1CEV
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ARGINASE FROM BACILLUS CALDOVELOX, NATIVE STRUCTURE AT PH 5.6
Descriptor:PROTEIN (ARGINASE), MANGANESE (II) ION
Authors:Bewley, M.C., Jeffrey, P.D., Patchett, M.L., Kanyo, Z.F., Baker, E.N.
Deposit date:1999-03-12
Release date:1999-04-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of Bacillus caldovelox arginase in complex with substrate and inhibitors reveal new insights into activation, inhibition and catalysis in the arginase superfamily.
Structure Fold.Des., 7, 1999
1D3V
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CRYSTAL STRUCTURE OF THE BINUCLEAR MANGANESE METALLOENZYME ARGINASE COMPLEXED WITH 2(S)-AMINO-6-BORONOHEXANOIC ACID, AN L-ARGININE ANALOG
Descriptor:PROTEIN (ARGINASE), MANGANESE (II) ION, 2(S)-AMINO-6-BORONOHEXANOIC ACID
Authors:Cox, J.D., Kim, N.N., Traish, A.M., Christianson, D.W.
Deposit date:1999-10-01
Release date:1999-11-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Arginase-boronic acid complex highlights a physiological role in erectile function.
Nat.Struct.Biol., 6, 1999
1GQ6
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PROCLAVAMINATE AMIDINO HYDROLASE FROM STREPTOMYCES CLAVULIGERUS
Descriptor:PROCLAVAMINATE AMIDINO HYDROLASE, MANGANESE (II) ION
Authors:Elkins, J.M., Clifton, I.J., Hernandez, H., Robinson, C.V., Schofield, C.J., Hewitson, K.S.
Deposit date:2001-11-20
Release date:2002-06-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Oligomeric Structure of Proclavaminic Acid Amidino Hydrolase: Evolution of a Hydrolytic Enzyme in Clavulanic Acid Biosynthesis
Biochem.J., 366, 2002
1GQ7
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PROCLAVAMINATE AMIDINO HYDROLASE FROM STREPTOMYCES CLAVULIGERUS
Descriptor:PROCLAVAMINATE AMIDINO HYDROLASE, MANGANESE (II) ION
Authors:Elkins, J.M., Clifton, I.J., Hernandez, H., Robinson, C.V., Schofield, C.J., Hewitson, K.S.
Deposit date:2001-11-20
Release date:2002-06-06
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis.
Biochem. J., 366, 2002
1HQ5
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CRYSTAL STRUCTURE OF THE BINUCLEAR MANGANESE METALLOENZYME ARGINASE COMPLEXED WITH S-(2-BORONOETHYL)-L-CYSTEINE, AN L-ARGININE ANALOGUE
Descriptor:ARGINASE 1, MANGANESE (II) ION, S-2-(BORONOETHYL)-L-CYSTEINE
Authors:Kim, N.N., Cox, J.D., Baggio, R.F., Emig, F.A., Mistry, S.K., Harper, S.L., Speicher, D.W., Morris Jr., S.M., Ash, D.E., Traish, A., Christianson, D.W.
Deposit date:2000-12-14
Release date:2001-04-04
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum.
Biochemistry, 40, 2001
1HQF
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CRYSTAL STRUCTURE OF THE BINUCLEAR MANGANESE METALLOENZYME ARGINASE COMPLEXED WITH N-HYDROXY-L-ARGININE
Descriptor:ARGINASE 1, MANGANESE (II) ION, N-OMEGA-HYDROXY-L-ARGININE
Authors:Cox, J.D., Cama, E., Colleluori, D.M., Ash, D.E., Christianson, D.W.
Deposit date:2000-12-16
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Mechanistic and metabolic inferences from the binding of substrate analogues and products to arginase.
Biochemistry, 40, 2001
1HQG
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CRYSTAL STRUCTURE OF THE H141C ARGINASE VARIANT COMPLEXED WITH PRODUCTS ORNITHINE AND UREA
Descriptor:ARGINASE 1, MANGANESE (II) ION, L-ornithine, ...
Authors:Cox, J.D., Cama, E., Colleluori, D.M., Ash, D.E., Christianson, D.W.
Deposit date:2000-12-16
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mechanistic and metabolic inferences from the binding of substrate analogues and products to arginase.
Biochemistry, 40, 2001
1HQH
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CRYSTAL STRUCTURE OF THE BINUCLEAR MANGANESE METALLOENZYME ARGINASE COMPLEXED WITH NOR-N-HYDROXY-L-ARGININE
Descriptor:ARGINASE 1, MANGANESE (II) ION, NOR-N-OMEGA-HYDROXY-L-ARGININE
Authors:Cox, J.D., Cama, E., Colleluori, D.M., Ash, D.E., Christianson, D.W.
Deposit date:2000-12-16
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mechanistic and metabolic inferences from the binding of substrate analogues and products to arginase.
Biochemistry, 40, 2001
1HQX
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R308K ARGINASE VARIANT
Descriptor:ARGINASE, MANGANESE (II) ION
Authors:Lavulo, L.T., Sossong Jr., T.M., Brigham-Burke, M.R., Doyle, M.L., Cox, J.D., Christianson, D.W., Ash, D.E.
Deposit date:2000-12-20
Release date:2001-06-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Subunit-subunit interactions in trimeric arginase. Generation of active monomers by mutation of a single amino acid.
J.Biol.Chem., 276, 2001
1P8M
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STRUCTURAL AND FUNCTIONAL IMPORTANCE OF FIRST-SHELL METAL LIGANDS IN THE BINUCLEAR MANGANESE CLUSTER OF ARGINASE I.
Descriptor:Arginase 1, MANGANESE (II) ION
Authors:Cama, E., Emig, F.A., Ash, E.-D., Christianson, D.W.
Deposit date:2003-05-07
Release date:2003-06-17
Last modified:2017-02-08
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Structural and functional importance of first-shell metal ligands in the binuclear manganese cluster of arginase I.
Biochemistry, 42, 2003
1P8N
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STRUCTURAL AND FUNCTIONAL IMPORTANCE OF FIRST-SHELL METAL LIGANDS IN THE BINUCLEAR MANGANESE CLUSTER OF ARGINASE I.
Descriptor:Arginase 1, MANGANESE (II) ION, GLYCEROL
Authors:Cama, E., Emig, F.A., Ash, D.E., Christianson, D.W.
Deposit date:2003-05-07
Release date:2003-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural and functional importance of first-shell metal ligands in the binuclear manganese cluster of arginase I
Biochemistry, 42, 2003
1P8O
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STRUCTURAL AND FUNCTIONAL IMPORTANCE OF FIRST-SHELL METAL LIGANDS IN THE BINUCLEAR MANGANESE CLUSTER OF ARGINASE I.
Descriptor:Arginase 1, MANGANESE (II) ION
Authors:Cama, E., Emig, F.A., Ash, D.E., Christianson, D.W.
Deposit date:2003-05-07
Release date:2003-06-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:Structural and functional importance of first-shell metal ligands in the binuclear manganese cluster of arginase I
Biochemistry, 42, 2003
1P8P
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STRUCTURAL AND FUNCTIONAL IMPORTANCE OF FIRST-SHELL METAL LIGANDS IN THE BINUCLEAR MANGANESE CLUSTER OF ARGINASE I.
Descriptor:Arginase 1, MANGANESE (II) ION
Authors:Cama, E., Emig, F.A., Ash, D.E., Christianson, D.W.
Deposit date:2003-05-07
Release date:2003-06-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and functional importance of first-shell metal ligands in the binuclear manganese cluster of arginase I
Biochemistry, 42, 2003
1P8Q
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STRUCTURAL AND FUNCTIONAL IMPORTANCE OF FIRST-SHELL METAL LIGANDS IN THE BINUCLEAR CLUSTER OF ARGINASE I.
Descriptor:Arginase 1, MANGANESE (II) ION, GLYCEROL
Authors:Cama, E., Emig, F.A., Ash, D.E., Christianson, D.W.
Deposit date:2003-05-07
Release date:2003-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural and functional importance of first-shell metal ligands in the binuclear manganese cluster of arginase I
Biochemistry, 42, 2003
1P8R
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STRUCTURAL AND FUNCTIONAL IMPORTANCE OF FIRST-SHELL METAL LIGANDS IN THE BINUCLEAR MANGANESE CLUSTER OF ARGINASE I.
Descriptor:Arginase 1, CHLORIDE ION, MANGANESE (II) ION, ...
Authors:Cama, E., Emig, F.A., Ash, D.E., Christianson, D.W.
Deposit date:2003-05-07
Release date:2003-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and functional importance of first-shell metal ligands in the binuclear manganese cluster of arginase I
Biochemistry, 42, 2003
1P8S
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STRUCTURAL AND FUNCTIONAL IMPORTANCE OF FIRST-SHELL METAL LIGANDS IN THE BINUCLEAR MANGANESE CLUSTER OF ARGINASE I.
Descriptor:Arginase 1, MANGANESE (II) ION
Authors:Cama, E., Emig, F.A., Ash, D.E., Christianson, D.W.
Deposit date:2003-05-07
Release date:2003-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural and functional importance of first-shell metal ligands in the binuclear manganese cluster of arginase I
Biochemistry, 42, 2003
1PQ3
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HUMAN ARGINASE II: CRYSTAL STRUCTURE AND PHYSIOLOGICAL ROLE IN MALE AND FEMALE SEXUAL AROUSAL
Descriptor:Arginase II, mitochondrial precursor, SULFATE ION, ...
Authors:Cama, E., Colleluori, D.M., Emig, F.A., Shin, H., Kim, S.W., Kim, N.N., Traish, A.M., Ash, D.E., Christianson, D.W.
Deposit date:2003-06-17
Release date:2003-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Human Arginase II: Crystal Structure and Physiological Role in Male and Female Sexual Arousal
Biochemistry, 42, 2003
1R1O
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AMINO ACID SULFONAMIDES AS TRANSITION-STATE ANALOGUE INHIBITORS OF ARGINASE
Descriptor:Arginase 1, MANGANESE (II) ION, S-[2-(AMINOSULFONYL)ETHYL]-D-CYSTEINE
Authors:Cama, E., Shin, H., Christianson, D.W.
Deposit date:2003-09-24
Release date:2003-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Design of Amino Acid Sulfonamides as Transition-State Analogue Inhibitors of Arginase
J.Am.Chem.Soc., 125, 2003
1RLA
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THREE-DIMENSIONAL STRUCTURE OF RAT LIVER ARGINASE, THE BINUCLEAR MANGANESE METALLOENZYME OF THE UREA CYCLE
Descriptor:ARGINASE, MANGANESE (II) ION
Authors:Kanyo, Z., Scolnick, L., Ash, D., Christianson, D.
Deposit date:1996-08-15
Release date:1997-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of a unique binuclear manganese cluster in arginase.
Nature, 383, 1996
1T4P
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ARGINASE-DEHYDRO-ABH COMPLEX
Descriptor:Arginase 1, MANGANESE (II) ION, [(1E,5S)-5-AMINO-5-CARBOXYPENT-1-ENYL](TRIHYDROXY)BORATE(1-)
Authors:Cama, E., Pethe, S., Boucher, J.-L., Han, S., Emig, F.A., Ash, D.E., Viola, R.E., Mansuy, D., Christianson, D.W.
Deposit date:2004-04-30
Release date:2005-04-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Inhibitor coordination interactions in the binuclear manganese cluster of arginase
Biochemistry, 43, 2004
1T4R
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ARGINASE-DESCARBOXY-NOR-NOHA COMPLEX
Descriptor:Arginase 1, MANGANESE (II) ION, 3-{[(E)-AMINO(HYDROXYIMINO)METHYL]AMINO}PROPAN-1-AMINIUM
Authors:Cama, E., Pethe, S., Boucher, J.-L., Shoufa, H., Emig, F.A., Ash, D.E., Viola, R.E., Mansuy, D., Christianson, D.W.
Deposit date:2004-04-30
Release date:2005-04-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Inhibitor coordination interactions in the binuclear manganese cluster of arginase
Biochemistry, 43, 2004
1T4S
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ARGINASE-L-VALINE COMPLEX
Descriptor:Arginase 1, MANGANESE (II) ION, VALINE
Authors:Cama, E., Pethe, S., Boucher, J.-L., Shoufa, H., Emig, F.A., Ash, D.E., Viola, R.E., Mansuy, D., Christianson, D.W.
Deposit date:2004-04-30
Release date:2004-10-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Inhibitor coordination interactions in the binuclear manganese cluster of arginase
Biochemistry, 43, 2004
1T4T
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ARGINASE-DINOR-NOHA COMPLEX
Descriptor:Arginase 1, MANGANESE (II) ION, 3-{[(E)-AMINO(HYDROXYIMINO)METHYL]AMINO}ALANINE
Authors:Cama, E., Pethe, S., Boucher, J.-L., Shoufa, H., Emig, F.A., Ash, D.E., Viola, R.E., Mansuy, D., Christianson, D.W.
Deposit date:2004-04-30
Release date:2005-04-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Inhibitor coordination interactions in the binuclear manganese cluster of arginase
Biochemistry, 43, 2004
1T5F
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ARGINASE I-AOH COMPLEX
Descriptor:Arginase 1, MANGANESE (II) ION, (S)-2-AMINO-7,7-DIHYDROXYHEPTANOIC ACID
Authors:Shin, H., Cama, E., Christianson, D.W.
Deposit date:2004-05-04
Release date:2005-05-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Design of amino acid aldehydes as transition-state analogue inhibitors of arginase
J.Am.Chem.Soc., 126, 2004
1T5G
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ARGINASE-F2-L-ARGININE COMPLEX
Descriptor:Arginase 1, FLUORIDE ION, MANGANESE (II) ION, ...
Authors:Cama, E., Pethe, S., Boucher, J.-L., Han, S., Emig, F.A., Ash, D.E., Viola, R.E., Mansuy, D., Christianson, D.W.
Deposit date:2004-05-04
Release date:2004-10-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Inhibitor coordination interactions in the binuclear manganese cluster of arginase
Biochemistry, 43, 2004
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