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7DR4
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BU of 7dr4 by Molmil
Complex of anti-human IL-2 antibody and human IL-2
Descriptor: Interleukin-2, anti-human IL-2 antibody, mouse Ig G, ...
Authors:Kim, M.S, Kim, J.E.
Deposit date:2020-12-25
Release date:2021-04-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Crystal structure of human interleukin-2 in complex with TCB2, a new antibody-drug candidate with antitumor activity.
Oncoimmunology, 10, 2021
7M2G
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BU of 7m2g by Molmil
INTERLEUKIN-2 (human) mutant P65K, C125S
Descriptor: GLYCEROL, Interleukin-2, SULFATE ION
Authors:Ptacin, J.L, Milla, M.E, Steinbacher, S, Maskos, K, Thomsen, M.
Deposit date:2021-03-16
Release date:2021-08-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism.
Nat Commun, 12, 2021
3INK
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BU of 3ink by Molmil
UNRAVELING THE STRUCTURE OF INTERLEUKIN-2: REPLY
Descriptor: INTERLEUKIN-2
Authors:Mckay, D.B, Brandhuber, B.J.
Deposit date:1992-12-09
Release date:1993-10-31
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Response.
Science, 257, 1992
7RA9
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BU of 7ra9 by Molmil
Designed StabIL-2 seq1
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Interleukin-2, PHOSPHATE ION
Authors:Jude, K.M, Chu, A.E, Huang, P.-S, Garcia, K.C.
Deposit date:2021-06-30
Release date:2022-03-16
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Interleukin-2 superkines by computational design.
Proc.Natl.Acad.Sci.USA, 119, 2022
7RAA
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BU of 7raa by Molmil
Designed StabIL-2 seq15
Descriptor: Interleukin-2, MAGNESIUM ION
Authors:Jude, K.M, Chu, A.E, Huang, P.-S, Garcia, K.C.
Deposit date:2021-06-30
Release date:2022-03-16
Last modified:2023-03-29
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Interleukin-2 superkines by computational design.
Proc.Natl.Acad.Sci.USA, 119, 2022
5LQB
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BU of 5lqb by Molmil
Complex structure of human IL2 mutant, Proleukin, with Fab fragment of NARA1 antibody
Descriptor: Interleukin-2, anti-hIL2 FAB fragment heavy chain, anti-hIL2 FAB fragment light chain
Authors:Zou, C, Wirth, E.
Deposit date:2016-08-16
Release date:2016-12-14
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Improved cancer immunotherapy by a CD25-mimobody conferring selectivity to human interleukin-2.
Sci Transl Med, 8, 2016
6YE3
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BU of 6ye3 by Molmil
IL-2 in complex with a Fab fragment from UFKA-20
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chains: A,D,G, Chains: B,E,H, ...
Authors:Karakus, U, Mittl, P, Boyman, O.
Deposit date:2020-03-23
Release date:2020-12-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Receptor-gated IL-2 delivery by an anti-human IL-2 antibody activates regulatory T cells in three different species.
Sci Transl Med, 12, 2020
4NEM
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BU of 4nem by Molmil
Small molecular fragment bound to crystal contact interface of Interleukin-2
Descriptor: 5-[(2,3-dichlorophenoxy)methyl]furan-2-carboxylic acid, Interleukin-2
Authors:Jehle, S, Brenke, R, Vajda, S, Allen, K.N, Kozakov, D.
Deposit date:2013-10-29
Release date:2014-11-19
Method:X-RAY DIFFRACTION (1.934 Å)
Cite:Small molecular fragments bound to binding energy hot-spot in crystal contact interface of Interleukin-2
To be Published
4NEJ
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BU of 4nej by Molmil
Small molecular fragment bound to crystal contact interface of Interleukin-2
Descriptor: 5-methylfuran-2-carboxylic acid, Interleukin-2
Authors:Brenke, R, Jehle, S, Vajda, S, Allen, K.N, Kozakov, D.
Deposit date:2013-10-29
Release date:2014-11-19
Method:X-RAY DIFFRACTION (1.919 Å)
Cite:Small molecular fragments bound to binding energy hot-spot in crystal contact interface of Interleukin-2
To be Published
3QB1
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BU of 3qb1 by Molmil
Interleukin-2 mutant D10
Descriptor: Interleukin-2
Authors:Levin, A.M, Bates, D.L, Ring, A.M, Lin, J.T, Su, L, Krieg, C, Bowman, G.R, Novick, P, Pande, V.S, Khort, H.E, Boyman, O, Fathman, C.G, Garcia, K.C.
Deposit date:2011-01-12
Release date:2012-04-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'
Nature, 484, 2012
4YUE
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BU of 4yue by Molmil
Mouse IL-2 Bound to S4B6 Fab Fragment
Descriptor: GLYCEROL, Interleukin-2, S4B6 Fab heavy chain, ...
Authors:Spangler, J.B, Jude, K.M, Garcia, K.C.
Deposit date:2015-03-18
Release date:2015-07-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.194 Å)
Cite:Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms.
Immunity, 42, 2015
4YQX
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BU of 4yqx by Molmil
Mouse IL-2 Bound to JES6-1 scFv Fragment
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-2, JES6-1 VH domain, ...
Authors:Spangler, J.B, Luca, V.C, Jude, K.M, Garcia, K.C.
Deposit date:2015-03-13
Release date:2015-07-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.826 Å)
Cite:Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms.
Immunity, 42, 2015
4ZF7
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BU of 4zf7 by Molmil
Crystal structure of ferret interleukin-2
Descriptor: DI(HYDROXYETHYL)ETHER, Interleukin 2, PENTAETHYLENE GLYCOL, ...
Authors:Ren, B, Newman, J, McKinstry, W.J, Adams, T.E.
Deposit date:2015-04-21
Release date:2015-11-04
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.893 Å)
Cite:Structural and functional characterisation of ferret interleukin-2.
Dev.Comp.Immunol., 55, 2015
1NBP
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BU of 1nbp by Molmil
Crystal Structure Of Human Interleukin-2 Y31C Covalently Modified At C31 With 3-Mercapto-1-(1,3,4,9-tetrahydro-B-carbolin-2-yl)-propan-1-one
Descriptor: 3-MERCAPTO-1-(1,3,4,9-TETRAHYDRO-B-CARBOLIN-2-YL)-PROPAN-1-ONE, Interleukin-2, SULFATE ION
Authors:Hyde, J, Braisted, A.C, Randal, M, Arkin, M.R.
Deposit date:2002-12-03
Release date:2002-12-18
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery and characterization of cooperative ligand binding in the adaptive region of interleukin-2
Biochemistry, 42, 2003
1PW6
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BU of 1pw6 by Molmil
Low Micromolar Small Molecule Inhibitor of IL-2
Descriptor: 2-CYCLOHEXYL-N-(2-{4-[5-(2,3-DICHLORO-PHENYL)-2H-PYRAZOL-3-YL]-PIPERIDIN-1-YL}-2-OXO-ETHYL)-2-GUANIDINO-ACETAMIDE, Interleukin-2, SULFATE ION
Authors:Thanos, C.D, Randal, M, Wells, J.A.
Deposit date:2003-06-30
Release date:2004-01-13
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Potent small-molecule binding to a dynamic hot spot on IL-2.
J.Am.Chem.Soc., 125, 2003
1PY2
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BU of 1py2 by Molmil
Structure of a 60 nM Small Molecule Bound to a Hot Spot on IL-2
Descriptor: 5-[2,3-DICHLORO-4-(5-{1-[2-(2-GUANIDINO-4-METHYL-PENTANOYLAMINO)-ACETYL]-PIPERIDIN-4-YL}-1-METHYL-1H-PYRAZOL-3-YL)-PHENOXYMETHYL]-FURAN-2-CARBOXYLIC ACID, Interleukin-2, ZINC ION
Authors:Thanos, C.D, Randal, M, Wells, J.A.
Deposit date:2003-07-07
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Potent small-molecule binding to a dynamic hot spot on IL-2.
J.Am.Chem.Soc., 125, 2003
1QVN
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BU of 1qvn by Molmil
Structure of SP4160 Bound to IL-2 V69A
Descriptor: 2-GUANIDINO-4-METHYL-PENTANOIC ACID [2-(4-{5-[4-(4-ACETYLAMINO-BENZYLOXY)-2,3-DICHLORO-PHENYL]-2-METHYL-2H-PYRAZOL-3-YL}-PIPERIDIN-1-YL)-2-OXO-ETHYL]-AMIDE, Interleukin-2, ZINC ION
Authors:Thanos, C.D, Delano, W.L, Wells, J.A.
Deposit date:2003-08-28
Release date:2005-04-05
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Hot-spot mimicry of a cytokine receptor by a small molecule.
Proc.Natl.Acad.Sci.USA, 103, 2006
1IRL
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BU of 1irl by Molmil
THE SOLUTION STRUCTURE OF THE F42A MUTANT OF HUMAN INTERLEUKIN 2
Descriptor: INTERLEUKIN-2
Authors:Mott, H.R, Baines, B.S, Hall, R.M, Cooke, R.M, Driscoll, P.C, Weir, M.P, Campbell, I.D.
Deposit date:1995-08-25
Release date:1995-12-07
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:The solution structure of the F42A mutant of human interleukin 2.
J.Mol.Biol., 247, 1995
1M4B
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BU of 1m4b by Molmil
Crystal Structure of Human Interleukin-2 K43C Covalently Modified at C43 with 2-[2-(2-Cyclohexyl-2-guanidino-acetylamino)-acetylamino]-N-(3-mercapto-propyl)-propionamide
Descriptor: 2-[2-(2-CYCLOHEXYL-2-GUANIDINO-ACETYLAMINO)-ACETYLAMINO]-N-(3-MERCAPTO-PROPYL)-PROPIONAMIDE, interleukin-2
Authors:Arkin, M.A, Randal, M, DeLano, W.L, Hyde, J, Luong, T.N, Oslob, J.D, Raphael, D.R, Taylor, L, Wang, J, McDowell, R.S, Wells, J.A, Braisted, A.C.
Deposit date:2002-07-02
Release date:2002-07-31
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Binding of small molecules to an adaptive protein-protein interface
Proc.Natl.Acad.Sci.USA, 100, 2003
1M48
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BU of 1m48 by Molmil
Crystal Structure of Human IL-2 Complexed with (R)-N-[2-[1-(Aminoiminomethyl)-3-piperidinyl]-1-oxoethyl]-4-(phenylethynyl)-L-phenylalanine methyl ester
Descriptor: 2-[3-METHYL-4-(N-METHYL-GUANIDINO)-BUTYRYLAMINO]-3-(4-PHENYLETHYNYL-PHENYL)-PROPIONIC ACID METHYL ESTER, interleukin-2
Authors:Arkin, M.A, Randal, M, DeLano, W.L, Hyde, J, Luong, T.N, Oslob, J.D, Raphael, D.R, Taylor, L, Wang, J, McDowell, R.S, Wells, J.A, Braisted, A.C.
Deposit date:2002-07-02
Release date:2002-07-31
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Binding of small molecules to an adaptive protein-protein interface
Proc.Natl.Acad.Sci.USA, 100, 2003
1M47
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BU of 1m47 by Molmil
Crystal Structure of Human Interleukin-2
Descriptor: SULFATE ION, interleukin-2
Authors:Arkin, M.A, Randal, M, DeLano, W.L, Hyde, J, Luong, T.N, Oslob, J.D, Raphael, D.R, Taylor, L, Wang, J, Wells, J.A, McDowell, R.S, Wells, J.A, Braisted, A.C.
Deposit date:2002-07-02
Release date:2002-07-31
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Binding of small molecules to an adaptive protein-protein interface.
Proc.Natl.Acad.Sci.USA, 100, 2003
1M4C
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BU of 1m4c by Molmil
Crystal Structure of Human Interleukin-2
Descriptor: interleukin-2
Authors:Arkin, M.A, Randal, M, DeLano, W.L, Hyde, J, Luong, T.N, Oslob, J.D, Raphael, D.R, Taylor, L, Wang, J, McDowell, R.S, Wells, J.A, Braisted, A.C.
Deposit date:2002-07-02
Release date:2002-07-31
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Binding of small molecules to an adaptive protein-protein interface
Proc.Natl.Acad.Sci.USA, 100, 2003
1M4A
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BU of 1m4a by Molmil
Crystal Structure of Human Interleukin-2 Y31C Covalently Modified at C31 with (1H-Indol-3-yl)-(2-mercapto-ethoxyimino)-acetic acid
Descriptor: (1H-INDOL-3-YL)-(2-MERCAPTO-ETHOXYIMINO)-ACETIC ACID, GLYCEROL, interleukin-2
Authors:Arkin, M.A, Randal, M, DeLano, W.L, Hyde, J, Luong, T.N, Oslob, J.D, Raphael, D.R, Taylor, L, Wang, J, McDowell, R.S, Wells, J.A, Braisted, A.C.
Deposit date:2002-07-02
Release date:2002-07-31
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Binding of small molecules to an adaptive protein-protein interface
Proc.Natl.Acad.Sci.USA, 100, 2003
1M49
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BU of 1m49 by Molmil
Crystal Structure of Human Interleukin-2 Complexed with SP-1985
Descriptor: 2-[2-(1-CARBAMIMIDOYL-PIPERIDIN-3-YL)-ACETYLAMINO]-3-{4-[2-(3-OXALYL-1H-INDOL-7-YL)ETHYL]-PHENYL}-PROPIONIC ACID METHYL ESTER, interleukin-2
Authors:Arkin, M.A, Randal, M, DeLano, W.L, Hyde, J, Luong, T.N, Oslob, J.D, Raphael, D.R, Taylor, L, Wang, J, McDowell, R.S, Wells, J.A, Braisted, A.C.
Deposit date:2002-07-02
Release date:2002-07-31
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Binding of small molecules to an adaptive protein-protein interface
Proc.Natl.Acad.Sci.USA, 100, 2003
5UTZ
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BU of 5utz by Molmil
Human IL-2/Fab complex
Descriptor: Fab 5111 heavy chain, Fab 5111 light chain, GLYCEROL, ...
Authors:Jude, K.M, Garcia, K.C.
Deposit date:2017-02-15
Release date:2018-07-11
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.747 Å)
Cite:A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism.
Nat. Med., 24, 2018

 

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數據於2024-03-27公開中

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