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7ZGD
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Structure of yeast Sec14p with NPPM244
Descriptor: (4-bromanyl-3-nitro-phenyl)-[4-(2-fluorophenyl)piperazin-1-yl]methanone, SEC14 cytosolic factor
Authors:Hong, Z, Johnen, P, Schaaf, G, Bono, F.
Deposit date:2022-04-03
Release date:2023-01-25
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity.
J.Biol.Chem., 299, 2023
7ZGC
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BU of 7zgc by Molmil
Structure of yeast Sec14p with NPPM481
Descriptor: (4-chloranyl-3-nitro-phenyl)-[4-(2-fluorophenyl)piperazin-1-yl]methanone, PHOSPHATE ION, SEC14 cytosolic factor
Authors:Hong, Z, Johnen, P, Schaaf, G, Bono, F.
Deposit date:2022-04-03
Release date:2023-01-25
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.236 Å)
Cite:Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity.
J.Biol.Chem., 299, 2023
7ZGB
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BU of 7zgb by Molmil
Structure of yeast Sec14p with NPPM112
Descriptor: 4-fluoranyl-~{N}-[(4-pyrrolidin-1-ylphenyl)methyl]benzamide, SEC14 cytosolic factor
Authors:Hong, Z, Johnen, P, Schaaf, G, Bono, F.
Deposit date:2022-04-03
Release date:2023-01-25
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity.
J.Biol.Chem., 299, 2023
7ZGA
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BU of 7zga by Molmil
Structure of yeast Sec14p with ergoline
Descriptor: SEC14 cytosolic factor, ~{O}9-methyl ~{O}4-[2,2,2-tris(chloranyl)ethyl] (5~{a}~{S},6~{a}~{S},9~{R},10~{a}~{S})-7-methyl-3-nitro-5,5~{a},6,6~{a},8,9,10,10~{a}-octahydroindolo[4,3-fg]quinoline-4,9-dicarboxylate
Authors:Hong, Z, Johnen, P, Schaaf, G, Bono, F.
Deposit date:2022-04-03
Release date:2023-01-25
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.302 Å)
Cite:Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity.
J.Biol.Chem., 299, 2023
7ZG9
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BU of 7zg9 by Molmil
Structure of yeast Sec14p with himbacine
Descriptor: Himbacine, SEC14 cytosolic factor
Authors:Hong, Z, Johnen, P, Schaaf, G, Bono, F.
Deposit date:2022-04-03
Release date:2023-01-25
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.764 Å)
Cite:Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity.
J.Biol.Chem., 299, 2023
7Y11
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BU of 7y11 by Molmil
Crystal structure of AtSFH5-Sec14 in complex with egg PA
Descriptor: (2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate, CHLORIDE ION, NICKEL (II) ION, ...
Authors:Lu, Y.Q, Wang, X.Q, Luo, Z.P, Wu, J.W.
Deposit date:2022-06-06
Release date:2023-04-19
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Arabidopsis Sec14 proteins (SFH5 and SFH7) mediate interorganelle transport of phosphatidic acid and regulate chloroplast development.
Proc.Natl.Acad.Sci.USA, 120, 2023
7Y10
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BU of 7y10 by Molmil
Crystal structure of AtSFH5-Sec14 in complex with DPPA
Descriptor: 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, NICKEL (II) ION, Phosphatidylinositol/phosphatidylcholine transfer protein SFH5
Authors:Lu, Y.Q, Wang, X.Q, Luo, Z.P, Wu, J.W.
Deposit date:2022-06-06
Release date:2023-05-31
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Arabidopsis Sec14 proteins (SFH5 and SFH7) mediate interorganelle transport of phosphatidic acid and regulate chloroplast development.
Proc.Natl.Acad.Sci.USA, 120, 2023
7WWG
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Crystal structure of Saccharomyces cerevisiae Sfh2 complexed with phosphatidylinositol in an open conformation
Descriptor: (1R)-2-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, Phosphatidylinositol transfer protein CSR1
Authors:Chen, L, Tan, L, Im, Y.J.
Deposit date:2022-02-12
Release date:2022-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural basis of ligand recognition and transport by Sfh2, a yeast phosphatidylinositol transfer protein of the Sec14 superfamily.
Acta Crystallogr D Struct Biol, 78, 2022
7WWE
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BU of 7wwe by Molmil
Crystal structure of Saccharomyces cerevisiae Sfh2 in an apo form
Descriptor: Phosphatidylinositol transfer protein CSR1
Authors:Chen, L, Tan, L, Im, Y.J.
Deposit date:2022-02-12
Release date:2022-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of ligand recognition and transport by Sfh2, a yeast phosphatidylinositol transfer protein of the Sec14 superfamily.
Acta Crystallogr D Struct Biol, 78, 2022
7WWD
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BU of 7wwd by Molmil
Crystal structure of Saccharomyces cerevisiae Sfh2 complexed with squalene
Descriptor: (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene, Phosphatidylinositol transfer protein CSR1
Authors:Chen, L, Tan, L, Im, Y.J.
Deposit date:2022-02-12
Release date:2022-07-13
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structural basis of ligand recognition and transport by Sfh2, a yeast phosphatidylinositol transfer protein of the Sec14 superfamily.
Acta Crystallogr D Struct Biol, 78, 2022
7WVT
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BU of 7wvt by Molmil
Crystal structure of Saccharomyces cerevisiae Sfh2 complexed with phosphatidylinositol
Descriptor: (1R)-2-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, Phosphatidylinositol transfer protein CSR1
Authors:Chen, L, Tan, L, Im, Y.J.
Deposit date:2022-02-11
Release date:2022-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis of ligand recognition and transport by Sfh2, a yeast phosphatidylinositol transfer protein of the Sec14 superfamily.
Acta Crystallogr D Struct Biol, 78, 2022
6ZPD
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BU of 6zpd by Molmil
gamma-tocopherol transfer protein
Descriptor: (2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Alpha-tocopherol transfer protein, ...
Authors:Aeschimann, W, Kammer, S, Staats, S, Stocker, A.
Deposit date:2020-07-08
Release date:2020-12-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Engineering of a functional gamma-tocopherol transfer protein.
Redox Biol, 38, 2020
6W32
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BU of 6w32 by Molmil
Crystal structure of Sfh5
Descriptor: PROTOPORPHYRIN IX CONTAINING FE, Phosphatidylinositol transfer protein SFH5
Authors:Gulten, G, Khan, D, Aggarwal, A, Krieger, I, Sacchettini, J.C, Bankaitis, V.A.
Deposit date:2020-03-08
Release date:2020-11-25
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A Sec14-like phosphatidylinositol transfer protein paralog defines a novel class of heme-binding proteins.
Elife, 9, 2020
6SLD
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BU of 6sld by Molmil
Structure of the Phosphatidylcholine Binding Mutant of Yeast Sec14 Homolog Sfh1 (S175I,T177I) in Complex with Phosphatidylinositol
Descriptor: (1R)-2-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CRAL-TRIO domain-containing protein YKL091C
Authors:Berger, J, Fitz, M, Johnen, P, Shanmugaratnam, S, Hocker, B, Stiel, A.C, Schaaf, G.
Deposit date:2019-08-19
Release date:2020-08-19
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure of the Phosphatidylcholine Binding Mutant of Yeast Sec14 Homolog Sfh1 (S175I,T177I) in Complex with Phosphatidylinositol
To Be Published
6F0E
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BU of 6f0e by Molmil
Structure of yeast Sec14p with a picolinamide compound
Descriptor: SEC14 cytosolic factor, ~{N}-(1,3-benzodioxol-5-ylmethyl)-5-bromanyl-3-fluoranyl-pyridine-2-carboxamide
Authors:Hong, Z, Johnen, P, Schaaf, G, Bono, F.
Deposit date:2017-11-20
Release date:2018-01-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties.
Cell Chem Biol, 25, 2018
5MUG
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BU of 5mug by Molmil
Self-assembled alpha-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E Delivery Across an Endothelial Barrier
Descriptor: (2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL, Alpha-tocopherol transfer protein, CHLORIDE ION, ...
Authors:Stocker, A, Aeschimann, W.
Deposit date:2017-01-13
Release date:2017-07-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Self-assembled alpha-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E Delivery Across an Endothelial Barrier.
Sci Rep, 7, 2017
5MUE
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BU of 5mue by Molmil
Self-assembled alpha-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E Delivery Across an Endothelial Barrier
Descriptor: (2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL, Alpha-tocopherol transfer protein, CHLORIDE ION, ...
Authors:Stocker, A, Aeschimann, W.
Deposit date:2017-01-13
Release date:2017-07-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.397 Å)
Cite:Self-assembled alpha-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E Delivery Across an Endothelial Barrier.
Sci Rep, 7, 2017
4UYB
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BU of 4uyb by Molmil
Crystal structure of SEC14-like protein 3
Descriptor: 1,2-ETHANEDIOL, SEC14-LIKE PROTEIN 3, UNKNOWN LIGAND
Authors:Kopec, J, Goubin, S, Krojer, T, Burgess-Brown, N, von Delft, F, Arrowsmith, C, Edwards, A, Bountra, C, Yue, W.W.
Deposit date:2014-08-29
Release date:2014-09-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of Sec14-Like Protein 3
To be Published
4TLG
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BU of 4tlg by Molmil
Crystal structure of SEC14-like protein 4 (SEC14L4)
Descriptor: 1,2-ETHANEDIOL, SEC14-like protein 4, UNDECANOIC ACID
Authors:Vollmar, M, Kopec, J, Kiyani, W, Shrestha, L, Sorrell, F, Krojer, T, Williams, E, Burgess-Brown, N, von Delft, F, Arrowsmith, C, Edwards, A, Bountra, C, Yue, W.W.
Deposit date:2014-05-29
Release date:2014-07-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Crystal structure of SEC14-like protein 4 (SEC14L4)
To Be Published
4OMK
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BU of 4omk by Molmil
Crystal structure of SPF bound to squalene
Descriptor: (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene, CHLORIDE ION, ISOPROPYL ALCOHOL, ...
Authors:Christen, M, Marcaida, M.J, Lamprakis, C, Cascella, M, Stocker, A.
Deposit date:2014-01-27
Release date:2015-04-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural insights on cholesterol endosynthesis: Binding of squalene and 2,3-oxidosqualene to supernatant protein factor.
J.Struct.Biol., 190, 2015
4OMJ
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BU of 4omj by Molmil
Crystal structure of SPF bound to 2,3-oxidosqualene
Descriptor: (3S)-2,2-dimethyl-3-[(3E,7E,11E,15E)-3,7,12,16,20-pentamethylhenicosa-3,7,11,15,19-pentaen-1-yl]oxirane, CHLORIDE ION, SEC14-like protein 2, ...
Authors:Christen, M, Marcaida, M.J, Lamprakis, C, Cascella, M, Stocker, A.
Deposit date:2014-01-27
Release date:2015-04-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural insights on cholesterol endosynthesis: Binding of squalene and 2,3-oxidosqualene to supernatant protein factor.
J.Struct.Biol., 190, 2015
4M8Z
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BU of 4m8z by Molmil
Crystal Structure of SFH3, a phosphatidylinositol transfer protein that integrates phosphoinositide signaling with lipid droplet metabolism
Descriptor: Phosphatidylinositol transfer protein PDR16
Authors:Ortlund, E.O, Pathak, M.C.
Deposit date:2013-08-14
Release date:2014-09-10
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.928 Å)
Cite:A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress-induced membrane biogenesis.
Mol Biol Cell, 25, 2014
4J7Q
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BU of 4j7q by Molmil
Crystal structure of Saccharomyces cerevisiae Sfh3 complexed with phosphatidylinositol
Descriptor: (1R)-2-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, Phosphatidylinositol transfer protein PDR16
Authors:Yang, H, Im, Y.J.
Deposit date:2013-02-14
Release date:2013-07-03
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural determinants for phosphatidylinositol recognition by Sfh3 and substrate-induced dimer-monomer transition during lipid transfer cycles.
Febs Lett., 587, 2013
4J7P
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BU of 4j7p by Molmil
Crystal structure of Saccharomyces cerevisiae Sfh3
Descriptor: Phosphatidylinositol transfer protein PDR16
Authors:Yang, H, Im, Y.J.
Deposit date:2013-02-14
Release date:2013-07-03
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural determinants for phosphatidylinositol recognition by Sfh3 and substrate-induced dimer-monomer transition during lipid transfer cycles.
Febs Lett., 587, 2013
4FMM
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BU of 4fmm by Molmil
Dimeric Sec14 family homolog 3 from Saccharomyces cerevisiae presents some novel features of structure that lead to a surprising "dimer-monomer" state change induced by substrate binding
Descriptor: GLYCEROL, MAGNESIUM ION, Phosphatidylinositol transfer protein PDR16
Authors:Yuan, Y, Zhao, W, Wang, X, Gao, Y, Niu, L, Teng, M.
Deposit date:2012-06-18
Release date:2013-02-27
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Dimeric Sfh3 has structural changes in its binding pocket that are associated with a dimer-monomer state transformation induced by substrate binding.
Acta Crystallogr.,Sect.D, 69, 2013

 

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