1BKD
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COMPLEX OF HUMAN H-RAS WITH HUMAN SOS-1
Descriptor:H-RAS, SON OF SEVENLESS-1
Authors:Boriack-Sjodin, P.A., Margarit, S.M., Sagi, D.B., Kuriyan, J.
Deposit date:1998-07-06
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The structural basis of the activation of Ras by Sos.
Nature, 394, 1998
1NVU
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STRUCTURAL EVIDENCE FOR FEEDBACK ACTIVATION BY RASGTP OF THE RAS-SPECIFIC NUCLEOTIDE EXCHANGE FACTOR SOS
Descriptor:Transforming protein p21/H-RAS-1, Son of sevenless protein homolog 1, MAGNESIUM ION, ...
Authors:Margarit, S.M., Sondermann, H., Hall, B.E., Nagar, B., Hoelz, A., Pirruccello, M., Bar-Sagi, D., Kuriyan, J.
Deposit date:2003-02-04
Release date:2003-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS
Cell(Cambridge,Mass.), 112, 2003
1NVV
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STRUCTURAL EVIDENCE FOR FEEDBACK ACTIVATION BY RASGTP OF THE RAS-SPECIFIC NUCLEOTIDE EXCHANGE FACTOR SOS
Descriptor:Transforming protein p21/H-RAS-1, Son of sevenless protein homolog 1, MAGNESIUM ION, ...
Authors:Margarit, S.M., Sondermann, H., Hall, B.E., Nagar, B., Hoelz, A., Pirruccello, M., Bar-Sagi, D., Kuriyan, J.
Deposit date:2003-02-04
Release date:2003-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS
Cell(Cambridge,Mass.), 112, 2003
1NVW
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STRUCTURAL EVIDENCE FOR FEEDBACK ACTIVATION BY RASGTP OF THE RAS-SPECIFIC NUCLEOTIDE EXCHANGE FACTOR SOS
Descriptor:Transforming protein p21/H-RAS-1, Son of sevenless protein homolog 1, MAGNESIUM ION, ...
Authors:Margarit, S.M., Sondermann, H., Hall, B.E., Nagar, B., Hoelz, A., Pirruccello, M., Bar-Sagi, D., Kuriyan, J.
Deposit date:2003-02-04
Release date:2003-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS
Cell(Cambridge,Mass.), 112, 2003
1NVX
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STRUCTURAL EVIDENCE FOR FEEDBACK ACTIVATION BY RASGTP OF THE RAS-SPECIFIC NUCLEOTIDE EXCHANGE FACTOR SOS
Descriptor:Transforming protein p21/H-RAS-1, Son of sevenless protein homolog 1, MAGNESIUM ION, ...
Authors:Margarit, S.M., Sondermann, H., Hall, B.E., Nagar, B., Hoelz, A., Pirruccello, M., Bar-Sagi, D., Kuriyan, J.
Deposit date:2003-02-04
Release date:2003-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS
Cell(Cambridge,Mass.), 112, 2003
1XD2
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CRYSTAL STRUCTURE OF A TERNARY RAS:SOS:RAS*GDP COMPLEX
Descriptor:Transforming protein p21/H-Ras-1, Son of sevenless protein homolog 1, MAGNESIUM ION, ...
Authors:Sondermann, H., Soisson, S.M., Boykevisch, S., Yang, S.S., Bar-Sagi, D., Kuriyan, J.
Deposit date:2004-09-03
Release date:2004-11-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural analysis of autoinhibition in the ras activator son of sevenless.
Cell(Cambridge,Mass.), 119, 2004
1XD4
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CRYSTAL STRUCTURE OF THE DH-PH-CAT MODULE OF SON OF SEVENLESS (SOS)
Descriptor:Son of sevenless protein homolog 1
Authors:Sondermann, H., Soisson, S.M., Boykevisch, S., Yang, S.S., Bar-Sagi, D., Kuriyan, J.
Deposit date:2004-09-03
Release date:2004-11-02
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3.64 Å)
Cite:Structural analysis of autoinhibition in the ras activator son of sevenless.
Cell(Cambridge,Mass.), 119, 2004
1XDV
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EXPERIMENTALLY PHASED STRUCTURE OF HUMAN THE SON OF SEVENLESS PROTEIN AT 4.1 ANG.
Descriptor:Son of sevenless protein homolog 1
Authors:Sondermann, H., Soisson, S.M., Boykevisch, S., Yang, S.S., Bar-Sagi, D., Kuriyan, J.
Deposit date:2004-09-08
Release date:2004-11-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Structural analysis of autoinhibition in the ras activator son of sevenless.
Cell(Cambridge,Mass.), 119, 2004
2BYV
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STRUCTURE OF THE CAMP RESPONSIVE EXCHANGE FACTOR EPAC2 IN ITS AUTO- INHIBITED STATE
Descriptor:RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4
Authors:Rehmann, H., Wittinghofer, A., Bos, J.L.
Deposit date:2005-08-08
Release date:2006-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of the Cyclic-AMP Responsive Exchange Factor Epac2 in its Auto-Inhibited State
Nature, 439, 2006
2II0
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CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF SON OF SEVENLESS (REM-CDC25) IN THE ABSENCE OF RAS
Descriptor:Son of sevenless homolog 1
Authors:Freedman, T.S., Sondermann, H., Friedland, G.D., Kortemme, T., Bar-Sagi, D., Marqusee, S., Kuriyan, J.
Deposit date:2006-09-27
Release date:2006-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:A Ras-induced conformational switch in the Ras activator Son of sevenless.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2IJE
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CRYSTAL STRUCTURE OF THE CDC25 DOMAIN OF RASGRF1
Descriptor:Guanine nucleotide-releasing protein, GLYCEROL
Authors:Freedman, T.S., Kuriyan, J.
Deposit date:2006-09-29
Release date:2006-10-31
Last modified:2014-04-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A Ras-induced conformational switch in the Ras activator Son of sevenless.
Proc.Natl.Acad.Sci.Usa, 103, 2006
3KSY
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CRYSTAL STRUCTURE OF THE HISTONE DOMAIN, DH-PH UNIT, AND CATALYTIC UNIT OF THE RAS ACTIVATOR SON OF SEVENLESS (SOS)
Descriptor:Son of sevenless homolog 1
Authors:Gureasko, J., Kuchment, O., Kuriyan, J.
Deposit date:2009-11-24
Release date:2010-02-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.178 Å)
Cite:Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless.
Proc.Natl.Acad.Sci.USA, 107, 2010
3QXL
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CRYSTAL STRUCTURE OF THE CDC25 DOMAIN FROM RAL-SPECIFIC GUANINE-NUCLEOTIDE EXCHANGE FACTOR RALGPS1A
Descriptor:Ras-specific guanine nucleotide-releasing factor RalGPS1
Authors:Peng, W., Xu, J., Guan, X., Sun, Y., Li, X., Zhang, X.C., Rao, Z.
Deposit date:2011-03-02
Release date:2011-05-11
Last modified:2011-08-17
Method:X-RAY DIFFRACTION (2.237 Å)
Cite:Structural study of the Cdc25 domain from Ral-specific guanine-nucleotide exchange factor RalGPS1a.
Protein Cell, 2, 2011
3T6A
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STRUCTURE OF THE C-TERMINAL DOMAIN OF BCAR3
Descriptor:Breast cancer anti-estrogen resistance protein 3, (20S)-2,5,8,11,14,17-HEXAMETHYL-3,6,9,12,15,18-HEXAOXAHENICOSANE-1,20-DIOL, UNKNOWN ATOM OR ION
Authors:Mace, P.D., Robinson, H., Riedl, S.J.
Deposit date:2011-07-28
Release date:2011-11-23
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling.
Nat.Struct.Mol.Biol., 18, 2011
3T6G
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STRUCTURE OF THE COMPLEX BETWEEN NSP3 (SHEP1) AND P130CAS
Descriptor:SH2 domain-containing protein 3C, Breast cancer anti-estrogen resistance protein 1, ACETATE ION
Authors:Mace, P.D., Robinson, H., Riedl, S.J.
Deposit date:2011-07-28
Release date:2011-11-23
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling.
Nat.Struct.Mol.Biol., 18, 2011
4F7Z
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CONFORMATIONAL DYNAMICS OF EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP
Descriptor:Rap guanine nucleotide exchange factor 4, GLYCEROL
Authors:White, M.A., Tsalkova, T.N., Mei, F.C., Liu, T., Woods, V.L., Cheng, X.
Deposit date:2012-05-16
Release date:2012-10-03
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural analyses of a constitutively active mutant of exchange protein directly activated by cAMP.
Plos One, 7, 2012
4JGW
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THE CONFORMATION OF A DOCKING SITE FOR SH3 DOMAINS IS PRE-SELECTED IN THE GUANINE NUCLEOTIDE EXCHANGE FACTOR RLF
Descriptor:Ral guanine nucleotide dissociation stimulator-like 2
Authors:Rehmann, H., Popovic, M., Jakobi, A.J.
Deposit date:2013-03-04
Release date:2013-09-11
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The guanine nucleotide exchange factor Rlf interacts with SH3 domain-containing proteins via a binding site with a preselected conformation.
J.Struct.Biol., 183, 2013
4L9M
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AUTOINHIBITED STATE OF THE RAS-SPECIFIC EXCHANGE FACTOR RASGRP1
Descriptor:RAS guanyl-releasing protein 1, CITRIC ACID, GLYCEROL, ...
Authors:Iwig, J.S., Vercoulen, Y., Das, R., Barros, T., Limnander, A., Che, Y., Pelton, J.G., Wemmer, D.E., Roose, J.P., Kuriyan, J.
Deposit date:2013-06-18
Release date:2013-08-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1.
Elife, 2, 2013
4MGI
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SELECTIVE ACTIVATION OF EPAC1 AND EPAC2
Descriptor:Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ...
Authors:Rehmann, H.
Deposit date:2013-08-28
Release date:2014-09-03
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Selective activation of Epac1 and Epac2
To be Published
4MGK
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SELECTIVE ACTIVATION OF EPAC1 AND EPAC2
Descriptor:Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ...
Authors:Rehmann, H.
Deposit date:2013-08-28
Release date:2014-09-03
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Selective activation of Epac1 and Epac2
To be Published
4MGY
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SELECTIVE ACTIVATION OF EPAC1 AND EPAC2
Descriptor:Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, (2S,4aR,6R,7R,7aR)-6-{6-amino-8-[(4-chlorophenyl)sulfanyl]-9H-purin-9-yl}-7-methoxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-ol 2-oxide, ...
Authors:Rehmann, H.
Deposit date:2013-08-29
Release date:2014-09-03
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Selective activation of Epac1 and Epac2
To be Published
4MGZ
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SELECTIVE ACTIVATION OF EPAC1 AND EPAC2
Descriptor:Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, (2S,4aR,6R,7R,7aS)-6-[6-amino-8-(benzylsulfanyl)-9H-purin-9-yl]-2-sulfanyltetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol 2-oxide, ...
Authors:Rehmann, H.
Deposit date:2013-08-29
Release date:2014-09-03
Method:X-RAY DIFFRACTION (3 Å)
Cite:Selective activation of Epac1 and Epac2
To be Published
4MH0
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SELECTIVE ACTIVATION OF EPAC1 AND EPAC2
Descriptor:Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, (2S,4aR,6R,7R,7aS)-6-{6-amino-8-[(4-fluorobenzyl)sulfanyl]-9H-purin-9-yl}-2-sulfanyltetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol 2-oxide, ...
Authors:Rehmann, H.
Deposit date:2013-08-29
Release date:2014-09-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Selective activation of Epac1 and Epac2
To be Published
4NYI
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APPROACH FOR TARGETING RAS WITH SMALL MOLECULES THAT ACTIVATE SOS-MEDIATED NUCLEOTIDE EXCHANGE
Descriptor:GTPase HRas, Son of sevenless homolog 1, MAGNESIUM ION, ...
Authors:Burns, M.C., Sun, Q., Phan, J., Fesik, S.W.
Deposit date:2013-12-10
Release date:2014-03-12
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.9612 Å)
Cite:Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.
Proc.Natl.Acad.Sci.USA, 111, 2014
4NYJ
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APPROACH FOR TARGETING RAS WITH SMALL MOLECULES THAT ACTIVATE SOS-MEDIATED NUCLEOTIDE EXCHANGE
Descriptor:GTPase HRas, Son of sevenless homolog 1, MAGNESIUM ION, ...
Authors:Burns, M.C., Sun, Q., Phan, J., Fesik, S.W.
Deposit date:2013-12-10
Release date:2014-03-12
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.8522 Å)
Cite:Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.
Proc.Natl.Acad.Sci.USA, 111, 2014
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