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7DKL
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BU of 7dkl by Molmil
Crystal structure of the tandem DEP domains of DEPTOR
Descriptor: DEP domain-containing mTOR-interacting protein
Authors:Weng, Z.F, Shen, X.X, Liu, Y.F.
Deposit date:2020-11-24
Release date:2021-12-08
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Basis of DEPTOR to Recognize Phosphatidic Acid Using its Tandem DEP Domains.
J.Mol.Biol., 433, 2021
5SUZ
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BU of 5suz by Molmil
Domain-swapped dimer of human Dishevelled2 DEP domain: C-centered monoclinic crystal form crystallised from monomeric fraction
Descriptor: Segment polarity protein dishevelled homolog DVL-2
Authors:Renko, M, Gammons, M.V, Bienz, M.
Deposit date:2016-08-04
Release date:2016-10-12
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled.
Mol.Cell, 64, 2016
5SUY
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BU of 5suy by Molmil
Domain-swapped dimer of human Dishevelled2 DEP domain: monoclinic crystal form crystallised from dimeric fraction
Descriptor: SULFATE ION, Segment polarity protein dishevelled homolog DVL-2
Authors:Renko, M, Gammons, M.V, Bienz, M.
Deposit date:2016-08-04
Release date:2016-10-12
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled.
Mol.Cell, 64, 2016
7PED
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BU of 7ped by Molmil
DEPTOR DEP domain tandem (DEPt)
Descriptor: DEP domain-containing mTOR-interacting protein
Authors:Waelchli, M, Jakob, R, Maier, T.
Deposit date:2021-08-09
Release date:2021-09-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Regulation of human mTOR complexes by DEPTOR.
Elife, 10, 2021
2PBI
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BU of 2pbi by Molmil
The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure
Descriptor: GLYCEROL, Guanine nucleotide-binding protein subunit beta 5, Regulator of G-protein signaling 9
Authors:Cheever, M.L, Snyder, J.T, Gershburg, S, Siderovski, D.P, Harden, T.K, Sondek, J.
Deposit date:2007-03-28
Release date:2008-01-29
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of the multifunctional Gbeta5-RGS9 complex.
Nat.Struct.Mol.Biol., 15, 2008
5LNP
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BU of 5lnp by Molmil
Domain-swapped dimer of human Dishevelled2 DEP domain: monoclinic crystal form crystallised from monomeric fraction
Descriptor: SULFATE ION, Segment polarity protein dishevelled homolog DVL-2
Authors:Renko, M, Gammons, M.V, Bienz, M.
Deposit date:2016-08-05
Release date:2016-10-12
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled.
Mol.Cell, 64, 2016
6N9G
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BU of 6n9g by Molmil
Crystal Structure of RGS7-Gbeta5 dimer
Descriptor: Guanine nucleotide-binding protein subunit beta-5, Regulator of G-protein signaling 7
Authors:Patil, D.N, Rangarajan, E, Izard, T, Martemyanov, K.A.
Deposit date:2018-12-03
Release date:2019-01-09
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.129 Å)
Cite:Structural organization of a major neuronal G protein regulator, the RGS7-G beta 5-R7BP complex.
Elife, 7, 2018
6H7E
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BU of 6h7e by Molmil
GEF regulatory domain
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SULFATE ION, cDNA FLJ56134, ...
Authors:Ferrandez, Y, Cherfils, J, Peurois, F.
Deposit date:2018-07-31
Release date:2020-02-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Membranes prime the RapGEF EPAC1 to transduce cAMP signaling.
Nat Commun, 14, 2023
1O7F
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BU of 1o7f by Molmil
CRYSTAL STRUCTURE OF THE REGULATORY DOMAIN OF EPAC2
Descriptor: CAMP-DEPENDENT RAP1 GUANINE-NUCLEOTIDE EXCHANGE FACTOR
Authors:Rehmann, H, Prakash, B, Wolf, E, Rueppel, A, De Rooij, J, Bos, J.L, Wittinghofer, A.
Deposit date:2002-11-04
Release date:2002-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure and Regulation of the Camp-Binding Domains of Epac2
Nat.Struct.Biol., 10, 2002
4F7Z
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BU of 4f7z by Molmil
Conformational dynamics of exchange protein directly activated by cAMP
Descriptor: GLYCEROL, Rap guanine nucleotide exchange factor 4
Authors:White, M.A, Tsalkova, T.N, Mei, F.C, Liu, T, Woods, V.L, Cheng, X.
Deposit date:2012-05-16
Release date:2012-10-03
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural analyses of a constitutively active mutant of exchange protein directly activated by cAMP.
Plos One, 7, 2012
8AE6
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BU of 8ae6 by Molmil
Cryo-EM structure of the SEA complex wing (SEACIT)
Descriptor: Maintenance of telomere capping protein 5, Nitrogen permease regulator 2, Nitrogen permease regulator 3, ...
Authors:Tafur, L, Loewith, R.
Deposit date:2022-07-12
Release date:2022-11-02
Last modified:2023-05-10
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Cryo-EM structure of the SEA complex.
Nature, 611, 2022
2BYV
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BU of 2byv by Molmil
Structure of the cAMP responsive exchange factor Epac2 in its auto- inhibited state
Descriptor: RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4
Authors:Rehmann, H, Wittinghofer, A, Bos, J.L.
Deposit date:2005-08-08
Release date:2006-02-02
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of the Cyclic-AMP Responsive Exchange Factor Epac2 in its Auto-Inhibited State
Nature, 439, 2006
8ADL
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BU of 8adl by Molmil
Cryo-EM structure of the SEA complex
Descriptor: Maintenance of telomere capping protein 5, Nitrogen permease regulator 2, Nitrogen permease regulator 3, ...
Authors:Tafur, L, Loewith, R.
Deposit date:2022-07-08
Release date:2022-11-02
Last modified:2023-05-10
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Cryo-EM structure of the SEA complex.
Nature, 611, 2022
8FW5
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BU of 8fw5 by Molmil
Chimeric HsGATOR1-SpGtr-SpLam complex
Descriptor: ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ...
Authors:Tettoni, S.D, Egri, S.B, Doxsey, D.D, Ouch, C, Chang, J, Song, K, Xu, C, Shen, K.
Deposit date:2023-01-20
Release date:2023-07-26
Last modified:2023-09-20
Method:ELECTRON MICROSCOPY (3.08 Å)
Cite:Structure of the Schizosaccharomyces pombe Gtr-Lam complex reveals evolutionary divergence of mTORC1-dependent amino acid sensing.
Structure, 31, 2023
6VSK
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BU of 6vsk by Molmil
Crystal structure of the P-Rex1 DEP1 domain
Descriptor: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Authors:Tesmer, J, Ravala, S.K.
Deposit date:2020-02-11
Release date:2020-07-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding.
J.Biol.Chem., 295, 2020
6PCV
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BU of 6pcv by Molmil
Single Particle Reconstruction of Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 bound to G protein beta gamma subunits
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1
Authors:Cash, J.N, Cianfrocco, M.A, Tesmer, J.J.G.
Deposit date:2019-06-18
Release date:2019-10-23
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-electron microscopy structure and analysis of the P-Rex1-G beta gamma signaling scaffold.
Sci Adv, 5, 2019
7PE8
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BU of 7pe8 by Molmil
cryo-EM structure of DEPTOR bound to human mTOR complex 2, focussed on one protomer
Descriptor: ACETYL GROUP, DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Waelchli, M, Maier, T.
Deposit date:2021-08-09
Release date:2021-09-08
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Regulation of human mTOR complexes by DEPTOR.
Elife, 10, 2021
7RX9
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BU of 7rx9 by Molmil
Structure of autoinhibited P-Rex1
Descriptor: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Endolysin chimera, SULFATE ION
Authors:Ellisdon, A.M, Chang, Y.
Deposit date:2021-08-22
Release date:2022-08-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism.
Nat.Struct.Mol.Biol., 29, 2022
7SHF
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BU of 7shf by Molmil
Cryo-EM structure of GPR158 coupled to the RGS7-Gbeta5 complex
Descriptor: (2S)-1-{[(S)-hydroxy{[(1s,2R,3R,4R,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5E,8E,11E,14E)-icosa-5,8,11,14-tetraenoate, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CHOLESTEROL, ...
Authors:Patil, D.N, Singh, S, Singh, A.K, Martemyanov, K.A.
Deposit date:2021-10-08
Release date:2021-12-01
Last modified:2022-01-19
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structure of human GPR158 receptor coupled to the RGS7-G beta 5 signaling complex.
Science, 375, 2022
7PE7
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BU of 7pe7 by Molmil
cryo-EM structure of DEPTOR bound to human mTOR complex 2, overall refinement
Descriptor: ACETYL GROUP, DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Waelchli, M, Maier, T.
Deposit date:2021-08-09
Release date:2021-09-15
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (3.41 Å)
Cite:Regulation of human mTOR complexes by DEPTOR.
Elife, 10, 2021
3ML6
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BU of 3ml6 by Molmil
a complex between Dishevelled2 and clathrin adaptor AP-2
Descriptor: Chimeric complex between protein Dishevelled2 homolog dvl-2 and clathrin adaptor AP-2 complex subunit mu
Authors:Yu, A, Xing, Y, Harrison, S.C, Kirchhausen, T.L.
Deposit date:2010-04-16
Release date:2010-08-11
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling.
Structure, 18, 2010
7PEB
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BU of 7peb by Molmil
cryo-EM structure of DEPTOR bound to human mTOR complex 1, focussed on one protomer
Descriptor: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ...
Authors:Waelchli, M, Maier, T.
Deposit date:2021-08-09
Release date:2021-09-08
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (3.67 Å)
Cite:Regulation of human mTOR complexes by DEPTOR.
Elife, 10, 2021
7PE9
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BU of 7pe9 by Molmil
cryo-EM structure of DEPTOR bound to human mTOR complex 2, DEPt-bound subset local refinement
Descriptor: ACETYL GROUP, DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Waelchli, M, Maier, T.
Deposit date:2021-08-09
Release date:2021-09-08
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Regulation of human mTOR complexes by DEPTOR.
Elife, 10, 2021
7T3B
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BU of 7t3b by Molmil
GATOR1-RAG-RAGULATOR - GAP Complex
Descriptor: ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ...
Authors:Egri, S.B, Shen, K.
Deposit date:2021-12-07
Release date:2022-04-06
Last modified:2022-06-01
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.
Mol.Cell, 82, 2022
6CES
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BU of 6ces by Molmil
Cryo-EM structure of GATOR1-RAG
Descriptor: GATOR complex protein DEPDC5, GATOR complex protein NPRL2, GATOR complex protein NPRL3, ...
Authors:Shen, K, Huang, R.K, Brignole, E.J, Yu, Z, Sabatini, D.M.
Deposit date:2018-02-12
Release date:2018-03-28
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.
Nature, 556, 2018

 

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