6MKS
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CRYO-EM STRUCTURE OF NLRC4-CARD FILAMENT
Descriptor:Chimera protein of NLR family CARD domain-containing protein 4 and EGFP
Authors:Zheng, W., Matyszewski, M., Sohn, J., Egelman, E.H.
Deposit date:2018-09-26
Release date:2018-11-07
Last modified:2018-11-14
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structure of the NLRC4CARDfilament provides insights into how symmetric and asymmetric supramolecular structures drive inflammasome assembly.
J. Biol. Chem., 2018
6GWM
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SOLUTION STRUCTURE OF RAT RIP2 CASPASE RECRUITMENT DOMAIN
Descriptor:Receptor-interacting serine/threonine-protein kinase 2
Authors:Mineev, K.S., Goncharuk, S.A., Artemieva, L.E., Arseniev, A.S.
Deposit date:2018-06-25
Release date:2018-10-31
Method:SOLUTION NMR
Cite:CARD domain of rat RIP2 kinase: Refolding, solution structure, pH-dependent behavior and protein-protein interactions.
PLoS ONE, 13, 2018
6GK2
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HELICAL RECONSTRUCTION OF BCL10 CARD AND MALT1 DEATH DOMAIN COMPLEX
Descriptor:B-cell lymphoma/leukemia 10, Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Authors:Schlauderer, F., Desfosses, A., Gutsche, I., Hopfner, K.P., Lammens, K.
Deposit date:2018-05-18
Release date:2018-10-31
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Molecular architecture and regulation of BCL10-MALT1 filaments.
Nat Commun, 9, 2018
6GGS
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STRUCTURE OF RIP2 CARD FILAMENT
Descriptor:Receptor-interacting serine/threonine-protein kinase 2
Authors:Pellegrini, E., Cusack, S., Desfosses, A., Schoehn, G., Malet, H., Gutsche, I., Sachse, C., Hons, M.
Deposit date:2018-05-03
Release date:2018-10-17
Method:ELECTRON MICROSCOPY (3.94 Å)
Cite:RIP2 filament formation is required for NOD2 dependent NF-kappa B signalling.
Nat Commun, 9, 2018
6E28
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THE CARD9 CARD DOMAIN-SWAPPED DIMER
Descriptor:Caspase recruitment domain-containing protein 9
Authors:Holliday, M.J., Ferrao, R., Boenig, G., Deuber, E.C., Fairbrother, W.J.
Deposit date:2018-07-10
Release date:2018-09-26
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9.
J. Biol. Chem., 293, 2018
6E27
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THE CARD9 CARD DOMAIN-SWAPPED DIMER WITH A ZINC ION BOUND TO ONE OF THE TWO ZINC BINDING SITES
Descriptor:Caspase recruitment domain-containing protein 9, ZINC ION
Authors:Holliday, M.J., Ferrao, R., Boenig, G., Deuber, E.C., Fairbrother, W.J.
Deposit date:2018-07-10
Release date:2018-09-26
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (1.811 Å)
Cite:Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9.
J. Biol. Chem., 293, 2018
6E26
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NMR SOLUTION STRUCTURE OF THE CARD9 CARD
Descriptor:Caspase recruitment domain-containing protein 9
Authors:Holliday, M.J., Dueber, E.C., Fairbrother, W.J.
Deposit date:2018-07-10
Release date:2018-09-26
Last modified:2018-11-07
Method:SOLUTION NMR
Cite:Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9.
J. Biol. Chem., 293, 2018
6E25
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NMR SOLUTION STRUCTURE OF THE CARD9 CARD BOUND TO ZINC
Descriptor:Caspase recruitment domain-containing protein 9, ZINC ION
Authors:Holliday, M.J., Dueber, E.C., Fairbrother, W.J.
Deposit date:2018-07-10
Release date:2018-09-26
Last modified:2018-11-07
Method:SOLUTION NMR
Cite:Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9.
J. Biol. Chem., 293, 2018
6BZE
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CRYO-EM STRUCTURE OF BCL10 CARD FILAMENT
Descriptor:B-cell lymphoma/leukemia 10
Authors:David, L., Li, Y., Ma, J., Garner, E., Zhang, X., Wu, H.
Deposit date:2017-12-23
Release date:2018-02-14
Last modified:2018-02-28
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Assembly mechanism of the CARMA1-BCL10-MALT1-TRAF6 signalosome.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6B5B
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CRYO-EM STRUCTURE OF THE NAIP5-NLRC4-FLAGELLIN INFLAMMASOME
Descriptor:Baculoviral IAP repeat-containing protein 1e, NLR family CARD domain-containing protein 4, Flagellin
Authors:Tenthorey, J.L., Haloupek, N., Lopez-Blanco, J.R., Grob, P., Adamson, E., Hartenian, E., Lind, N.A., Bourgeois, N.M., Chacon, P., Nogales, E., Vance, R.E.
Deposit date:2017-09-29
Release date:2017-11-15
Last modified:2017-12-06
Method:ELECTRON MICROSCOPY (5.2 Å)
Cite:The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion.
Science, 358, 2017
5WVE
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APAF-1-CASPASE-9 HOLOENZYME
Descriptor:Apoptotic protease-activating factor 1, Cytochrome c, Caspase, ...
Authors:Li, Y., Zhou, M., Hu, Q., Shi, Y.
Deposit date:2016-12-24
Release date:2017-02-08
Last modified:2017-03-01
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5WVC
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STRUCTURE OF THE CARD-CARD DISK
Descriptor:Apoptotic protease-activating factor 1, Caspase, IODIDE ION
Authors:Lin, S.C., Lo, Y.C., Su, T.W.
Deposit date:2016-12-24
Release date:2017-04-19
Method:X-RAY DIFFRACTION (2.993 Å)
Cite:Structural Insights into DD-Fold Assembly and Caspase-9 Activation by the Apaf-1 Apoptosome.
Structure, 25, 2017
5JUY
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ACTIVE HUMAN APOPTOSOME WITH PROCASPASE-9
Descriptor:Apoptotic protease-activating factor 1, Cytochrome c, Caspase-9, ...
Authors:Cheng, T.C., Hong, C., Akey, I.V., Yuan, S., Akey, C.W.
Deposit date:2016-05-10
Release date:2016-10-19
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:A near atomic structure of the active human apoptosome.
Elife, 5, 2016
5AJ2
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CRYO ELECTRON TOMOGRAPHY OF THE NAIP5-NLRC4 INFLAMMASOME
Descriptor:NLR FAMILY CARD DOMAIN-CONTAINING PROTEIN 4
Authors:Diebolder, C.A., Halff, E.F., Koster, A.J., Huizinga, E.G., Koning, R.I.
Deposit date:2015-02-20
Release date:2015-11-11
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (40 Å)
Cite:Cryoelectron Tomography of the Naip5/Nlrc4 Inflammasome: Implications for Nlr Activation.
Structure, 23, 2015
4RHW
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CRYSTAL STRUCTURE OF APAF-1 CARD AND CASPASE-9 CARD COMPLEX
Descriptor:Apoptotic protease-activating factor 1, Caspase-9, SULFATE ION, ...
Authors:Hu, Q., Wu, D., Yan, C., Shi, Y.
Deposit date:2014-10-03
Release date:2014-10-15
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome.
Proc. Natl. Acad. Sci. U.S.A., 111, 2014
4M9Z
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CRYSTAL STRUCTURE OF CED-4 BOUND CED-3 FRAGMENT
Descriptor:Cell death protein 4, CED-3 fragment, MAGNESIUM ION, ...
Authors:Huang, W.J., Jinag, T.Y., Choi, W.Y., Wang, J.W., Shi, Y.G.
Deposit date:2013-08-15
Release date:2013-10-23
Method:X-RAY DIFFRACTION (3.405 Å)
Cite:Mechanistic insights into CED-4-mediated activation of CED-3.
Genes Dev., 27, 2013
4M9Y
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CRYSTAL STRUCTURE OF CED-4 BOUND CED-3 FRAGMENT
Descriptor:Cell death protein 4, CED-3 fragment, MAGNESIUM ION, ...
Authors:Huang, W.J., Jinag, T.Y., Choi, W.Y., Wang, J.W., Shi, Y.G.
Deposit date:2013-08-15
Release date:2013-10-23
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Mechanistic insights into CED-4-mediated activation of CED-3.
Genes Dev., 27, 2013
4M9X
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CRYSTAL STRUCTURE OF CED-4 BOUND CED-3 FRAGMENT
Descriptor:Cell death protein 4, CED-3 fragment, MAGNESIUM ION, ...
Authors:Huang, W.J., Jinag, T.Y., Choi, W.Y., Wang, J.W., Shi, Y.G.
Deposit date:2013-08-15
Release date:2013-10-23
Method:X-RAY DIFFRACTION (3.344 Å)
Cite:Mechanistic insights into CED-4-mediated activation of CED-3.
Genes Dev., 27, 2013
4M9S
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CRYSTAL STRUCTURE OF CED-4 BOUND CED-3 FRAGMENT
Descriptor:Cell death protein 4, CED-3 fragment, MAGNESIUM ION, ...
Authors:Huang, W.J., Jinag, T.Y., Choi, W.Y., Wang, J.W., Shi, Y.G.
Deposit date:2013-08-15
Release date:2013-10-23
Method:X-RAY DIFFRACTION (3.207 Å)
Cite:Mechanistic insights into CED-4-mediated activation of CED-3.
Genes Dev., 27, 2013
4LWD
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HUMAN CARMA1 CARD DOMAIN
Descriptor:Caspase recruitment domain-containing protein 11, SULFATE ION, MAGNESIUM ION
Authors:Zheng, C., Wu, H.
Deposit date:2013-07-26
Release date:2013-10-16
Method:X-RAY DIFFRACTION (1.792 Å)
Cite:Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly.
Mol.Cell, 51, 2013
4KXF
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CRYSTAL STRUCTURE OF NLRC4 REVEALS ITS AUTOINHIBITION MECHANISM
Descriptor:NLR family CARD domain-containing protein 4, ADENOSINE-5'-DIPHOSPHATE, SULFATE ION
Authors:Chai, J., Hu, Z.
Deposit date:2013-05-25
Release date:2013-07-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of NLRC4 reveals its autoinhibition mechanism
Science, 341, 2013
4JUP
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DIMERIC STRUCTURE OF CARMA1 CARD
Descriptor:Caspase recruitment domain-containing protein 11
Authors:Park, H.H.
Deposit date:2013-03-25
Release date:2014-02-05
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Novel Disulfide Bond-Mediated Dimerization of the CARD Domain Was Revealed by the Crystal Structure of CARMA1 CARD
Plos One, 8, 2013
4JQW
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CRYSTAL STRUCTURE OF A COMPLEX OF NOD1 CARD AND UBIQUITIN
Descriptor:Nucleotide-binding oligomerization domain-containing protein 1, Polyubiquitin-C, PHOSPHATE ION
Authors:Ver Heul, A.M., Gakhar, L., Piper, R.C., Ramaswamy, S.
Deposit date:2013-03-20
Release date:2014-03-26
Last modified:2014-12-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of a complex of NOD1 CARD and ubiquitin
Plos One, 9, 2014
4IRL
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X-RAY STRUCTURE OF THE CARD DOMAIN OF ZEBRAFISH GBP-NLRP1 LIKE PROTEIN
Descriptor:Maltose-binding periplasmic protein, Novel protein similar to vertebrate guanylate binding protein family, MALTOTETRAOSE, ...
Authors:Jin, T., Huang, M., Smith, P., Xiao, T.
Deposit date:2013-01-15
Release date:2013-08-07
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Structure of the caspase-recruitment domain from a zebrafish guanylate-binding protein.
Acta Crystallogr.,Sect.F, 69, 2013
4IKM
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X-RAY STRUCTURE OF CARD8 CARD DOMAIN
Descriptor:Maltose-binding periplasmic protein, Caspase recruitment domain-containing protein 8, MALTOSE, ...
Authors:Jin, T., Huang, M., Smith, P., Jiang, J., Xiao, T.
Deposit date:2012-12-26
Release date:2013-05-08
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.4606 Å)
Cite:The structure of the CARD8 caspase-recruitment domain suggests its association with the FIIND domain and procaspases through adjacent surfaces.
Acta Crystallogr.,Sect.F, 69, 2013
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