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8UR1	Crystal structure N-acetylneuraminate lyase (NanA) from Klebsiella aerogenes (pyruvate bound halide free active site) Descriptor: CHLORIDE ION, GLYCEROL, N-acetylneuraminate lyase, ... Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-10-25 Release date: 2023-11-08 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structure N-acetylneuraminate lyase (NanA) from Klebsiella aerogenes (pyruvate bound halide free active site) To be published
8U91	Crystal structure of N-acetylneuraminate lyase (NanA) from Klebsiella aerogenes (Apo, Orthorhombic P form) Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, N-acetylneuraminate lyase Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-09-18 Release date: 2023-09-27 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Crystal structure of N-acetylneuraminate lyase (NanA) from Klebsiella aerogenes (Apo, Orthorhombic P form) To be published
8U8W	Crystal structure of N-acetylneuraminate lyase (NanA) from Klebsiella aerogenes (pyruvate and halides bound) Descriptor: CHLORIDE ION, GLYCEROL, IODIDE ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-09-18 Release date: 2023-09-27 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of N-acetylneuraminate lyase (NanA) from Klebsiella aerogenes (pyruvate and halides bound) To be published
8U90	Crystal structure of N-acetylneuraminate lyase (NanA) from Klebsiella aerogenes (Apo, hexagonal form) Descriptor: CHLORIDE ION, GLYCEROL, IODIDE ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-09-18 Release date: 2023-09-27 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Crystal structure of N-acetylneuraminate lyase (NanA) from Klebsiella aerogenes (Apo, hexagonal form) To be published
8U93	Crystal structure of N-acetylneuraminate lyase (NanA) from Klebsiella aerogenes (PEG bound) Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, CHLORIDE ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-09-18 Release date: 2023-09-27 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of N-acetylneuraminate lyase (NanA) from Klebsiella aerogenes (PEG bound) To be published
8U92	Crystal structure of N-acetylneuraminate lyase (NanA) from Klebsiella aerogenes (pyruvate bound, Orthorhombic P form) Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, GLYCEROL, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-09-18 Release date: 2023-09-27 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structure of N-acetylneuraminate lyase (NanA) from Klebsiella aerogenes (pyruvate bound, Orthorhombic P form) To be published
8GEK	Dihydrodipicolinate synthase with pyruvate from Candidatus Liberibacter solanacearum Descriptor: 4-hydroxy-tetrahydrodipicolinate synthase Authors: Gilkes, J.M, Frampton, R.A, Board, A, Sheen, C.R, Smith, G.R, Dobson, R.C.J. Deposit date: 2023-03-06 Release date: 2024-03-20 Method: X-RAY DIFFRACTION (1.93 Å) Cite: Dihydrodipicolinate synthase with pyruvate from the plant pathogen, Candidatus Liberibacter solanacearum To Be Published
8DO5	Crystal structure of NahE in complex with intermediate (R)-4-hydroxy-4-(2-hydroxyphenyl)-2-iminobutanoate Descriptor: (4R)-4-hydroxy-4-(2-hydroxyphenyl)butanoic acid, DIMETHYL SULFOXIDE, Trans-ohydrobenzylidenepyruvate hydratase aldolase Authors: LeVieux, J.A, Hardtke, H.A, Zhang, Y.J. Deposit date: 2022-07-12 Release date: 2022-12-28 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.1 Å) Cite: A mutagenic analysis of NahE, a hydratase-aldolase in the naphthalene degradative pathway. Arch.Biochem.Biophys., 733, 2023
7MJF	Crystal structure of Candidatus Liberibacter solanacearum dihydrodipicolinate synthase with pyruvate and succinic semi-aldehyde bound in active site Descriptor: (4R)-4-oxidanyl-2-oxidanylidene-heptanedioic acid, (4S)-4-hydroxy-2-oxoheptanedioic acid, 4-hydroxy-tetrahydrodipicolinate synthase Authors: Gilkes, J, Frampton, R.A, Board, A.J, Sheen, C.R, Smith, G.R, Dobson, R.C.J. Deposit date: 2021-04-20 Release date: 2021-07-14 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structure of Candidatus Liberibacter solanacearum dihydrodipicolinate synthase with pyruvate and succinic semi-aldehyde bound in active site To Be Published
7MDS	Crystal structure of AtDHDPS1 in complex with MBDTA-2 Descriptor: 4-hydroxy-tetrahydrodipicolinate synthase 1, chloroplastic, CHLORIDE ION, ... Authors: Hall, C.J, Soares da Costa, T.P, Panjikar, S. Deposit date: 2021-04-06 Release date: 2021-08-04 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.295 Å) Cite: Towards novel herbicide modes of action by inhibiting lysine biosynthesis in plants. Elife, 10, 2021
7M06	Dihydrodipicolinate synthase (DHDPS) from C.jejuni, Y110F mutant with R,R-bislysine bound at the allosteric site at 2.7 Angstrom Descriptor: (2R,5R)-2,5-diamino-2,5-bis(4-aminobutyl)hexanedioic acid, 1,2-ETHANEDIOL, 4-hydroxy-tetrahydrodipicolinate synthase, ... Authors: Saran, S, Sanders, D.A.R. Deposit date: 2021-03-10 Release date: 2022-03-16 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.7 Å) Cite: B-FACTOR ANALYSIS SUGGEST THAT L-LYSINE AND R, R-BISLYSINE ALLOSTERICALLY INHIBIT Cj.DHDPS ENZYME BY DECREASING PROTEIN DYNAMICS To Be Published
7LVL	Dihydrodipicolinate synthase bound with allosteric inhibitor (S)-lysine from Candidatus Liberibacter solanacearum Descriptor: 4-hydroxy-tetrahydrodipicolinate synthase, LYSINE Authors: Gilkes, J.M, Frampton, R.A, Board, A.J, Sheen, C.R, Smith, G.R, Dobson, R.C.J.D. Deposit date: 2021-02-25 Release date: 2021-03-10 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Dihydrodipicolinate synthase bound with allosteric inhibitor (S)-lysine from Candidatus Liberibacter solanacearum To Be Published
7LOY	Dihydrodipicolinate synthase with pyruvate from Candidatus Liberibacter solanacearum Descriptor: 4-hydroxy-tetrahydrodipicolinate synthase Authors: Gilkes, J.M, Frampton, R.A, Board, A, Sheen, C.R, Smith, G.R, Dobson, R.C.J. Deposit date: 2021-02-11 Release date: 2021-03-03 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Dihydrodipicolinate synthase with pyruvate from the plant pathogen, Candidatus Liberibacter solanacearum To Be Published
7LCF	Dihydrodipicolinate synthase (DHDPS) from C.jejuni, with pyruvate bound in the active site and L-lysine bound at the allosteric site in C121 space group Descriptor: 4-hydroxy-tetrahydrodipicolinate synthase, LYSINE, MAGNESIUM ION Authors: Saran, S, Sanders, D.A.R. Deposit date: 2021-01-10 Release date: 2022-01-12 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.69 Å) Cite: B-factors: L- lysine and R, R- bisLysine allosterically inhibit Cj. DHDPS Enzyme by decreasing its protein dynamics To Be Published
7LBD	Dihydrodipicolinate synthase (DHDPS) from C.jejuni, H59K mutant with pyruvate bound in the active site in C2221 space group Descriptor: 1,2-ETHANEDIOL, 4-hydroxy-tetrahydrodipicolinate synthase, ACETATE ION, ... Authors: Saran, S, Yazdi, M.M, Sanders, D.A.R. Deposit date: 2021-01-07 Release date: 2022-01-12 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Reversing the roles of a crucial hydrogen-bonding pair: a lysine-insensitive mutant of Campylobacter jejuni dihydrodipicolinate synthase, H59K, binds histidine in its allosteric site To Be Published
7L4B	Dihydrodipicolinate synthase (DHDPS) from C.jejuni with pyruvate bound in the active site in P1211 space group Descriptor: 1,2-ETHANEDIOL, 4-hydroxy-tetrahydrodipicolinate synthase, ACETATE ION, ... Authors: Saran, S, Sanders, D.A.R. Deposit date: 2020-12-18 Release date: 2021-12-22 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.42 Å) Cite: B-FACTOR ANALYSIS SUGGEST THAT L-LYSINE AND R, R-BISLYSINE ALLOSTERICALLY INHIBIT Cj.DHDPS ENZYME BY DECREASING PROTEIN DYNAMICS. To Be Published
7KZ2	Dihydrodipicolinate synthase (DHDPS) from C.jejuni, Y110F mutant with pyruvate bound in the active site and L-lysine bound at the allosteric site in C2221 space group Descriptor: 1,2-ETHANEDIOL, 4-hydroxy-tetrahydrodipicolinate synthase, ACETATE ION, ... Authors: Saran, S, Sanders, D.A.R. Deposit date: 2020-12-09 Release date: 2021-12-15 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: B-FACTOR ANALYSIS SUGGEST THAT L-LYSINE AND R, R-BISLYSINE ALLOSTERICALLY INHIBIT Cj.DHDPS ENZYME BY DECREASING PROTEIN DYNAMICS. To Be Published
7KXG	Dihydrodipicolinate synthase (DHDPS) from C.jejuni with pyruvate bound in the active site and L-histidine bound at the allosteric site Descriptor: 1,2-ETHANEDIOL, 4-hydroxy-tetrahydrodipicolinate synthase, ACETATE ION, ... Authors: Saran, S, Sanders, D.A.R. Deposit date: 2020-12-03 Release date: 2021-12-08 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Reversing the roles of a crucial hydrogen-bonding pair: a lysine-insensitive mutant of Campylobacter jejuni dihydrodipicolinate synthase, H59K, binds histidine in its allosteric site To Be Published
7KXH	Dihydrodipicolinate synthase (DHDPS) from C.jejuni with pyruvate bound in the active site and R,R-bislysine bound at the allosteric site in C2221 space group Descriptor: (2R,5R)-2,5-diamino-2,5-bis(4-aminobutyl)hexanedioic acid, 1,2-ETHANEDIOL, 4-hydroxy-tetrahydrodipicolinate synthase, ... Authors: Saran, S, Sanders, D.A.R. Deposit date: 2020-12-03 Release date: 2021-12-08 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.94 Å) Cite: B-FACTOR ANALYSIS SUGGEST THAT L-LYSINE AND R, R-BISLYSINE ALLOSTERICALLY INHIBIT Cj.DHDPS ENZYME BY DECREASING PROTEIN DYNAMICS. To Be Published
7KX1	Dihydrodipicolinate synthase (DHDPS) from C.jejuni, Y110F mutant with pyruvate bound in the active in C2221 space group Descriptor: 1,2-ETHANEDIOL, 4-hydroxy-tetrahydrodipicolinate synthase, ACETATE ION, ... Authors: Saran, S, Sanders, D.A.R. Deposit date: 2020-12-02 Release date: 2021-12-08 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.04 Å) Cite: B-FACTOR ANALYSIS SUGGEST THAT L-LYSINE AND R, R-BISLYSINE ALLOSTERICALLY INHIBIT Cj.DHDPS ENZYME BY DECREASING PROTEIN DYNAMICS To Be Published
7KWP	Dihydrodipicolinate synthase (DHDPS) from C.jejuni with pyruvate bound in the active site and L-lysine bound at the allosteric site in C2221 space group Descriptor: 1,2-ETHANEDIOL, 4-hydroxy-tetrahydrodipicolinate synthase, DI(HYDROXYETHYL)ETHER, ... Authors: Saran, S, Sanders, D.A.R. Deposit date: 2020-12-01 Release date: 2021-12-08 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.26 Å) Cite: B-FACTOR ANALYSIS SUGGEST THAT L-LYSINE AND R, R-BISLYSINE ALLOSTERICALLY INHIBIT Cj.DHDPS ENZYME BY DECREASING PROTEIN DYNAMICS. To Be Published
7KWN	Dihydrodipicolinate synthase from C. jejuni with pyruvate bound to the active site in C2221 space group Descriptor: 1,2-ETHANEDIOL, 4-hydroxy-tetrahydrodipicolinate synthase, ACETATE ION, ... Authors: Saran, S, Sanders, D.A.R. Deposit date: 2020-12-01 Release date: 2021-12-08 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.24 Å) Cite: B-FACTOR ANALYSIS SUGGEST THAT L-LYSINE AND R, R-BISLYSINE ALLOSTERICALLY INHIBIT Cj.DHDPS ENZYME BY DECREASING PROTEIN DYNAMICS. To Be Published
7KWF	Dihydrodipicolinate synthase (DHDPS) from C.jejuni, H56N mutant with pyruvate bound in the active site and R,R-bislysine bound at the allosteric site Descriptor: (2R,5R)-2,5-diamino-2,5-bis(4-aminobutyl)hexanedioic acid, 4-hydroxy-tetrahydrodipicolinate synthase, ACETATE ION, ... Authors: Saran, S, Sanders, D.A.R. Deposit date: 2020-11-30 Release date: 2021-12-08 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.82 Å) Cite: ALLOSTERIC SITE RESIDUE 'H56' CAPS THE INHIBITOR AT THE TIGHT DIMER INTERFACE FOR TRANSMITTING THE ALLOSTERIC INHIBITION SIGNALS IN Cj.DHDPS To Be Published
7KUZ	Dihydrodipicolinate synthase (DHDPS) from C.jejuni, H56N mutant with pyruvate bound in the active site and L-lysine bound at the allosteric site Descriptor: 1,2-ETHANEDIOL, 4-hydroxy-tetrahydrodipicolinate synthase, ACETATE ION, ... Authors: Saran, S, Sanders, D.A.R. Deposit date: 2020-11-25 Release date: 2021-12-01 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.25 Å) Cite: ALLOSTERIC SITE RESIDUE 'H56' CAPS THE INHIBITOR AT THE TIGHT DIMER INTERFACE FOR TRANSMITTING THE ALLOSTERIC INHIBITION SIGNALS IN Cj.DHDPS To Be Published
7KTO	Dihydrodipicolinate synthase (DHDPS) from C.jejuni, H56A mutant with pyruvate bound in the active site and R,R-bislysine bound at the allosteric site Descriptor: (2R,5R)-2,5-diamino-2,5-bis(4-aminobutyl)hexanedioic acid, 1,2-ETHANEDIOL, 4-hydroxy-tetrahydrodipicolinate synthase, ... Authors: Saran, S, Sanders, D.A.R. Deposit date: 2020-11-24 Release date: 2021-12-01 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.13 Å) Cite: ALLOSTERIC SITE RESIDUE 'H56' CAPS THE INHIBITOR AT THE TIGHT DIMER INTERFACE FOR TRANSMITTING THE ALLOSTERIC INHIBITION SIGNALS IN Cj.DHDPS To Be Published

 

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