1CY5
| CRYSTAL STRUCTURE OF THE APAF-1 CARD | Descriptor: | BETA-MERCAPTOETHANOL, PROTEIN (APOPTOTIC PROTEASE ACTIVATING FACTOR 1), ZINC ION | Authors: | Vaughn, D.E, Joshua-Tor, L. | Deposit date: | 1999-08-31 | Release date: | 1999-09-13 | Last modified: | 2018-01-31 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Crystal structure of Apaf-1 caspase recruitment domain: an alpha-helical Greek key fold for apoptotic signaling. J.Mol.Biol., 293, 1999
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6E28
| The CARD9 CARD domain-swapped dimer | Descriptor: | Caspase recruitment domain-containing protein 9 | Authors: | Holliday, M.J, Ferrao, R, Boenig, G, Deuber, E.C, Fairbrother, W.J. | Deposit date: | 2018-07-10 | Release date: | 2018-09-26 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.36 Å) | Cite: | Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9. J. Biol. Chem., 293, 2018
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4IRL
| X-ray structure of the CARD domain of zebrafish GBP-NLRP1 like protein | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Jin, T, Huang, M, Smith, P, Xiao, T. | Deposit date: | 2013-01-15 | Release date: | 2013-08-07 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Structure of the caspase-recruitment domain from a zebrafish guanylate-binding protein. Acta Crystallogr.,Sect.F, 69, 2013
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2P1H
| Rapid Folding and Unfolding of Apaf-1 CARD | Descriptor: | Apoptotic protease-activating factor 1, ZINC ION | Authors: | Milam, S.L, Nicely, N.I, Feeney, B, Mattos, C, Clark, A.C. | Deposit date: | 2007-03-05 | Release date: | 2007-05-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Rapid Folding and Unfolding of Apaf-1 CARD. J.Mol.Biol., 369, 2007
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2YGS
| CARD DOMAIN FROM APAF-1 | Descriptor: | APOPTOTIC PROTEASE ACTIVATING FACTOR 1 | Authors: | Shi, Y. | Deposit date: | 1999-05-08 | Release date: | 2000-04-19 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1. Nature, 399, 1999
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4I16
| Crystal structure of CARMA1 CARD | Descriptor: | Caspase recruitment domain-containing protein 11, SULFATE ION | Authors: | Li, S, Yang, X, Shen, Y. | Deposit date: | 2012-11-20 | Release date: | 2012-12-26 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.751 Å) | Cite: | Structural insights into the assembly of CARMA1 and BCL10 Plos One, 7, 2012
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4LWD
| Human CARMA1 CARD domain | Descriptor: | Caspase recruitment domain-containing protein 11, MAGNESIUM ION, SULFATE ION | Authors: | Zheng, C, Wu, H. | Deposit date: | 2013-07-26 | Release date: | 2013-10-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.792 Å) | Cite: | Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly. Mol.Cell, 51, 2013
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6E27
| The CARD9 CARD domain-swapped dimer with a zinc ion bound to one of the two zinc binding sites | Descriptor: | Caspase recruitment domain-containing protein 9, ZINC ION | Authors: | Holliday, M.J, Ferrao, R, Boenig, G, Deuber, E.C, Fairbrother, W.J. | Deposit date: | 2018-07-10 | Release date: | 2018-09-26 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.811 Å) | Cite: | Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9. J. Biol. Chem., 293, 2018
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3T6P
| IAP antagonist-induced conformational change in cIAP1 promotes E3 ligase activation via dimerization | Descriptor: | Baculoviral IAP repeat-containing protein 2, ZINC ION | Authors: | Dueber, E.C, Schoeffler, A.J, Lingel, A, Elliott, M, Fedorova, A.V, Giannetti, A.M, Zobel, K, Maurer, B, Varfolomeev, E, Wu, P, Wallweber, H, Hymowitz, S, Deshayes, K, Vucic, D, Fairbrother, W.J. | Deposit date: | 2011-07-28 | Release date: | 2011-11-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.897 Å) | Cite: | Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination. Science, 334, 2011
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2NZ7
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4IFP
| X-ray Crystal Structure of Human NLRP1 CARD Domain | Descriptor: | MALONATE ION, Maltose-binding periplasmic protein,NACHT, LRR and PYD domains-containing protein 1, ... | Authors: | Jin, T, Curry, J, Smith, P, Jiang, J, Xiao, T. | Deposit date: | 2012-12-14 | Release date: | 2013-04-03 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.9948 Å) | Cite: | Structure of the NLRP1 caspase recruitment domain suggests potential mechanisms for its association with procaspase-1. Proteins, 81, 2013
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2NSN
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6KI0
| Crystal Structure of Human ASC-CARD | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Apoptosis-associated speck-like protein containing a CARD, SULFATE ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Xu, Z.H, Jin, T.C. | Deposit date: | 2019-07-16 | Release date: | 2020-07-22 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Homotypic CARD-CARD interaction is critical for the activation of NLRP1 inflammasome. Cell Death Dis, 12, 2021
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5GPQ
| Crystal Structure of zebrafish ASC CARD Domain | Descriptor: | CITRIC ACID, Maltose-binding periplasmic protein,Apoptosis-associated speck-like protein containing a CARD, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Jin, T, Li, Y. | Deposit date: | 2016-08-04 | Release date: | 2017-08-09 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Functional and structural characterization of zebrafish ASC. FEBS J., 285, 2018
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4RHW
| Crystal structure of Apaf-1 CARD and caspase-9 CARD complex | Descriptor: | Apoptotic protease-activating factor 1, CHLORIDE ION, Caspase-9, ... | Authors: | Hu, Q, Wu, D, Yan, C, Shi, Y. | Deposit date: | 2014-10-03 | Release date: | 2014-10-15 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome. Proc. Natl. Acad. Sci. U.S.A., 111, 2014
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4E9M
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1Z6T
| Structure of the apoptotic protease-activating factor 1 bound to ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Apoptotic protease activating factor 1 | Authors: | Riedl, S.J, Li, W, Chao, Y, Schwarzenbacher, R, Shi, Y. | Deposit date: | 2005-03-23 | Release date: | 2005-04-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Structure of the apoptotic protease-activating factor 1 bound to ADP Nature, 434, 2005
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4UZ0
| Crystal Structure of apoptosis repressor with CARD (ARC) | Descriptor: | GLYCEROL, NUCLEOLAR PROTEIN 3 | Authors: | Kim, S.H, Jeong, J.H, Jang, T.H, Kim, Y.G, Park, H.H. | Deposit date: | 2014-09-04 | Release date: | 2015-07-01 | Last modified: | 2017-07-12 | Method: | X-RAY DIFFRACTION (2.399 Å) | Cite: | Crystal Structure of Caspase Recruiting Domain (Card) of Apoptosis Repressor with Card (Arc) and its Implication in Inhibition of Apoptosis. Sci.Rep., 5, 2015
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4IKM
| X-ray structure of CARD8 CARD domain | Descriptor: | 1,2-ETHANEDIOL, IODIDE ION, Maltose-binding periplasmic protein, ... | Authors: | Jin, T, Huang, M, Smith, P, Jiang, J, Xiao, T. | Deposit date: | 2012-12-26 | Release date: | 2013-05-08 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.4606 Å) | Cite: | The structure of the CARD8 caspase-recruitment domain suggests its association with the FIIND domain and procaspases through adjacent surfaces. Acta Crystallogr.,Sect.F, 69, 2013
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3YGS
| APAF-1 CARD IN COMPLEX WITH PRODOMAIN OF PROCASPASE-9 | Descriptor: | APOPTOTIC PROTEASE ACTIVATING FACTOR 1, PROCASPASE 9 | Authors: | Qin, H, Srinivasula, S, Wu, G, Fernandes-Alnemri, T, Alnemri, E, Shi, Y. | Deposit date: | 1999-05-08 | Release date: | 2000-04-19 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1. Nature, 399, 1999
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6J52
| Crystal structure of CARD-only protein in frog virus 3 | Descriptor: | Caspase recruitment domain-only protein | Authors: | Park, H.H, Kwon, S. | Deposit date: | 2019-01-10 | Release date: | 2019-02-20 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.504 Å) | Cite: | Structural transformation-mediated dimerization of caspase recruitment domain revealed by the crystal structure of CARD-only protein in frog virus 3. J. Struct. Biol., 205, 2019
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2A5Y
| Structure of a CED-4/CED-9 complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Apoptosis regulator ced-9, MAGNESIUM ION, ... | Authors: | Yan, N, Liu, Q, Hao, Q, Gu, L, Shi, Y. | Deposit date: | 2005-07-01 | Release date: | 2005-10-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans. Nature, 437, 2005
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7BKP
| CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, MAGNESIUM ION, ... | Authors: | Singh, R, Herrero del Valle, A, Yu, Q, Modis, Y. | Deposit date: | 2021-01-16 | Release date: | 2021-11-17 | Last modified: | 2021-12-01 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA. Nat Commun, 12, 2021
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8XQK
| The Crystal Structure of Apaf from Biortus. | Descriptor: | Apoptotic protease-activating factor 1, PHOSPHATE ION | Authors: | Wang, F, Cheng, W, Lv, Z, Ju, C, Ni, C. | Deposit date: | 2024-01-05 | Release date: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | The Crystal Structure of Apaf from Biortus. To Be Published
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6X6C
| Cryo-EM structure of NLRP1-DPP9-VbP complex | Descriptor: | Dipeptidyl peptidase 9, NACHT, LRR and PYD domains-containing protein 1, ... | Authors: | Hollingsworth, L.R, Sharif, H, Griswold, A.R, Fontana, P, Mintseris, J, Dagbay, K.B, Paulo, J.A, Gygi, S.P, Bachovchin, D.A, Wu, H. | Deposit date: | 2020-05-27 | Release date: | 2021-03-10 | Last modified: | 2021-05-12 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation. Nature, 592, 2021
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