8XGC
 
 | | Structure of yeast replisome associated with FACT and histone hexamer, Composite map | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, Chromosome segregation in meiosis protein 3, ... | | Authors: | Li, N, Gao, Y, Yu, D, Gao, N, Zhai, Y. | | Deposit date: | 2023-12-15 | | Release date: | 2024-02-14 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Parental histone transfer caught at the replication fork.
Nature, 627, 2024
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8W7S
 | | Yeast replisome in state IV | | Descriptor: | Cell division control protein 45, DNA (71-mer), DNA polymerase alpha-binding protein, ... | | Authors: | Dang, S, Zhai, Y, Feng, J, Yu, D. | | Deposit date: | 2023-08-31 | | Release date: | 2023-12-20 | | Method: | ELECTRON MICROSCOPY (7.39 Å) | | Cite: | Synergism between CMG helicase and leading strand DNA polymerase at replication fork.
Nat Commun, 14, 2023
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8W7M
 | | Yeast replisome in state V | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, DNA (71-mer), ... | | Authors: | Dang, S, Zhai, Y, Feng, J, Yu, D, Xu, Z. | | Deposit date: | 2023-08-30 | | Release date: | 2023-12-06 | | Method: | ELECTRON MICROSCOPY (4.12 Å) | | Cite: | Synergism between CMG helicase and leading strand DNA polymerase at replication fork.
Nat Commun, 14, 2023
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8KG6
 | | Yeast replisome in state I | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, Chromosome segregation in meiosis protein 3, ... | | Authors: | Dang, S, Zhai, Y, Feng, J, Yu, D, Xu, Z. | | Deposit date: | 2023-08-17 | | Release date: | 2023-12-06 | | Method: | ELECTRON MICROSCOPY (3.07 Å) | | Cite: | Synergism between CMG helicase and leading strand DNA polymerase at replication fork.
Nat Commun, 14, 2023
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8KG8
 | | Yeast replisome in state II | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, DNA (61-mer), ... | | Authors: | Dang, S, Zhai, Y, Feng, J, Yu, D, Xu, Z. | | Deposit date: | 2023-08-17 | | Release date: | 2023-12-06 | | Method: | ELECTRON MICROSCOPY (4.23 Å) | | Cite: | Synergism between CMG helicase and leading strand DNA polymerase at replication fork.
Nat Commun, 14, 2023
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8KG9
 | | Yeast replisome in state III | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, DNA (61-mer), ... | | Authors: | Dang, S, Zhai, Y, Feng, J, Yu, D, Xu, Z. | | Deposit date: | 2023-08-17 | | Release date: | 2023-12-06 | | Method: | ELECTRON MICROSCOPY (4.52 Å) | | Cite: | Synergism between CMG helicase and leading strand DNA polymerase at replication fork.
Nat Commun, 14, 2023
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8Q6O
 | | X. laevis CMG dimer bound to dimeric DONSON - without ATPase | | Descriptor: | Cell division control protein 45 homolog, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ... | | Authors: | Butryn, A, Cvetkovic, M.A, Costa, A. | | Deposit date: | 2023-08-14 | | Release date: | 2023-10-18 | | Last modified: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (3.14 Å) | | Cite: | The structural mechanism of dimeric DONSON in replicative helicase activation.
Mol.Cell, 83, 2023
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8Q6P
 | | X. laevis CMG dimer bound to dimeric DONSON - MCM ATPase | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA replication licensing factor mcm2, DNA replication licensing factor mcm4-B, ... | | Authors: | Butryn, A, Cvetkovic, M.A, Costa, A. | | Deposit date: | 2023-08-14 | | Release date: | 2023-10-18 | | Last modified: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (3.53 Å) | | Cite: | The structural mechanism of dimeric DONSON in replicative helicase activation.
Mol.Cell, 83, 2023
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8OUW
 | | Cryo-EM structure of CMG helicase bound to TIM-1/TIPN-1 and homodimeric DNSN-1 on fork DNA (Caenorhabditis elegans) | | Descriptor: | Cell division control protein 45 homolog, DNA Lagging Strand Template, DNA Leading Strand Template, ... | | Authors: | Jenkyn-Bedford, M, Yeeles, J.T.P, Labib, K.P.M. | | Deposit date: | 2023-04-25 | | Release date: | 2023-08-16 | | Last modified: | 2023-10-04 | | Method: | ELECTRON MICROSCOPY (3.75 Å) | | Cite: | DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans.
Science, 381, 2023
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8B9B
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8B9A
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8B9C
 | | S. cerevisiae pol alpha - replisome complex | | Descriptor: | Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha catalytic subunit A, ... | | Authors: | Jones, M.L, Yeeles, J.T.P. | | Deposit date: | 2022-10-05 | | Release date: | 2023-08-09 | | Last modified: | 2023-08-30 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication.
Mol.Cell, 83, 2023
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8B9D
 | | Human replisome bound by Pol Alpha | | Descriptor: | Cell division control protein 45 homolog, Claspin, DNA Molecule, ... | | Authors: | Jones, M.L, Yeeles, J.T.P. | | Deposit date: | 2022-10-05 | | Release date: | 2023-08-09 | | Last modified: | 2023-08-30 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication.
Mol.Cell, 83, 2023
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8S92
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8S94
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8S91
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7W68
 | | human single hexameric Mcm2-7 complex | | Descriptor: | DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ... | | Authors: | Xu, N.N, Lin, Q.P, Liu, C.D, Tian, H.L, Xiang, Y, Zhu, G. | | Deposit date: | 2021-12-01 | | Release date: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | human single hexameric Mcm2-7 complex
To Be Published
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7W1Y
 | | Human MCM double hexamer bound to natural DNA duplex (polyAT/polyTA) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (49-MER), ... | | Authors: | Li, J, Dong, J, Dang, S, Zhai, Y. | | Deposit date: | 2021-11-21 | | Release date: | 2023-02-08 | | Method: | ELECTRON MICROSCOPY (2.59 Å) | | Cite: | The human pre-replication complex is an open complex.
Cell, 186, 2023
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7WI7
 | | Crystal structure of human MCM8/9 complex | | Descriptor: | DNA helicase MCM8, DNA helicase MCM9, ZINC ION | | Authors: | Li, J, Liu, Y. | | Deposit date: | 2022-01-03 | | Release date: | 2023-01-25 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (6.6 Å) | | Cite: | Crystal structure of human MCM8/9 complex
To Be Published
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8EAH
 | | SsoMCM hexamer bound to Mg/ADP-BeFx and 16-mer oligo-dT. Class 1 | | Descriptor: | 16-mer oligo-dT, MAGNESIUM ION, Minichromosome maintenance protein MCM, ... | | Authors: | Meagher, M, Myasnikov, A, Enemark, E.J. | | Deposit date: | 2022-08-29 | | Release date: | 2022-12-14 | | Last modified: | 2022-12-21 | | Method: | ELECTRON MICROSCOPY (2.48 Å) | | Cite: | Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation.
Int J Mol Sci, 23, 2022
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8EAI
 | | SsoMCM hexamer bound to Mg/ADP-BeFx and 16-mer oligo-dT. Class 2 | | Descriptor: | 16-mer oligo-dT, MAGNESIUM ION, Minichromosome maintenance protein MCM, ... | | Authors: | Meagher, M, Myasnikov, A, Enemark, E.J. | | Deposit date: | 2022-08-29 | | Release date: | 2022-12-14 | | Last modified: | 2022-12-21 | | Method: | ELECTRON MICROSCOPY (2.76 Å) | | Cite: | Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation.
Int J Mol Sci, 23, 2022
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8EAJ
 | | SsoMCM hexamer bound to Mg/ADP-BeFx and 46-mer DNA strand. Class 1 | | Descriptor: | 46-mer DNA strand, MAGNESIUM ION, Minichromosome maintenance protein MCM, ... | | Authors: | Meagher, M, Myasnikov, A, Enemark, E.J. | | Deposit date: | 2022-08-29 | | Release date: | 2022-12-14 | | Last modified: | 2022-12-21 | | Method: | ELECTRON MICROSCOPY (2.45 Å) | | Cite: | Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation.
Int J Mol Sci, 23, 2022
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8EAF
 | | SsoMCM hexamer bound to Mg/ADP-BeFx and 12-mer oligo-dT. Class 1 | | Descriptor: | 12-mer oligo dT, MAGNESIUM ION, Minichromosome maintenance protein MCM, ... | | Authors: | Meagher, M, Myasnikov, A, Enemark, E.J. | | Deposit date: | 2022-08-29 | | Release date: | 2022-12-14 | | Last modified: | 2022-12-21 | | Method: | ELECTRON MICROSCOPY (2.62 Å) | | Cite: | Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation.
Int J Mol Sci, 23, 2022
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8EAL
 | | SsoMCM hexamer bound to Mg/ADP-BeFx and DNA. Class 1. Merged particles from datasets with 3 different DNA entities | | Descriptor: | DNA, MAGNESIUM ION, Minichromosome maintenance protein MCM, ... | | Authors: | Meagher, M, Myasnikov, A, Enemark, E.J. | | Deposit date: | 2022-08-29 | | Release date: | 2022-12-14 | | Last modified: | 2022-12-21 | | Method: | ELECTRON MICROSCOPY (2.34 Å) | | Cite: | Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation.
Int J Mol Sci, 23, 2022
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8EAG
 | | SsoMCM hexamer bound to Mg/ADP-BeFx and 12-mer oligo-dT. Class 2 | | Descriptor: | 12-mer oligo-dT, MAGNESIUM ION, Minichromosome maintenance protein MCM, ... | | Authors: | Meagher, M, Myasnikov, A, Enemark, E.J. | | Deposit date: | 2022-08-29 | | Release date: | 2022-12-14 | | Last modified: | 2022-12-21 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation.
Int J Mol Sci, 23, 2022
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