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8SSC	Full-Length Methionine synthase from Thermus thermophilus HB8 Descriptor: Methionine synthase, POTASSIUM ION, SULFATE ION Authors: Yamada, K, Mendoza, J, Koutmos, M. Deposit date: 2023-05-08 Release date: 2023-10-18 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Structure of full-length cobalamin-dependent methionine synthase and cofactor loading captured in crystallo. Nat Commun, 14, 2023
8SCD	Crystal structure of sulfonamide resistance enzyme Sul3 in complex with reaction intermediate Descriptor: 2-amino-6-methylidene-6,7-dihydropteridin-4(3H)-one, 4-AMINOBENZOIC ACID, CHLORIDE ION, ... Authors: Stogios, P.J, Venkatesan, M, Michalska, K, Mesa, N, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID), Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2023-04-05 Release date: 2023-05-03 Last modified: 2023-07-19 Method: X-RAY DIFFRACTION (2.06 Å) Cite: Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics. Nat Commun, 14, 2023
8G3H	Structure of cobalamin-dependent methionine synthase (MetH) in a resting state Descriptor: COBALAMIN, Methionine synthase, ZINC ION Authors: Watkins, M.B, Ando, N. Deposit date: 2023-02-07 Release date: 2023-06-28 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Conformational switching and flexibility in cobalamin-dependent methionine synthase studied by small-angle X-ray scattering and cryoelectron microscopy. Proc.Natl.Acad.Sci.USA, 120, 2023
7TQ1	Crystal structure of adaptive laboratory evolved sulfonamide-resistant Dihydropteroate Synthase (DHPS) from Escherichia coli in complex with 6-hydroxymethylpterin Descriptor: 6-HYDROXYMETHYLPTERIN, Dihydropteroate synthase Authors: Stogios, P.J, Skarina, T, Tan, K, Venkatesan, M, Fruci, M, Joachimiak, A, Savchenko, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID), Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2022-01-26 Release date: 2023-05-03 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.73 Å) Cite: Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics. Nat Commun, 14, 2023
7S2K	Crystal structure of sulfonamide resistance enzyme Sul2 in complex with 7,8-dihydropteroate, magnesium, and pyrophosphate Descriptor: 4-AMINOBENZOIC ACID, 7,8-DIHYDROPTEROATE, CHLORIDE ION, ... Authors: Stogios, P.J, Skarina, T, Michalska, K, Venkatesan, M, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID), Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2021-09-03 Release date: 2023-05-03 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics. Nat Commun, 14, 2023
7S2L	Crystal structure of sulfonamide resistance enzyme Sul3 apoenzyme Descriptor: CHLORIDE ION, GLYCEROL, SULFATE ION, ... Authors: Stogios, P.J, Venkatesan, M, Michalska, K, Mesa, N, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID), Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2021-09-03 Release date: 2023-05-03 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.79 Å) Cite: Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics. Nat Commun, 14, 2023
7S2J	Crystal structure of sulfonamide resistance enzyme Sul2 apoenzyme Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... Authors: Stogios, P.J, Skarina, T, Michalska, K, Venkatesan, M, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID), Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2021-09-03 Release date: 2023-05-03 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics. Nat Commun, 14, 2023
7S2I	Crystal structure of sulfonamide resistance enzyme Sul1 in complex with 6-hydroxymethylpterin Descriptor: 6-HYDROXYMETHYLPTERIN, CHLORIDE ION, GLYCEROL, ... Authors: Stogios, P.J, Skarina, T, Kim, Y, Venkatesan, M, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID), Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2021-09-03 Release date: 2023-05-03 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.32 Å) Cite: Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics. Nat Commun, 14, 2023
7S2M	Crystal structure of sulfonamide resistance enzyme Sul3 in complex with 6-hydroxymethylpterin Descriptor: 6-HYDROXYMETHYLPTERIN, Sul3 Authors: Stogios, P.J, Skarina, T, Venkatesan, M, Michalska, K, Mesa, N, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID), Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2021-09-03 Release date: 2023-05-03 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.42 Å) Cite: Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics. Nat Commun, 14, 2023
7MPY	Crystal structure of cytosolic HPPK-DHPS from A.thaliana Descriptor: Folate synthesis bifunctional protein Authors: Vadlamani, G, Bond, C.S. Deposit date: 2021-05-05 Release date: 2021-12-08 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structure of Arabidopsis thaliana HPPK/DHPS, a bifunctional enzyme and target of the herbicide asulam. Plant Commun., 3, 2022
7L6P	Crystal structure of dihydropteroate synthase from Stenotrophomonas maltophilia with active site-bound imidazole Descriptor: Dihydropteroate synthase, IMIDAZOLE Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2020-12-23 Release date: 2021-02-03 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Crystal structure of dihydropteroate synthase from Stenotrophomonas maltophilia with active site-bound imidazole to be published
6UCZ	Crystal structure of dihydropteroate synthase from Anaplasma phagocytophilum with bound 6-hydroxymethylpterin-monophosphate Descriptor: 1,2-ETHANEDIOL, ACETATE ION, CITRIC ACID, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2019-09-18 Release date: 2019-10-16 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of dihydropteroate synthase from Anaplasma phagocytophilum with bound 6-hydroxymethylpterin-monophosphate To be Published
6KCL	Crystal structure of Plasmodium falciparum HPPK-DHPS A437G/K540E with pterin and p-hydroxybenzoate Descriptor: 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, ACETATE ION, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Chitnumsub, P, Jaruwat, A, Yuthavong, Y. Deposit date: 2019-06-28 Release date: 2020-02-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.7 Å) Cite: The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance. Febs J., 287, 2020
6KCK	Crystal structure of Plasmodium falciparum HPPK-DHPS wild type with pterin and p-hydroxybenzoate Descriptor: 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, ACETATE ION, CALCIUM ION, ... Authors: Chitnumsub, P, Jaruwat, A, Yuthavong, Y. Deposit date: 2019-06-28 Release date: 2020-02-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance. Febs J., 287, 2020
6KCM	Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613S with pterin and p-hydrobenzoate Descriptor: 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, ACETATE ION, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Chitnumsub, P, Jaruwat, A, Yuthavong, Y. Deposit date: 2019-06-28 Release date: 2020-02-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance. Febs J., 287, 2020
6JWW	Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613T triple mutant with STZ-DHP Descriptor: 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, 4-{[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}-N-(1,3-thiazol-2-yl)benzenesulfonamide, 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, ... Authors: Chitnumsub, P, Jaruwat, A, Yuthavong, Y. Deposit date: 2019-04-21 Release date: 2020-02-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.75 Å) Cite: The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance. Febs J., 287, 2020
6JWY	Crystal structure of Plasmodium falciparum HPPK-DHPS A437G with SDX-DHP Descriptor: 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, 4-[(2-azanyl-4-oxidanylidene-7,8-dihydro-3~{H}-pteridin-6-yl)methylamino]-~{N}-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide, 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, ... Authors: Chitnumsub, P, Jaruwat, A, Yuthavong, Y. Deposit date: 2019-04-21 Release date: 2020-02-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance. Febs J., 287, 2020
6JWX	Crystal structure of Plasmodium falciparum HPPK-DHPS wild type with SDX-DHP Descriptor: 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, 4-[(2-azanyl-4-oxidanylidene-7,8-dihydro-3~{H}-pteridin-6-yl)methylamino]-~{N}-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide, 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, ... Authors: Chitnumsub, P, Jaruwat, A, Yuthavong, Y. Deposit date: 2019-04-21 Release date: 2020-02-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance. Febs J., 287, 2020
6JWV	Crystal structure of Plasmodium falciparum HPPK-DHPS A437G with STZ-DHP Descriptor: 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, 4-{[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}-N-(1,3-thiazol-2-yl)benzenesulfonamide, 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, ... Authors: Chitnumsub, P, Jaruwat, A, Yuthavong, Y. Deposit date: 2019-04-21 Release date: 2020-02-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.7 Å) Cite: The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance. Febs J., 287, 2020
6JWT	Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613T triple mutant with Pteroate Descriptor: 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, ACETATE ION, ADENOSINE MONOPHOSPHATE, ... Authors: Chitnumsub, P, Jaruwat, A, Yuthavong, Y. Deposit date: 2019-04-21 Release date: 2020-02-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.56 Å) Cite: The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance. Febs J., 287, 2020
6JWR	Crystal structure of Plasmodium falciparum HPPK-DHPS wild type with Pteroate Descriptor: 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, ACETATE ION, ... Authors: Chitnumsub, P, Jaruwat, A, Yuthavong, Y. Deposit date: 2019-04-21 Release date: 2020-02-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.6 Å) Cite: The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance. Febs J., 287, 2020
6JWZ	Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613S triple mutant with SDX-DHP Descriptor: 4-[(2-azanyl-4-oxidanylidene-7,8-dihydro-3~{H}-pteridin-6-yl)methylamino]-~{N}-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide, 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, ACETATE ION, ... Authors: Chitnumsub, P, Jaruwat, A, Yuthavong, Y. Deposit date: 2019-04-21 Release date: 2020-02-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.95 Å) Cite: The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance. Febs J., 287, 2020
6JWU	Crystal structure of Plasmodium falciparum HPPK-DHPS wild type with STZ-DHP Descriptor: 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, 4-{[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}-N-(1,3-thiazol-2-yl)benzenesulfonamide, 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, ... Authors: Chitnumsub, P, Jaruwat, A, Yuthavong, Y. Deposit date: 2019-04-21 Release date: 2020-02-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.65 Å) Cite: The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance. Febs J., 287, 2020
6JWQ	Crystal structure of Plasmodium falciparum HPPK-DHPS wild type Descriptor: 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, ACETATE ION, ADENOSINE MONOPHOSPHATE, ... Authors: Chitnumsub, P, Jaruwat, A, Yuthavong, Y. Deposit date: 2019-04-21 Release date: 2020-02-12 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance. Febs J., 287, 2020
6JWS	Crystal structure of Plasmodium falciparum HPPK-DHPS A437G with Pteroate Descriptor: 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, ACETATE ION, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Chitnumsub, P, Jaruwat, A, Yuthavong, Y. Deposit date: 2019-04-21 Release date: 2020-02-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance. Febs J., 287, 2020

 

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