1BBN
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THREE-DIMENSIONAL SOLUTION STRUCTURE OF HUMAN INTERLEUKIN-4 BY MULTI-DIMENSIONAL HETERONUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
Descriptor:INTERLEUKIN-4
Authors:Clore, G.M., Powers, B., Garrett, D.S., Gronenborn, A.M.
Deposit date:1992-05-01
Release date:1993-10-31
Last modified:2012-09-05
Method:SOLUTION NMR
Cite:Three-dimensional solution structure of human interleukin-4 by multidimensional heteronuclear magnetic resonance spectroscopy.
Science, 256, 1992
1BCN
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THREE-DIMENSIONAL SOLUTION STRUCTURE OF HUMAN INTERLEUKIN-4 BY MULTI-DIMENSIONAL HETERONUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
Descriptor:INTERLEUKIN-4
Authors:Clore, G.M., Powers, B., Garrett, D.S., Gronenborn, A.M.
Deposit date:1992-05-01
Release date:1993-10-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Three-dimensional solution structure of human interleukin-4 by multidimensional heteronuclear magnetic resonance spectroscopy.
Science, 256, 1992
1CYL
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ASPECTS OF RECEPTOR BINDING AND SIGNALLING OF INTERLEUKIN-4 INVESTIGATED BY SITE-DIRECTED MUTAGENESIS AND NMR SPECTROSCOPY
Descriptor:INTERLEUKIN-4
Authors:Mueller, T., Sebald, W., Oschkinat, H.
Deposit date:1994-02-21
Release date:1994-09-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Aspects of receptor binding and signalling of interleukin-4 investigated by site-directed mutagenesis and NMR spectroscopy.
J.Mol.Biol., 237, 1994
1HIJ
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INTERLEUKIN-4 MUTANT WITH ARG 88 REPLACED WITH GLN (R88Q)
Descriptor:INTERLEUKIN-4
Authors:Mueller, T., Buehner, M.
Deposit date:1995-06-01
Release date:1996-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Human interleukin-4 and variant R88Q: phasing X-ray diffraction data by molecular replacement using X-ray and nuclear magnetic resonance models.
J.Mol.Biol., 247, 1995
1HIK
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INTERLEUKIN-4 (WILD-TYPE)
Descriptor:INTERLEUKIN-4
Authors:Mueller, T., Buehner, M.
Deposit date:1995-06-01
Release date:1996-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Human interleukin-4 and variant R88Q: phasing X-ray diffraction data by molecular replacement using X-ray and nuclear magnetic resonance models.
J.Mol.Biol., 247, 1995
1HZI
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INTERLEUKIN-4 MUTANT E9A
Descriptor:INTERLEUKIN-4, SULFATE ION
Authors:Hulsmeyer, M., Scheufler, C., Dreyer, M.K.
Deposit date:2001-01-25
Release date:2001-08-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure of interleukin 4 mutant E9A suggests polar steering in receptor-complex formation.
Acta Crystallogr.,Sect.D, 57, 2001
1ITI
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THE HIGH RESOLUTION THREE-DIMENSIONAL SOLUTION STRUCTURE OF HUMAN INTERLEUKIN-4 DETERMINED BY MULTI-DIMENSIONAL HETERONUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
Descriptor:INTERLEUKIN-4
Authors:Clore, G.M., Powers, B., Garrett, D.S., Gronenborn, A.M.
Deposit date:1993-04-12
Release date:1993-07-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The high-resolution, three-dimensional solution structure of human interleukin-4 determined by multidimensional heteronuclear magnetic resonance spectroscopy.
Biochemistry, 32, 1993
1ITL
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HUMAN INTERLEUKIN 4: THE SOLUTION STRUCTURE OF A FOUR-HELIX-BUNDLE PROTEIN
Descriptor:INTERLEUKIN-4
Authors:Smith, L.J., Redfield, C., Boyd, J., Lawrence, G.M.P., Edwards, R.G., Smith, R.A.G., Dobson, C.M.
Deposit date:1992-02-08
Release date:1993-04-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Human interleukin 4. The solution structure of a four-helix bundle protein.
J.Mol.Biol., 224, 1992
1ITM
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ANALYSIS OF THE SOLUTION STRUCTURE OF HUMAN INTERLEUKIN 4 DETERMINED BY HETERONUCLEAR THREE-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE TECHNIQUES
Descriptor:INTERLEUKIN-4
Authors:Redfield, C., Smith, L.J., Boyd, J., Lawrence, G.M.P., Edwards, R.G., Gershater, C.J., Smith, R.A.G., Dobson, C.M.
Deposit date:1994-02-28
Release date:1994-05-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Analysis of the solution structure of human interleukin-4 determined by heteronuclear three-dimensional nuclear magnetic resonance techniques.
J.Mol.Biol., 238, 1994
1RCB
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CRYSTAL STRUCTURE OF HUMAN RECOMBINANT INTERLEUKIN-4 AT 2.25 ANGSTROMS RESOLUTION
Descriptor:INTERLEUKIN-4
Authors:Wlodawer, A., Pavlovsky, A., Gustchina, A.
Deposit date:1992-08-26
Release date:1993-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of human recombinant interleukin-4 at 2.25 A resolution.
FEBS Lett., 309, 1992
2B8U
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CRYSTAL STRUCTURE OF WILDTYPE HUMAN INTERLEUKIN-4
Descriptor:Interleukin-4, SULFATE ION
Authors:Kraich, M., Klein, M., Patino, E., Harrer, H., Sebald, W., Mueller, T.D.
Deposit date:2005-10-10
Release date:2006-05-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
2B8X
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CRYSTAL STRUCTURE OF THE INTERLEUKIN-4 VARIANT F82D
Descriptor:Interleukin-4, SULFATE ION
Authors:Kraich, M., Klein, M., Patino, E., Harrer, H., Sebald, W., Mueller, T.D.
Deposit date:2005-10-10
Release date:2006-05-30
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
2B8Y
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CRYSTAL STRUCTURE OF THE INTERLEUKIN-4 VARIANT T13DF82D
Descriptor:Interleukin-4, SULFATE ION
Authors:Kraich, M., Klein, M., Patino, E., Harrer, H., Sebald, W., Mueller, T.D.
Deposit date:2005-10-10
Release date:2006-05-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
2B8Z
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CRYSTAL STRUCTURE OF THE INTERLEUKIN-4 VARIANT R85A
Descriptor:Interleukin-4, SULFATE ION
Authors:Kraich, M., Klein, M., Patino, E., Harrer, H., Sebald, W., Mueller, T.D.
Deposit date:2005-10-10
Release date:2006-05-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
2B90
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CRYSTAL STRUCTURE OF THE INTERLEUKIN-4 VARIANT T13DR85A
Descriptor:Interleukin-4, SULFATE ION
Authors:Kraich, M., Klein, M., Patino, E., Harrer, H., Sebald, W., Mueller, T.D.
Deposit date:2005-10-10
Release date:2006-05-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
2B91
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CRYSTAL STRUCTURE OF THE INTERLEUKIN-4 VARIANT F82DR85A
Descriptor:Interleukin-4, SULFATE ION
Authors:Kraich, M., Klein, M., Patino, E., Harrer, H., Sebald, W., Mueller, T.D.
Deposit date:2005-10-10
Release date:2006-05-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
2CYK
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ASPECTS OF RECEPTOR BINDING AND SIGNALLING OF INTERLEUKIN-4 INVESTIGATED BY SITE-DIRECTED MUTAGENESIS AND NMR SPECTROSCOPY
Descriptor:INTERLEUKIN-4
Authors:Mueller, T., Sebald, W., Oschkinat, H.
Deposit date:1994-08-16
Release date:1994-12-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Aspects of receptor binding and signalling of interleukin-4 investigated by site-directed mutagenesis and NMR spectroscopy.
J.Mol.Biol., 237, 1994
2D48
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CRYSTAL STRUCTURE OF THE INTERLEUKIN-4 VARIANT T13D
Descriptor:Interleukin-4, SULFATE ION
Authors:Kraich, M., Klein, M., Patino, E., Harrer, H., Sebald, W., Mueller, T.D.
Deposit date:2005-10-11
Release date:2006-05-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
2INT
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CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-4
Descriptor:INTERLEUKIN-4
Authors:Walter, M.R., Cook, W.J., Zhao, B.G., Cameron Junior, R., Ealick, S.E., Walter Junior, R.L., Reichert, P., Nagabhushan, T.L., Trotta, P.P., Bugg, C.E.
Deposit date:1993-07-22
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structure of recombinant human interleukin-4.
J.Biol.Chem., 267, 1992
4YDY
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CRYSTAL STRUCTURE OF DARPIN 44C12V5 IN COMPLEX WITH HUMAN IL-4
Descriptor:DARPIN 44C12V5, Interleukin-4, GLYCEROL, ...
Authors:Teplyakov, A., Obmolova, G., Gilliland, G.
Deposit date:2015-02-23
Release date:2015-03-04
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:CRYSTAL STRUCTURE OF DARPIN 44C12V5 IN COMPLEX WITH HUMAN IL-4
To Be Published
1IAR
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INTERLEUKIN-4 / RECEPTOR ALPHA CHAIN COMPLEX
Descriptor:PROTEIN (INTERLEUKIN-4), PROTEIN (INTERLEUKIN-4 RECEPTOR ALPHA CHAIN)
Authors:Hage, T., Sebald, W., Reinemer, P.
Deposit date:1999-02-25
Release date:2000-03-03
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface.
Cell(Cambridge,Mass.), 97, 1999
3BPL
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CRYSTAL STRUCTURE OF THE IL4-IL4R-COMMON GAMMA TERNARY COMPLEX
Descriptor:Interleukin-4, Interleukin-4 receptor alpha chain, Cytokine receptor common gamma chain, ...
Authors:Garcia, K.C.
Deposit date:2007-12-18
Release date:2008-02-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System.
Cell(Cambridge,Mass.), 132, 2008
3BPN
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CRYSTAL STRUCTURE OF THE IL4-IL4R-IL13RA TERNARY COMPLEX
Descriptor:Interleukin-4, Interleukin-4 receptor alpha chain, Interleukin-13 receptor alpha-1 chain, ...
Authors:Garcia, K.C.
Deposit date:2007-12-18
Release date:2008-02-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System.
Cell(Cambridge,Mass.), 132, 2008
3QB7
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INTERLEUKIN-4 MUTANT RGA BOUND TO CYTOKINE RECEPTOR COMMON GAMMA
Descriptor:Interleukin 4, Cytokine receptor common subunit gamma, SULFATE ION, ...
Authors:Bates, D.L., Junttila, I.S., Creusot, R.J., Moraga, I., Lupardus, P., Fathman, C.G., Paul, W.E., Garcia, K.C.
Deposit date:2011-01-12
Release date:2012-04-25
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.245 Å)
Cite:Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines.
Nat.Chem.Biol., 8, 2012
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