PDB: 74 resultsInfo pagesStatus searchChemie searchBIRD

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4P79	Crystal structure of mouse claudin-15 Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Claudin-15 Authors: Suzuki, H, Nishizawa, T, Tani, K, Yamazaki, Y, Tamura, A, Ishitani, R, Dohmae, N, Tsukita, S, Nureki, O, Fujiyoshi, Y. Deposit date: 2014-03-26 Release date: 2014-04-30 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure of a claudin provides insight into the architecture of tight junctions. Science, 344, 2014
3X29	CRYSTAL STRUCTURE of MOUSE CLAUDIN-19 IN COMPLEX with C-TERMINAL FRAGMENT OF CLOSTRIDIUM PERFRINGENS ENTEROTOXIN Descriptor: Claudin-19, Heat-labile enterotoxin B chain Authors: Saitoh, Y, Suzuki, H, Tani, K, Nishikawa, K, Irie, K, Ogura, Y, Tamura, A, Tsukita, S, Fujiyoshi, Y. Deposit date: 2014-12-13 Release date: 2015-01-21 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (3.7 Å) Cite: Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin Science, 347, 2015
8U5B	Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain and sFab COP-1 Descriptor: COP-1 sFab Heavy Chain, COP-1 sFab Light Chain, Claudin-4, ... Authors: Vecchio, A.J. Deposit date: 2023-09-12 Release date: 2023-09-27 Last modified: 2023-12-13 Method: ELECTRON MICROSCOPY (5.3 Å) Cite: Cryo-EM structures of a synthetic antibody against 22 kDa claudin-4 reveal its complex with Clostridium perfringens enterotoxin To be published
8U4V	Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain, sFab COP-1, and Nanobody Descriptor: Anti-fab nanobody, COP-1 sFab Heavy Chain, COP-1 sFab Light Chain, ... Authors: Vecchio, A.J. Deposit date: 2023-09-11 Release date: 2023-10-25 Last modified: 2023-12-13 Method: ELECTRON MICROSCOPY (2.99 Å) Cite: Cryo-EM structures of a synthetic antibody against 22 kDa claudin-4 reveal its complex with Clostridium perfringens enterotoxin To be published
6AKF	Crystal structure of mouse claudin-3 P134A mutant in complex with C-terminal fragment of Clostridium perfringens enterotoxin Descriptor: Claudin-3, Heat-labile enterotoxin B chain Authors: Nakamura, S, Irie, K, Fujiyoshi, Y. Deposit date: 2018-08-31 Release date: 2019-02-20 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.9 Å) Cite: Morphologic determinant of tight junctions revealed by claudin-3 structures. Nat Commun, 10, 2019
6AKG	Crystal structure of mouse claudin-3 P134G mutant in complex with C-terminal fragment of Clostridium perfringens enterotoxin Descriptor: Claudin-3, Heat-labile enterotoxin B chain Authors: Nakamura, S, Irie, K, Fujiyoshi, Y. Deposit date: 2018-08-31 Release date: 2019-02-20 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (4.3 Å) Cite: Morphologic determinant of tight junctions revealed by claudin-3 structures. Nat Commun, 10, 2019
6AKE	Crystal structure of mouse claudin-3 in complex with C-terminal fragment of Clostridium perfringens enterotoxin Descriptor: Claudin-3, Heat-labile enterotoxin B chain Authors: Nakamura, S, Irie, K, Fujiyoshi, Y. Deposit date: 2018-08-31 Release date: 2019-02-27 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Morphologic determinant of tight junctions revealed by claudin-3 structures. Nat Commun, 10, 2019
7KP4	Crystal structure of human claudin-4 in complex with Clostridium perfringens enterotoxin C-terminal domain Descriptor: Claudin-4, Heat-labile enterotoxin B chain Authors: Vecchio, A.J, Stroud, R.M. Deposit date: 2020-11-10 Release date: 2020-12-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.37 Å) Cite: Structural basis for Clostridium perfringens enterotoxin targeting of claudins at tight junctions in mammalian gut. Proc.Natl.Acad.Sci.USA, 118, 2021
6OV3	Crystal structure of human claudin-9 in complex with Clostridium perfringens entertoxin C-terminal domain in open form Descriptor: Claudin-9, Heat-labile enterotoxin B chain Authors: Vecchio, A.J, Stroud, R.M. Deposit date: 2019-05-06 Release date: 2019-09-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.25 Å) Cite: Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown. Proc.Natl.Acad.Sci.USA, 116, 2019
6OV2	Crystal structure of human claudin-9 in complex with Clostridium perfringens entertoxin C-terminal domain in closed form Descriptor: Claudin-9, GLYCEROL, Heat-labile enterotoxin B chain Authors: Vecchio, A.J, Stroud, R.M. Deposit date: 2019-05-06 Release date: 2019-09-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown. Proc.Natl.Acad.Sci.USA, 116, 2019
7TDM	CryoEM Structure of sFab COP-2 Complex with human claudin-4 and Clostridium perfringens enterotoxin C-terminal domain Descriptor: COP-2 Fab Heavy chain, COP-2 Fab Light chain, Claudin-4, ... Authors: Vecchio, A.J. Deposit date: 2022-01-01 Release date: 2022-02-09 Last modified: 2024-01-17 Method: ELECTRON MICROSCOPY (6.9 Å) Cite: Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes. J.Biol.Chem., 298, 2022
7TDN	CryoEM Structure of sFab COP-3 Complex with human claudin-4 and Clostridium perfringens enterotoxin C-terminal domain Descriptor: COP-3 Fab Heavy chain, COP-3 Fab Light chain, Claudin-4, ... Authors: Vecchio, A.J. Deposit date: 2022-01-01 Release date: 2022-02-09 Last modified: 2024-01-17 Method: ELECTRON MICROSCOPY (5 Å) Cite: Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes. J.Biol.Chem., 298, 2022
5B2G	Crystal structure of human claudin-4 in complex with C-terminal fragment of Clostridium perfringens enterotoxin Descriptor: Endolysin,Claudin-4, Heat-labile enterotoxin B chain Authors: Shinoda, T, Kimura-Someya, T, Shirouzu, M, Yokoyama, S. Deposit date: 2016-01-15 Release date: 2016-10-05 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Structural basis for disruption of claudin assembly in tight junctions by an enterotoxin Sci Rep, 6, 2016
5KBS	Cryo-EM structure of GluA2-0xSTZ at 8.7 Angstrom resolution Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid Authors: Twomey, E.C, Yelshanskaya, M.V, Grassucci, R.A, Frank, J, Sobolevsky, A.I. Deposit date: 2016-06-03 Release date: 2016-07-13 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (8.7 Å) Cite: Elucidation of AMPA receptor-stargazin complexes by cryo-electron microscopy. Science, 353, 2016
6QKC	GluA1/2 In complex with auxiliary subunit gamma-8 Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide, Glutamate receptor 1, ... Authors: Herguedas, B, Garcia-Nafria, J, Greger, I.G. Deposit date: 2019-01-28 Release date: 2019-03-27 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP gamma 8. Science, 364, 2019
6QKZ	Full length GluA1/2-gamma8 complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide, ... Authors: Herguedas, B, Garcia-Nafria, J, Greger, I.G. Deposit date: 2019-01-30 Release date: 2019-03-27 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (6.3 Å) Cite: Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP gamma 8. Science, 364, 2019
7QHB	Active state of GluA1/2 in complex with TARP gamma 8, L-glutamate and CTZ Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate, CYCLOTHIAZIDE, ... Authors: Herguedas, B, Kohegyi, B, Zhang, D, Greger, I.H. Deposit date: 2021-12-11 Release date: 2022-02-23 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Mechanisms underlying TARP modulation of the GluA1/2-gamma 8 AMPA receptor. Nat Commun, 13, 2022
7QHH	Desensitized state of GluA1/2 AMPA receptor in complex with TARP-gamma 8 (TMD-LBD) Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate, GLUTAMIC ACID, ... Authors: Herguedas, B, Kohegyi, B, Dohrke, J.N, Watson, J.F, Zhang, D, Ho, H, Shaikh, S, Lape, R, Krieger, J.M, Greger, I.H. Deposit date: 2021-12-12 Release date: 2022-02-23 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Mechanisms underlying TARP modulation of the GluA1/2-gamma 8 AMPA receptor. Nat Commun, 13, 2022
5KBU	Cryo-EM structure of GluA2-2xSTZ complex at 7.8 Angstrom resolution Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid Authors: Twomey, E.C, Yelshanskaya, M.V, Grassucci, R.A, Frank, J, Sobolevsky, A.I. Deposit date: 2016-06-03 Release date: 2016-07-13 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (7.8 Å) Cite: Elucidation of AMPA receptor-stargazin complexes by cryo-electron microscopy. Science, 353, 2016
5KBT	Cryo-EM structure of GluA2-1xSTZ complex at 6.4 Angstrom resolution Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid Authors: Twomey, E.C, Yelshanskaya, M.V, Grassucci, R.A, Frank, J, Sobolevsky, A.I. Deposit date: 2016-06-03 Release date: 2016-07-13 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (6.4 Å) Cite: Elucidation of AMPA receptor-stargazin complexes by cryo-electron microscopy. Science, 353, 2016
5KK2	Architecture of fully occupied GluA2 AMPA receptor - TARP complex elucidated by single particle cryo-electron microscopy Descriptor: Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit Authors: Zhao, Y, Chen, S, Yoshioka, C, Baconguis, I, Gouaux, E. Deposit date: 2016-06-20 Release date: 2016-07-06 Last modified: 2018-07-18 Method: ELECTRON MICROSCOPY (7.3 Å) Cite: Architecture of fully occupied GluA2 AMPA receptor-TARP complex elucidated by cryo-EM. Nature, 536, 2016
6DM0	Open state GluA2 in complex with STZ and blocked by IEM-1460, after micelle signal subtraction Descriptor: CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit, ... Authors: Twomey, E.C, Yelshanskaya, M.V, Vassilevski, A.A, Sobolevsky, A.I. Deposit date: 2018-06-04 Release date: 2018-08-22 Last modified: 2019-12-18 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors. Neuron, 99, 2018
6DM1	Open state GluA2 in complex with STZ and blocked by NASPM, after micelle signal subtraction Descriptor: CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit, ... Authors: Twomey, E.C, Yelshanskaya, M.V, Vassilevski, A.A, Sobolevsky, A.I. Deposit date: 2018-06-04 Release date: 2018-08-22 Last modified: 2019-12-18 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors. Neuron, 99, 2018
6DLZ	Open state GluA2 in complex with STZ after micelle signal subtraction Descriptor: CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit Authors: Twomey, E.C, Yelshanskaya, M.V, Vassilevski, A.A, Sobolevsky, A.I. Deposit date: 2018-06-04 Release date: 2018-08-22 Last modified: 2019-12-18 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors. Neuron, 99, 2018
7OCA	Resting state full-length GluA1/A2 heterotertramer in complex with TARP gamma 8 and CNIH2 Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Zhang, D, Watson, J.F, Matthews, P.M, Cais, O, Greger, I.H. Deposit date: 2021-04-26 Release date: 2021-06-09 Last modified: 2021-06-30 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Gating and modulation of a hetero-octameric AMPA glutamate receptor. Nature, 594, 2021

 

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