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8P2M
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C. elegans TIR-1 protein.
Descriptor: NAD(+) hydrolase tir-1
Authors:Isupov, M.N, Opatowsky, Y.
Deposit date:2023-05-16
Release date:2023-09-06
Method:ELECTRON MICROSCOPY (3.82 Å)
Cite:Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans.
Cell Rep, 42, 2023
8J1I
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Crystal Structure of EphA8/SASH1 Complex
Descriptor: Ephrin type-A receptor 8, SAM and SH3 domain-containing protein 1
Authors:Liu, W, Li, J, Ding, Y.
Deposit date:2023-04-12
Release date:2024-02-28
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of EphA8 and SASH1 complex at 1.60 Angstroms resolution
To Be Published
8IJR
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BU of 8ijr by Molmil
The cryo-EM structure of human sphingomyelin synthase-related protein in complex with diacylglycerol/phosphoethanolamine
Descriptor: (2S)-1-(hexadecanoyloxy)-3-hydroxypropan-2-yl (11Z)-octadec-11-enoate, PHOSPHORIC ACID MONO-(2-AMINO-ETHYL) ESTER, Sphingomyelin synthase-related protein 1
Authors:Hu, K, Zhang, Q, Chen, Y, Yao, D, Zhou, L, Cao, Y.
Deposit date:2023-02-28
Release date:2024-02-28
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.29 Å)
Cite:Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis.
Nat.Struct.Mol.Biol., 2024
8BW9
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Cryo-EM structure of the RAF activating complex KSR-MEK-CNK-HYP
Descriptor: Connector enhancer of KSR protein CNK, Dual specificity mitogen-activated protein kinase kinase dSOR1, KSR, ...
Authors:Maisonneuve, P, Fronzes, R, Sicheri, F.
Deposit date:2022-12-06
Release date:2024-02-21
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction.
Nat.Struct.Mol.Biol., 2024
8BW8
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Crystal structure of the dCNK-SAM-CRIC-PDZ/dHYP-SAM complex
Descriptor: Connector enhancer of KSR protein CNK, GLYCEROL, Protein aveugle
Authors:Maisonneuve, P, Kurinov, I, Sicheri, F.
Deposit date:2022-12-06
Release date:2024-02-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction.
Nat.Struct.Mol.Biol., 2024
8B10
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BU of 8b10 by Molmil
Crystal Structure of Shank2-SAM mutant domain - L1800W
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Bento, I, Gracia Alai, M, Kreienkamp, J.-H.
Deposit date:2022-09-08
Release date:2022-11-30
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural deficits in key domains of Shank2 lead to alterations in postsynaptic nanoclusters and to a neurodevelopmental disorder in humans.
Mol Psychiatry, 2022
8ATJ
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Crystal Structure of Shank2-SAM domain
Descriptor: CHLORIDE ION, FORMIC ACID, Isoform 4 of SH3 and multiple ankyrin repeat domains protein 2, ...
Authors:Bento, I, Gracia Alai, M, Kreienkamp, J.-H.
Deposit date:2022-08-23
Release date:2022-11-30
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.117 Å)
Cite:Structural deficits in key domains of Shank2 lead to alterations in postsynaptic nanoclusters and to a neurodevelopmental disorder in humans.
Mol Psychiatry, 2022
7KJC
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Crystal structure of the EphA2 S901E mutant intracellular KD-SAM domains
Descriptor: Ephrin type-A receptor 2, GLYCEROL, MAGNESIUM ION, ...
Authors:Lechtenberg, B.C, Pasquale, E.B.
Deposit date:2020-10-26
Release date:2021-02-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker.
Nat Commun, 12, 2021
7KJB
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Crystal structure of the EphA2 S897E/S901E mutant intracellular KD-SAM domains
Descriptor: CESIUM ION, Ephrin type-A receptor 2
Authors:Lechtenberg, B.C, Pasquale, E.B.
Deposit date:2020-10-26
Release date:2021-02-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker.
Nat Commun, 12, 2021
7KJA
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Crystal structure of the EphA2 intracellular KD-SAM domains
Descriptor: Ephrin type-A receptor 2, GLYCEROL, MAGNESIUM ION, ...
Authors:Lechtenberg, B.C, Pasquale, E.B.
Deposit date:2020-10-26
Release date:2021-02-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker.
Nat Commun, 12, 2021
6LUK
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BU of 6luk by Molmil
Crystal structure of the SAMD1 SAM domain in another crystal form
Descriptor: Atherin, SULFATE ION
Authors:Cao, Y, Zhou, Y, Wang, Z.
Deposit date:2020-01-29
Release date:2021-02-03
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.054 Å)
Cite:The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands.
Sci Adv, 7, 2021
6LUJ
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BU of 6luj by Molmil
Crystal structure of the SAMD1 SAM domain
Descriptor: Atherin, SULFATE ION
Authors:Cao, Y, Zhou, Y, Wang, Z.
Deposit date:2020-01-29
Release date:2021-02-03
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands.
Sci Adv, 7, 2021
6KR4
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Crystal structure of the liprin-alpha3_SAM123/LAR_D1D2 complex
Descriptor: HEXAETHYLENE GLYCOL, Liprin-alpha-3, PHOSPHATE ION, ...
Authors:Xie, X, Liang, M, Luo, L, Wei, Z.
Deposit date:2019-08-20
Release date:2020-01-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural basis of liprin-alpha-promoted LAR-RPTP clustering for modulation of phosphatase activity.
Nat Commun, 11, 2020
6KIP
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BU of 6kip by Molmil
Crystal structure of PTPRD phosphatase domain in complex with Liprin-alpha3 tandem SAM domains
Descriptor: Liprin-alpha-3, Receptor-type tyrosine-protein phosphatase delta
Authors:Wakita, M, Yamagata, A, Fukai, S.
Deposit date:2019-07-19
Release date:2020-02-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.911 Å)
Cite:Structural insights into selective interaction between type IIa receptor protein tyrosine phosphatases and Liprin-alpha.
Nat Commun, 11, 2020
6G8O
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BU of 6g8o by Molmil
Solution structure of the cross-linked SAM domain dimer of murine SLy1
Descriptor: SAM and SH3 domain-containing protein 3
Authors:Kukuk, L.K, Dingley, A.J, Koenig, B.W.
Deposit date:2018-04-09
Release date:2019-01-30
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure of the SLy1 SAM homodimer reveals a new interface for SAM domain self-association.
Sci Rep, 9, 2019
6FXF
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BU of 6fxf by Molmil
Crystal structure of the SAM domain of murine SLy1
Descriptor: SAM and SH3 domain-containing protein 3
Authors:Kukuk, L.K, Granzin, J, Batra-Safferling, R, Koenig, B.W.
Deposit date:2018-03-09
Release date:2019-01-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure of the SLy1 SAM homodimer reveals a new interface for SAM domain self-association.
Sci Rep, 9, 2019
6F7M
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BU of 6f7m by Molmil
NMR structure of EphA2-Sam stapled peptides (S13ST)
Descriptor: Ephrin type-A receptor 2
Authors:Mercurio, F.A, Leone, M.
Deposit date:2017-12-11
Release date:2018-08-01
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Sam domain-based stapled peptides: Structural analysis and interaction studies with the Sam domains from the EphA2 receptor and the lipid phosphatase Ship2.
Bioorg. Chem., 80, 2018
5ZRZ
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BU of 5zrz by Molmil
Crystal Structure of EphA5/SAMD5 Complex
Descriptor: Ephrin type-A receptor 5, Sterile alpha motif domain-containing protein 5
Authors:Wang, Y, Shang, Y, Li, J, Chen, W, Li, G, Wan, J, Liu, W, Zhang, M.
Deposit date:2018-04-25
Release date:2018-05-30
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions.
Elife, 7, 2018
5ZRY
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BU of 5zry by Molmil
Crystal Structure of EphA6/Odin Complex
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Ankyrin repeat and SAM domain-containing protein 1A,Ephrin type-A receptor 6, ...
Authors:Wang, Y, Shang, Y, Li, J, Chen, W, Li, G, Wan, J, Liu, W, Zhang, M.
Deposit date:2018-04-25
Release date:2018-05-30
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions.
Elife, 7, 2018
5ZRX
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BU of 5zrx by Molmil
Crystal Structure of EphA2/SHIP2 Complex
Descriptor: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2,Ephrin type-A receptor 2
Authors:Wang, Y, Shang, Y, Li, J, Chen, W, Li, G, Wan, J, Liu, W, Zhang, M.
Deposit date:2018-04-25
Release date:2018-05-30
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions.
Elife, 7, 2018
5NZ9
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BU of 5nz9 by Molmil
NMR structure of an EphA2-Sam fragment
Descriptor: Ephrin type-A receptor 2
Authors:Mercurio, F.A, Leone, M.
Deposit date:2017-05-12
Release date:2017-12-20
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The Sam-Sam interaction between Ship2 and the EphA2 receptor: design and analysis of peptide inhibitors.
Sci Rep, 7, 2017
5L1M
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BU of 5l1m by Molmil
CASKIN2 SAM domain tandem
Descriptor: Caskin-2
Authors:Donaldson, L.W, Kwan, J.J, Saridakis, V.
Deposit date:2016-07-29
Release date:2016-08-10
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.751 Å)
Cite:A new mode of SAM domain mediated oligomerization observed in the CASKIN2 neuronal scaffolding protein.
Cell Commun. Signal, 14, 2016
5J8Y
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BU of 5j8y by Molmil
Crystal structure of the Scm-SAM and Sfmbt-SAM heterodimer
Descriptor: Polycomb protein Scm, Polycomb protein Sfmbt
Authors:Frey, F, Benda, C, Mueller, J.
Deposit date:2016-04-08
Release date:2016-05-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Molecular basis of PRC1 targeting to Polycomb response elements by PhoRC.
Genes Dev., 30, 2016
5F3X
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BU of 5f3x by Molmil
Crystal structure of Harmonin NPDZ1 in complex with ANKS4B SAM-PBM
Descriptor: Ankyrin repeat and SAM domain-containing protein 4B, CHLORIDE ION, Harmonin
Authors:Li, J, He, Y, Lu, Q, Zhang, M.
Deposit date:2015-12-03
Release date:2016-03-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.649 Å)
Cite:Mechanistic Basis of Organization of the Harmonin/USH1C-Mediated Brush Border Microvilli Tip-Link Complex
Dev.Cell, 36, 2016
4RQN
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BU of 4rqn by Molmil
Crystal structure of the native BICC1 SAM Domain R924E mutant
Descriptor: Protein bicaudal C homolog 1, ZINC ION
Authors:Leettola, C.N, Cascio, D, Bowie, J.U.
Deposit date:2014-11-03
Release date:2016-01-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Bicc1 SAM Polymer and Mapping of Interactions between the Ciliopathy-Associated Proteins Bicc1, ANKS3, and ANKS6.
Structure, 26, 2018

 

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