PDB: 142 resultsInfo pagesStatus searchChemie searchBIRD

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4U4A	Complex Structure of BRCA1 BRCT with singly phospho Abraxas Descriptor: BRCA1-A complex subunit Abraxas, Breast cancer type 1 susceptibility protein Authors: Badgujar, D, Hosur, M.V, Varma, A.K. Deposit date: 2014-07-23 Release date: 2015-08-26 Method: X-RAY DIFFRACTION (3.51 Å) Cite: Complex Structure of BRCA1 BRCT with singly phospho Abraxas To Be Published
7P0L	Crystal structure of S.pombe Mdb1 BRCT domains in complex with a H2A phosphopeptide Descriptor: DNA damage response protein Mdb1, Histone H2A-beta Authors: Day, M, Oliver, A.W, Pearl, L.H. Deposit date: 2021-06-29 Release date: 2021-12-01 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1. DNA Repair (Amst), 108, 2021
1CDZ	BRCT DOMAIN FROM DNA-REPAIR PROTEIN XRCC1 Descriptor: PROTEIN (DNA-REPAIR PROTEIN XRCC1) Authors: Zhang, X, Morera, S, Bates, P, Whitehead, P, Coffer, A, Hainbucher, K, Nash, R, Sternberg, M, Lindahl, T, Freemont, P. Deposit date: 1999-03-04 Release date: 2000-02-28 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structure of an XRCC1 BRCT domain: a new protein-protein interaction module. EMBO J., 17, 1998
7P0J	Crystal structure of S.pombe Mdb1 BRCT domains Descriptor: CITRIC ACID, DNA damage response protein Mdb1, MAGNESIUM ION, ... Authors: Day, M, Oliver, A.W, Pearl, L.H. Deposit date: 2021-06-29 Release date: 2022-07-13 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.48 Å) Cite: Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1. DNA Repair (Amst), 108, 2021
6RML	Crystal structure of TOPBP1 BRCT0,1,2 in complex with a 53BP1 phosphopeptide Descriptor: 53BP1, DNA topoisomerase 2-binding protein 1 Authors: Day, M, Oliver, A.W, Pearl, L.H. Deposit date: 2019-05-07 Release date: 2019-06-12 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.81 Å) Cite: Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint. Elife, 8, 2019
3COJ	Crystal Structure of the BRCT Domains of Human BRCA1 in Complex with a Phosphorylated Peptide from Human Acetyl-CoA Carboxylase 1 Descriptor: Acetyl-CoA carboxylase 1, Breast cancer type 1 susceptibility protein Authors: Shen, Y, Tong, L. Deposit date: 2008-03-28 Release date: 2008-05-27 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3.21 Å) Cite: Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1 Biochemistry, 47, 2008
6RMM	Crystal structure of TOPBP1 BRCT4,5 in complex with a 53BP1 phosphopeptide Descriptor: 53BP1, DNA topoisomerase 2-binding protein 1 Authors: Day, M, Oliver, A.W, Pearl, L.H. Deposit date: 2019-05-07 Release date: 2019-06-12 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3.53 Å) Cite: Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint. Elife, 8, 2019
7CMZ	Crystal Structure of BRCT7/8 in Complex with the APS Motif of PHF8 Descriptor: DNA topoisomerase 2-binding protein 1, Histone lysine demethylase PHF8, POTASSIUM ION, ... Authors: Che, S.Y, Ma, S, Cao, C, Yao, Z, Shi, L, Yang, N. Deposit date: 2020-07-29 Release date: 2021-03-17 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.695 Å) Cite: PHF8-promoted TOPBP1 demethylation drives ATR activation and preserves genome stability. Sci Adv, 7, 2021
6WH2	Structure of the C-terminal BRCT domain of human XRCC1 Descriptor: X-ray repair cross complementing protein 1 variant Authors: Pourfarjam, Y, Ellenberger, T, Tainer, J.A, Tomkinson, A.E, Kim, I.K. Deposit date: 2020-04-07 Release date: 2020-12-02 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.414 Å) Cite: An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase III alpha within a flexible DNA repair complex. Nucleic Acids Res., 49, 2021
4OFB	Crystal structure of human BRCA1 BRCT in complex with nonphosphopeptide inhibitor Descriptor: Breast cancer type 1 susceptibility protein, nonphosphopeptide inhibitor Authors: Sun, L, Edwards, R.A, Glover, J.N.M. Deposit date: 2014-01-14 Release date: 2015-04-15 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (3.05 Å) Cite: Peptide Library Approach to Uncover Phosphomimetic Inhibitors of the BRCA1 C-Terminal Domain. Acs Chem.Biol., 10, 2015
3FA2	Crystal Structure of the BRCA1 Associated Ring Domain (BARD1) Tandem BRCT Domains Descriptor: BRCA1-associated RING domain protein 1, GLYCEROL, PHOSPHATE ION Authors: Fox III, D, Le Trong, I, Stenkamp, R.E, Klevit, R.E. Deposit date: 2008-11-14 Release date: 2008-12-23 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal Structure of the BRCA1 Associated Ring Domain (BARD1) Tandem BRCT Domains TO BE PUBLISHED
4Y18	Structure of BRCA1 BRCT domains in complex with Abraxas double phosphorylated peptide Descriptor: BRCA1-A complex subunit Abraxas, Breast cancer type 1 susceptibility protein Authors: Wu, Q, Blundell, T.L. Deposit date: 2015-02-06 Release date: 2016-01-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites. Mol.Cell, 61, 2016
4Y2G	Structure of BRCA1 BRCT domains in complex with Abraxas single phosphorylated peptide Descriptor: BRCA1-A complex subunit Abraxas, Breast cancer type 1 susceptibility protein Authors: Wu, Q, Blundell, T.L. Deposit date: 2015-02-09 Release date: 2016-01-27 Last modified: 2016-02-17 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites. Mol.Cell, 61, 2016
3UEN	Crystal structure of TopBP1 BRCT4/5 domains Descriptor: DNA topoisomerase 2-binding protein 1, GLYCEROL, THIOCYANATE ION Authors: Leung, C.C, Glover, J.N.M. Deposit date: 2011-10-31 Release date: 2013-07-03 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural insights into recognition of MDC1 by TopBP1 in DNA replication checkpoint control. Structure, 21, 2013
3UEO	Crystal structure of TopBP1 BRCT4/5 domains in complex with a phospho-peptide Descriptor: DNA topoisomerase 2-binding protein 1, phospho-peptide Authors: Leung, C.C, Glover, J.N.M. Deposit date: 2011-10-31 Release date: 2013-07-03 Last modified: 2014-03-26 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural insights into recognition of MDC1 by TopBP1 in DNA replication checkpoint control. Structure, 21, 2013
4IGK	Structure of human BRCA1 BRCT in complex with ATRIP peptide Descriptor: ATRIP peptide, Breast cancer type 1 susceptibility protein, GLYCEROL Authors: Liu, X, Ladias, J.A.A. Deposit date: 2012-12-17 Release date: 2013-10-30 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural Basis for the BRCA1 BRCT Interaction with the Proteins ATRIP and BAAT1. Biochemistry, 52, 2013
1WF6	The third BRCA1 C-terminus (BRCT) domain of Similar to S.pombe rad4+/cut5+ product Descriptor: Similar to S.pombe -rad4+/cut5+product (A40727) Authors: Nagashima, T, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2004-05-26 Release date: 2004-11-26 Last modified: 2022-03-02 Method: SOLUTION NMR Cite: The third BRCA1 C-terminus (BRCT) domain of Similar to S.pombe rad4+/cut5+ product TO BE PUBLISHED
4IFI	Structure of human BRCA1 BRCT in complex with BAAT peptide Descriptor: ACETATE ION, BAAT peptide, Breast cancer type 1 susceptibility protein Authors: Liu, X, Ladias, J.A.A. Deposit date: 2012-12-14 Release date: 2013-10-30 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural Basis for the BRCA1 BRCT Interaction with the Proteins ATRIP and BAAT1. Biochemistry, 52, 2013
4JLU	Crystal structure of BRCA1 BRCT with doubly phosphorylated Abraxas Descriptor: BRCA1-A complex subunit Abraxas, Breast cancer type 1 susceptibility protein Authors: Badgujar, D, Varma, A.K. Deposit date: 2013-03-13 Release date: 2014-09-10 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Crystal structure of BRCA1 BRCT with doubly phosphorylated Abraxas To be Published
1Y98	Structure of the BRCT repeats of BRCA1 bound to a CtIP phosphopeptide. Descriptor: Breast cancer type 1 susceptibility protein, COBALT (II) ION, CtIP PHOSPHORYLATED PEPTIDE, ... Authors: Varma, A.K, Brown, R.S, Birrane, G, Ladias, J.A.A. Deposit date: 2004-12-14 Release date: 2005-08-30 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural Basis for Cell Cycle Checkpoint Control by the BRCA1-CtIP Complex. Biochemistry, 44, 2005
1Z56	Co-Crystal Structure of Lif1p-Lig4p Descriptor: DNA ligase IV, Ligase interacting factor 1 Authors: Dore, A.S, Furnham, N, Davies, O.R, Sibanda, B.L, Chirgadze, D.Y, Jackson, S.P, Pellegrini, L, Blundell, T.L. Deposit date: 2005-03-17 Release date: 2006-01-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (3.92 Å) Cite: Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode. DNA REPAIR, 5, 2006
2XNH	Structure and function of the Rad9-binding region of the DNA damage checkpoint adaptor TopBP1 Descriptor: DNA TOPOISOMERASE 2-BINDING PROTEIN 1, IODIDE ION Authors: Rappas, M, Oliver, A.W, Pearl, L.H. Deposit date: 2010-08-02 Release date: 2010-09-01 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structure and Function of the Rad9-Binding Region of the DNA-Damage Checkpoint Adaptor Topbp1. Nucleic Acids Res., 39, 2011
2XNK	Structure and function of the Rad9-binding region of the DNA damage checkpoint adaptor TopBP1 Descriptor: DNA TOPOISOMERASE 2-BINDING PROTEIN 1, GLYCEROL Authors: Rappas, M, Oliver, A.W, Pearl, L.H. Deposit date: 2010-08-03 Release date: 2010-09-01 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure and Function of the Rad9-Binding Region of the DNA-Damage Checkpoint Adaptor Topbp1. Nucleic Acids Res., 39, 2011
1JNX	Crystal structure of the BRCT repeat region from the breast cancer associated protein, BRCA1 Descriptor: BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN, NICKEL (II) ION Authors: Williams, R.S, Green, R, Glover, J.N.M. Deposit date: 2001-07-26 Release date: 2001-09-21 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1. Nat.Struct.Biol., 8, 2001
4BMD	Crystal structure of S.pombe Rad4 BRCT3,4 Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, S-M CHECKPOINT CONTROL PROTEIN RAD4 Authors: Meng, Q, Rappas, M, Wardlaw, C.P, Garcia, V, Carr, A.M, Oliver, A.W, Du, L.L, Pearl, L.H. Deposit date: 2013-05-07 Release date: 2013-10-09 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4(Topbp1.). Mol.Cell, 51, 2013

 

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