6J7I
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FUSION PROTEIN OF HEME OXYGENASE-1 AND NADPH CYTOCHROME P450 REDUCTASE (15AA)
Descriptor:Heme oxygenase 1,NADPH--cytochrome P450 reductase, PROTOPORPHYRIN IX CONTAINING FE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Sugishima, M., Sato, H., Wada, K., Yamamoto, K.
Deposit date:2019-01-18
Release date:2019-04-10
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal structure of a NADPH-cytochrome P450 oxidoreductase (CYPOR) and heme oxygenase 1 fusion protein implies a conformational change in CYPOR upon NADPH/NADP+binding.
Febs Lett., 593, 2019
6J79
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FUSION PROTEIN OF HEME OXYGENASE-1 AND NADPH-CYTOCHROME P450 REDUCTASE (13AA)
Descriptor:Heme oxygenase 1,NADPH--cytochrome P450 reductase, FLAVIN-ADENINE DINUCLEOTIDE, FLAVIN MONONUCLEOTIDE, ...
Authors:Sugishima, M., Wada, K.
Deposit date:2019-01-17
Release date:2019-04-10
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (3.331 Å)
Cite:Crystal structure of a NADPH-cytochrome P450 oxidoreductase (CYPOR) and heme oxygenase 1 fusion protein implies a conformational change in CYPOR upon NADPH/NADP+binding.
Febs Lett., 593, 2019
6J7A
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FUSION PROTEIN OF HEME OXYGENASE-1 AND NADPH CYTOCHROME P450 REDUCTASE (17AA)
Descriptor:Heme oxygenase 1,NADPH--cytochrome P450 reductase, PROTOPORPHYRIN IX CONTAINING FE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Sugishima, M., Sato, H., Wada, K., Yamamoto, K.
Deposit date:2019-01-17
Release date:2019-04-10
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (3.269 Å)
Cite:Crystal structure of a NADPH-cytochrome P450 oxidoreductase (CYPOR) and heme oxygenase 1 fusion protein implies a conformational change in CYPOR upon NADPH/NADP+binding.
Febs Lett., 593, 2019
6NJR
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SPIN-LABELED T177C/A637C MUTANT OF RAT CYPOR
Descriptor:NADPH--cytochrome P450 reductase, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Xia, C., Kim, J.J.K.
Deposit date:2019-01-04
Release date:2019-02-27
Last modified:2019-05-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Functional Studies of the Membrane-Binding Domain of NADPH-Cytochrome P450 Oxidoreductase.
Biochemistry, 58, 2019
6EFV
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THE NADPH-DEPENDENT SULFITE REDUCTASE FLAVOPROTEIN ADOPTS AN EXTENDED CONFORMATION THAT IS UNIQUE TO THIS DIFLAVIN REDUCTASE
Descriptor:Sulfite reductase [NADPH] flavoprotein alpha-component, FLAVIN-ADENINE DINUCLEOTIDE, FLAVIN MONONUCLEOTIDE, ...
Authors:Tavolieri, A.M., Askenasy, I., Murray, D.T., Pennington, J.M., Stroupe, M.E.
Deposit date:2018-08-17
Release date:2019-02-27
Method:X-RAY DIFFRACTION (2.341 Å)
Cite:NADPH-dependent sulfite reductase flavoprotein adopts an extended conformation unique to this diflavin reductase.
J. Struct. Biol., 2019
5URD
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WILD TYPE RAT CYPOR BOUND WITH NADP+ - OXIDIZED FORM
Descriptor:NADPH--cytochrome P450 reductase, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Xia, C., Kim, J.J.
Deposit date:2017-02-10
Release date:2018-02-14
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Kinetic Studies of Asp632 Mutants and Fully Reduced NADPH-Cytochrome P450 Oxidoreductase Define the Role of Asp632 Loop Dynamics in the Control of NADPH Binding and Hydride Transfer.
Biochemistry, 57, 2018
5URE
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WILD TYPE RAT CYPOR BOUND WITH NADP+ - REDUCED FORM
Descriptor:NADPH--cytochrome P450 reductase, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Xia, C., Kim, J.J.
Deposit date:2017-02-10
Release date:2018-02-14
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and Kinetic Studies of Asp632 Mutants and Fully Reduced NADPH-Cytochrome P450 Oxidoreductase Define the Role of Asp632 Loop Dynamics in the Control of NADPH Binding and Hydride Transfer.
Biochemistry, 57, 2018
5URG
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RAT CYPOR D632F MUTANT
Descriptor:NADPH--cytochrome P450 reductase, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Xia, C., Kim, J.J.
Deposit date:2017-02-10
Release date:2018-02-14
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and Kinetic Studies of Asp632 Mutants and Fully Reduced NADPH-Cytochrome P450 Oxidoreductase Define the Role of Asp632 Loop Dynamics in the Control of NADPH Binding and Hydride Transfer.
Biochemistry, 57, 2018
5URH
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CYPOR/D632A WITH NADP+
Descriptor:NADPH--cytochrome P450 reductase, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Xia, C., Kim, J.J.
Deposit date:2017-02-10
Release date:2018-02-14
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and Kinetic Studies of Asp632 Mutants and Fully Reduced NADPH-Cytochrome P450 Oxidoreductase Define the Role of Asp632 Loop Dynamics in the Control of NADPH Binding and Hydride Transfer.
Biochemistry, 57, 2018
5URI
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RAT CYPOR/D632A WITH 2'-AMP
Descriptor:NADPH--cytochrome P450 reductase, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Xia, C., Kim, J.J.
Deposit date:2017-02-10
Release date:2018-02-14
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Kinetic Studies of Asp632 Mutants and Fully Reduced NADPH-Cytochrome P450 Oxidoreductase Define the Role of Asp632 Loop Dynamics in the Control of NADPH Binding and Hydride Transfer.
Biochemistry, 57, 2018
5GXU
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CYSTAL STRUCTURE OF ARABIDOPSIS ATR2
Descriptor:NADPH--cytochrome P450 reductase 2, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Niu, G., Liu, L.
Deposit date:2016-09-20
Release date:2017-01-25
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the Arabidopsis thaliana NADPH-cytochrome P450 reductase 2 (ATR2) provides insight into its function
FEBS J., 284, 2017
5FA6
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WILD TYPE HUMAN CYPOR
Descriptor:NADPH--cytochrome P450 reductase, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Xia, C., Marohnic, C., Panda, S., Masters, B.S., Kim, J.J.K.
Deposit date:2015-12-11
Release date:2016-08-17
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Instability of the Human Cytochrome P450 Reductase A287P Variant Is the Major Contributor to Its Antley-Bixler Syndrome-like Phenotype.
J.Biol.Chem., 291, 2016
5EMN
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CRYSTAL STRUCTURE OF HUMAN NADPH-CYTOCHROME P450 REDUCTASE(A287P MUTANT)
Descriptor:NADPH--cytochrome P450 reductase, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Xia, C., Marohnic, C., Panda, S., Masters, B.S., Kim, J.J.K.
Deposit date:2015-11-06
Release date:2016-08-17
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Instability of the Human Cytochrome P450 Reductase A287P Variant Is the Major Contributor to Its Antley-Bixler Syndrome-like Phenotype.
J.Biol.Chem., 291, 2016
4Y9R
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RAT CYPOR MUTANT - G141DEL
Descriptor:NADPH--cytochrome P450 reductase, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Xia, C., Kim, J.J.P.
Deposit date:2015-02-17
Release date:2016-03-02
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone.
J.Biol.Chem., 291, 2016
4Y9U
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RAT CYPOR MUTANT - G143DEL
Descriptor:NADPH--cytochrome P450 reductase, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Xia, C., Kim, J.J.P.
Deposit date:2015-02-17
Release date:2016-03-02
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone.
J.Biol.Chem., 291, 2016
4YAF
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RAT CYPOR WITH 2'-AMP
Descriptor:NADPH--cytochrome P450 reductase, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Xia, C., Kim, J.J.P.
Deposit date:2015-02-17
Release date:2016-03-09
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone.
J.Biol.Chem., 291, 2016
4YAL
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REDUCED CYPOR WITH 2'-AMP
Descriptor:NADPH--cytochrome P450 reductase, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Xia, C., Kim, J.J.P.
Deposit date:2015-02-17
Release date:2016-03-02
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone.
J.Biol.Chem., 291, 2016
4YAO
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REDUCED CYPOR MUTANT - G143DEL
Descriptor:NADPH--cytochrome P450 reductase, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Xia, C., Kim, J.J.P.
Deposit date:2015-02-17
Release date:2016-03-02
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone.
J.Biol.Chem., 291, 2016
4YAU
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REDUCED CYPOR MUTANT - G141DEL/E142N
Descriptor:NADPH--cytochrome P450 reductase, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Xia, C., Kim, J.J.P.
Deposit date:2015-02-17
Release date:2016-03-02
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone.
J.Biol.Chem., 291, 2016
4YAW
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REDUCED CYPOR MUTANT - G141DEL
Descriptor:NADPH--cytochrome P450 reductase, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Xia, C., Kim, J.J.P.
Deposit date:2015-02-17
Release date:2016-03-02
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone.
J.Biol.Chem., 291, 2016
4Y7C
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RAT CYPOR MUTANT - G141DEL/E142N
Descriptor:NADPH--cytochrome P450 reductase, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Xia, C., Kim, J.J.P.
Deposit date:2015-02-13
Release date:2016-02-24
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone.
J.Biol.Chem., 291, 2016
3WKT
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COMPLEX STRUCTURE OF AN OPEN FORM OF NADPH-CYTOCHROME P450 REDUCTASE AND HEME OXYGENASE-1
Descriptor:NADPH-cytochrome P450 reductase, Heme oxygenase 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Sugishima, M., Sato, H., Higashimoto, Y., Harada, J., Wada, K., Fukuyama, K., Noguchi, M.
Deposit date:2013-10-31
Release date:2014-01-29
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Structural basis for the electron transfer from an open form of NADPH-cytochrome P450 oxidoreductase to heme oxygenase.
Proc.Natl.Acad.Sci.USA, 111, 2014
3QFR
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CRYSTAL STRUCTURE OF HUMAN NADPH-CYTOCHROME P450 REDUCTASE (R457H MUTANT)
Descriptor:NADPH--cytochrome P450 reductase, FLAVIN-ADENINE DINUCLEOTIDE, FLAVIN MONONUCLEOTIDE, ...
Authors:Xia, C., Marohnic, C., Panda, S.P., Masters, B.S., Kim, J.-J.P.
Deposit date:2011-01-22
Release date:2011-08-03
Last modified:2011-08-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency.
Proc.Natl.Acad.Sci.USA, 108, 2011
3QFS
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CRYSTAL STRUCTURE OF NADPH-CYTOCHROME P450 REDUCTASE (FAD/NADPH DOMAIN)
Descriptor:NADPH--cytochrome P450 reductase, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Xia, C., Marohnic, C., Panda, S.P., Masters, B.S., Kim, J.-J.P.
Deposit date:2011-01-22
Release date:2011-08-17
Last modified:2011-08-31
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency.
Proc.Natl.Acad.Sci.USA, 108, 2011
3QFT
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CRYSTAL STRUCTURE OF NADPH-CYTOCHROME P450 REDUCTASE (FAD/NADPH DOMAIN AND R457H MUTANT)
Descriptor:NADPH--cytochrome P450 reductase, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Xia, C., Marohnic, C., Panda, S.P., Masters, B.S., Kim, J.-J.P.
Deposit date:2011-01-22
Release date:2011-08-17
Last modified:2011-08-31
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency.
Proc.Natl.Acad.Sci.USA, 108, 2011
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