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8GJF
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BU of 8gjf by Molmil
afupcna bound with peptide mimetic
Descriptor: LYS-ARG-ARG-GLN-THR-SER-MET-THR-ASP-PHE-TYR-HIS-SER-LYS-ARG, Proliferating cell nuclear antigen
Authors:Vandborg, B, Bruning, J.B.
Deposit date:2023-03-15
Release date:2024-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Towards a High-Affinity Peptidomimetic Targeting Proliferating Cell Nuclear Antigen from Aspergillus fumigatus.
J Fungi, 9, 2023
8GJ5
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BU of 8gj5 by Molmil
fungal pcna and peptidomimetic
Descriptor: Proliferating cell nuclear antigen, THR-ASP-ILE-ARG-ASN-PHE-PHE-HIS-SER
Authors:Vandborg, B, Bruning, J.B.
Deposit date:2023-03-14
Release date:2024-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Towards a High-Affinity Peptidomimetic Targeting Proliferating Cell Nuclear Antigen from Aspergillus fumigatus.
J Fungi, 9, 2023
8PPU
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BU of 8ppu by Molmil
Pyrococcus abyssi DNA polymerase D (PolD) in its editing mode bound to a primer/template substrate containing three consecutive mismatches
Descriptor: DNA (5'-D(P*AP*GP*CP*AP*CP*GP*GP*CP*TP*CP*GP*GP*CP*CP*CP*GP*G)-3'), DNA (5'-D(P*CP*CP*GP*GP*GP*CP*CP*GP*AP*GP*CP*CP*GP*TP*(GS)P*(C7R)P*(PST)P*(PST)P*(PST))-3'), DNA polymerase II small subunit, ...
Authors:Betancurt-Anzola, L, Martinez-Carranza, M, Zatopek, K.M, Gardner, A.F, Sauguet, L.
Deposit date:2023-07-10
Release date:2023-12-20
Last modified:2023-12-27
Method:ELECTRON MICROSCOPY (3.02 Å)
Cite:Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases.
Nat Commun, 14, 2023
8PPT
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BU of 8ppt by Molmil
Pyrococcus abyssi DNA polymerase D (PolD) in its editing mode bound to a primer/template substrate containing a mismatch
Descriptor: DNA (5'-D(P*AP*GP*CP*AP*CP*GP*GP*CP*TP*CP*GP*GP*CP*CP*CP*GP*G)-3'), DNA (5'-D(P*CP*CP*GP*GP*GP*CP*CP*GP*AP*GP*CP*CP*GP*TP*GP*CP*TP*TP*T)-3'), DNA polymerase II small subunit, ...
Authors:Betancurt-Anzola, L, Martinez-Carranza, M, Zatopek, K.M, Gardner, A.F, Sauguet, L.
Deposit date:2023-07-10
Release date:2023-12-20
Last modified:2023-12-27
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases.
Nat Commun, 14, 2023
8PPV
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BU of 8ppv by Molmil
Intermediate conformer of Pyrococcus abyssi DNA polymerase D (PolD) bound to a primer/template substrate containing three consecutive mismatches
Descriptor: DNA (5'-D(*P*CP*CP*GP*GP*GP*CP*CP*GP*AP*GP*CP*CP*GP*TP*(GS)P*(G7P)P*(PST)P*(PST)P*(PST))-3'), DNA (5'-D(P*AP*GP*CP*AP*CP*GP*GP*CP*TP*CP*GP*GP*CP*CP*CP*GP*G)-3'), DNA polymerase II small subunit, ...
Authors:Betancurt-Anzola, L, Martinez-Carranza, M, Zatopek, K.M, Gardner, A.F, Sauguet, L.
Deposit date:2023-07-10
Release date:2023-12-20
Last modified:2023-12-27
Method:ELECTRON MICROSCOPY (3.02 Å)
Cite:Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases.
Nat Commun, 14, 2023
8P9O
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BU of 8p9o by Molmil
PCNA from Chaetomium thermophilum in complex with PolD3 peptide
Descriptor: Proliferating cell nuclear antigen, Synthetic peptide corresponding to amino acids 437 to 451 of PolD3 from Chaetomium thermophilum
Authors:Alphey, M.S, Wolford, C.B, MacNeill, S.A.
Deposit date:2023-06-06
Release date:2023-12-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Canonical binding of Chaetomium thermophilum DNA polymerase delta / zeta subunit PolD3 and flap endonuclease Fen1 to PCNA.
Front Mol Biosci, 10, 2023
8Q7I
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BU of 8q7i by Molmil
PCNA from Chaetomium thermophilum in complex with Fen1 peptide
Descriptor: Flap endonuclease 1, Proliferating cell nuclear antigen, SODIUM ION
Authors:Alphey, M.S, Wolford, C.B, MacNeill, S.A.
Deposit date:2023-08-16
Release date:2023-12-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Canonical binding of Chaetomium thermophilum DNA polymerase delta / zeta subunit PolD3 and flap endonuclease Fen1 to PCNA.
Front Mol Biosci, 10, 2023
8F5Q
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BU of 8f5q by Molmil
Crystal structure of human PCNA in complex with the PIP box of FBH1
Descriptor: F-box DNA helicase 1, Proliferating cell nuclear antigen
Authors:Liu, J, Chaves-Arquero, B, Wei, P, Tencer, H, Zhang, G, Blanco, F, Kutateladze, T.
Deposit date:2022-11-15
Release date:2023-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular insight into the PCNA-binding mode of FBH1.
Structure, 31, 2023
8GL9
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BU of 8gl9 by Molmil
Co-crystal structure of caPCNA bound to AOH1160 derivative 1LE
Descriptor: CHLORIDE ION, N~2~-(naphthalene-1-carbonyl)-N-(2-phenoxyphenyl)-L-alpha-glutamine, Proliferating cell nuclear antigen
Authors:Jossart, J, Kenjic, N, Malkas, L.H, Hickey, R.J, Perry, J.J.
Deposit date:2023-03-21
Release date:2023-07-26
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Small molecule targeting of transcription-replication conflict for selective chemotherapy.
Cell Chem Biol, 30, 2023
8GLA
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BU of 8gla by Molmil
Co-crystal structure of caPCNA bound to the AOH1996 derivative, AOH1996-1LE
Descriptor: CHLORIDE ION, N-[2-(3-methoxyphenoxy)phenyl]-N~2~-(naphthalene-1-carbonyl)-L-alpha-glutamine, Proliferating cell nuclear antigen
Authors:Jossart, J, Perry, J.J.
Deposit date:2023-03-21
Release date:2023-07-26
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.77 Å)
Cite:Small molecule targeting of transcription-replication conflict for selective chemotherapy.
Cell Chem Biol, 30, 2023
8COB
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BU of 8cob by Molmil
Crystal structure of human PCNA in complex with ERCC6L2 PIP box peptide
Descriptor: DNA excision repair protein ERCC-6-like 2, Proliferating cell nuclear antigen
Authors:Ariza, A.
Deposit date:2023-02-27
Release date:2023-04-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:ERCC6L2 mitigates replication stress and promotes centromere stability.
Cell Rep, 42, 2023
8E84
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BU of 8e84 by Molmil
Human PCNA mutant- C148S
Descriptor: Proliferating cell nuclear antigen
Authors:Magrino, J, Page, B, Gaubitz, C, Kelch, B.A.
Deposit date:2022-08-25
Release date:2023-04-12
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A thermosensitive PCNA allele underlies an ataxia-telangiectasia-like disorder.
J.Biol.Chem., 299, 2023
7QO1
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BU of 7qo1 by Molmil
complex of DNA ligase I and FEN1 on PCNA and DNA
Descriptor: ADENOSINE MONOPHOSPHATE, DNA ligase 1, Flap endonuclease 1, ...
Authors:Blair, K, Tehseen, M, Raducanu, V.S, Shahid, T, Lancey, C, Cruehet, R, Hamdan, S, De Biasio, A.
Deposit date:2021-12-23
Release date:2023-01-11
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing.
Nat Commun, 13, 2022
7QNZ
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BU of 7qnz by Molmil
human Lig1-DNA-PCNA complex reconstituted in absence of ATP
Descriptor: ADENOSINE MONOPHOSPHATE, DNA ligase 1, Oligo13P, ...
Authors:Blair, K, Tehseen, M, Raducanu, V.S, Shahid, T, Lancey, C, Cruehet, R, Hamdan, S, De Biasio, A.
Deposit date:2021-12-23
Release date:2023-01-11
Method:ELECTRON MICROSCOPY (4.58 Å)
Cite:Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing.
Nat Commun, 13, 2022
8B8T
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BU of 8b8t by Molmil
Open conformation of the complex of DNA ligase I on PCNA and DNA in the presence of ATP
Descriptor: DNA ligase 1, Proliferating cell nuclear antigen
Authors:Blair, K, Tehseen, M, Raducanu, V.S, Shahid, T, Lancey, C, Cruehet, R, Hamdan, S, De Biasio, A.
Deposit date:2022-10-05
Release date:2023-01-11
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing.
Nat Commun, 13, 2022
7TFH
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BU of 7tfh by Molmil
Atomic model of the S. cerevisiae clamp-clamp loader complex PCNA-RFC bound to two DNA molecules, one at the 5'-recessed end and the other at the 3'-recessed end
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H.
Deposit date:2022-01-06
Release date:2022-11-16
Method:ELECTRON MICROSCOPY (3.09 Å)
Cite:Cryo-EM structures reveal that RFC recognizes both the 3'- and 5'-DNA ends to load PCNA onto gaps for DNA repair.
Elife, 11, 2022
7TFI
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BU of 7tfi by Molmil
Atomic model of the S. cerevisiae clamp-clamp loader complex PCNA-RFC bound to DNA with an open clamp
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H.
Deposit date:2022-01-06
Release date:2022-11-16
Method:ELECTRON MICROSCOPY (3.41 Å)
Cite:Cryo-EM structures reveal that RFC recognizes both the 3'- and 5'-DNA ends to load PCNA onto gaps for DNA repair.
Elife, 11, 2022
7TFJ
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BU of 7tfj by Molmil
Atomic model of S. cerevisiae clamp-clamp loader complex PCNA-RFC bound to DNA with a closed clamp ring
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H.
Deposit date:2022-01-06
Release date:2022-11-16
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structures reveal that RFC recognizes both the 3'- and 5'-DNA ends to load PCNA onto gaps for DNA repair.
Elife, 11, 2022
8DR6
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BU of 8dr6 by Molmil
Closed state of RFC:PCNA bound to a nicked dsDNA
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (32-MER), DNA (5'-D(P*CP*CP*CP*CP*CP*CP*GP*GP*CP*CP*CP*CP*CP*CP*CP*GP*GP*C)-3'), ...
Authors:Schrecker, M, Hite, R.K.
Deposit date:2022-07-20
Release date:2022-08-24
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (2.39 Å)
Cite:Multistep loading of a DNA sliding clamp onto DNA by replication factor C.
Elife, 11, 2022
8DQX
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BU of 8dqx by Molmil
Open state of RFC:PCNA bound to a 3' ss/dsDNA junction
Descriptor: DNA (5'-D(*TP*TP*TP*TP*TP*T)-3'), DNA (5'-D(P*TP*CP*CP*GP*AP*GP*CP*GP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*GP*CP*CP*CP*GP*GP*A)-3'), ...
Authors:Schrecker, M, Hite, R.K.
Deposit date:2022-07-20
Release date:2022-08-24
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (2.1 Å)
Cite:Multistep loading of a DNA sliding clamp onto DNA by replication factor C.
Elife, 11, 2022
8DR0
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BU of 8dr0 by Molmil
Closed state of RFC:PCNA bound to a 3' ss/dsDNA junction
Descriptor: DNA (5'-D(P*CP*CP*CP*CP*GP*GP*GP*GP*CP*CP*CP*CP*CP*CP*CP*GP*GP*C)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*CP*GP*GP*GP*GP*GP*GP*GP*CP*CP*CP*CP*GP*GP*GP*G)-3'), GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Schrecker, M, Hite, R.K.
Deposit date:2022-07-20
Release date:2022-08-24
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (2.42 Å)
Cite:Multistep loading of a DNA sliding clamp onto DNA by replication factor C.
Elife, 11, 2022
8DQZ
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BU of 8dqz by Molmil
Intermediate state of RFC:PCNA bound to a 3' ss/dsDNA junction
Descriptor: DNA (5'-D(P*CP*CP*CP*CP*GP*GP*GP*GP*CP*CP*CP*CP*CP*CP*CP*GP*GP*C)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*CP*GP*GP*GP*GP*GP*GP*GP*CP*CP*CP*CP*GP*GP*GP*G)-3'), GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Schrecker, M, Hite, R.K.
Deposit date:2022-07-20
Release date:2022-08-24
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (2.92 Å)
Cite:Multistep loading of a DNA sliding clamp onto DNA by replication factor C.
Elife, 11, 2022
8DR7
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BU of 8dr7 by Molmil
Open state of RFC:PCNA bound to a nicked dsDNA
Descriptor: DNA (26-MER), DNA (5'-D(P*AP*GP*GP*GP*GP*GP*GP*GP*GP*GP*G)-3'), DNA (5'-D(P*GP*GP*CP*CP*CP*CP*CP*CP*CP*GP*GP*C)-3'), ...
Authors:Schrecker, M, Hite, R.K.
Deposit date:2022-07-20
Release date:2022-08-17
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Multistep loading of a DNA sliding clamp onto DNA by replication factor C.
Elife, 11, 2022
8DR4
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BU of 8dr4 by Molmil
Open state of RFC:PCNA bound to a 3' ss/dsDNA junction (DNA2) without NTD
Descriptor: DNA (5'-D(P*AP*AP*GP*GP*GP*GP*GP*GP*GP*GP*GP*G)-3'), DNA (5'-D(P*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*TP*TP*T)-3'), DNA (5'-D(P*CP*CP*CP*CP*CP*CP*GP*GP*CP*CP*CP*CP*CP*CP*CP*GP*GP*C)-3'), ...
Authors:Schrecker, M, Hite, R.K.
Deposit date:2022-07-20
Release date:2022-08-17
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (2.45 Å)
Cite:Multistep loading of a DNA sliding clamp onto DNA by replication factor C.
Elife, 11, 2022
8DR1
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BU of 8dr1 by Molmil
Consensus closed state of RFC:PCNA bound to a 3' ss/dsDNA junction (DNA2)
Descriptor: DNA (5'-D(P*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*TP*TP*T)-3'), DNA (5'-D(P*CP*CP*CP*CP*CP*CP*GP*GP*CP*CP*CP*CP*CP*CP*CP*GP*GP*C)-3'), DNA (5'-D(P*TP*TP*AP*GP*GP*GP*GP*GP*GP*GP*GP*GP*A)-3'), ...
Authors:Schrecker, M, Hite, R.K.
Deposit date:2022-07-20
Release date:2022-08-17
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (2.14 Å)
Cite:Multistep loading of a DNA sliding clamp onto DNA by replication factor C.
Elife, 11, 2022

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PDB entries from 2024-03-27

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