7L78
 
 | | H235C variant of Yeast Ferrochelatase | | Descriptor: | CHOLIC ACID, Ferrochelatase, mitochondrial | | Authors: | Lanzilotta, W.N, Medlock, A.E. | | Deposit date: | 2020-12-27 | | Release date: | 2021-11-24 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Mitochondrial contact site and cristae organizing system (MICOS) machinery supports heme biosynthesis by enabling optimal performance of ferrochelatase.
Redox Biol, 46, 2021
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4MK4
 | | S197C variant of human ferrochelatase. | | Descriptor: | CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, Ferrochelatase, ... | | Authors: | Lanzilotta, W.N, Medlock, A.E, Dailey, T.E, Dailey, H.A. | | Deposit date: | 2013-09-04 | | Release date: | 2013-09-25 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | S197C variant of human ferrochelatase.
To be Published
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3W1W
 | | Protein-drug complex | | Descriptor: | 1,2-ETHANEDIOL, 2-HYDROXYBENZOIC ACID, CHOLIC ACID, ... | | Authors: | Ishii, R, Gupta, V, Yamaguchi, Y, Handa, H, Nureki, O. | | Deposit date: | 2012-11-21 | | Release date: | 2013-10-09 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.006 Å) | | Cite: | Salicylic Acid induces mitochondrial injury by inhibiting ferrochelatase heme biosynthesis activity
Mol.Pharmacol., 84, 2013
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4F4D
 | | F337R variant of human ferrochelatase | | Descriptor: | CHLORIDE ION, CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, ... | | Authors: | Lanzilotta, W.N, Medlock, A.E, Dailey, T.E, Dailey, H.A. | | Deposit date: | 2012-05-10 | | Release date: | 2012-09-12 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | F337R Variant of Human Ferrochelatase
TO BE PUBLISHED
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3AQI
 | | H240A variant of human ferrochelatase | | Descriptor: | CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, Ferrochelatase, ... | | Authors: | Lanzilotta, W.N, Medlock, A.E, Dailey, T.A, Dailey, H.A. | | Deposit date: | 2010-11-03 | | Release date: | 2012-01-25 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | H240A variant of human ferrochelatase
To be published
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3GOQ
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1DOZ
 | | CRYSTAL STRUCTURE OF FERROCHELATASE | | Descriptor: | FERROCHELATASE, MAGNESIUM ION | | Authors: | Lecerof, D, Fodje, M, Hansson, A, Hansson, M, Al-Karadaghi, S. | | Deposit date: | 1999-12-22 | | Release date: | 2000-01-12 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural and mechanistic basis of porphyrin metallation by ferrochelatase.
J.Mol.Biol., 297, 2000
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6RWV
 | | Structure of apo-LmCpfC | | Descriptor: | Ferrochelatase, GLYCEROL, PHOSPHATE ION, ... | | Authors: | Hofbauer, S, Helm, J, Djinovic-Carugo, K, Furtmueller, P.G. | | Deposit date: | 2019-06-06 | | Release date: | 2019-12-18 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.6386379 Å) | | Cite: | Crystal structures and calorimetry reveal catalytically relevant binding mode of coproporphyrin and coproheme in coproporphyrin ferrochelatase.
Febs J., 287, 2020
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8OFL
 | | Coproporphyrin III - LmCpfC complex soaked 4min with Fe2+ | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Coproporphyrin III ferrochelatase, ... | | Authors: | Gabler, T, Hofbauer, S. | | Deposit date: | 2023-03-16 | | Release date: | 2023-04-05 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Iron insertion into coproporphyrin III-ferrochelatase complex: Evidence for an intermediate distorted catalytic species.
Protein Sci., 32, 2023
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8OMM
 | | Coproporphyrin III - LmCpfC complex soaked 3min with Fe2+ | | Descriptor: | 1,2-ETHANEDIOL, Coproporphyrin III ferrochelatase, FE (II) ION, ... | | Authors: | Gabler, T, Hofbauer, S. | | Deposit date: | 2023-03-31 | | Release date: | 2023-05-03 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Iron insertion into coproporphyrin III-ferrochelatase complex: Evidence for an intermediate distorted catalytic species.
Protein Sci., 32, 2023
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7CT7
 | | FECH - inhibitor complex 2 | | Descriptor: | 2-[[(4-chlorophenyl)amino]methyl]-5-propyl-6H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one, FE2/S2 (INORGANIC) CLUSTER, Ferrochelatase, ... | | Authors: | Lee, S.J, Park, J. | | Deposit date: | 2020-08-18 | | Release date: | 2021-08-18 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | FECH - inhibitor complex 1
to be published
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7CTC
 | | FECH - inhibitor complex 1 | | Descriptor: | 2-(4-tert-butylphenyl)-5-[(quinolin-2-ylamino)methyl]-6H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one, FE2/S2 (INORGANIC) CLUSTER, Ferrochelatase, ... | | Authors: | Lee, S.J, Park, J. | | Deposit date: | 2020-08-18 | | Release date: | 2021-08-18 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | FECH - inhibitor complex 1
to be published
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6SV3
 | | Structure of coproheme-LmCpfC | | Descriptor: | 1,3,5,8-TETRAMETHYL-PORPHINE-2,4,6,7-TETRAPROPIONIC ACID FERROUS COMPLEX, Ferrochelatase, GLYCEROL | | Authors: | Hofbauer, S, Helm, J, Djinovic-Carugo, K, Furtmueller, P.G. | | Deposit date: | 2019-09-17 | | Release date: | 2019-12-18 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.64000869 Å) | | Cite: | Crystal structures and calorimetry reveal catalytically relevant binding mode of coproporphyrin and coproheme in coproporphyrin ferrochelatase.
Febs J., 287, 2020
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1HRK
 | | CRYSTAL STRUCTURE OF HUMAN FERROCHELATASE | | Descriptor: | CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, FERROCHELATASE | | Authors: | Wu, C.K, Dailey, H.A, Rose, J.P, Burden, A, Sellers, V.M, Wang, B.-C. | | Deposit date: | 2000-12-21 | | Release date: | 2001-06-22 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The 2.0 A structure of human ferrochelatase, the terminal enzyme of heme biosynthesis.
Nat.Struct.Biol., 8, 2001
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2AC2
 | | Crystal structure of the Tyr13Phe mutant variant of Bacillus subtilis Ferrochelatase with Zn(2+) bound at the active site | | Descriptor: | Ferrochelatase, ZINC ION | | Authors: | Shipovskov, S, Karlberg, T, Fodje, M, Hansson, M.D, Ferreira, G.C, Hansson, M, Reimann, C.T, Al-Karadaghi, S. | | Deposit date: | 2005-07-18 | | Release date: | 2005-09-20 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Metallation of the Transition-state Inhibitor N-methyl Mesoporphyrin by Ferrochelatase: Implications for the Catalytic Reaction Mechanism.
J.Mol.Biol., 352, 2005
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2AC4
 | | Crystal structure of the His183Cys mutant variant of Bacillus subtilis Ferrochelatase | | Descriptor: | Ferrochelatase | | Authors: | Shipovskov, S, Karlberg, T, Fodje, M, Hansson, M.D, Ferreira, G.C, Hansson, M, Reimann, C.T, Al-Karadaghi, S. | | Deposit date: | 2005-07-18 | | Release date: | 2005-09-20 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Metallation of the Transition-state Inhibitor N-methyl Mesoporphyrin by Ferrochelatase: Implications for the Catalytic Reaction Mechanism.
J.Mol.Biol., 352, 2005
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8BBV
 | | Coproporphyrin III - LmCpfC complex soaked 2min with Fe2+ | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Coproporphyrin III ferrochelatase, ... | | Authors: | Gabler, T, Hofbauer, S. | | Deposit date: | 2022-10-14 | | Release date: | 2023-01-11 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.19 Å) | | Cite: | Iron insertion into coproporphyrin III-ferrochelatase complex: Evidence for an intermediate distorted catalytic species.
Protein Sci., 32, 2023
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8AT8
 | | Structure of coproporphyrin III-LmCpfC | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... | | Authors: | Gabler, T, Hofbauer, S. | | Deposit date: | 2022-08-22 | | Release date: | 2022-12-28 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.51 Å) | | Cite: | Active site architecture of coproporphyrin ferrochelatase with its physiological substrate coproporphyrin III: Propionate interactions and porphyrin core deformation.
Protein Sci., 32, 2023
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8AW7
 | | Structure of coproporphyrin III-LmCpfC R45L | | Descriptor: | Coproporphyrin III ferrochelatase, GLYCEROL, coproporphyrin III | | Authors: | Gabler, T, Hofbauer, S, Pfanzagl, V. | | Deposit date: | 2022-08-29 | | Release date: | 2022-12-28 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.64 Å) | | Cite: | Active site architecture of coproporphyrin ferrochelatase with its physiological substrate coproporphyrin III: Propionate interactions and porphyrin core deformation.
Protein Sci., 32, 2023
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1AK1
 | | FERROCHELATASE FROM BACILLUS SUBTILIS | | Descriptor: | FERROCHELATASE | | Authors: | Al-Karadaghi, S, Hansson, M, Nikonov, S, Jonsson, B, Hederstedt, L. | | Deposit date: | 1997-05-28 | | Release date: | 1997-12-03 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of ferrochelatase: the terminal enzyme in heme biosynthesis.
Structure, 5, 1997
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1C1H
 | | CRYSTAL STRUCTURE OF BACILLUS SUBTILIS FERROCHELATASE IN COMPLEX WITH N-METHYL MESOPORPHYRIN | | Descriptor: | FERROCHELATASE, MAGNESIUM ION, N-METHYLMESOPORPHYRIN | | Authors: | Lecerof, D, Fodje, M, Hansson, A, Hansson, M, Al-Karadaghi, S. | | Deposit date: | 1999-07-22 | | Release date: | 2000-03-17 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural and mechanistic basis of porphyrin metallation by ferrochelatase.
J.Mol.Biol., 297, 2000
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1C9E
 | | STRUCTURE OF FERROCHELATASE WITH COPPER(II) N-METHYLMESOPORPHYRIN COMPLEX BOUND AT THE ACTIVE SITE | | Descriptor: | MAGNESIUM ION, N-METHYLMESOPORPHYRIN CONTAINING COPPER, PROTOHEME FERROLYASE | | Authors: | Lecerof, D, Fodje, M.N, Hansson, A, Hansson, M, Al-Karadaghi, S. | | Deposit date: | 1999-08-02 | | Release date: | 2000-03-22 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural and mechanistic basis of porphyrin metallation by ferrochelatase.
J.Mol.Biol., 297, 2000
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2C8J
 | | CRYSTAL STRUCTURE OF ferrochelatase HemH-1 from Bacillus anthracis, str. Ames | | Descriptor: | FERROCHELATASE 1 | | Authors: | Muller, A, Lebedev, A.A, Moroz, O.V, Blagova, E.V, Levdikov, V.M, Fogg, M.J, Brannigan, J.A, Wilkinson, A.J, Wilson, K.S. | | Deposit date: | 2005-12-05 | | Release date: | 2007-05-01 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal Structure of Ferrochelatase Hemh-1 from Bacillus Anthracis, Str. Ames
To be Published
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1LBQ
 | | The crystal structure of Saccharomyces cerevisiae ferrochelatase | | Descriptor: | Ferrochelatase | | Authors: | Karlberg, T, Lecerof, D, Gora, M, Silvegren, G, Labbe-Bois, R, Hansson, M, Al-Karadaghi, S. | | Deposit date: | 2002-04-04 | | Release date: | 2002-11-20 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Metal binding to Saccharomyces cerevisiae ferrochelatase
Biochemistry, 41, 2002
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1L8X
 | | Crystal Structure of Ferrochelatase from the Yeast, Saccharomyces cerevisiae, with Cobalt(II) as the Substrate Ion | | Descriptor: | COBALT (II) ION, Ferrochelatase | | Authors: | Karlberg, T, Lecerof, D, Gora, M, Silvegren, G, Labbe-Bois, R, Hansson, M, Al-Karadaghi, S. | | Deposit date: | 2002-03-22 | | Release date: | 2002-11-20 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Metal Binding to Saccharomyces cerevisiae Ferrochelatase
Biochemistry, 41, 2002
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