7EXI
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1BUO
| BTB DOMAIN FROM PLZF | Descriptor: | PROTEIN (PROMYELOCYTIC LEUKEMIA ZINC FINGER PROTEIN PLZF) | Authors: | Ahmad, K.F, Engel, C.K, Prive, G.G. | Deposit date: | 1998-09-04 | Release date: | 1998-10-14 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of the BTB domain from PLZF. Proc.Natl.Acad.Sci.USA, 95, 1998
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1CS3
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4ZOU
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8WFG
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2IF5
| Structure of the POZ domain of human LRF, a master regulator of oncogenesis | Descriptor: | PRASEODYMIUM ION, Zinc finger and BTB domain-containing protein 7A | Authors: | Schubot, F.D, Waugh, D.S, Tropea, J. | Deposit date: | 2006-09-20 | Release date: | 2006-11-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of the POZ domain of human LRF, a master regulator of oncogenesis. Biochem.Biophys.Res.Commun., 351, 2006
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2IHC
| Crystal structure of the bric-a-brac (BTB) domain of human BACH1 | Descriptor: | Transcription regulator protein BACH1 | Authors: | Amos, A.L, Turnbull, A.P, Bunkoczi, G, Papagrigoriou, E, Gorrec, F, Umeano, C, Bullock, A, von Delft, F, Weigelt, J, Edwards, A, Arrowsmith, C, Sundstrom, M, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2006-09-26 | Release date: | 2006-10-31 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | Crystal structure of the bric-a-brac (BTB) domain of human BACH1 To be Published
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5X9O
| Crystal structure of the BCL6 BTB domain in complex with Compound 1a | Descriptor: | 1,2-ETHANEDIOL, 5-[(2-chloranyl-4-nitro-phenyl)amino]-1,3-dihydrobenzimidazol-2-one, B-cell lymphoma 6 protein, ... | Authors: | Sogabe, S, Ida, K, Lane, W, Snell, G. | Deposit date: | 2017-03-08 | Release date: | 2017-08-16 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design Bioorg. Med. Chem., 25, 2017
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5X4N
| Crystal structure of the BCL6 BTB domain in complex with Compound 4 | Descriptor: | 1,2-ETHANEDIOL, 5-chloro-N4-phenylpyrimidine-2,4-diamine, B-cell lymphoma 6 protein | Authors: | Sogabe, S, Ida, K, Lane, W, Snell, G. | Deposit date: | 2017-02-13 | Release date: | 2017-05-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Discovery of a B-Cell Lymphoma 6 Protein-Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach J. Med. Chem., 60, 2017
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6N34
| Crystal structure of the BTB domain of Human NS1-BP | Descriptor: | Influenza virus NS1A-binding protein | Authors: | Zhang, K, Shang, G, Padavannil, A, Fontoura, B, Chook, Y.M. | Deposit date: | 2018-11-14 | Release date: | 2018-12-12 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5GIT
| BTB domain of KEAP1 in complex with XX3 | Descriptor: | Kelch-like ECH-associated protein 1, [(3aS,5R,5aS,6S,8S,8aS,9S,9aR)-9-acetyloxy-8-hydroxy-5,8a-dimethyl-1-methylidene-2-oxo-4,5,5a,6,7,8,9,9a-octahydro-3aH-azuleno[6,5-b]furan-6-yl] acetate | Authors: | Zhu, L.L, Li, H.L, Wu, F.S, Xiong, R. | Deposit date: | 2016-06-25 | Release date: | 2017-06-28 | Last modified: | 2019-01-23 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Britanin Ameliorates Cerebral Ischemia-Reperfusion Injury by Inducing the Nrf2 Protective Pathway. Antioxid. Redox Signal., 27, 2017
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7AZW
| Crystal structure of the MIZ1-BTB-domain | Descriptor: | GLYCEROL, Zinc finger and BTB domain-containing protein 17 isoform X1 | Authors: | Orth, B, Sander, B, Diederichs, K, Lorenz, S. | Deposit date: | 2020-11-17 | Release date: | 2021-06-23 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Identification of an atypical interaction site in the BTB domain of the MYC-interacting zinc-finger protein 1. Structure, 29, 2021
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7AZX
| Crystal structure of the MIZ1-BTB-domain in complex with a HUWE1-derived peptide | Descriptor: | E3 ubiquitin-protein ligase HUWE1, Zinc finger and BTB domain-containing protein 17 isoform X1 | Authors: | Orth, B, Sander, B, Diederichs, K, Lorenz, S. | Deposit date: | 2020-11-17 | Release date: | 2021-06-30 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Identification of an atypical interaction site in the BTB domain of the MYC-interacting zinc-finger protein 1. Structure, 29, 2021
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5H7H
| Crystal structure of the BCL6 BTB domain in complex with F1324(10-13) | Descriptor: | 1,2-ETHANEDIOL, B-cell lymphoma 6 protein, F1324 peptide residues 10-13 | Authors: | Sogabe, S, Ida, K, Lane, W, Snell, G. | Deposit date: | 2016-11-18 | Release date: | 2016-12-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Discovery of high-affinity BCL6-binding peptide and its structure-activity relationship. Biochem. Biophys. Res. Commun., 482, 2017
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5H7G
| Crystal structure of the BCL6 BTB domain in complex with F1324 | Descriptor: | B-cell lymphoma 6 protein, F1324 peptide, SULFATE ION | Authors: | Sogabe, S, Ida, K, Lane, W, Snell, G. | Deposit date: | 2016-11-18 | Release date: | 2016-12-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Discovery of high-affinity BCL6-binding peptide and its structure-activity relationship. Biochem. Biophys. Res. Commun., 482, 2017
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7BDE
| HUMAN BCL6 BTB-DOMAIN IN COMPLEX WITH GSK137 | Descriptor: | 5-[(5S,7R)-3-fluoranyl-7-(2-methylpyridin-3-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-5-yl]quinolin-2-amine, DIMETHYL SULFOXIDE, GLYCEROL, ... | Authors: | Somers, D.O. | Deposit date: | 2020-12-21 | Release date: | 2021-07-28 | Last modified: | 2021-08-18 | Method: | X-RAY DIFFRACTION (2.044 Å) | Cite: | GSK137, a potent small-molecule BCL6 inhibitor with in vivo activity, suppresses antibody responses in mice. J.Biol.Chem., 297, 2021
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5DAF
| Crystal Structure of Human KEAP1 BTB Domain in Complex with Small Molecule TX64063 | Descriptor: | (5aS,6S,9aS)-7-hydroxy-2,6,9a-trimethyl-3-(pyridin-3-yl)-4,5,5a,6,9,9a-hexahydro-2H-benzo[g]indazole-8-carbonitrile, Kelch-like ECH-associated protein 1 | Authors: | Huerta, C, Jiang, X, Trevino, I, Bender, C.F, Swinger, K.K, Stoll, V.S, Ferguson, D.A, Thomas, P.J, Probst, B, Dulubova, I, Visnick, M, Wigley, W.C. | Deposit date: | 2015-08-19 | Release date: | 2016-08-10 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding. Biochim.Biophys.Acta, 1860, 2016
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2NN2
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5DAD
| Crystal Structure of Human KEAP1 BTB Domain in Complex with Small Molecule TX64014 | Descriptor: | (6aS,7S,10aS)-8-hydroxy-4-methoxy-2,7,10a-trimethyl-5,6,6a,7,10,10a-hexahydrobenzo[h]quinazoline-9-carbonitrile, Kelch-like ECH-associated protein 1 | Authors: | Huerta, C, Jiang, X, Trevino, I, Bender, C.F, Swinger, K.K, Stoll, V.S, Ferguson, D.A, Thomas, P.J, Probst, B, Dulubova, I, Visnick, M, Wigley, W.C. | Deposit date: | 2015-08-19 | Release date: | 2016-08-10 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding. Biochim.Biophys.Acta, 1860, 2016
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5EUP
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2PPI
| Structure of the BTB (Tramtrack and Bric a brac) domain of human Gigaxonin | Descriptor: | Gigaxonin | Authors: | Amos, A, Turnbull, A.P, Tickle, J, Keates, T, Bullock, A, Savitsky, P, Burgess-Brown, N, Debreczeni, J.E, Ugochukwu, E, Umeano, C, Pike, A.C.W, Papagrigoriou, E, Sundstrom, M, Arrowsmith, C.H, Weigelt, J, Edwards, A, von Delft, F, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2007-04-30 | Release date: | 2007-05-08 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of the BTB (Tramtrack and Bric a brac) domain of human Gigaxonin. To be Published
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1R2B
| Crystal structure of the BCL6 BTB domain complexed with a SMRT co-repressor peptide | Descriptor: | B-cell lymphoma 6 protein, Nuclear receptor co-repressor 2 | Authors: | Ahmad, K.F, Melnick, A, Lax, S.A, Bouchard, D, Liu, J, Kiang, C.L, Mayer, S, Licht, J.D, Prive, G.G. | Deposit date: | 2003-09-26 | Release date: | 2003-12-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain. Mol.Cell, 12, 2003
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1R28
| Crystal Structure of the B-Cell Lymphoma 6 (BCL6) BTB domain to 2.2 Angstrom | Descriptor: | B-cell lymphoma 6 protein | Authors: | Ahmad, K.F, Melnick, A, Lax, S.A, Bouchard, D, Liu, J, Kiang, C.L, Mayer, S, Licht, J.D, Prive, G.G. | Deposit date: | 2003-09-26 | Release date: | 2003-12-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain. Mol.Cell, 12, 2003
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2Q81
| Crystal Structure of the Miz-1 BTB/POZ domain | Descriptor: | Miz-1 protein, TETRAETHYLENE GLYCOL | Authors: | Stead, M.A, Trinh, C.H, Garnett, J.A, Carr, S.B, Edwards, T.A, Wright, S.C. | Deposit date: | 2007-06-08 | Release date: | 2007-11-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A Beta-Sheet Interaction Interface Directs the Tetramerisation of the Miz-1 POZ Domain J.Mol.Biol., 373, 2007
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1R29
| Crystal Structure of the B-Cell Lymphoma 6 (BCL6) BTB Domain to 1.3 Angstrom | Descriptor: | B-cell lymphoma 6 protein | Authors: | Ahmad, K.F, Melnick, A, Lax, S.A, Bouchard, D, Liu, J, Kiang, C.L, Mayer, S, Licht, J.D, Prive, G.G. | Deposit date: | 2003-09-26 | Release date: | 2003-12-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain. Mol.Cell, 12, 2003
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