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1NEX
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BU of 1nex by Molmil
Crystal Structure of ScSkp1-ScCdc4-CPD peptide complex
Descriptor: CDC4 protein, Centromere DNA-binding protein complex CBF3 subunit D, GLL(TPO)PPQSG
Authors:Orlicky, S, Tang, X, Willems, A, Tyers, M, Sicheri, F.
Deposit date:2002-12-12
Release date:2003-02-18
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis for Phosphodependent Substrate Selection and Orientation by the SCFCdc4 Ubiquitin Ligase
Cell(Cambridge,Mass.), 112, 2003
2E31
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BU of 2e31 by Molmil
Structural basis for selection of glycosylated substrate by SCFFbs1 ubiquitin ligase
Descriptor: F-box only protein 2, S-phase kinase-associated protein 1A
Authors:Mizushima, T, Yoshida, Y, Kumanomidou, T, Hasegawa, Y, Yamane, T, Tanaka, K.
Deposit date:2006-11-20
Release date:2007-03-20
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for the selection of glycosylated substrates by SCFFbs1 ubiquitin ligase
Proc.Natl.Acad.Sci.Usa, 104, 2007
2E32
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BU of 2e32 by Molmil
Structural basis for selection of glycosylated substrate by SCFFbs1 ubiquitin ligase
Descriptor: F-box only protein 2, S-phase kinase-associated protein 1A
Authors:Mizushima, T, Yoshida, Y, Kumanomidou, T, Hasegawa, Y, Yamane, T, Tanaka, K.
Deposit date:2006-11-20
Release date:2007-03-20
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.52 Å)
Cite:Structural basis for the selection of glycosylated substrates by SCFFbs1 ubiquitin ligase
Proc.Natl.Acad.Sci.Usa, 104, 2007
2P1M
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BU of 2p1m by Molmil
TIR1-ASK1 complex structure
Descriptor: INOSITOL HEXAKISPHOSPHATE, SKP1-like protein 1A, TRANSPORT INHIBITOR RESPONSE 1 protein
Authors:Tan, X, Calderon-Villalobos, L.I.A, Sharon, M, Robinson, C.V, Estelle, M, Zheng, N.
Deposit date:2007-03-05
Release date:2007-04-10
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanism of auxin perception by the TIR1 ubiquitin ligase
Nature, 446, 2007
2P1N
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BU of 2p1n by Molmil
Mechanism of Auxin Perception by the TIR1 Ubiqutin Ligase
Descriptor: (2,4-DICHLOROPHENOXY)ACETIC ACID, Auxin-responsive protein IAA7, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Tan, X, Calderon-Villalobos, L.I.A, Sharon, M, Robinson, C.V, Estelle, M, Zheng, C, Zheng, N.
Deposit date:2007-03-06
Release date:2007-04-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanism of auxin perception by the TIR1 ubiquitin ligase
Nature, 446, 2007
2P1O
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BU of 2p1o by Molmil
Mechanism of Auxin Perception by the TIR1 ubiquitin ligase
Descriptor: Auxin-responsive protein IAA7, INOSITOL HEXAKISPHOSPHATE, NAPHTHALEN-1-YL-ACETIC ACID, ...
Authors:Tan, X, Calderon-Villalobos, L.I.A, Sharon, M, Robinson, C.V, Estelle, M, Zheng, N.
Deposit date:2007-03-06
Release date:2007-04-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanism of auxin perception by the TIR1 ubiquitin ligase
Nature, 446, 2007
2P1P
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BU of 2p1p by Molmil
Mechanism of Auxin Perception by the TIR1 ubiquitin ligase
Descriptor: 1H-INDOL-3-YLACETIC ACID, INOSITOL HEXAKISPHOSPHATE, SKP1-like protein 1A, ...
Authors:Tan, X, Calderon-Villalobos, L.I.A, Sharon, M, Robinson, C.V, Estelle, M, Zheng, N.
Deposit date:2007-03-06
Release date:2007-04-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Mechanism of auxin perception by the TIR1 ubiquitin ligase
Nature, 446, 2007
2P1Q
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BU of 2p1q by Molmil
Mechanism of Auxin Perception by the TIR1 ubiquitin ligase
Descriptor: 1H-INDOL-3-YLACETIC ACID, Auxin-responsive protein IAA7, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Tan, X, Calderon-Villalobos, L.I.A, Sharon, M, Robinson, C.V, Estelle, M, Zheng, N.
Deposit date:2007-03-06
Release date:2007-04-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Mechanism of auxin perception by the TIR1 ubiquitin ligase.
Nature, 446, 2007
3C6N
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BU of 3c6n by Molmil
Small molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling
Descriptor: (2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid, INOSITOL HEXAKISPHOSPHATE, SKP1-like protein 1A, ...
Authors:Tan, X, Zheng, N, Hayashi, K.
Deposit date:2008-02-04
Release date:2008-04-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Small-molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3C6O
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BU of 3c6o by Molmil
Small molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling
Descriptor: (2S)-2-(1H-indol-3-yl)hexanoic acid, INOSITOL HEXAKISPHOSPHATE, SKP1-like protein 1A, ...
Authors:Tan, X.
Deposit date:2008-02-04
Release date:2008-04-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Small-molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3C6P
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BU of 3c6p by Molmil
Small molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling
Descriptor: (2S)-2-(1H-indol-3-yl)pentanoic acid, INOSITOL HEXAKISPHOSPHATE, SKP1-like protein 1A, ...
Authors:Tan, X.
Deposit date:2008-02-04
Release date:2008-04-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Small-molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3L2O
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BU of 3l2o by Molmil
Structure-Based Mechanism of Dimerization-Dependent Ubiquitination by the SCFFbx4 Ubiquitin Ligase
Descriptor: F-box only protein 4, S-phase kinase-associated protein 1
Authors:Li, Y, Hao, B.
Deposit date:2009-12-15
Release date:2010-02-23
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligase.
J.Biol.Chem., 285, 2010
3MKS
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BU of 3mks by Molmil
Crystal Structure of yeast Cdc4/Skp1 in complex with an allosteric inhibitor SCF-I2
Descriptor: 1,1'-binaphthalene-2,2'-dicarboxylic acid, Cell division control protein 4, GLYCEROL, ...
Authors:Orlicky, S, Sicheri, F, Tyers, M, Tang, X.
Deposit date:2010-04-15
Release date:2010-07-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase.
Nat.Biotechnol., 28, 2010
3V7D
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BU of 3v7d by Molmil
Crystal Structure of ScSkp1-ScCdc4-pSic1 peptide complex
Descriptor: Cell division control protein 4, Protein SIC1, Suppressor of kinetochore protein 1
Authors:Tang, X, Orlicky, S, Mittag, T, Csizmok, V, Pawson, T, Forman-Kay, J, Sicheri, F, Tyers, M.
Deposit date:2011-12-20
Release date:2012-05-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.306 Å)
Cite:Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4UI9
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BU of 4ui9 by Molmil
Atomic structure of the human Anaphase-Promoting Complex
Descriptor: ANAPHASE-PROMOTING COMPLEX SUBUNIT 1, ANAPHASE-PROMOTING COMPLEX SUBUNIT 10, ANAPHASE-PROMOTING COMPLEX SUBUNIT 11, ...
Authors:Chang, L, Zhang, Z, Yang, J, McLaughlin, S.H, Barford, D.
Deposit date:2015-03-27
Release date:2015-06-17
Last modified:2019-04-24
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Atomic Structure of the Apc and its Mechanism of Protein Ubiquitination
Nature, 522, 2015
6BYH
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BU of 6byh by Molmil
Ubiquitin Variant (UbV.Fl11.1) bound to a human Skp1-Fbl11 fragment complex.
Descriptor: Lysine-specific demethylase 2A, Polyubiquitin-B, S-phase kinase-associated protein 1
Authors:Manczyk, N, Sicheri, F.
Deposit date:2017-12-20
Release date:2018-07-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases.
Structure, 26, 2018
6C16
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BU of 6c16 by Molmil
Ubiquitin variant (UbV.Fbl10.1) bound to a human Skp1-Fbl11 fragment complex.
Descriptor: Lysine-specific demethylase 2A, Polyubiquitin-B, S-phase kinase-associated protein 1
Authors:Manczyk, N, Sicheri, F.
Deposit date:2018-01-04
Release date:2018-07-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.27 Å)
Cite:A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases.
Structure, 26, 2018
6O60
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BU of 6o60 by Molmil
Crystal structure of GGTase3-FBXL2-SKP1 complex
Descriptor: F-box/LRR-repeat protein 2, Geranylgeranyl transferase type-2 subunit beta, Protein prenyltransferase alpha subunit repeat-containing protein 1, ...
Authors:Wang, H, Zheng, N.
Deposit date:2019-03-04
Release date:2019-06-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:GGTase3 is a newly identified geranylgeranyltransferase targeting a ubiquitin ligase.
Nat.Struct.Mol.Biol., 26, 2019
7PMK
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BU of 7pmk by Molmil
S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation I)
Descriptor: Cell division control protein 45,Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA helicase, ...
Authors:Jenkyn-Bedford, M, Yeeles, J.T.P, Deegan, T.D.
Deposit date:2021-09-02
Release date:2021-11-10
Last modified:2022-02-02
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:A conserved mechanism for regulating replisome disassembly in eukaryotes.
Nature, 600, 2021
7PMN
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BU of 7pmn by Molmil
S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation II)
Descriptor: Cell division control protein 45,Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha-binding protein, ...
Authors:Jenkyn-Bedford, M, Yeeles, J.T.P, Deegan, T.D.
Deposit date:2021-09-02
Release date:2021-11-10
Last modified:2022-01-26
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:A conserved mechanism for regulating replisome disassembly in eukaryotes.
Nature, 600, 2021
7QE7
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BU of 7qe7 by Molmil
High-resolution structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to co-activator Cdh1
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
Authors:Hoefler, A, Yu, J, Chang, L, Zhang, Z, Yang, J, Boland, A, Barford, D.
Deposit date:2021-12-01
Release date:2022-01-26
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:High-resolution structure of the Anaphase-promoting complex (APC/C) bound to co-activator Cdh1
To Be Published
7Z8B
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BU of 7z8b by Molmil
Structure of CRL7FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation
Descriptor: Cullin-7, E3 ubiquitin-protein ligase RBX1, F-box/WD repeat-containing protein 8, ...
Authors:Hopf, L.V.M, Schulman, B.A.
Deposit date:2022-03-17
Release date:2022-08-24
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structure of CRL7 FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation.
Nat.Struct.Mol.Biol., 29, 2022
8S4G
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BU of 8s4g by Molmil
Cryo-EM structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to co-activator Cdh1 at 3.2 Angstrom resolution
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
Authors:Hoefler, A, Yu, J, Chang, L, Zhang, Z, Yang, J, Boland, A, Barford, D.
Deposit date:2024-02-21
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:New structural features of the APC/C revealed by high resolution cryo-EM structures of apo-APC/C and the APC/C-CDH1-EMI1 complex
To Be Published

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PDB entries from 2024-03-27

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