6BJR
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CRYSTAL STRUCTURE OF PROTHROMBIN MUTANT S101C/A470C
Descriptor:Prothrombin, MAGNESIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Chinnaraj, M., Chen, Z., Pelc, L., Grese, Z., Bystranowska, D., Di Cera, E., Pozzi, N.
Deposit date:2017-11-06
Release date:2018-06-27
Method:X-RAY DIFFRACTION (6 Å)
Cite:Structure of prothrombin in the closed form reveals new details on the mechanism of activation.
Sci Rep, 8, 2018
6C2W
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CRYSTAL STRUCTURE OF HUMAN PROTHROMBIN MUTANT S101C/A470C
Descriptor:Prothrombin, MAGNESIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Chinnaraj, M., Chen, Z., Pelc, L., Grese, Z., Bystranowska, D., Di Cera, E., Pozzi, N.
Deposit date:2018-01-09
Release date:2018-02-28
Method:X-RAY DIFFRACTION (4.12 Å)
Cite:Structure of prothrombin in the closed form reveals new details on the mechanism of activation.
Sci Rep, 8, 2018
5EDK
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CRYSTAL STRUCTURE OF PROTHROMBIN DELETION MUTANT RESIDUES 146-167 ( FORM II ).
Descriptor:Prothrombin, N-ACETYL-D-GLUCOSAMINE, MAGNESIUM ION
Authors:Pozzi, N., Chen, Z., Di Cera, E.
Deposit date:2015-10-21
Release date:2016-01-20
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (3.214 Å)
Cite:How the Linker Connecting the Two Kringles Influences Activation and Conformational Plasticity of Prothrombin.
J.Biol.Chem., 291, 2016
5EDM
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CRYSTAL STRUCTURE OF PROTHROMBIN DELETION MUTANT RESIDUES 154-167 ( FORM I )
Descriptor:Prothrombin, MAGNESIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Pozzi, N., Chen, Z., Di Cera, E.
Deposit date:2015-10-21
Release date:2016-01-20
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:How the Linker Connecting the Two Kringles Influences Activation and Conformational Plasticity of Prothrombin.
J.Biol.Chem., 291, 2016
4YLQ
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CRYSTAL STRUCTURE OF A FVIIA-TRYPSIN CHIMERA (FT) IN COMPLEX WITH SOLUBLE TISSUE FACTOR
Descriptor:Coagulation factor VII, Tissue factor, CALCIUM ION, ...
Authors:Sorensen, A.B., Svensson, L.A., Gandhi, P.S.
Deposit date:2015-03-05
Release date:2015-12-30
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity.
J.Biol.Chem., 291, 2016
4ZMA
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CRYSTAL STRUCTURE OF A FVIIA-TRYPSIN CHIMERA (ST) IN COMPLEX WITH SOLUBLE TISSUE FACTOR
Descriptor:Coagulation factor VII, Tissue factor, CALCIUM ION, ...
Authors:Sorensen, A.B., Svensson, L.A., Gandhi, P.S.
Deposit date:2015-05-02
Release date:2015-12-30
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity.
J.Biol.Chem., 291, 2016
4NZQ
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CRYSTAL STRUCTURE OF CA2+-FREE PROTHROMBIN DELETION MUTANT RESIDUES 146-167
Descriptor:Prothrombin, N-ACETYL-D-GLUCOSAMINE
Authors:Pozzi, N., Chen, Z., Shropshire, D.B., Pelc, L.A., Di Cera, E.
Deposit date:2013-12-12
Release date:2014-05-21
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.807 Å)
Cite:The linker connecting the two kringles plays a key role in prothrombin activation.
Proc.Natl.Acad.Sci.USA, 111, 2014
4O03
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CRYSTAL STRUCTURE OF CA2+ BOUND PROTHROMBIN DELETION MUTANT RESIDUES 146-167
Descriptor:Prothrombin, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE
Authors:Pozzi, N., Chen, Z., Shropshire, D.B., Pelc, L.A., Di Cera, E.
Deposit date:2013-12-13
Release date:2014-05-21
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (3.38 Å)
Cite:The linker connecting the two kringles plays a key role in prothrombin activation.
Proc.Natl.Acad.Sci.USA, 111, 2014
4IBL
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RUBIDIUM SITES IN BLOOD COAGULATION FACTOR VIIA
Descriptor:Coagulation factor VII, Tissue factor, BETA-D-GLUCOSE, ...
Authors:Vadivel, K., Schmidt, A., Cascio, D., Padmanabhan, K., Bajaj, S.P.
Deposit date:2012-12-08
Release date:2014-04-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Sodium Site in blood Coagulation Factor VIIa: Absence of occupancy by Rubidium
To be Published
4BXS
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CRYSTAL STRUCTURE OF THE PROTHROMBINASE COMPLEX FROM THE VENOM OF PSEUDONAJA TEXTILIS
Descriptor:FACTOR X-LIKE PROTEASE, VENOM PROTHROMBIN ACTIVATOR PSEUTARIN-C NON-CATALYTIC SUBUNIT, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Lechtenberg, B.C., Murray-Rust, T.A., Johnson, D.J.D., Adams, T.E., Krishnaswamy, S., Camire, R.M., Huntington, J.A.
Deposit date:2013-07-15
Release date:2013-07-31
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (3.32 Å)
Cite:Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis.
Blood, 122, 2013
4BXW
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CRYSTAL STRUCTURE OF THE PROTHROMBINASE COMPLEX FROM THE VENOM OF PSEUDONAJA TEXTILIS
Descriptor:FACTOR XA, COAGULATION FACTOR V, L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide, ...
Authors:Lechtenberg, B.C., Murray-Rust, T.A., Johnson, D.J.D., Adams, T.E., Krishnaswamy, S., Camire, R.M., Huntington, J.A.
Deposit date:2013-07-16
Release date:2013-07-31
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis.
Blood, 122, 2013
3TH2
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MG2+ IS REQUIRED FOR OPTIMAL FOLDING OF THE GAMMA-CARBOXYGLUTAMIC ACID (GLA) DOMAINS OF VITAMIN K-DEPENDENT CLOTTING FACTORS AT PHYSIOLOGICAL CA2+
Descriptor:Coagulation factor VII light chain, Coagulation factor VII heavy chain, Tissue factor, ...
Authors:Vadivel, K., Agah, S., Cascio, D., Padmanabhan, K., Bajaj, S.P.
Deposit date:2011-08-18
Release date:2012-08-22
Last modified:2014-07-30
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Mg2+ Is Required for Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors At Physiological Ca2+
To be Published
3TH3
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MG2+ IS REQUIRED FOR OPTIMAL FOLDING OF THE GAMMA-CARBOXYGLUTAMIC ACID (GLA) DOMAINS OF VITAMIN K-DEPENDENT CLOTTING FACTORS AT PHYSIOLOGICAL CA2+
Descriptor:Coagulation factor VII light chain, Coagulation factor VII heavy chain, Tissue factor, ...
Authors:Vadivel, K., Agah, S., Cascio, D., Padmanabhan, K., Bajaj, S.P.
Deposit date:2011-08-18
Release date:2012-08-22
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mg2+ Is Required for Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors At Physiological Ca2+
To be Published
3TH4
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MG2+ IS REQUIRED FOR OPTIMAL FOLDING OF THE GAMMA-CARBOXYGLUTAMIC ACID (GLA) DOMAINS OF VITAMIN K-DEPENDENT CLOTTING FACTORS AT PHYSIOLOGICAL CA2+
Descriptor:Coagulation factor VII light chain, Coagulation factor VII heavy chain, Tissue factor, ...
Authors:Vadivel, K., Agah, S., Cascio, D., Padmanabhan, K., Bajaj, S.P.
Deposit date:2011-08-18
Release date:2012-08-22
Last modified:2015-04-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mg2+ Is Required for Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors At Physiological Ca2+
To be Published
2ZZU
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HUMAN FACTOR VIIA-TISSUE FACTOR COMPLEXED WITH ETHYLSULFONAMIDE-D-5-(3-CARBOXYBENZYLOXY)-TRP-GLN-P-AMINOBENZAMIDINE
Descriptor:Factor VII light chain, Factor VII heavy chain, Tissue factor, ...
Authors:Kadono, S., Sakamoto, A., Kikuchi, Y., Oh-Eda, M., Yabuta, N., Koga, T., Hattori, K., Shiraishi, T., Haramura, M., Sato, H., Ohta, M., Kozono, T.
Deposit date:2009-02-25
Release date:2009-03-24
Last modified:2011-11-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Design and synthesis of peptidomimetic factor VIIa inhibitors
Chem.Pharm.Bull., 58, 2010
2ZWL
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HUMAN FACTOR VIIA-TISSUE FACTOR COMPLEXED WITH HIGHLY SELECTIVE PEPTIDE INHIBITOR
Descriptor:Factor VII light chain, Factor VII heavy chain, Tissue factor, ...
Authors:Kadono, S., Sakamoto, A., Kikuchi, Y., Oh-Eda, M., Yabuta, N., Koga, T., Hattori, K., Shiraishi, T., Haramura, M., Sato, H., Ohta, M., Kozono, T.
Deposit date:2008-12-16
Release date:2009-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Human factor viia-tissue factor complexed with highly selective peptide inhibitor
To be Published
3ELA
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CRYSTAL STRUCTURE OF ACTIVE SITE INHIBITED COAGULATION FACTOR VIIA MUTANT IN COMPLEX WITH SOLUBLE TISSUE FACTOR
Descriptor:Coagulation factor VIIA light chain, Coagulation factor VIIA heavy chain, Tissue factor, ...
Authors:Bjelke, J.R., Fodje, M., Svensson, L.A.
Deposit date:2008-09-21
Release date:2008-11-04
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mechanism of the Ca2+-induced enhancement of the intrinsic factor VIIa activity
J.Biol.Chem., 283, 2008
2ZP0
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HUMAN FACTOR VIIA-TISSUE FACTOR COMPLEXED WITH BENZYLSULFONAMIDE-D-ILE-GLN-P-AMINOBENZAMIDINE
Descriptor:Factor VII light chain, Factor VII heavy chain, Tissue factor, ...
Authors:Kadono, S., Sakamoto, A., Kikuchi, Y., Oh-eda, M., Yabuta, N., Koga, T., Hattori, K., Shiraishi, T., Haramura, M., Kodama, H.
Deposit date:2008-06-20
Release date:2008-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Peptide Mimetic Factor VIIa Inhibitor: Importance of Hydrophilic Pocket in S2 Site to Improve Selectivity aganist Thrombin
LETT.DRUG DES.DISCOVERY, 2, 2005
2EC9
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CRYSTAL STRUCTURE ANALYSIS OF HUMAN FACTOR VIIA , SOULUBLE TISSUE FACTOR COMPLEXED WITH BCX-3607
Descriptor:Coagulation factor VII, Tissue factor, 1,5-ANHYDROSORBITOL, ...
Authors:Raman, K., Yarlagadda, B.
Deposit date:2007-02-13
Release date:2008-02-19
Last modified:2012-09-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Probing the S2 site of factor VIIa to generate potent and selective inhibitors: the structure of BCX-3607 in complex with tissue factor-factor VIIa.
Acta Crystallogr.,Sect.D, 63, 2007
2B8O
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CRYSTAL STRUCTURE OF GLU-GLY-ARG-CHLOROMETHYL KETONE-FACTOR VIIA/SOLUBLE TISSUE FACTOR COMPLEX
Descriptor:Coagulation factor VII light chain, Coagulation factor VII heavy chain, Tissue factor, ...
Authors:Bajaj, S.P., Schmidt, A.E., Padmanabhan, K.
Deposit date:2005-10-08
Release date:2007-02-13
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of Factor VIIa/soluble Tissue Factor complexed with Glu-Gly-Arg-Chloromethyl ketone
To be published
2FLR
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NOVEL 5-AZAINDOLE FACTOR VIIA INHIBITORS
Descriptor:Coagulation factor VII, Tissue factor, [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA
Authors:Riggs, J.R., Hu, H., Kolesnikov, A., Tong, Z., Leahy, E.M., Wesson, K.E., Shrader, W.D., Vijaykumar, D., Wahl, T.A., Sprengeler, P.A., Green, M.J., Yu, C., Katz, B.A., Young, W.B.
Deposit date:2006-01-06
Release date:2007-01-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Novel 5-azaindole factor VIIa inhibitors.
Bioorg.Med.Chem.Lett., 16, 2006
2C4F
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CRYSTAL STRUCTURE OF FACTOR VII.STF COMPLEXED WITH PD0297121
Descriptor:COAGULATION FACTOR VII PRECURSOR, TISSUE FACTOR PRECURSOR, CALCIUM ION, ...
Authors:Kohrt, J.T., Zhang, E.
Deposit date:2005-10-18
Release date:2006-10-18
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:The Discovery of Fluoropyridine-Based Inhibitors of the Factor Viia/Tf Complex--Part 2
Bioorg.Med.Chem.Lett., 16, 2006
2AEI
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CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF FACTOR VIIA/TISSUE FACTOR AND 2-[[6-[3-(AMINOIMINOMETHYL)PHENOXY]-3,5-DIFLURO-4-[(1-METHYL-3-PHENYLPROPYL)AMINO]-2-PYRIDINYL]OXY]-BENZOIC ACID
Descriptor:Coagulation factor VII, Tissue factor, CALCIUM ION, ...
Authors:Adler, M., Whitlow, M.
Deposit date:2005-07-22
Release date:2006-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex.
Bioorg.Med.Chem.Lett., 15, 2005
2FIR
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CRYSTAL STRUCTURE OF DFPR-VIIA/STF
Descriptor:Coagulation factor VII Light chain, Coagulation factor VII Heavy Chain (EC 3.4.21.21), Tissue factor, ...
Authors:Bajaj, S.P., Schmidt, A.E., Padmanabhan, K., Bajaj, M.S., Prevost, D., Schreuder, H.
Deposit date:2005-12-30
Release date:2006-07-11
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:High Resolution Structures of p-Aminobenzamidine- and Benzamidine-VIIa/Soluble Tissue Factor: Unpredicted conformation of the 192-193 peptide bond and mapping of Ca2+, Mg2+, Na+ and Zn2+ sites in factor VIIa
J.Biol.Chem., 281, 2006
2A2Q
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COMPLEX OF ACTIVE-SITE INHIBITED HUMAN COAGULATION FACTOR VIIA WITH HUMAN SOLUBLE TISSUE FACTOR IN THE PRESENCE OF CA2+, MG2+, NA+, AND ZN2+
Descriptor:Coagulation factor VII, Tissue factor, ALPHA-D-GLUCOSE, ...
Authors:Bajaj, S.P., Bajaj, M., Schmidt, A.E., Padmanabhan, K.
Deposit date:2005-06-22
Release date:2006-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:High resolution structures of p-aminobenzamidine- and benzamidine-VIIa/soluble tissue factor: unpredicted conformation of the 192-193 peptide bond and mapping of Ca2+, Mg2+, Na+, and Zn2+ sites in factor VIIa.
J.Biol.Chem., 281, 2006
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