6GGR
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CRYSTAL STRUCTURE OF SALMONELLA ZINC METALLOPROTEASE EFFECTOR GTGA IN COMPLEX WITH P65
Descriptor:Transcription factor p65, Bacteriophage virulence determinant, CHLORIDE ION
Authors:Jennings, E., Esposito, D., Rittinger, K., Thurston, T.
Deposit date:2018-05-03
Release date:2018-08-29
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (2.097 Å)
Cite:Structure-function analyses of the bacterial zinc metalloprotease effector protein GtgA uncover key residues required for deactivating NF-kappa B.
J. Biol. Chem., 293, 2018
5ZMC
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STRUCTURAL BASIS FOR REACTIVATION OF -146C>T MUTANT TERT PROMOTER BY COOPERATIVE BINDING OF P52 AND ETS1/2
Descriptor:DNA (5'-D(P*CP*GP*GP*GP*GP*AP*CP*CP*CP*GP*GP*AP*AP*GP*GP*G)-3'), DNA (5'-D(P*GP*CP*CP*CP*TP*TP*CP*CP*GP*GP*GP*TP*CP*CP*CP*C)-3'), Protein C-ets-1, ...
Authors:Xu, X., Bharath, S.R., Song, H.
Deposit date:2018-04-02
Release date:2018-09-19
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1.
Nat Commun, 9, 2018
5U01
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COOPERATIVE DNA BINDING BY TWO RELA DIMERS
Descriptor:Transcription factor p65, DNA (27-MER)
Authors:Ghosh, G., Huang, D.
Deposit date:2016-11-22
Release date:2017-09-27
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:DNA-binding affinity and transcriptional activity of the RelA homodimer of nuclear factor kappa B are not correlated.
J. Biol. Chem., 292, 2017
3QRF
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STRUCTURE OF A DOMAIN-SWAPPED FOXP3 DIMER
Descriptor:Nuclear factor of activated T-cells, cytoplasmic 2, Forkhead box protein P3, ...
Authors:Bandukwala, H.S., Wu, Y., Feurer, M., Chen, Y., Barbosa, B., Ghosh, S., Stroud, J.C., Benoist, C., Mathis, D., Rao, A., Chen, L.
Deposit date:2011-02-17
Release date:2011-04-20
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T Cells.
Immunity, 34, 2011
3GUT
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CRYSTAL STRUCTURE OF A HIGHER-ORDER COMPLEX OF P50:RELA BOUND TO THE HIV-1 LTR
Descriptor:Transcription factor p65, Nuclear factor NF-kappa-B p105 subunit, HIV-LTR Core Forward Strand, ...
Authors:Stroud, J.C., Oltman, A.J., Han, A., Bates, D.L., Chen, L.
Deposit date:2009-03-30
Release date:2009-09-08
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.59 Å)
Cite:Structural basis of HIV-1 activation by NF-kappaB--a higher-order complex of p50:RelA bound to the HIV-1 LTR.
J.Mol.Biol., 393, 2009
3DO7
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X-RAY STRUCTURE OF A NF-KB P52/RELB/DNA COMPLEX
Descriptor:5'-D(*DCP*DGP*DGP*DGP*DAP*DAP*DTP*DTP*DCP*DCP*DC)-3', Avian reticuloendotheliosis viral (V-rel) oncogene related B, Nuclear factor NF-kappa-B p100 subunit
Authors:Fusco, A., Huang, D.B., Miller, D., Vu, D., Ghosh, G.
Deposit date:2008-07-03
Release date:2009-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:NF-kapppaB p52:RelB heterodimer uses different binding modes to recognize different kappaB DNA
TO BE PUBLISHED
2V2T
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X-RAY STRUCTURE OF A NF-KB P50-RELB-DNA COMPLEX
Descriptor:TRANSCRIPTION FACTOR RELB, NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT, 5'-D(*CP*GP*GP*GP*AP*AP*TP*TP*CP*CP*CP)-3'
Authors:Moorthy, A.K., Huang, D.B., Wang, V.Y., Vu, D., Ghosh, G.
Deposit date:2007-06-07
Release date:2007-07-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:X-Ray Structure of a NF-kappaB p50/Relb/DNA Complex Reveals Assembly of Multiple Dimers on Tandem kappaB Sites.
J.Mol.Biol., 373, 2007
2O93
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CRYSTAL STRUCTURE OF NFAT BOUND TO THE HIV-1 LTR TANDEM KAPPAB ENHANCER ELEMENT
Descriptor:kappaB enhancer element, DNA 25-mer, actor of activated T-cells, ...
Authors:Bates, D.L., Chen, L.
Deposit date:2006-12-13
Release date:2007-06-19
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Crystal structure of NFAT bound to the HIV-1 LTR tandem kappaB enhancer element
Structure, 16, 2008
2O61
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CRYSTAL STRUCTURE OF NFKB, IRF7, IRF3 BOUND TO THE INTERFERON-B ENHANCER
Descriptor:36-MER, 34-MER, Transcription factor p65/Interferon regulatory factor 7/Interferon regulatory factor 3 fusion protein, ...
Authors:Panne, D.
Deposit date:2006-12-06
Release date:2007-07-24
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:An Atomic Model of the Interferon-beta Enhanceosome.
Cell(Cambridge,Mass.), 129, 2007
2I9T
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STRUCTURE OF NF-KB P65-P50 HETERODIMER BOUND TO PRDII ELEMENT OF B-INTERFERON PROMOTER
Descriptor:5'-D(*AP*GP*TP*GP*GP*GP*AP*AP*AP*TP*TP*CP*CP*TP*CP*TP*G)-3', 5'-D(*CP*AP*GP*AP*GP*GP*AP*AP*TP*TP*TP*CP*CP*CP*AP*CP*T)-3', Transcription factor p65, ...
Authors:Escalante, C.R., Shen, L., Thanos, D., Aggarwal, A.K.
Deposit date:2006-09-06
Release date:2007-02-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of NF-kappaB p50/p65 heterodimer bound to the PRDII DNA element from the interferon-beta promoter
Structure, 10, 2002
2AS5
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STRUCTURE OF THE DNA BINDING DOMAINS OF NFAT AND FOXP2 BOUND SPECIFICALLY TO DNA.
Descriptor:5'-D(TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*GP*)-3', 5'-D(AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*TP*)-3', Nuclear factor of activated T-cells, ...
Authors:Wu, Y., Stroud, J.C., Borde, M., Bates, D.L., Guo, L., Han, A., Rao, A., Chen, L.
Deposit date:2005-08-22
Release date:2006-08-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT.
Cell(Cambridge,Mass.), 126, 2006
1S9K
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CRYSTAL STRUCTURE OF HUMAN NFAT1 AND FOS-JUN ON THE IL-2 ARRE1 SITE
Descriptor:Human IL-2 ARRE1 Promoter Element, Plus Strand, Minus Strand, ...
Authors:Wang, D., Stroud, J.C., Chen, L.
Deposit date:2004-02-04
Release date:2005-06-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal Structure of Human NFAT1 and Fos-Jun on the IL-2 ARRE1 Site
To be Published
1PZU
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AN ASYMMETRIC NFAT1-RHR HOMODIMER ON A PSEUDO-PALINDROMIC, KAPPA-B SITE
Descriptor:5'-D(*TP*TP*GP*AP*GP*GP*AP*AP*TP*TP*TP*CP*CP*A)-3', 5'-D(*AP*AP*TP*GP*GP*AP*AP*AP*TP*TP*CP*CP*TP*C)-3', Nuclear factor of activated T-cells, ...
Authors:Jin, L., Sliz, P., Chen, L., Macian, F., Rao, A., Hogan, P.G., Harrison, S.C.
Deposit date:2003-07-14
Release date:2003-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:An asymmetric NFAT1 dimer on a pseudo-palindromic KB-like DNA site
Nat.Struct.Biol., 10, 2003
1P7H
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STRUCTURE OF NFAT1 BOUND AS A DIMER TO THE HIV-1 LTR KB ELEMENT
Descriptor:5'-D(*AP*AP*TP*GP*GP*GP*GP*AP*CP*TP*TP*TP*CP*CP*A)-3', 5'-D(*TP*TP*TP*GP*GP*AP*AP*AP*GP*TP*CP*CP*CP*CP*A)-3', Nuclear factor of activated T-cells, ...
Authors:Giffin, M.J., Stroud, J.C., Bates, D.L., von Koenig, K.D., Hardin, J., Chen, L.
Deposit date:2003-05-01
Release date:2003-09-23
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of NFAT1 bound as a dimer to the HIV-1 LTR kappa B element
Nat.Struct.Biol., 10, 2003
1OWR
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CRYSTAL STRUCTURE OF HUMAN NFAT1 BOUND MONOMERICALLY TO DNA
Descriptor:NFAT1 Monomeric Binding Site, Plus Strand, Minus Strand, ...
Authors:Stroud, J.C., Chen, L.
Deposit date:2003-03-29
Release date:2004-02-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of NFAT Bound to DNA as a Monomer
J.Mol.Biol., 334, 2003
1OOA
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CRYSTAL STRUCTURE OF NF-KB(P50)2 COMPLEXED TO A HIGH-AFFINITY RNA APTAMER
Descriptor:RNA aptamer, Nuclear factor NF-kappa-B p105 subunit
Authors:Huang, D.B., Vu, D., Cassiday, L.A., Zimmerman, J.M., Maher III, L.J., Ghosh, G.
Deposit date:2003-03-03
Release date:2003-07-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of NF-kappaB (p50)2 complexed to a high-affinity RNA aptamer.
Proc.Natl.Acad.Sci.USA, 100, 2003
1LE5
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CRYSTAL STRUCTURE OF A NF-KB HETERODIMER BOUND TO AN IFNB-KB
Descriptor:5'-D(*TP*GP*GP*GP*AP*AP*AP*TP*TP*CP*CP*T)-3', 5'-D(*AP*AP*GP*GP*AP*AP*TP*TP*TP*CP*CP*C)-3', Nuclear factor NF-kappa-B p65 subunit, ...
Authors:Berkowitz, B., Huang, D.B., Chen-Park, F.E., Sigler, P.B., Ghosh, G.
Deposit date:2002-04-09
Release date:2003-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:The X-ray crystal structure of the NF-kB p50/p65 heterodimer bound to the Interferon beta-kB site
J.Biol.Chem., 277, 2002
1LE9
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CRYSTAL STRUCTURE OF A NF-KB HETERODIMER BOUND TO THE IG/HIV-KB SITI
Descriptor:5'-D(*TP*GP*GP*GP*AP*CP*TP*TP*TP*CP*CP*T)-3', 5'-D(*AP*AP*GP*GP*AP*AP*AP*GP*TP*CP*CP*C)-3', NUCLEAR FACTOR NF-KAPPA-B P65 SUBUNIT, ...
Authors:Benjamin, B., Huang, D.B., Chen-Park, F.E., Sigler, P.B., Ghosh, G.
Deposit date:2002-04-09
Release date:2003-04-15
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:The x-ray crystal structure of the NF-kappa B p50.p65 heterodimer bound to the interferon beta -kappa B site.
J.Biol.Chem., 277, 2002
1LEI
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THE KB DNA SEQUENCE FROM THE HLV-LTR FUNCTIONS AS AN ALLOSTERIC REGULATOR OF HIV TRANSCRIPTION
Descriptor:5'-D(*CP*TP*CP*AP*GP*GP*GP*AP*AP*AP*GP*TP*AP*CP*AP*GP*A)-3', 5'-D(*TP*CP*TP*GP*5ITP*AP*CP*5ITP*5ITP*5ITP*CP*CP*CP*TP*GP*AP*G)-3', NUCLEAR FACTOR NF-KAPPA-B P65 SUBUNIT, ...
Authors:Chen-Park, F., Huang, D.B., Ghosh, G.
Deposit date:2002-04-09
Release date:2003-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The kB DNA sequence from the HIV Long Terminal Repeat functions as an allosteric regulator of HIV transcription
J.Biol.Chem., 277, 2002
1GJI
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CRYSTAL STRUCTURE OF C-REL BOUND TO DNA
Descriptor:IL-2 CD28RE DNA, C-REL PROTO-ONCOGENE PROTEIN
Authors:Huang, D.B., Chen, Y.Q., Ruetsche, M., Phelps, C.B., Ghosh, G.
Deposit date:2001-05-30
Release date:2002-05-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2.
Structure, 9, 2001
1IMH
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TONEBP/DNA COMPLEX
Descriptor:5'-D(*TP*TP*GP*CP*TP*GP*GP*AP*AP*AP*AP*AP*TP*AP*G)-3', 5'-D(*AP*AP*CP*TP*AP*TP*TP*TP*TP*TP*CP*CP*AP*GP*C)-3', NUCLEAR FACTOR OF ACTIVATED T CELLS 5
Authors:Stroud, J.C., Lopez-Rodriguez, C., Rao, A., Chen, L.
Deposit date:2001-05-10
Release date:2002-02-01
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Structure of a TonEBP-DNA complex reveals DNA encircled by a transcription factor.
Nat.Struct.Biol., 9, 2002
1IKN
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IKAPPABALPHA/NF-KAPPAB COMPLEX
Descriptor:PROTEIN (NF-KAPPA-B P65 SUBUNIT), PROTEIN (NF-KAPPA-B P50D SUBUNIT), PROTEIN (I-KAPPA-B-ALPHA)
Authors:Huxford, T., Huang, D.-B., Malek, S., Ghosh, G.
Deposit date:1998-11-13
Release date:1999-04-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation.
Cell(Cambridge,Mass.), 95, 1998
1BVO
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DORSAL HOMOLOGUE GAMBIF1 BOUND TO DNA
Descriptor:DNA DUPLEX, TRANSCRIPTION FACTOR GAMBIF1
Authors:Cramer, P., Varrot, A., Barillas-Mury, C., Kafatos, F.C., Mueller, C.W.
Deposit date:1998-09-16
Release date:1999-07-12
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of the specificity domain of the Dorsal homologue Gambif1 bound to DNA.
Structure Fold.Des., 7, 1999
1NFI
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I-KAPPA-B-ALPHA/NF-KAPPA-B COMPLEX
Descriptor:NF-KAPPA-B P65, NF-KAPPA-B P50, I-KAPPA-B-ALPHA
Authors:Jacobs, M.D., Harrison, S.C.
Deposit date:1998-08-25
Release date:1998-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of an IkappaBalpha/NF-kappaB complex.
Cell(Cambridge,Mass.), 95, 1998
1A66
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SOLUTION NMR STRUCTURE OF THE CORE NFATC1/DNA COMPLEX, 18 STRUCTURES
Descriptor:DNA (5'-D(*CP*GP*AP*GP*GP*AP*AP*AP*AP*TP*TP*G)-3'), DNA (5'-D(*CP*AP*AP*TP*TP*TP*TP*CP*CP*TP*CP*G)-3'), CORE NFATC1
Authors:Zhou, P., Sun, L.J., Doetsch, V., Wagner, G., Verdine, G.L.
Deposit date:1998-03-06
Release date:1998-06-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the core NFATC1/DNA complex.
Cell(Cambridge,Mass.), 92, 1998
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