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2H95
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BU of 2h95 by Molmil
Structure of the Amantadine-Blocked Influenza A M2 Proton Channel Trans-membrane Domain by Solid-state NMR spectroscopy
Descriptor: Matrix protein 2
Authors:Hu, J, Asbury, T, Cross, T.A.
Deposit date:2006-06-08
Release date:2007-04-24
Last modified:2022-03-09
Method:SOLID-STATE NMR
Cite:Backbone structure of the amantadine-blocked trans-membrane domain m2 proton channel from influenza a virus.
Biophys.J., 92, 2007
2RLF
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BU of 2rlf by Molmil
Proton Channel M2 from Influenza A in complex with inhibitor rimantadine
Descriptor: Matrix protein 2, RIMANTADINE
Authors:Chou, J.J, Schnell, J.R.
Deposit date:2007-07-11
Release date:2008-01-29
Last modified:2021-11-10
Method:SOLUTION NMR
Cite:Structure and mechanism of the M2 proton channel of influenza A virus.
Nature, 451, 2008
2KIH
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BU of 2kih by Molmil
S31N mutant of M2 proton channel
Descriptor: Matrix protein 2
Authors:Pielak, R.M.
Deposit date:2009-05-05
Release date:2009-05-19
Last modified:2021-10-13
Method:SOLUTION NMR
Cite:Mechanism of drug inhibition and drug resistance of influenza A M2 channel.
Proc.Natl.Acad.Sci.USA, 106, 2009
2KWX
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BU of 2kwx by Molmil
The V27A mutant of influenza A M2 proton channel
Descriptor: Matrix protein 2
Authors:Pielak, R.M, Chou, J.J.
Deposit date:2010-04-20
Release date:2010-09-29
Last modified:2021-10-06
Method:SOLUTION NMR
Cite:Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel.
Biochem.Biophys.Res.Commun., 401, 2010
2L0J
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BU of 2l0j by Molmil
Solid State NMR structure of the M2 proton channel from Influenza A Virus in hydrated lipid bilayer
Descriptor: Matrix protein 2
Authors:Sharma, M, Yi, M, Dong, H, Qin, H, Peterson, E, Busath, D.D, Zhou, H.X, Cross, T.A.
Deposit date:2010-07-08
Release date:2010-11-03
Last modified:2011-07-13
Method:SOLID-STATE NMR
Cite:Insight into the mechanism of the influenza a proton channel from a structure in a lipid bilayer.
Science, 330, 2010
2LY0
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BU of 2ly0 by Molmil
Solution NMR structure of the influenza A virus S31N mutant (19-49) in presence of drug M2WJ332
Descriptor: (3S,5S,7S)-N-{[5-(thiophen-2-yl)-1,2-oxazol-3-yl]methyl}tricyclo[3.3.1.1~3,7~]decan-1-aminium, Membrane ion channel M2
Authors:Wu, Y, Wang, J, DeGrado, W.
Deposit date:2012-09-10
Release date:2013-01-09
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus.
Proc.Natl.Acad.Sci.USA, 110, 2013
2MUV
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BU of 2muv by Molmil
NOE-based model of the influenza A virus M2 (19-49) bound to drug 11
Descriptor: (3s,5s,7s)-N-[(5-bromothiophen-2-yl)methyl]tricyclo[3.3.1.1~3,7~]decan-1-aminium, Matrix protein 2
Authors:Wu, Y, Wang, J, DeGrado, W.
Deposit date:2014-09-18
Release date:2014-12-24
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Flipping in the Pore: Discovery of Dual Inhibitors That Bind in Different Orientations to the Wild-Type versus the Amantadine-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel.
J.Am.Chem.Soc., 136, 2014
2MUW
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BU of 2muw by Molmil
NOE-based model of the influenza A virus N31S mutant (19-49) bound to drug 11
Descriptor: (3s,5s,7s)-N-[(5-bromothiophen-2-yl)methyl]tricyclo[3.3.1.1~3,7~]decan-1-aminium, Matrix protein 2
Authors:Wu, Y, Wang, J, DeGrado, W.
Deposit date:2014-09-18
Release date:2014-12-24
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Flipping in the Pore: Discovery of Dual Inhibitors That Bind in Different Orientations to the Wild-Type versus the Amantadine-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel.
J.Am.Chem.Soc., 136, 2014
2N70
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BU of 2n70 by Molmil
Two-fold symmetric structure of the 18-60 construct of S31N M2 from Influenza A in lipid bilayers
Descriptor: Matrix protein 2
Authors:Andreas, L.B, Reese, M, Eddy, M.T, Gelev, V, Ni, Q, Miller, E.A, Emsley, L, Pintacuda, G, Chou, J.J, Griffin, R.G.
Deposit date:2015-09-01
Release date:2015-09-23
Last modified:2023-06-14
Method:SOLID-STATE NMR
Cite:Structure and Mechanism of the Influenza A M218-60 Dimer of Dimers.
J.Am.Chem.Soc., 137, 2015
6OUG
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BU of 6oug by Molmil
Structure of drug-resistant V27A mutant of the influenza M2 proton channel bound to spiroadamantyl amine inhibitor, TM + cytosolic helix construct
Descriptor: (1r,1'S,3'S,5'S,7'S)-spiro[cyclohexane-1,2'-tricyclo[3.3.1.1~3,7~]decan]-4-amine, Matrix protein 2
Authors:Thomaston, J.L, Liu, L, DeGrado, W.F.
Deposit date:2019-05-04
Release date:2020-01-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance.
Biochemistry, 59, 2020
6US9
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BU of 6us9 by Molmil
Influenza A M2 proton channel wild type TM domain bound to R-rimantadine
Descriptor: CHLORIDE ION, Matrix protein 2, RIMANTADINE
Authors:Thomaston, J.L, DeGrado, W.F.
Deposit date:2019-10-25
Release date:2020-10-28
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Rimantadine Binds to and Inhibits the Influenza A M2 Proton Channel without Enantiomeric Specificity.
Biochemistry, 2021
6US8
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BU of 6us8 by Molmil
Influenza A M2 proton channel wild type TM domain bound to S-rimantadine
Descriptor: (1S)-1-[(3R,5R,7R)-tricyclo[3.3.1.1~3,7~]decan-1-yl]ethan-1-amine, CHLORIDE ION, Matrix protein 2
Authors:Thomaston, J.L, DeGrado, W.F.
Deposit date:2019-10-25
Release date:2020-10-28
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Rimantadine Binds to and Inhibits the Influenza A M2 Proton Channel without Enantiomeric Specificity.
Biochemistry, 2021

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