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5IZA
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BU of 5iza by Molmil
Protein-protein interaction
Descriptor: ACE-GLY-GLY-GLU-ALA-LEU-ALA-TRP-NH2, Adenomatous polyposis coli protein
Authors:Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J.
Deposit date:2016-03-25
Release date:2017-07-05
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Nat. Chem. Biol., 13, 2017
3TT9
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BU of 3tt9 by Molmil
Crystal structure of the stable degradation fragment of human plakophilin 2 isoform a (PKP2a) C752R variant
Descriptor: GLYCEROL, Plakophilin-2
Authors:Schuetz, A, Roske, Y, Gerull, B, Heinemann, U.
Deposit date:2011-09-14
Release date:2012-08-01
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations.
Circ Cardiovasc Genet, 5, 2012
3NMW
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BU of 3nmw by Molmil
Crystal structure of armadillo repeats domain of APC
Descriptor: APC variant protein, SULFATE ION
Authors:Zhang, Z, Chen, L, Gao, L, Lin, K, Wu, G.
Deposit date:2010-06-22
Release date:2011-07-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis for the recognition of Asef by adenomatous polyposis coli.
Cell Res., 22, 2012
6BW9
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BU of 6bw9 by Molmil
Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 1
Descriptor: Importin subunit alpha-3, Protein W
Authors:Tsimbalyuk, S, Smith, K.M, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K.
Deposit date:2017-12-14
Release date:2018-07-04
Last modified:2023-03-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.
Nat Commun, 9, 2018
4UAF
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BU of 4uaf by Molmil
Importin alpha 1 delta IBB in complex with Influenza PB2 nuclear localization domain
Descriptor: Importin subunit alpha-1, PHOSPHATE ION, Polymerase basic protein 2
Authors:Pumroy, R.A, Cingolani, G.
Deposit date:2014-08-08
Release date:2015-02-04
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.698 Å)
Cite:Molecular Determinants for Nuclear Import of Influenza A PB2 by Importin alpha Isoforms 3 and 7.
Structure, 23, 2015
5CTT
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BU of 5ctt by Molmil
Crystal structure of human SART3/TIP110 NLS-mouse importin alpha complex
Descriptor: Importin subunit alpha-1, Squamous cell carcinoma antigen recognized by T-cells 3
Authors:Park, J.K, Kim, E.E.
Deposit date:2015-07-24
Release date:2016-04-27
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for recruiting and shuttling of the spliceosomal deubiquitinase USP4 by SART3
Nucleic Acids Res., 44, 2016
4YK6
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BU of 4yk6 by Molmil
Crystal structure of APC-ARM in complexed with Amer1-A4
Descriptor: APC membrane recruitment protein 1, Adenomatous polyposis coli protein
Authors:Zhang, Z, Xiao, Y, Wu, G.
Deposit date:2015-03-04
Release date:2016-03-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners
Cell Discov, 1, 2015
6IUA
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BU of 6iua by Molmil
Crystal structure of importin-alpha1 bound to the 53BP1 nuclear localization signal (S1678D)
Descriptor: Importin subunit alpha-1, Peptide from TP53-binding protein 1
Authors:Matsuura, Y.
Deposit date:2018-11-27
Release date:2019-01-30
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and biochemical characterization of the recognition of the 53BP1 nuclear localization signal by importin-alpha.
Biochem. Biophys. Res. Commun., 510, 2019
4WV6
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BU of 4wv6 by Molmil
Heterodimer of Importin alpha 1 with nuclear localization signal of TAF8
Descriptor: 1,2-ETHANEDIOL, Importin subunit alpha-1, Transcription initiation factor TFIID subunit 8
Authors:Trowitzsch, S.
Deposit date:2014-11-04
Release date:2015-01-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Cytoplasmic TAF2-TAF8-TAF10 complex provides evidence for nuclear holo-TFIID assembly from preformed submodules.
Nat Commun, 6, 2015
6K06
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BU of 6k06 by Molmil
Crystal structure of Importin-alpha and phosphomimetic GM130
Descriptor: Importin subunit alpha-1, Peptide from Golgin subfamily A member 2
Authors:Chang, C.-C, Chen, C.-J, Pien, Y.-C, Tsai, S.-Y, Hsia, K.-C.
Deposit date:2019-05-05
Release date:2019-10-02
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-alpha.
Nat Commun, 10, 2019
4RXH
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BU of 4rxh by Molmil
Crystal Structure of Importin-alpha from Neurospora crassa complexed with SV40NLS
Descriptor: Importin subunit alpha, Large T antigen
Authors:Bernardes, N.E, Takeda, A.A.S, Fontes, M.R.M.
Deposit date:2014-12-11
Release date:2015-07-01
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7553 Å)
Cite:Structure of Importin-alpha from a Filamentous Fungus in Complex with a Classical Nuclear Localization Signal.
Plos One, 10, 2015
5Z8H
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BU of 5z8h by Molmil
APC with an inhibitor
Descriptor: Adenomatous polyposis coli protein, GLYCEROL, Peptide inhibitor
Authors:Zhang, J, Yang, X.Y, Song, K.
Deposit date:2018-01-31
Release date:2019-02-06
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:APC with an inhibitor
To Be Published
8HE0
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BU of 8he0 by Molmil
Crystal structure of importin-alpha1 bound to the HIF-1alpha nuclear localization signal (wild-type)
Descriptor: Hypoxia-inducible factor 1-alpha, Importin subunit alpha-1
Authors:Matsuura, Y.
Deposit date:2022-11-07
Release date:2023-02-22
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of importin-alpha bound to the wild-type and an internal deletion mutant of the bipartite nuclear localization signal of HIF-1 alpha.
Biochem.Biophys.Res.Commun., 652, 2023
4YI0
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BU of 4yi0 by Molmil
Structure of mouse importin a1 bound to Pom121NLS
Descriptor: Importin subunit alpha-1, Nuclear envelope pore membrane protein POM 121
Authors:Lokareddy, R.K, Cingolani, G.
Deposit date:2015-02-27
Release date:2016-01-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.806 Å)
Cite:Mammalian Pom121 and yeast Heh2 share IBB-like NLSs that support targeting to the inner nuclear membrane
To Be Published
7AFW
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BU of 7afw by Molmil
Beta-Catenin in complex with compound 6
Descriptor: 3-[(2~{R})-4-methyl-5-oxidanylidene-2,3-dihydro-1,4-benzoxazepin-2-yl]benzenecarbonitrile, Catenin beta-1
Authors:Boettcher, J, Kessler, D.
Deposit date:2020-09-21
Release date:2020-12-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.814 Å)
Cite:Getting a Grip on the Undrugged: Targeting beta-Catenin with Fragment-Based Methods.
Chemmedchem, 16, 2021
7RG1
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BU of 7rg1 by Molmil
Importin alpha2 in complex with MERS ORF4B H26A mutant
Descriptor: Importin subunit alpha-1, ORF4b
Authors:Munasinghe, T.S, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K.
Deposit date:2021-07-14
Release date:2021-07-28
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Importin alpha2 in complex with MERS ORF4B NLS H26A mutant
To Be Published
4MZ6
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BU of 4mz6 by Molmil
Structure of importin-alpha: dUTPase S11E NLS mutant complex
Descriptor: Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, Importin subunit alpha-1
Authors:Marfori, M, Rona, G, Vertessy, B.G, Kobe, B.
Deposit date:2013-09-29
Release date:2013-11-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights.
Acta Crystallogr.,Sect.D, 69, 2013
8HKW
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BU of 8hkw by Molmil
Crystal structure of importin-alpha3 bound to the 53BP1 nuclear localization signal
Descriptor: Importin subunit alpha-3, Peptide from TP53-binding protein 1
Authors:Matsuura, Y.
Deposit date:2022-11-28
Release date:2022-12-21
Last modified:2023-03-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystallographic data of an importin-alpha 3 dimer in which the two protomers are bridged by a bipartite nuclear localization signal.
Data Brief, 47, 2023
4YJE
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BU of 4yje by Molmil
Crystal structure of APC-ARM in complexed with Amer1-A1
Descriptor: APC membrane recruitment protein 1, Adenomatous polyposis coli protein
Authors:Zhang, Z, Xiao, Y, Wu, G.
Deposit date:2015-03-03
Release date:2016-03-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners
Cell Discov, 1, 2015
8FUA
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BU of 8fua by Molmil
Crystal structure of mouse Importin alpha in complex with Hendra virus matrix protein NLS1
Descriptor: Importin subunit alpha-1, Matrix protein
Authors:Donnelly, C.M, Basler, C.F, Scott, C, Forwood, J.K.
Deposit date:2023-01-17
Release date:2023-02-08
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Henipavirus Matrix Protein Employs a Non-Classical Nuclear Localization Signal Binding Mechanism.
Viruses, 15, 2023
1JDH
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BU of 1jdh by Molmil
CRYSTAL STRUCTURE OF BETA-CATENIN AND HTCF-4
Descriptor: BETA-CATENIN, hTcf-4
Authors:Graham, T.A, Ferkey, D.M, Mao, F, Kimelman, D, Xu, W.
Deposit date:2001-06-13
Release date:2001-12-05
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Tcf4 can specifically recognize beta-catenin using alternative conformations.
Nat.Struct.Biol., 8, 2001
5D5K
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BU of 5d5k by Molmil
Crystal Structure NLS from human PARP-2 complexed with Importin alpha delta IBB
Descriptor: Importin subunit alpha-1, Poly [ADP-ribose] polymerase 2
Authors:Riccio, A.A, Cingolani, G, Pascal, J.M.
Deposit date:2015-08-10
Release date:2016-06-22
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage.
Nucleic Acids Res., 44, 2016
5UMZ
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BU of 5umz by Molmil
Structure of TNRC6A NLS in complex with importin-alpha
Descriptor: GLYCEROL, Importin subunit alpha-1, TNRC6A
Authors:Chaston, J, Stewart, A.G, Christie, M.
Deposit date:2017-01-30
Release date:2017-12-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural characterisation of TNRC6A nuclear localisation signal in complex with importin-alpha.
PLoS ONE, 12, 2017
6IU7
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BU of 6iu7 by Molmil
Crystal structure of importin-alpha1 bound to the 53BP1 nuclear localization signal (wild-type)
Descriptor: Importin subunit alpha-1, Peptide from TP53-binding protein 1
Authors:Matsuura, Y.
Deposit date:2018-11-27
Release date:2019-01-30
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and biochemical characterization of the recognition of the 53BP1 nuclear localization signal by importin-alpha.
Biochem. Biophys. Res. Commun., 510, 2019
3UL1
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BU of 3ul1 by Molmil
Mouse importin alpha: nucleoplasmin cNLS peptide complex
Descriptor: Importin subunit alpha-2, Nucleoplasmin
Authors:Marfori, M, Forwood, J.K, Lonhienne, T.G, Kobe, B.
Deposit date:2011-11-10
Release date:2012-10-03
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis of High-Affinity Nuclear Localization Signal Interactions with Importin-alpha
Traffic, 13, 2012

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