1EFN
 
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2NEF
 | | HIV-1 NEF (REGULATORY FACTOR), NMR, 40 STRUCTURES | | Descriptor: | NEGATIVE FACTOR (F-PROTEIN) | | Authors: | Grzesiek, S, Bax, A, Clore, G.M, Gronenborn, A.M, Hu, J.S, Kaufman, J, Palmer, I, Stahl, S.J, Tjandra, N, Wingfield, P.T. | | Deposit date: | 1997-02-12 | | Release date: | 1997-07-07 | | Last modified: | 2017-11-29 | | Method: | SOLUTION NMR | | Cite: | Refined solution structure and backbone dynamics of HIV-1 Nef.
Protein Sci., 6, 1997
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1AVV
 | | HIV-1 NEF PROTEIN, UNLIGANDED CORE DOMAIN | | Descriptor: | NEGATIVE FACTOR | | Authors: | Arold, S, Franken, P, Dumas, C. | | Deposit date: | 1997-09-21 | | Release date: | 1998-03-25 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling.
Structure, 5, 1997
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1AVZ
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3IK5
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3IOZ
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2XI1
 | | Crystal structure of the HIV-1 Nef sequenced from a patient's sample | | Descriptor: | NEF | | Authors: | Yadav, G.P, Singh, P, Gupta, S, Tripathi, A.K, Tripathi, R.K, Ramachandran, R. | | Deposit date: | 2010-06-25 | | Release date: | 2011-08-10 | | Last modified: | 2011-11-23 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | A Novel Dimer-Tetramer Transition Captured by the Crystal Structure of the HIV-1 Nef.
Plos One, 6, 2011
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3RBB
 | | HIV-1 NEF protein in complex with engineered HCK SH3 domain | | Descriptor: | 1,2-ETHANEDIOL, Protein Nef, Tyrosine-protein kinase HCK | | Authors: | Horenkamp, F.A, Schulte, A, Weyand, M, Geyer, M. | | Deposit date: | 2011-03-29 | | Release date: | 2011-04-27 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Conformation of the Dileucine-Based Sorting Motif in HIV-1 Nef Revealed by Intermolecular Domain Assembly.
Traffic, 12, 2011
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3REB
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3REA
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3TB8
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4D8D
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4EN2
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4EMZ
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4NEE
 | | crystal structure of AP-2 alpha/simga2 complex bound to HIV-1 Nef | | Descriptor: | AP-2 complex subunit alpha-2, AP-2 complex subunit sigma, Protein Nef | | Authors: | Hurley, J.H, Bonifacino, J.S, Ren, X, Park, S.Y. | | Deposit date: | 2013-10-29 | | Release date: | 2014-01-29 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.8841 Å) | | Cite: | How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4.
Elife, 3, 2014
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4ORZ
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4U5W
 | | Crystal Structure of HIV-1 Nef-SF2 Core Domain in Complex with the Src Family Kinase Hck SH3-SH2 Tandem Regulatory Domains | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, IODIDE ION, Protein Nef, ... | | Authors: | Alvarado, J.J, Yeh, J.I, Smithgall, T.E. | | Deposit date: | 2014-07-25 | | Release date: | 2014-08-20 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Interaction with the Src Homology (SH3-SH2) Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment.
J.Biol.Chem., 289, 2014
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5NUI
 | | Crystal structure of SIVmac239 Nef in an ExxxLM endocytic sorting motif bound state | | Descriptor: | Protein Nef, SER-GLN-ILE-LYS-ARG-LEU-LEU-SER | | Authors: | Manrique, S, Horenkamp, F.A, Anand, K, Geyer, M. | | Deposit date: | 2017-04-30 | | Release date: | 2017-08-16 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3.
Nat Commun, 8, 2017
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5NUH
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6B72
 | | A novel HIV-1 Nef dimer interface induced by a single octyl-glucoside molecule | | Descriptor: | Protein Nef, octyl beta-D-glucopyranoside | | Authors: | Wu, M, Augelli-Szafran, C.E, Ptak, R.G, Smithgall, T.E. | | Deposit date: | 2017-10-03 | | Release date: | 2018-02-21 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | A single beta-octyl glucoside molecule induces HIV-1 Nef dimer formation in the absence of partner protein binding.
PLoS ONE, 13, 2018
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6CM9
 | | Structure of the cargo bound AP-1:Arf1:tetherin-Nef closed trimer monomeric subunit | | Descriptor: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | | Authors: | Morris, K.L, Buffalo, C.Z, Ren, X, Hurley, J.H. | | Deposit date: | 2018-03-03 | | Release date: | 2018-08-08 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.73 Å) | | Cite: | HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation.
Cell, 174, 2018
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6CRI
 | | Structure of the cargo bound AP-1:Arf1:tetherin-Nef stable closed trimer | | Descriptor: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | | Authors: | Morris, K.L, Buffalo, C.Z, Hurley, J.H. | | Deposit date: | 2018-03-18 | | Release date: | 2018-08-01 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (6.8 Å) | | Cite: | HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation.
Cell, 174, 2018
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6D84
 | | Structure of the cargo bound AP-1:Arf1:tetherin-Nef (L164A, L165A) dileucine mutant dimer | | Descriptor: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | | Authors: | Buffalo, C.Z, Morris, K.L, Hurley, J.H. | | Deposit date: | 2018-04-25 | | Release date: | 2018-08-08 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (6.72 Å) | | Cite: | HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation.
Cell, 174, 2018
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6D83
 | | Structure of the cargo bound AP-1:Arf1:tetherin-Nef (L164A, L165A) dileucine mutant dimer monomeric subunit | | Descriptor: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | | Authors: | Buffalo, C.Z, Morris, K.L, Hurley, J.H. | | Deposit date: | 2018-04-25 | | Release date: | 2018-08-08 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.27 Å) | | Cite: | HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation.
Cell, 174, 2018
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6DFF
 | | Structure of the cargo bound AP-1:Arf1:tetherin-Nef monomer | | Descriptor: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | | Authors: | Morris, K.L, Buffalo, C.Z, Ren, X, Hurley, J.H. | | Deposit date: | 2018-05-14 | | Release date: | 2018-08-08 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation.
Cell, 174, 2018
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