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1AF3
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RAT BCL-XL AN APOPTOSIS INHIBITORY PROTEIN
Descriptor: APOPTOSIS REGULATOR BCL-X
Authors:Aritomi, M, Kunishima, N, Inohara, N, Ishibashi, Y, Ohta, S, Morikawa, K.
Deposit date:1997-03-21
Release date:1997-07-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of rat Bcl-xL. Implications for the function of the Bcl-2 protein family.
J.Biol.Chem., 272, 1997
1BXL
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STRUCTURE OF BCL-XL/BAK PEPTIDE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor: BAK PEPTIDE, BCL-XL
Authors:Sattler, M, Liang, H, Nettesheim, D, Meadows, R.P, Harlan, J.E, Eberstadt, M, Yoon, H, Shuker, S.B, Chang, B.S, Minn, A.J, Thompson, C.B, Fesik, S.W.
Deposit date:1996-10-16
Release date:1997-10-29
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis.
Science, 275, 1997
1F16
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SOLUTION STRUCTURE OF A PRO-APOPTOTIC PROTEIN BAX
Descriptor: PROTEIN (APOPTOSIS REGULATOR BAX, MEMBRANE ISOFORM ALPHA)
Authors:Suzuki, M, Youle, R.J, Tjandra, N.
Deposit date:2000-05-18
Release date:2000-11-22
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Structure of Bax: coregulation of dimer formation and intracellular localization.
Cell(Cambridge,Mass.), 103, 2000
1G5J
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COMPLEX OF BCL-XL WITH PEPTIDE FROM BAD
Descriptor: APOPTOSIS REGULATOR BCL-X, BAD PROTEIN
Authors:Petros, A.M, Nettesheim, D.G, Wang, Y, Olejniczak, E.T, Meadows, R.P, Mack, J, Swift, K, Matayoshi, E.D, Zhang, H, Thompson, C.B, Fesik, S.W.
Deposit date:2000-11-01
Release date:2001-02-07
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies.
Protein Sci., 9, 2000
1G5M
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HUMAN BCL-2, ISOFORM 1
Descriptor: PROTEIN (APOPTOSIS REGULATOR BCL-2 WITH PUTATIVE FLEXIBLE LOOP REPLACED WITH A PORTION OF APOPTOSIS REGULATOR BCL-X PROTEIN)
Authors:Petros, A.M, Medek, A, Nettesheim, D.G, Kim, D.H, Yoon, H.S, Swift, K, Matayoshi, E.D, Oltersdorf, T, Fesik, S.W.
Deposit date:2000-11-01
Release date:2001-03-21
Last modified:2022-12-21
Method:SOLUTION NMR
Cite:Solution structure of the antiapoptotic protein bcl-2.
Proc.Natl.Acad.Sci.USA, 98, 2001
1GJH
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HUMAN BCL-2, ISOFORM 2
Descriptor: PROTEIN (APOPTOSIS REGULATOR BCL-2 WITH PUTATIVE FLEXIBLE LOOP REPLACED WITH A PORTION OF APOPTOSIS REGULATOR BCL-X PROTEIN)
Authors:Petros, A.M, Medek, A, Nettesheim, D.G, Kim, D.H, Yoon, H.S, Swift, K, Matayoshi, E.D, Oltersdorf, T, Fesik, S.W.
Deposit date:2001-05-31
Release date:2001-06-13
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Solution structure of the antiapoptotic protein bcl-2.
Proc.Natl.Acad.Sci.USA, 98, 2001
1K3K
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Solution Structure of a Bcl-2 Homolog from Kaposi's Sarcoma Virus
Descriptor: functional anti-apoptotic factor vBCL-2 homolog
Authors:Huang, Q, Petros, A.M, Virgin, H.W, Fesik, S.W, Olejniczak, E.T.
Deposit date:2001-10-03
Release date:2002-04-10
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus.
Proc.Natl.Acad.Sci.USA, 99, 2002
1LXL
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NMR STRUCTURE OF BCL-XL, AN INHIBITOR OF PROGRAMMED CELL DEATH, MINIMIZED AVERAGE STRUCTURE
Descriptor: BCL-XL
Authors:Muchmore, S.W, Sattler, M, Liang, H, Meadows, R.P, Harlan, J.E, Yoon, H.S, Nettesheim, D, Chang, B.S, Thompson, C.B, Wong, S.L, Ng, S.C, Fesik, S.W.
Deposit date:1996-04-04
Release date:1997-04-21
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death.
Nature, 381, 1996
1MAZ
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X-RAY STRUCTURE OF BCL-XL, AN INHIBITOR OF PROGRAMMED CELL DEATH
Descriptor: Bcl-2-like protein 1
Authors:Muchmore, S.W, Sattler, M, Liang, H, Meadows, R.P, Harlan, J.E, Yoon, H.S, Nettesheim, D, Chang, B.S, Thompson, C.B, Wong, S.L, Ng, S.C, Fesik, S.W.
Deposit date:1996-04-09
Release date:1997-04-21
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death.
Nature, 381, 1996
1MK3
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SOLUTION STRUCTURE OF HUMAN BCL-W PROTEIN
Descriptor: Apoptosis regulator Bcl-W
Authors:Denisov, A.Y, Madiraju, M.S, Chen, G, Khadir, A, Beauparlant, P, Attardo, G, Shore, G.C, Gehring, K.
Deposit date:2002-08-28
Release date:2003-06-03
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix
J.BIOL.CHEM., 278, 2003
1O0L
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THE STRUCTURE OF BCL-W REVEALS A ROLE FOR THE C-TERMINAL RESIDUES IN MODULATING BIOLOGICAL ACTIVITY
Descriptor: Apoptosis regulator Bcl-W
Authors:Hinds, M.G, Lackmann, M, Skea, G.L, Harrison, P.J, Huang, D.C.S, Day, C.L.
Deposit date:2003-02-22
Release date:2003-04-01
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity
Embo J., 22, 2003
1OHU
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Structure of Caenorhabditis elegans CED-9
Descriptor: APOPTOSIS REGULATOR CED-9
Authors:Jeong, J.-S, Ha, N.-C, Oh, B.-H.
Deposit date:2003-05-31
Release date:2003-08-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Unique Structural Features of a Bcl-2 Family Protein Ced-9 and Biophysical Characterization of Ced-9/Egl-1 Interactions
Cell Death Differ., 10, 2003
1PQ0
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Crystal structure of mouse Bcl-xl
Descriptor: Apoptosis regulator Bcl-X
Authors:Liu, X, Dai, S, Zhu, Y, Marrack, P, Kappler, J.W.
Deposit date:2003-06-17
Release date:2003-09-23
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of a Bcl-xl/Bim fragment complex: Implications for Bim function
Immunity, 19, 2003
1PQ1
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Crystal structure of Bcl-xl/Bim
Descriptor: Apoptosis regulator Bcl-X, BCL2-like protein 11
Authors:Liu, X, Dai, S, Zhu, Y, Marrack, P, Kappler, J.W.
Deposit date:2003-06-17
Release date:2003-09-23
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The structure of a Bcl-xl/Bim fragment complex: Implications for Bim function
Immunity, 19, 2003
1Q59
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Solution Structure of the BHRF1 Protein From Epstein-Barr Virus, a Homolog of Human Bcl-2
Descriptor: Early antigen protein R
Authors:Huang, Q, Petros, A.M, Virgin, H.W, Fesik, S.W, Olejniczak, E.T.
Deposit date:2003-08-06
Release date:2003-09-23
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution Structure of the BHRF1 Protein From Epstein-Barr Virus, a Homolog of Human Bcl-2
J.Mol.Biol., 332, 2003
1R2D
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Structure of Human Bcl-XL at 1.95 Angstroms
Descriptor: Apoptosis regulator Bcl-X
Authors:O'Neill, J.W, Manion, M.K, Giedt, C.D, Kim, K.M, Zhang, K.Y, Hockenbery, D.M.
Deposit date:2003-09-26
Release date:2004-02-03
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Bcl-XL mutations suppress cellular sensitivity to antimycin A.
J.Biol.Chem., 279, 2004
1R2E
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Human Bcl-XL containing a Glu to Leu mutation at position 92
Descriptor: Apoptosis regulator Bcl-X
Authors:O'Neill, J.W, Manion, M.K, Giedt, C.D, Kim, K.M, Zhang, K.Y, Hockenbery, D.M.
Deposit date:2003-09-26
Release date:2004-02-03
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Bcl-XL mutations suppress cellular sensitivity to antimycin A.
J.Biol.Chem., 279, 2004
1R2G
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Human Bcl-XL containing a Phe to Trp mutation at position 97
Descriptor: Apoptosis regulator Bcl-X
Authors:O'Neill, J.W, Manion, M.K, Giedt, C.D, Kim, K.M, Zhang, K.Y, Hockenbery, D.M.
Deposit date:2003-09-26
Release date:2004-02-03
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Bcl-XL mutations suppress cellular sensitivity to antimycin A.
J.Biol.Chem., 279, 2004
1R2H
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Human Bcl-XL containing an Ala to Leu mutation at position 142
Descriptor: Apoptosis regulator Bcl-X
Authors:O'Neill, J.W, Manion, M.K, Giedt, C.D, Kim, K.M, Zhang, K.Y, Hockenbery, D.M.
Deposit date:2003-09-26
Release date:2004-02-03
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Bcl-XL mutations suppress cellular sensitivity to antimycin A.
J.Biol.Chem., 279, 2004
1R2I
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Human Bcl-XL containing a Phe to Leu mutation at position 146
Descriptor: Apoptosis regulator Bcl-X
Authors:O'Neill, J.W, Manion, M.K, Giedt, C.D, Kim, K.M, Zhang, K.Y, Hockenbery, D.M.
Deposit date:2003-09-26
Release date:2004-02-03
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Bcl-XL mutations suppress cellular sensitivity to antimycin A.
J.Biol.Chem., 279, 2004
1TY4
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Crystal structure of a CED-9/EGL-1 complex
Descriptor: Apoptosis regulator ced-9, EGg Laying defective EGL-1, programmed cell death activator
Authors:Yan, N, Gu, L, Kokel, D, Xue, D, Shi, Y.
Deposit date:2004-07-07
Release date:2004-09-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural, Biochemical, and Functional Analyses of CED-9 Recognition by the Proapoptotic Proteins EGL-1 and CED-4
Mol.Cell, 15, 2004
1WSX
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Solution structure of MCL-1
Descriptor: myeloid cell leukemia sequence 1
Authors:Day, C.L, Chen, L, Richardson, S.J, Harrison, P.J, Huang, D.C, Hinds, M.G.
Deposit date:2004-11-12
Release date:2004-11-23
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution Structure of Prosurvival Mcl-1 and Characterization of Its Binding by Proapoptotic BH3-only Ligands
J.Biol.Chem., 280, 2005
1YSG
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Solution Structure of the Anti-apoptotic Protein Bcl-xL in Complex with "SAR by NMR" Ligands
Descriptor: 4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID, 5,6,7,8-TETRAHYDRONAPHTHALEN-1-OL, Apoptosis regulator Bcl-X
Authors:Oltersdorf, T, Elmore, S.W, Shoemaker, A.R, Armstrong, R.C, Augeri, D.J, Belli, B.A, Bruncko, M, Deckwerth, T.L, Dinges, J, Hajduk, P.J, Joseph, M.K, Kitada, S, Korsmeyer, S.J, Kunzer, A.R, Letai, A, Li, C, Mitten, M.J, Nettesheim, D.G, Ng, S, Nimmer, P.M, O'Connor, J.M, Oleksijew, A, Petros, A.M, Reed, J.C, Shen, W, Tahir, S.K, Thompson, C.B, Tomaselli, K.J, Wang, B, Wendt, M.D, Zhang, H, Fesik, S.W, Rosenberg, S.H.
Deposit date:2005-02-08
Release date:2005-06-07
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:An inhibitor of Bcl-2 family proteins induces regression of solid tumours
Nature, 435, 2005
1YSI
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Solution structure of the anti-apoptotic protein Bcl-xL in complex with an acyl-sulfonamide-based ligand
Descriptor: Apoptosis regulator Bcl-X, N-[(4'-FLUORO-1,1'-BIPHENYL-4-YL)CARBONYL]-3-NITRO-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE
Authors:Oltersdorf, T, Elmore, S.W, Shoemaker, A.R, Armstrong, R.C, Augeri, D.J, Belli, B.A, Bruncko, M, Deckwerth, T.L, Dinges, J, Hajduk, P.J, Joseph, M.K, Kitada, S, Korsmeyer, S.J, Kunzer, A.R, Letai, A, Li, C, Mitten, M.J, Nettesheim, D.G, Ng, S, Nimmer, P.M, O'Connor, J.M, Oleksijew, A, Petros, A.M, Reed, J.C, Shen, W, Tahir, S.K, Thompson, C.B, Tomaselli, K.J, Wang, B, Wendt, M.D, Zhang, H, Fesik, S.W, Rosenberg, S.H.
Deposit date:2005-02-08
Release date:2005-06-07
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:An inhibitor of Bcl-2 family proteins induces regression of solid tumours
Nature, 435, 2005
1YSN
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Solution structure of the anti-apoptotic protein Bcl-xL complexed with an acyl-sulfonamide-based ligand
Descriptor: 3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE, Apoptosis regulator Bcl-X
Authors:Oltersdorf, T, Elmore, S.W, Shoemaker, A.R, Armstrong, R.C, Augeri, D.J, Belli, B.A, Bruncko, M, Deckwerth, T.L, Dinges, J, Hajduk, P.J, Joseph, M.K, Kitada, S, Korsmeyer, S.J, Kunzer, A.R, Letai, A, Li, C, Mitten, M.J, Nettesheim, D.G, Ng, S, Nimmer, P.M, O'Connor, J.M, Oleksijew, A, Petros, A.M, Reed, J.C, Shen, W, Tahir, S.K, Thompson, C.B, Tomaselli, K.J, Wang, B, Wendt, M.D, Zhang, H, Fesik, S.W, Rosenberg, S.H.
Deposit date:2005-02-08
Release date:2005-06-07
Last modified:2023-11-29
Method:SOLUTION NMR
Cite:An inhibitor of Bcl-2 family proteins induces regression of solid tumours
Nature, 435, 2005

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