1AS0
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GTP-GAMMA-S BOUND G42V GIA1
Descriptor:GIA1, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Authors:Raw, A.S., Coleman, D.E., Gilman, A.G., Sprang, S.R.
Deposit date:1997-08-11
Release date:1997-11-12
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and biochemical characterization of the GTPgammaS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 --> Val mutant of Gialpha1.
Biochemistry, 36, 1997
1AS2
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GDP+PI BOUND G42V GIA1
Descriptor:GIA1, GUANOSINE-5'-DIPHOSPHATE
Authors:Raw, A.S., Coleman, D.E., Gilman, A.G., Sprang, S.R.
Deposit date:1997-08-11
Release date:1997-11-12
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and biochemical characterization of the GTPgammaS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 --> Val mutant of Gialpha1.
Biochemistry, 36, 1997
1AS3
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GDP BOUND G42V GIA1
Descriptor:GIA1, GUANOSINE-5'-DIPHOSPHATE
Authors:Raw, A.S., Coleman, D.E., Gilman, A.G., Sprang, S.R.
Deposit date:1997-08-11
Release date:1997-11-12
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and biochemical characterization of the GTPgammaS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 --> Val mutant of Gialpha1.
Biochemistry, 36, 1997
1AZT
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GS-ALPHA COMPLEXED WITH GTP-GAMMA-S
Descriptor:GS-ALPHA, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Authors:Tesmer, J.J.G., Sprang, S.R.
Deposit date:1997-11-20
Release date:1998-02-25
Last modified:2013-08-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the adenylyl cyclase activator Gsalpha
Science, 278, 1997
1BOF
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GI-ALPHA-1 BOUND TO GDP AND MAGNESIUM
Descriptor:GI ALPHA 1, GUANOSINE-5'-DIPHOSPHATE
Authors:Coleman, D.E., Sprang, S.R.
Deposit date:1998-08-04
Release date:1999-01-06
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of the G protein Gi alpha 1 complexed with GDP and Mg2+: a crystallographic titration experiment.
Biochemistry, 37, 1998
1CIP
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GI-ALPHA-1 SUBUNIT OF GUANINE NUCLEOTIDE-BINDING PROTEIN COMPLEXED WITH A GTP ANALOGUE
Descriptor:GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT
Authors:Coleman, D., Sprang, S.
Deposit date:1999-04-05
Release date:1999-04-09
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of Gialpha1.GppNHp, autoinhibition in a galpha protein-substrate complex.
J.Biol.Chem., 274, 1999
1GDD
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TERTIARY AND QUATERNARY STRUCTURAL CHANGES IN GIA1 INDUCED BY GTP HYDROLYSIS
Descriptor:GI ALPHA 1, GUANOSINE-5'-DIPHOSPHATE
Authors:Mixon, M.B., Sprang, S.R.
Deposit date:1995-07-25
Release date:1995-11-27
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis.
Science, 270, 1995
1GFI
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STRUCTURES OF ACTIVE CONFORMATIONS OF GI ALPHA 1 AND THE MECHANISM OF GTP HYDROLYSIS
Descriptor:GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-1 SUBUNIT (G(I)-ALPHA-1) (ACTIVE FORM) COMPLEXED WITH GDP-ALF4
Authors:Coleman, D.E., Berghuis, A.M., Sprang, S.R.
Deposit date:1994-11-11
Release date:1995-03-31
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis.
Science, 265, 1994
1GIA
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STRUCTURE OF ACTIVE CONFORMATIONS OF GIA1 AND THE MECHANISM OF GTP HYDROLYSIS
Descriptor:GI ALPHA 1 (ACTIVE FORM WITH BOUND GTP-GAMMA-S)
Authors:Berghuis, A.M., Coleman, D.E., Sprang, S.R.
Deposit date:1994-07-20
Release date:1994-09-30
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis.
Science, 265, 1994
1GIL
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STRUCTURE OF ACTIVE CONFORMATIONS OF GIA1 AND THE MECHANISM OF GTP HYDROLYSIS
Descriptor:G I ALPHA1 (GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-1 SUBUNIT) MUTANT WITH GLN 204 REPLACED BY LEU (Q204L) COMPLEXED WITH GTP-GAMMA-S AND MAGNESIUM
Authors:Coleman, D.E., Berghuis, A.M., Sprang, S.R.
Deposit date:1995-01-02
Release date:1995-02-14
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis.
Science, 265, 1994
1GIT
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STRUCTURE OF GTP-BINDING PROTEIN
Descriptor:G PROTEIN GI ALPHA 1, GUANOSINE-5'-DIPHOSPHATE
Authors:Berghuis, A.M., Lee, E., Sprang, S.R.
Deposit date:1996-10-16
Release date:1997-02-12
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the GDP-Pi complex of Gly203-->Ala gialpha1: a mimic of the ternary product complex of galpha-catalyzed GTP hydrolysis.
Structure, 4, 1996
1SVK
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STRUCTURE OF THE K180P MUTANT OF GI ALPHA SUBUNIT BOUND TO ALF4 AND GDP
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit (E.C.3.6.1.46)
Authors:Thomas, C.J., Du, X., Li, P., Wang, Y., Ross, E.M., Sprang, S.R.
Deposit date:2004-03-29
Release date:2004-06-01
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein {alpha}-subunit.
Proc.Natl.Acad.Sci.USA, 101, 2004
1SVS
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STRUCTURE OF THE K180P MUTANT OF GI ALPHA SUBUNIT BOUND TO GPPNHP.
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit
Authors:Thomas, C.J., Du, X., Li, P., Wang, Y., Ross, E.M., Sprang, S.R.
Deposit date:2004-03-29
Release date:2004-06-01
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein {alpha}-subunit.
Proc.Natl.Acad.Sci.USA, 101, 2004
1ZCA
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CRYSTAL STRUCTURE OF G ALPHA 12 IN COMPLEX WITH GDP, MG2+ AND ALF4-
Descriptor:Galphai/12
Authors:Nance, M.R., Tesmer, J.J.G.
Deposit date:2005-04-11
Release date:2005-11-15
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteins.
Biochemistry, 45, 2006
1ZCB
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CRYSTAL STRUCTURE OF G ALPHA 13 IN COMPLEX WITH GDP
Descriptor:G alpha i/13
Authors:Nance, M.R., Tesmer, J.J.G.
Deposit date:2005-04-11
Release date:2005-11-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteins.
Biochemistry, 45, 2006
2ZJY
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STRUCTURE OF THE K349P MUTANT OF GI ALPHA 1 SUBUNIT BOUND TO ALF4 AND GDP
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit (E.C.3.6.5.1)
Authors:Morikawa, T., Muroya, A., Sugio, S., Wakamatsu, K., Kohno, T.
Deposit date:2008-03-11
Release date:2009-03-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:How GPCRs activate G proteins: Structural changes form C-terminal tail to GDP binding pocket
To be Published
2ZJZ
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STRUCTURE OF THE K349P MUTANT OF GI ALPHA 1 SUBUNIT BOUND TO GDP
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit (E.C.3.6.5.1)
Authors:Morikawa, T., Muroya, A., Sugio, S., Wakamatsu, K., Kohno, T.
Deposit date:2008-03-11
Release date:2009-03-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:How GPCRs activate G proteins: Structural changes from C-terminal tail to GDP binding pocket
To be Published
3D7M
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CRYSTAL STRUCTURE OF THE G PROTEIN FAST-EXCHANGE DOUBLE MUTANT I56C/Q333C
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit
Authors:Funk, M.A., Preininger, A.M., Oldham, W.M., Meier, S.M., Hamm, H.E., Iverson, T.M.
Deposit date:2008-05-21
Release date:2009-03-03
Last modified:2009-09-22
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits.
Biochemistry, 48, 2009
3FFA
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CRYSTAL STRUCTURE OF A FAST ACTIVATING G PROTEIN MUTANT
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit
Authors:Chauhan, R., Kapoor, N.
Deposit date:2008-12-02
Release date:2009-10-06
Last modified:2009-11-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural evidence for a sequential release mechanism for activation of heterotrimeric g proteins.
J.Mol.Biol., 393, 2009
3FFB
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GI-ALPHA-1 MUTANT IN GDP BOUND FORM
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit
Authors:Chauhan, R., Kapoor, N.
Deposit date:2008-12-02
Release date:2009-10-06
Last modified:2009-11-03
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Structural evidence for a sequential release mechanism for activation of heterotrimeric g proteins.
J.Mol.Biol., 393, 2009
3UMR
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CRYSTAL STRUCTURE OF THE G202D MUTANT OF HUMAN G-ALPHA-I1
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1
Authors:Johnston, C.A., Afshar, K., Snyder, J.T., Tall, G.G., Gonczy, P., Siderovski, D.P., Willard, F.S.
Deposit date:2011-11-14
Release date:2012-10-24
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural Determinants Underlying the Temperature-sensitive Nature of a G-alpha Mutant in Asymmetric Cell Division of Caenorhabditis elegans
To be Published
3UMS
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CRYSTAL STRUCTURE OF THE G202A MUTANT OF HUMAN G-ALPHA-I1
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1
Authors:Lambert, N.A., Johnston, C.A., Cappell, S.D., Kuravi, S., Kimple, A.J., Willard, F.S., Siderovski, D.P.
Deposit date:2011-11-14
Release date:2012-02-08
Method:X-RAY DIFFRACTION (2.343 Å)
Cite:Correction for Regulators of G-protein Signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity
Proc.Natl.Acad.Sci.USA, 2012
3V00
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STUDIES OF A CONSTITUTIVELY ACTIVE G-ALPHA SUBUNIT PROVIDE INSIGHTS INTO THE MECHANISM OF G PROTEIN ACTIVATION.
Descriptor:Guanine nucleotide-binding protein G(t) subunit alpha-1 (E.C.3.6.5.1)
Authors:Singh, G., Cerione, R.A.
Deposit date:2011-12-07
Release date:2012-04-18
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A constitutively active G-alpha subunit provide insights into the mechanism of G protein activation
Biochemistry, 51, 2012
4N0D
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CRYSTAL STRUCTURE OF THE K345L VARIANT OF THE GI ALPHA1 SUBUNIT BOUND TO GTPGAMMAS
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1 (E.C.3.6.5.1)
Authors:Thaker, T.M., Preininger, A.M., Sarwar, M., Hamm, H.E., Iverson, T.M.
Deposit date:2013-10-01
Release date:2014-03-12
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:A Transient Interaction between the Phosphate Binding Loop and Switch I Contributes to the Allosteric Network between Receptor and Nucleotide in G alpha i1.
J.Biol.Chem., 289, 2014
4N0E
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CRYSTAL STRUCTURE OF THE K345L VARIANT OF THE GI ALPHA1 SUBUNIT BOUND TO GDP
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1 (E.C.3.6.5.1)
Authors:Thaker, T.M., Preininger, A.M., Sarwar, M., Hamm, H.E., Iverson, T.M.
Deposit date:2013-10-01
Release date:2014-03-12
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Transient Interaction between the Phosphate Binding Loop and Switch I Contributes to the Allosteric Network between Receptor and Nucleotide in G alpha i1.
J.Biol.Chem., 289, 2014
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