMDG, 330uM CTZ, and 100mM L-glutamate (Open-Ca10)
Descriptor: CALCIUM ION, CHLORIDE ION, Glutamate receptor 2, ...
Authors:Nakagawa, T.
Deposit date:2023-01-05
Release date:2024-02-28
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (2.36 Å)
Cite:The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport.
Nat.Struct.Mol.Biol., 2024
8FPS
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BU of 8fps by Molmil
GluA2 flip Q isoform N619K mutant of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg/N619K)
Descriptor: CHLORIDE ION, Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit
Authors:Nakagawa, T.
Deposit date:2023-01-05
Release date:2024-02-28
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (2.38 Å)
Cite:The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport.
Nat.Struct.Mol.Biol., 2024
8FP4
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BU of 8fp4 by Molmil
GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 500mM NaCl, 330uM CTZ, and 100mM glutamate (Open-Na610)
Descriptor: CHLORIDE ION, Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit
Authors:Nakagawa, T.
Deposit date:2023-01-04
Release date:2024-02-28
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport.
Nat.Struct.Mol.Biol., 2024
4P79
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BU of 4p79 by Molmil
Crystal structure of mouse claudin-15
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Claudin-15
Authors:Suzuki, H, Nishizawa, T, Tani, K, Yamazaki, Y, Tamura, A, Ishitani, R, Dohmae, N, Tsukita, S, Nureki, O, Fujiyoshi, Y.
Deposit date:2014-03-26
Release date:2014-04-30
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of a claudin provides insight into the architecture of tight junctions.
Science, 344, 2014
8FP9
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BU of 8fp9 by Molmil
GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg)
Descriptor: CALCIUM ION, CHLORIDE ION, Glutamate receptor 2, ...
Authors:Nakagawa, T.
Deposit date:2023-01-04
Release date:2024-02-28
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (2.44 Å)
Cite:The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport.
Nat.Struct.Mol.Biol., 2024
8C2H
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BU of 8c2h by Molmil
Transmembrane domain of active state homomeric GluA1 AMPA receptor in tandem with TARP gamma 3
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 1 flip isoform, ...
Authors:Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I.
Deposit date:2022-12-22
Release date:2023-08-30
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (2.64 Å)
Cite:Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor.
Nature, 621, 2023
8C2I
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BU of 8c2i by Molmil
Transmembrane domain of resting state homomeric GluA1 AMPA receptor in complex with TARP gamma 3
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 1 flip isoform, ...
Authors:Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I.
Deposit date:2022-12-22
Release date:2023-08-30
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor.
Nature, 621, 2023
8AYN
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BU of 8ayn by Molmil
Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand LY3130481
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 6-[(1~{S})-1-[1-[5-(2-hydroxyethyloxy)pyridin-2-yl]pyrazol-3-yl]ethyl]-3~{H}-1,3-benzothiazol-2-one, ...
Authors:Zhang, D, Lape, R, Shaikh, S, Kohegyi, B, Watson, J.F, Cais, O, Nakagawa, T, Greger, I.H.
Deposit date:2022-09-02
Release date:2023-04-19
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Modulatory mechanisms of TARP gamma 8-selective AMPA receptor therapeutics.
Nat Commun, 14, 2023
8C1Q
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BU of 8c1q by Molmil
Resting state homomeric GluA1 AMPA receptor in complex with TARP gamma 3
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 1 flip isoform, ...
Authors:Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I.
Deposit date:2022-12-21
Release date:2023-08-30
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (2.82 Å)
Cite:Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor.
Nature, 621, 2023
8C1P
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BU of 8c1p by Molmil
Active state homomeric GluA1 AMPA receptor in complex with TARP gamma 3
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CYCLOTHIAZIDE, ...
Authors:Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I.
Deposit date:2022-12-21
Release date:2023-08-30
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor.
Nature, 621, 2023
8P3Q
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BU of 8p3q by Molmil
Homomeric GluA2 flip R/G-unedited Q/R-edited F231A mutant in tandem with TARP gamma-2, desensitized conformation 3
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 2, ...
Authors:Zhang, D, Krieger, J.M, Yamashita, K, Greger, I.
Deposit date:2023-05-18
Release date:2023-08-30
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor.
Nature, 621, 2023
8P3S
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BU of 8p3s by Molmil
Homomeric GluA2 flip R/G-unedited Q/R-edited F231A mutant in tandem with TARP gamma-2, desensitized conformation 2
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 2, ...
Authors:Zhang, D, Krieger, J.M, Yamashita, K, Greger, I.
Deposit date:2023-05-18
Release date:2023-08-30
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor.
Nature, 621, 2023
8U4V
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BU of 8u4v by Molmil
Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain, sFab COP-1, and Nanobody
Descriptor: Anti-fab nanobody, COP-1 sFab Heavy Chain, COP-1 sFab Light Chain, ...
Authors:Vecchio, A.J.
Deposit date:2023-09-11
Release date:2023-10-25
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (2.99 Å)
Cite:Cryo-EM structures of a synthetic antibody against 22 kDa claudin-4 reveal its complex with Clostridium perfringens enterotoxin
To be published
8C1S
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BU of 8c1s by Molmil
Transmembrane domain of resting state homomeric GluA2 F231A mutant AMPA receptor in complex with TARP gamma 2
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 2, ...
Authors:Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I.
Deposit date:2022-12-21
Release date:2023-08-30
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor.
Nature, 621, 2023
7OCE
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BU of 7oce by Molmil
Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD)
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide, CHOLESTEROL, ...
Authors:Zhang, D, Watson, J.F, Matthews, P.M, Cais, O, Greger, I.H.
Deposit date:2021-04-26
Release date:2021-06-09
Last modified:2021-06-30
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Gating and modulation of a hetero-octameric AMPA glutamate receptor.
Nature, 594, 2021
6OV2
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BU of 6ov2 by Molmil
Crystal structure of human claudin-9 in complex with Clostridium perfringens entertoxin C-terminal domain in closed form
Descriptor: Claudin-9, GLYCEROL, Heat-labile enterotoxin B chain
Authors:Vecchio, A.J, Stroud, R.M.
Deposit date:2019-05-06
Release date:2019-09-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown.
Proc.Natl.Acad.Sci.USA, 116, 2019
8AYL
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BU of 8ayl by Molmil
Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-61432059
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 5-[2-(4-fluorophenyl)-7-(4-oxidanylpiperidin-1-yl)pyrazolo[1,5-c]pyrimidin-3-yl]-1,3-dihydroindol-2-one, ...
Authors:Zhang, D, Lape, R, Shaikh, S, Kohegyi, B, Watson, J.F, Cais, O, Nakagawa, T, Greger, I.
Deposit date:2022-09-02
Release date:2023-04-19
Last modified:2023-05-24
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Modulatory mechanisms of TARP gamma 8-selective AMPA receptor therapeutics.
Nat Commun, 14, 2023
8C1R
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BU of 8c1r by Molmil
Resting state homomeric GluA2 F231A mutant AMPA receptor in complex with TARP gamma-2
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 2, ...
Authors:Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I.
Deposit date:2022-12-21
Release date:2023-08-30
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor.
Nature, 621, 2023
7LEP
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BU of 7lep by Molmil
The composite LBD-TMD structure combined from all hippocampal AMPAR subtypes at 3.25 Angstrom resolution
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 6-[2-chloro-6-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-ol, DECANE, ...
Authors:Yu, J, Rao, P, Gouaux, E.
Deposit date:2021-01-14
Release date:2021-05-12
Last modified:2021-06-30
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition.
Nature, 594, 2021
6OV3
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BU of 6ov3 by Molmil
Crystal structure of human claudin-9 in complex with Clostridium perfringens entertoxin C-terminal domain in open form
Descriptor: Claudin-9, Heat-labile enterotoxin B chain
Authors:Vecchio, A.J, Stroud, R.M.
Deposit date:2019-05-06
Release date:2019-09-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown.
Proc.Natl.Acad.Sci.USA, 116, 2019
8AYO
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BU of 8ayo by Molmil
Open state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-61432059
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 5-[2-(4-fluorophenyl)-7-(4-oxidanylpiperidin-1-yl)pyrazolo[1,5-c]pyrimidin-3-yl]-1,3-dihydroindol-2-one, ...
Authors:Zhang, D, Lape, R, Shaikh, S, Kohegyi, B, Watson, J.F, Cais, O, Nakagawa, T, Greger, I.H.
Deposit date:2022-09-02
Release date:2023-04-19
Last modified:2023-05-24
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Modulatory mechanisms of TARP gamma 8-selective AMPA receptor therapeutics.
Nat Commun, 14, 2023
8AYM
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BU of 8aym by Molmil
Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-55511118
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 6-[2-chloro-6-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-ol, ...
Authors:Zhang, D, Lape, R, Shaikh, S, Kohegyi, B, Watson, J.F, Cais, O, Nakagawa, T, Greger, I.H.
Deposit date:2022-09-02
Release date:2023-04-19
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Modulatory mechanisms of TARP gamma 8-selective AMPA receptor therapeutics.
Nat Commun, 14, 2023

 

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PDB entries from 2024-03-27

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