1BY1
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DBL HOMOLOGY DOMAIN FROM BETA-PIX
Descriptor:PROTEIN (PIX)
Authors:Aghazadeh, B., Zhu, K., Kubiseski, T.J., Liu, G.A., Pawson, T., Zheng, Y., Rosen, M.K.
Deposit date:1998-10-22
Release date:1999-10-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and Mutagenesis of the Dbl Homology Domain
Nat.Struct.Biol., 5, 1998
1F5X
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NMR STRUCTURE OF THE Y174 AUTOINHIBITED DBL HOMOLOGY DOMAIN
Descriptor:RHO-GEF VAV
Authors:Aghazadeh, B., Rosen, M.K., Lowry, W.E., Huang, X.Y.
Deposit date:2000-06-18
Release date:2000-09-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation.
Cell(Cambridge,Mass.), 102, 2000
1TXD
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CRYSTAL STRUCTURE OF THE DH/PH DOMAINS OF LEUKEMIA-ASSOCIATED RHOGEF
Descriptor:Rho guanine nucleotide exchange factor 12
Authors:Kristelly, R., Gao, G., Tesmer, J.J.
Deposit date:2004-07-03
Release date:2004-09-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor.
J.Biol.Chem., 279, 2004
2KR9
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KALIRIN DH1 NMR STRUCTURE
Descriptor:Kalirin
Authors:Gorbatyuk, V.Y., Schiller, M.R., Hoch, J.C.
Deposit date:2009-12-10
Release date:2010-12-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The solution NMR structure of the first Dbl domain of RhoGEF Kalirin.
To be Published
2Z0Q
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CRYSTAL STRUCTURE OF DH-PH DOMAIN OF RHOGEF3(XPLN)
Descriptor:Rho guanine nucleotide exchange factor 3, SULFATE ION
Authors:Murayama, K., Kato-Murayama, M., Terada, T., Shirouzu, M., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-05-07
Release date:2008-05-13
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structure of the Rho-specific guanine nucleotide-exchange factor Xpln
Acta Crystallogr.,Sect.F, 68, 2012
3EO2
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CRYSTAL STRUCTURE OF THE RHOGEF DOMAIN OF HUMAN NEUROEPITHELIAL CELL-TRANSFORMING GENE 1 PROTEIN
Descriptor:Neuroepithelial cell-transforming gene 1 protein, UNKNOWN ATOM OR ION
Authors:Nedyalkova, L., Tong, Y., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2008-09-26
Release date:2008-10-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the RhoGEF domain of human neuroepithelial cell-transforming gene 1 protein
To be Published
3ODO
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CRYSTAL STRUCTURE OF THE DH/PH DOMAINS OF P115-RHOGEF
Descriptor:Rho guanine nucleotide exchange factor 1
Authors:Chen, Z., Guo, L., Sprang, S.R., Sternweis, P.C.
Deposit date:2010-08-11
Release date:2011-01-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF
Protein Sci., 20, 2011
3ODW
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CRYSTAL STRUCTURE OF THE LINKER-DH/PH DOMAINS OF P115-RHOGEF
Descriptor:Rho guanine nucleotide exchange factor 1
Authors:Chen, Z., Guo, L., Sprang, S.R., Sternweis, P.C.
Deposit date:2010-08-11
Release date:2011-01-05
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF
Protein Sci., 20, 2011
3ODX
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CRYSTAL STRUCTURE OF AN N-TERMINALLY TRUNCATED LINKER-DH/PH DOMAINS OF P115-RHOGEF
Descriptor:Rho guanine nucleotide exchange factor 1
Authors:Chen, Z., Guo, L., Sprang, S.R., Sternweis, P.C.
Deposit date:2010-08-12
Release date:2011-01-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF
Protein Sci., 20, 2011
3P6A
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CRYSTAL STRUCTURE OF THE DH/PH DOMAINS OF P115-RHOGEF (R399E MUTANT)
Descriptor:Rho guanine nucleotide exchange factor 1
Authors:Chen, Z., Guo, L., Sprang, S.R., Sternweis, P.C.
Deposit date:2010-10-11
Release date:2011-01-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF
Protein Sci., 20, 2011
4D0O
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AKAP13 (AKAP-LBC) DH DOMAIN
Descriptor:A-KINASE ANCHOR PROTEIN 13
Authors:Abdul Azeez, K.R., Shrestha, L., Krojer, T., Allerston, C., von Delft, F., Bountra, C., Arrowsmith, C., Edwards, A.M., Knapp, S., Klussmann, E., Elkins, J.M.
Deposit date:2014-04-29
Release date:2014-05-21
Last modified:2014-11-26
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:The Crystal Structure of the Rhoa : Akap-Lbc Dh-Ph Domain Complex.
Biochem.J., 464, 2014
4GYV
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CRYSTAL STRUCTURE OF THE DH DOMAIN OF FARP2
Descriptor:FERM, RhoGEF and pleckstrin domain-containing protein 2
Authors:He, X., Zhang, X.
Deposit date:2012-09-05
Release date:2013-03-13
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2.
Structure, 21, 2013
4YON
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P-REX1:RAC1 COMPLEX
Descriptor:Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1
Authors:Lucato, C.M., Whisstock, J.C., Ellisdon, A.M.
Deposit date:2015-03-11
Release date:2015-07-01
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.
J.Biol.Chem., 290, 2015
5O33
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A STRUCTURE OF THE GEF KALIRIN DH1 DOMAIN IN COMPLEX WITH THE SMALL GTPASE RAC1
Descriptor:1,2-ETHANEDIOL, GUANOSINE-5'-DIPHOSPHATE, Kalirin, ...
Authors:Gray, J., Krojer, T., Talon, R., Fairhead, M., Bountra, C., Arrowsmith, C.H., Edwards, A., Brennan, P., von Delft, F.
Deposit date:2017-05-23
Release date:2017-05-31
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:A structure of the GEF Kalirin DH1 domain in complex with the small GTPase Rac1
To Be Published
3GF9
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CRYSTAL STRUCTURE OF HUMAN INTERSECTIN 2 RHOGEF DOMAIN
Descriptor:Intersectin 2, UNKNOWN ATOM OR ION
Authors:Shen, Y., Tong, Y., Tempel, W., Li, Y., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-02-26
Release date:2009-03-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human Intersectin 2 RhoGEF domain
To be Published
3JV3
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STRUCTURE OF SH3E-DH UNIT OF MURINE INTERSECTIN-1L
Descriptor:Intersectin-1
Authors:Ahmad, K.F.
Deposit date:2009-09-15
Release date:2010-07-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin.
Plos One, 5, 2010
5HZI
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CRYSTAL STRUCTURE OF PHOTOINHIBITABLE INTERSECTIN1 CONTAINING C450M MUTANT LOV2 DOMAIN
Descriptor:FLAVIN MONONUCLEOTIDE, Intersectin-1,NPH1-1,Intersectin-1
Authors:Tarnawski, M., Dagliyan, O., Chu, P.H., Shirvanyants, D., Dokholyan, N.V., Hahn, K.M., Schlichting, I.
Deposit date:2016-02-02
Release date:2016-12-21
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Engineering extrinsic disorder to control protein activity in living cells.
Science, 354, 2016
5HZJ
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CRYSTAL STRUCTURE OF PHOTOINHIBITABLE INTERSECTIN1 CONTAINING WILDTYPE LOV2 DOMAIN
Descriptor:FLAVIN MONONUCLEOTIDE, Intersectin-1,NPH1-1,Intersectin-1
Authors:Tarnawski, M., Dagliyan, O., Chu, P.H., Shirvanyants, D., Dokholyan, N.V., Hahn, K.M., Schlichting, I.
Deposit date:2016-02-02
Release date:2016-12-21
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Engineering extrinsic disorder to control protein activity in living cells.
Science, 354, 2016
1DBH
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DBL AND PLECKSTRIN HOMOLOGY DOMAINS FROM HSOS1
Descriptor:PROTEIN (HUMAN SOS 1)
Authors:Soisson, S.M., Kuriyan, J.
Deposit date:1998-12-17
Release date:1998-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein.
Cell(Cambridge,Mass.), 95, 1998
1FOE
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CRYSTAL STRUCTURE OF RAC1 IN COMPLEX WITH THE GUANINE NUCLEOTIDE EXCHANGE REGION OF TIAM1
Descriptor:RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE, SULFATE ION, T-LYMPHOMA INVASION AND METASTASIS INDUCING PROTEIN 1
Authors:Worthylake, D.K., Rossman, K.L., Sondek, J.
Deposit date:2000-08-27
Release date:2001-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1.
Nature, 408, 2000
1KI1
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GUANINE NUCLEOTIDE EXCHANGE REGION OF INTERSECTIN IN COMPLEX WITH CDC42
Descriptor:G25K GTP-binding protein, placental isoform, SULFATE ION, ...
Authors:Snyder, J.T., Pruitt, W.M., Der, C.J., Sondek, J.
Deposit date:2001-12-02
Release date:2002-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Nat.Struct.Biol., 9, 2002
1KZ7
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CRYSTAL STRUCTURE OF THE DH/PH FRAGMENT OF MURINE DBS IN COMPLEX WITH THE PLACENTAL ISOFORM OF HUMAN CDC42
Descriptor:CDC42 HOMOLOG, GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS
Authors:Rossman, K.L., Worthylake, D.K., Snyder, J.T., Siderovski, D.P., Campbell, S.L., Sondek, J.
Deposit date:2002-02-06
Release date:2002-03-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
EMBO J., 21, 2002
1KZG
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DBSCDC42(Y889F)
Descriptor:CDC42 HOMOLOG, GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS
Authors:Rossman, K.L., Worthylake, D.K., Snyder, J.T., Siderovski, D.P., Campbell, S.L., Sondek, J.
Deposit date:2002-02-06
Release date:2002-03-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
EMBO J., 21, 2002
1LB1
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CRYSTAL STRUCTURE OF THE DBL AND PLECKSTRIN HOMOLOGY DOMAINS OF DBS IN COMPLEX WITH RHOA
Descriptor:Guanine nucleotide exchange factor DBS, Transforming protein RhoA
Authors:Snyder, J.T., Worthylake, D.K., Rossman, K.L., Betts, L., Pruitt, W.M., Siderovski, D.P., Der, C.J., Sondek, J.
Deposit date:2002-04-01
Release date:2002-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Nat.Struct.Biol., 9, 2002
1NTY
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CRYSTAL STRUCTURE OF THE FIRST DH/PH DOMAIN OF TRIO TO 1.7 A
Descriptor:Triple functional domain protein
Authors:Skowronek, K.R., Zheng, Y., Nassar, N.
Deposit date:2003-01-30
Release date:2004-06-29
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipids.
J.Biol.Chem., 279, 2004
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