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8WE9
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Human L-type voltage-gated calcium channel Cav1.2 (Class I) in the presence of pinaverium at 3.0 Angstrom resolution
Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gao, S, Yao, X, Fan, X, Yan, N.
Deposit date:2023-09-17
Release date:2023-12-06
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine.
Cell, 186, 2023
8WE7
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Human L-type voltage-gated calcium channel Cav1.2 in the presence of calciseptine at 3.2 Angstrom resolution
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gao, S, Yao, X, Yan, N.
Deposit date:2023-09-17
Release date:2023-12-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine.
Cell, 186, 2023
8WE8
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Human L-type voltage-gated calcium channel Cav1.2 in the presence of calciseptine, amlodipine and pinaverium at 2.9 Angstrom resolution
Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gao, S, Yao, X, Yan, N.
Deposit date:2023-09-17
Release date:2023-12-06
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine.
Cell, 186, 2023
8WE6
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BU of 8we6 by Molmil
Human L-type voltage-gated calcium channel Cav1.2 at 2.9 Angstrom resolution
Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gao, S, Yao, X, Yan, N.
Deposit date:2023-09-17
Release date:2023-12-06
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine.
Cell, 186, 2023
8FHS
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Human L-type voltage-gated calcium channel Cav1.2 in the presence of amiodarone and sofosbuvir at 3.3 Angstrom resolution
Descriptor: (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gao, S, Yao, X, Yan, N.
Deposit date:2022-12-15
Release date:2023-12-13
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine.
Cell, 186, 2023
8FD7
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Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with gabapentin
Descriptor: (2R)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl heptadecanoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl dodecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chen, Z, Mondal, A, Minor, D.L.
Deposit date:2022-12-02
Release date:2023-03-22
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for Ca V alpha 2 delta :gabapentin binding.
Nat.Struct.Mol.Biol., 30, 2023
8EPL
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Human R-type voltage-gated calcium channel Cav2.3 at 3.1 Angstrom resolution
Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gao, S, Yao, X, Yan, N.
Deposit date:2022-10-06
Release date:2022-12-14
Last modified:2023-07-12
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structures of the R-type human Ca v 2.3 channel reveal conformational crosstalk of the intracellular segments.
Nat Commun, 13, 2022
8EOG
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Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with L-leucine
Descriptor: (2R)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl dodecanoate, (2R)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl heptadecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chen, Z, Mondal, A, Abderemane-Ali, F, Minor, D.L.
Deposit date:2022-10-03
Release date:2023-05-24
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:EMC chaperone-Ca V structure reveals an ion channel assembly intermediate.
Nature, 619, 2023
8EOI
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Structure of a human EMC:human Cav1.2 channel complex in GDN detergent
Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chen, Z, Mondal, A, Abderemane-Ali, F, Minor, D.L.
Deposit date:2022-10-03
Release date:2023-05-24
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:EMC chaperone-Ca V structure reveals an ion channel assembly intermediate.
Nature, 619, 2023
8EGL
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BU of 8egl by Molmil
Crystal Structure of Guanylate kinase from Pseudomonas aeruginosa PAO1 in complex with GMP and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-MONOPHOSPHATE, Guanylate kinase
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2022-09-12
Release date:2022-09-28
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal Structure of Guanylate kinase from Pseudomonas aeruginosa PAO1 in complex with GMP and ADP
to be published
8E5A
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BU of 8e5a by Molmil
Human L-type voltage-gated calcium channel Cav1.3 treated with 1.4 mM Sofosbuvir at 3.3 Angstrom resolution
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gao, S, Yao, X, Yan, N.
Deposit date:2022-08-20
Release date:2022-12-07
Last modified:2022-12-21
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Ca v channels.
Cell, 185, 2022
8E5B
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BU of 8e5b by Molmil
Human L-type voltage-gated calcium channel Cav1.3 in the presence of Amiodarone and Sofosbuvir at 3.3 Angstrom resolution
Descriptor: (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gao, S, Yao, X, Yan, N.
Deposit date:2022-08-20
Release date:2022-12-07
Last modified:2022-12-21
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Ca v channels.
Cell, 185, 2022
8E59
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BU of 8e59 by Molmil
Human L-type voltage-gated calcium channel Cav1.3 in the presence of Amiodarone at 3.1 Angstrom resolution
Descriptor: (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gao, S, Yao, X, Yan, N.
Deposit date:2022-08-20
Release date:2022-12-07
Last modified:2022-12-21
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Ca v channels.
Cell, 185, 2022
8E0E
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BU of 8e0e by Molmil
nbF3:CaV beta subunit 2a complex
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, GLYCEROL, ...
Authors:Nirwan, N, Minor, D.L.
Deposit date:2022-08-09
Release date:2023-01-18
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Selective posttranslational inhibition of Ca V beta 1 -associated voltage-dependent calcium channels with a functionalized nanobody.
Nat Commun, 13, 2022
7YKH
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BU of 7ykh by Molmil
Crystal structure of MAGI2 PDZ0-GK domain in complex with phospho-SAPAP1 GBR2 peptide
Descriptor: GLYCEROL, Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2, ...
Authors:Zhang, M, Lin, L, Zhu, J.
Deposit date:2022-07-22
Release date:2023-08-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Phosphorylation-dependent recognition of diverse protein targets by the cryptic GK domain of MAGI MAGUKs.
Sci Adv, 9, 2023
7YKF
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BU of 7ykf by Molmil
Crystal structure of MAGI2 PDZ0-GK/pEphexin4 complex
Descriptor: Ephexin4, Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
Authors:Zhang, M, Lin, L, Zhu, J.
Deposit date:2022-07-22
Release date:2023-08-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Phosphorylation-dependent recognition of diverse protein targets by the cryptic GK domain of MAGI MAGUKs.
Sci Adv, 9, 2023
7YKG
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BU of 7ykg by Molmil
Crystal structure of MAGI2 PDZ0-GK/pSGEF complex
Descriptor: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2, SGEF
Authors:Zhang, M, Lin, L, Zhu, J.
Deposit date:2022-07-22
Release date:2023-08-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Phosphorylation-dependent recognition of diverse protein targets by the cryptic GK domain of MAGI MAGUKs.
Sci Adv, 9, 2023
7YKI
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BU of 7yki by Molmil
Crystal structure of MAGI2 PDZ0-GK domain in complex with phospho-SAPAP1 GBR3 peptide
Descriptor: GLYCEROL, Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2, ...
Authors:Zhang, M, Lin, L, Zhu, J.
Deposit date:2022-07-22
Release date:2023-08-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Phosphorylation-dependent recognition of diverse protein targets by the cryptic GK domain of MAGI MAGUKs.
Sci Adv, 9, 2023
7YG5
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BU of 7yg5 by Molmil
Structure of human R-type voltage-gated CaV2.3-alpha2/delta1-beta1 channel complex in the topiramate-bound state
Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Gao, Y, Zhao, Y.
Deposit date:2022-07-11
Release date:2023-11-29
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insights into allosteric effects of antiepileptic drug topiramate on CaV2.3 channel.
To Be Published
8DAM
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BU of 8dam by Molmil
nbF3:nbE8:CaV beta subunit 1b complex
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Nanobody E8, SULFATE ION, ...
Authors:Nirwan, N, Minor, D.L.
Deposit date:2022-06-13
Release date:2022-12-21
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Selective posttranslational inhibition of Ca V beta 1 -associated voltage-dependent calcium channels with a functionalized nanobody.
Nat Commun, 13, 2022
7XLQ
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BU of 7xlq by Molmil
Structure of human R-type voltage-gated CaV2.3-alpha2/delta1-beta1 channel complex in the ligand-free (apo) state
Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Gao, Y, Qiu, Y, Wei, Y, Dong, Y, Zhang, X.C, Zhao, Y.
Deposit date:2022-04-22
Release date:2023-02-08
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Molecular insights into the gating mechanisms of voltage-gated calcium channel Ca V 2.3.
Nat Commun, 14, 2023
7UHG
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BU of 7uhg by Molmil
Human L-type voltage-gated calcium channel Cav1.3 at 3.0 Angstrom resolution
Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gao, S, Yao, X, Yan, N.
Deposit date:2022-03-26
Release date:2022-05-11
Last modified:2022-10-12
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for pore blockade of human voltage-gated calcium channel Ca v 1.3 by motion sickness drug cinnarizine.
Cell Res., 32, 2022
7UHF
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Human L-type voltage-gated calcium channel Cav1.3 in the presence of cinnarizine at 3.1 Angstrom resolution
Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1-(diphenylmethyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gao, S, Yao, X, Yan, N.
Deposit date:2022-03-26
Release date:2022-05-11
Last modified:2022-10-12
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for pore blockade of human voltage-gated calcium channel Ca v 1.3 by motion sickness drug cinnarizine.
Cell Res., 32, 2022
7U5F
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BU of 7u5f by Molmil
Crystal structure of guanylate kinase from Pseudomonas aeruginosa PAO1 in complex with GMP
Descriptor: GUANOSINE-5'-MONOPHOSPHATE, Guanylate kinase, MAGNESIUM ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2022-03-02
Release date:2022-03-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of guanylate kinase from Pseudomonas aeruginosa PAO1 in complex with GMP
To be Published
7SQC
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BU of 7sqc by Molmil
Ciliary C1 central pair apparatus isolated from Chlamydomonas reinhardtii
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CPC1, Calmodulin, ...
Authors:Gui, M, Wang, X, Dutcher, S.K, Brown, A, Zhang, R.
Deposit date:2021-11-05
Release date:2022-04-13
Last modified:2022-06-08
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Ciliary central apparatus structure reveals mechanisms of microtubule patterning.
Nat.Struct.Mol.Biol., 29, 2022

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