1C9Q
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AVERAGE NMR SOLUTION STRUCTURE OF THE BIR-2 DOMAIN OF XIAP
Descriptor:APOPTOSIS INHIBITOR IAP HOMOLOG, ZINC ION
Authors:Meadows, R.P., Fesik, S.W.
Deposit date:1999-08-03
Release date:2000-08-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP.
Nature, 401, 1999
1E31
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SURVIVIN DIMER H. SAPIENS
Descriptor:APOPTOSIS INHIBITOR SURVIVIN, ZINC ION, COBALT (II) ION
Authors:Chantalat, L., Skoufias, D.A., Margolis, R.L., Dideberg, O.
Deposit date:2000-06-04
Release date:2001-01-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Crystal Structure of Human Survivin Reveals a Bow Tie-Shaped Dimer with Two Unusual Alpha-Helical Extensions
Mol.Cell, 6, 2000
1F3H
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X-RAY CRYSTAL STRUCTURE OF THE HUMAN ANTI-APOPTOTIC PROTEIN SURVIVIN
Descriptor:SURVIVIN, ZINC ION, SULFATE ION
Authors:Verdecia, M.A., Huang, H., Dutil, E., Hunter, T., Noel, J.P.
Deposit date:2000-06-03
Release date:2000-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement.
Nat.Struct.Biol., 7, 2000
1F9X
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AVERAGE NMR SOLUTION STRUCTURE OF THE BIR-3 DOMAIN OF XIAP
Descriptor:INHIBITOR OF APOPTOSIS PROTEIN XIAP, ZINC ION
Authors:Sun, C., Cai, M., Meadows, R.P., Fesik, S.W.
Deposit date:2000-07-11
Release date:2001-07-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structure and mutagenesis of the third Bir domain of the inhibitor of apoptosis protein XIAP.
J.Biol.Chem., 275, 2000
1G3F
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NMR STRUCTURE OF A 9 RESIDUE PEPTIDE FROM SMAC/DIABLO COMPLEXED TO THE BIR3 DOMAIN OF XIAP
Descriptor:INHIBITOR OF APOPTOSIS PROTEIN 3, SMAC, ZINC ION
Authors:Liu, Z., Sun, C., Olejniczak, E.T., Meadows, R.P., Betz, S.F., Oost, T., Herrmann, J., Wu, J.C., Fesik, S.W.
Deposit date:2000-10-24
Release date:2001-01-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.
Nature, 408, 2000
1G73
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CRYSTAL STRUCTURE OF SMAC BOUND TO XIAP-BIR3 DOMAIN
Descriptor:SECOND MITOCHONDRIA-DERIVED ACTIVATOR OF CASPASES, INHIBITORS OF APOPTOSIS-LIKE PROTEIN ILP, ZINC ION
Authors:Wu, G., Chai, J., Suber, T.L., Wu, J.-W., Shi, Y.
Deposit date:2000-11-08
Release date:2001-01-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of IAP recognition by Smac/DIABLO.
Nature, 408, 2000
1I3O
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CRYSTAL STRUCTURE OF THE COMPLEX OF XIAP-BIR2 AND CASPASE 3
Descriptor:CASPASE 3, BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 4, ZINC ION
Authors:Riedl, S.J., Renatus, M., Schwarzenbacher, R., Zhou, Q., Sun, C., Fesik, S.W., Liddington, R.C., Salvesen, G.S.
Deposit date:2001-02-15
Release date:2001-03-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for the inhibition of caspase-3 by XIAP.
Cell(Cambridge,Mass.), 104, 2001
1I51
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CRYSTAL STRUCTURE OF CASPASE-7 COMPLEXED WITH XIAP
Descriptor:CASPASE-7 SUBUNIT P20, CASPASE-7 SUBUNIT P11, X-LINKED INHIBITOR OF APOPTOSIS PROTEIN
Authors:Chai, J., Shi, Y.
Deposit date:2001-02-23
Release date:2002-02-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural basis of caspase-7 inhibition by XIAP.
Cell(Cambridge,Mass.), 104, 2001
1JD4
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CRYSTAL STRUCTURE OF DIAP1-BIR2
Descriptor:APOPTOSIS 1 INHIBITOR, ZINC ION
Authors:Wu, J.W., Cocina, A.E., Chai, J., Hay, B.A., Shi, Y.
Deposit date:2001-06-12
Release date:2001-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides.
Mol.Cell, 8, 2001
1JD5
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CRYSTAL STRUCTURE OF DIAP1-BIR2/GRIM
Descriptor:APOPTOSIS 1 INHIBITOR, cell death protein GRIM, ZINC ION
Authors:Wu, J.W., Cocina, A.E., Chai, J., Hay, B.A., Shi, Y.
Deposit date:2001-06-12
Release date:2001-12-05
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides.
Mol.Cell, 8, 2001
1JD6
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CRYSTAL STRUCTURE OF DIAP1-BIR2/HID COMPLEX
Descriptor:APOPTOSIS 1 INHIBITOR, head involution defective protein, ZINC ION
Authors:Wu, J.W., Cocina, A.E., Chai, J., Hay, B.A., Shi, Y.
Deposit date:2001-06-12
Release date:2001-12-05
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides.
Mol.Cell, 8, 2001
1M4M
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MOUSE SURVIVIN
Descriptor:BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 5, ZINC ION
Authors:Muchmore, S.W., Chen, J., Jakob, C., Zakula, D., Matayoshi, E.D., Wu, W., Zhang, H., Li, F., Ng, S.C., Altieri, D.C.
Deposit date:2002-07-03
Release date:2002-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:CRYSTAL STRUCTURE AND MUTAGENIC ANALYSIS OF THE INHIBITOR-OF-APOPTOSIS PROTEIN SURVIVIN
MOL.CELL, 6, 2000
1OXN
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STRUCTURE AND FUNCTION ANALYSIS OF PEPTIDE ANTAGONISTS OF MELANOMA INHIBITOR OF APOPTOSIS (ML-IAP)
Descriptor:Baculoviral IAP repeat-containing protein 7, AEAVPWKSE peptide, ZINC ION, ...
Authors:Franklin, M.C., Kadkhodayan, S., Ackerly, H., Alexandru, D., Distefano, M.D., Elliott, L.O., Flygare, J.A., Vucic, D., Deshayes, K., Fairbrother, W.J.
Deposit date:2003-04-03
Release date:2003-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP)
Biochemistry, 42, 2003
1OXQ
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STRUCTURE AND FUNCTION ANALYSIS OF PEPTIDE ANTAGONISTS OF MELANOMA INHIBITOR OF APOPTOSIS (ML-IAP)
Descriptor:Baculoviral IAP repeat-containing protein 7, AVPIAQKSE (Smac) peptide, ZINC ION, ...
Authors:Franklin, M.C., Kadkhodayan, S., Ackerly, H., Alexandru, D., Distefano, M.D., Elliott, L.O., Flygare, J.A., Vucic, D., Deshayes, K., Fairbrother, W.J.
Deposit date:2003-04-03
Release date:2003-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP)
Biochemistry, 42, 2003
1OY7
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STRUCTURE AND FUNCTION ANALYSIS OF PEPTIDE ANTAGONISTS OF MELANOMA INHIBITOR OF APOPTOSIS (ML-IAP)
Descriptor:Baculoviral IAP repeat-containing protein 7, AEVVAVKSE peptide, ZINC ION, ...
Authors:Franklin, M.C., Kadkhodayan, S., Ackerly, H., Alexandru, D., Distefano, M.D., Elliott, L.O., Flygare, J.A., Vucic, D., Deshayes, K., Fairbrother, W.J.
Deposit date:2003-04-03
Release date:2003-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP)
Biochemistry, 42, 2003
1Q4Q
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CRYSTAL STRUCTURE OF A DIAP1-DRONC COMPLEX
Descriptor:Apoptosis 1 inhibitor, Nedd2-like caspase CG8091-PA, ZINC ION
Authors:Chai, J., Yan, N., Shi, Y.
Deposit date:2003-08-04
Release date:2003-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination
Nat.Struct.Biol., 10, 2003
1QBH
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SOLUTION STRUCTURE OF A BACULOVIRAL INHIBITOR OF APOPTOSIS (IAP) REPEAT
Descriptor:INHIBITOR OF APOPTOSIS PROTEIN (2MIHB/C-IAP-1), ZINC ION
Authors:Hinds, M.G., Norton, R.S., Vaux, D.L., Day, C.L.
Deposit date:1999-04-20
Release date:1999-10-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat.
Nat.Struct.Biol., 6, 1999
1SDZ
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CRYSTAL STRUCTURE OF DIAP1 BIR1 BOUND TO A REAPER PEPTIDE
Descriptor:Apoptosis 1 inhibitor, Reaper, ZINC ION
Authors:Yan, N., Wu, J.W., Shi, Y.
Deposit date:2004-02-15
Release date:2004-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim.
Nat.Struct.Mol.Biol., 11, 2004
1SE0
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CRYSTAL STRUCTURE OF DIAP1 BIR1 BOUND TO A GRIM PEPTIDE
Descriptor:Apoptosis 1 inhibitor, Cell death protein Grim, ZINC ION
Authors:Yan, N., Wu, J.W., Shi, Y.
Deposit date:2004-02-15
Release date:2004-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim.
Nat.Struct.Mol.Biol., 11, 2004
1TFQ
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NMR STRUCTURE OF AN ANTAGONISTS OF THE XIAP-CASPASE-9 INTERACTION COMPLEXED TO THE BIR3 DOMAIN OF XIAP
Descriptor:Baculoviral IAP repeat-containing protein 4, ZINC ION, N-METHYLALANYL-3-METHYLVALYL-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE
Authors:Oost, T.K., Sun, C., Armstrong, R.C., Al-Assaad, A.S., Betz, S.F., Deckwerth, T.L., Elmore, S.W., Meadows, R.P., Olejniczak, E.T., Oleksijew, A., Oltersdorf, T., Rosenberg, S.H., Shoemaker, A.R., Zou, H., Fesik, S.W.
Deposit date:2004-05-27
Release date:2004-09-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer.
J.Med.Chem., 47, 2004
1TFT
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NMR STRUCTURE OF AN ANTAGONISTS OF THE XIAP-CASPASE-9 INTERACTION COMPLEXED TO THE BIR3 DOMAIN OF XIAP
Descriptor:Baculoviral IAP repeat-containing protein 4, ZINC ION, 1-[3,3-DIMETHYL-2-(2-METHYLAMINO-PROPIONYLAMINO)-BUTYRYL]-4-PHENOXY-PYRROLIDINE-2-CARBOXYLIC ACID(1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YL)-AMIDE
Authors:Oost, T.K., Sun, C., Armstrong, R.C., Al-Assaad, A.S., Betz, S.F., Deckwerth, T.L., Elmore, S.W., Meadows, R.P., Olejniczak, E.T., Oleksijew, A.K., Oltersdorf, T., Rosenberg, S.H., Shoemaker, A.R., Zou, H., Fesik, S.W.
Deposit date:2004-05-27
Release date:2005-05-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
J.Med.Chem., 47, 2004
1TW6
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STRUCTURE OF AN ML-IAP/XIAP CHIMERA BOUND TO A 9MER PEPTIDE DERIVED FROM SMAC
Descriptor:Baculoviral IAP repeat-containing protein 7, Diablo homolog, mitochondrial, ...
Authors:Franklin, M.C., Vucic, D., Wallweber, H.J.A., Das, K., Shin, H., Elliott, L.O., Kadkhodayan, S., Deshayes, K., Salvesen, G.S., Fairbrother, W.J.
Deposit date:2004-06-30
Release date:2004-11-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.713 Å)
Cite:Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP
Biochem.J., 385, 2005
1XB0
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STRUCTURE OF THE BIR DOMAIN OF IAP-LIKE PROTEIN 2
Descriptor:Baculoviral IAP repeat-containing protein 8, Diablo homolog, mitochondrial, ...
Authors:Shin, H., Renatus, M., Eckelman, B.P., Nunes, V.A., Sampaio, C.A.M., Salvesen, G.S.
Deposit date:2004-08-27
Release date:2004-11-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition
Biochem.J., 385, 2005
1XB1
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THE STRUCTURE OF THE BIR DOMAIN OF IAP-LIKE PROTEIN 2
Descriptor:Baculoviral IAP repeat-containing protein 8, Diablo homolog, mitochondrial, ...
Authors:Shin, H., Renatus, M., Eckelman, B.P., Nunes, V.A., Sampaio, C.A.M., Salvesen, G.S.
Deposit date:2004-08-27
Release date:2004-11-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition
Biochem.J., 385, 2005
1XOX
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SOLUTION STRUCTURE OF HUMAN SURVIVIN
Descriptor:Apoptosis inhibitor survivin, ZINC ION
Authors:Sun, C., Nettesheim, D., Liu, Z., Olejniczak, E.T.
Deposit date:2004-10-07
Release date:2005-01-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of human survivin and its binding interface with smac/diablo
Biochemistry, 44, 2005
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