1GZN
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STRUCTURE OF PKB KINASE DOMAIN
Descriptor:RAC-BETA SERINE/THREONINE PROTEIN KINASE
Authors:Barford, D., Yang, J., Hemmings, B.A.
Deposit date:2002-05-24
Release date:2003-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular Mechanism for the Regulation of Protein Kinase B/Akt by Hydrophobic Motif Phosphorylation
Mol.Cell, 9, 2002
1MRV
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CRYSTAL STRUCTURE OF AN INACTIVE AKT2 KINASE DOMAIN
Descriptor:RAC-beta serine/threonine kinase
Authors:Huang, X., Begley, M., Morgenstern, K.A., Gu, Y., Rose, P., Zhao, H., Zhu, X.
Deposit date:2002-09-18
Release date:2003-09-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of an inactive akt2 kinase domain
Structure, 11, 2003
1MRY
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CRYSTAL STRUCTURE OF AN INACTIVE AKT2 KINASE DOMAIN
Descriptor:RAC-beta serine/threonine kinase
Authors:Huang, X., Begley, M., Morgenstern, K.A., Gu, Y., Rose, P., Zhao, H., Zhu, X.
Deposit date:2002-09-18
Release date:2003-09-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of an inactive akt2 kinase domain
Structure, 11, 2003
1O6K
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STRUCTURE OF ACTIVATED FORM OF PKB KINASE DOMAIN S474D WITH GSK3 PEPTIDE AND AMP-PNP
Descriptor:RAC-BETA SERINE/THREONINE PROTEIN KINASE, GLYCOGEN SYNTHASE KINASE-3 BETA, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Yang, J., Cron, P., Good, V.M., Thompson, V., Hemmings, B.A., Barford, D.
Deposit date:2002-10-08
Release date:2002-11-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of an Activated Akt/Protein Kinase B Ternary Complex with Gsk-3 Peptide and AMP-Pnp
Nat.Struct.Biol., 9, 2002
1O6L
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CRYSTAL STRUCTURE OF AN ACTIVATED AKT/PROTEIN KINASE B (PKB-PIF CHIMERA) TERNARY COMPLEX WITH AMP-PNP AND GSK3 PEPTIDE
Descriptor:RAC-BETA SERINE/THREONINE PROTEIN KINASE, GLYCOGEN SYNTHASE KINASE-3 BETA, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Yang, J., Cron, P., Good, V.M., Thompson, V., Hemmings, B.A., Barford, D.
Deposit date:2002-10-08
Release date:2002-11-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of an Activated Akt/Protein Kinase B Ternary Complex with Gsk-3 Peptide and AMP-Pnp
Nat.Struct.Biol., 9, 2002
1XJD
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CRYSTAL STRUCTURE OF PKC-THETA COMPLEXED WITH STAUROSPORINE AT 2A RESOLUTION
Descriptor:Protein kinase C, theta type, STAUROSPORINE
Authors:Xu, Z.B.
Deposit date:2004-09-23
Release date:2004-10-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Catalytic domain crystal structure of protein kinase C-theta (PKCtheta)
J.Biol.Chem., 279, 2004
1ZRZ
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF ATYPICAL PROTEIN KINASE C-IOTA
Descriptor:Protein kinase C, iota, 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
Authors:Messerschmidt, A., Macieira, S., Velarde, M., Baedeker, M., Benda, C., Jestel, A., Brandstetter, H., Neuefeind, T., Blaesse, M., Structural Proteomics in Europe (SPINE)
Deposit date:2005-05-23
Release date:2005-09-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structure of the Catalytic Domain of Human Atypical Protein Kinase C-iota Reveals Interaction Mode of Phosphorylation Site in Turn Motif
J.Mol.Biol., 352, 2005
2I0E
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STRUCTURE OF CATALYTIC DOMAIN OF HUMAN PROTEIN KINASE C BETA II COMPLEXED WITH A BISINDOLYLMALEIMIDE INHIBITOR
Descriptor:Protein Kinase C-beta II, 3-{1-[3-(DIMETHYLAMINO)PROPYL]-2-METHYL-1H-INDOL-3-YL}-4-(2-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
Authors:Grodsky, N.B., Love, R.L.
Deposit date:2006-08-10
Release date:2006-11-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the Catalytic Domain of Human Protein Kinase C beta II Complexed with a Bisindolylmaleimide Inhibitor
Biochemistry, 45, 2006
2JDO
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STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY) ETHYLAMINO)ETHYL)AMIDE
Descriptor:RAC-BETA SERINE/THREONINE-PROTEIN KINASE, GLYCOGEN SYNTHASE KINASE-3 BETA, ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE, ...
Authors:Davies, T.G., Verdonk, M.L., Graham, B., Saalau-Bethell, S., Hamlett, C.C.F., Mchardy, T., Collins, I., Garrett, M.D., Workman, P., Woodhead, S.J., Jhoti, H., Barford, D.
Deposit date:2007-01-11
Release date:2007-02-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A Structural Comparison of Inhibitor Binding to Pkb, Pka and Pka-Pkb Chimera
J.Mol.Biol., 367, 2007
2JDR
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STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH THE INHIBITOR A-443654
Descriptor:RAC-BETA SERINE/THREONINE-PROTEIN KINASE, GLYCOGEN SYNTHASE KINASE-3 BETA, (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
Authors:Davies, T.G., Verdonk, M.L., Graham, B., Saalau-Bethell, S., Hamlett, C.C.F., McHardy, T., Collins, I., Garrett, M.D., Workman, P., Woodhead, S.J., Jhoti, H., Barford, D.
Deposit date:2007-01-12
Release date:2007-02-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A Structural Comparison of Inhibitor Binding to Pkb, Pka and Pka-Pkb Chimera
J.Mol.Biol., 367, 2007
2JED
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THE CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF THE PROTEIN KINASE C THETA IN COMPLEX WITH NVP-XAA228 AT 2.32A RESOLUTION.
Descriptor:PROTEIN KINASE C THETA, 3-(8-DIMETHYLAMINOMETHYL-6,7,8,9-TETRAHYDRO-PYRIDO[1,2-A]INDOL-10-YL)-4-(1-METHYL-1H-INDOL-3-YL)-PYRROLE-2,5-DIONE, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Stark, W., Bitsch, F., Berner, A., Buelens, F., Graff, P., Depersin, H., Geiser, M., Knecht, R., Rahuel, J., Rummel, G., Schlaeppi, J.M., Schmitz, R., Strauss, A., Wagner, J.
Deposit date:2007-01-16
Release date:2008-02-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:The Crystal Structure of the Kinase Domain of the Protein Kinase C Theta in Complex with Nvp-Xaa228
To be Published
2R5T
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CRYSTAL STRUCTURE OF INACTIVE SERUM AND GLUCOCORTICOID- REGULATED KINASE 1 IN COMPLEX WITH AMP-PNP
Descriptor:Serine/threonine-protein kinase Sgk1, MAGNESIUM ION, SULFATE ION, ...
Authors:Zhao, B., Lehr, R., Smallwood, A.M., Ho, T.F., Maley, K., Randall, T., Head, M.S., Koretke, K.K., Schnackenberg, C.G.
Deposit date:2007-09-04
Release date:2008-09-09
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the kinase domain of serum and glucocorticoid-regulated kinase 1 in complex with AMP PNP.
Protein Sci., 16, 2007
2UW9
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STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH 4-(4-CHLORO-PHENYL)-4-(4-(1H-PYRAZOL-4-YL)-PHENYL)-PIPERIDINE
Descriptor:RAC-BETA SERINE/THREONINE-PROTEIN KINASE, GLYCOGEN SYNTHASE KINASE-3 BETA, 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
Authors:Davies, T.G., Saxty, G., Woodhead, S.J., Berdini, V., Verdonk, M.L., Wyatt, P.G., Boyle, R.G., Barford, D., Downham, R., Garrett, M.D., Carr, R.A.
Deposit date:2007-03-19
Release date:2007-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery.
J.Med.Chem., 50, 2007
2X39
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STRUCTURE OF 4-AMINO-N-(4-CHLOROBENZYL)-1-(7H-PYRROLO(2,3-D)PYRIMIDIN- 4-YL)PIPERIDINE-4-CARBOXAMIDE BOUND TO PKB
Descriptor:RAC-BETA SERINE/THREONINE-PROTEIN KINASE, GLYCOGEN SYNTHASE KINASE-3 BETA, 4-AMINO-N-(4-CHLOROBENZYL)-1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDINE-4-CARBOXAMIDE
Authors:Davies, T.G., McHardy, T., Caldwell, J.J., Cheung, K.M., Hunter, L.J., Taylor, K., Rowlands, M., Ruddle, R., Henley, A., Brandon, A.D., Valenti, M., Fazal, L., Seavers, L., Raynaud, F.I., Eccles, S.A., Aherne, G.W., Garrett, M.D., Collins, I.
Deposit date:2010-01-22
Release date:2010-02-23
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Discovery of 4-Amino-1-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Piperidine-4-Carboxamides as Selective, Orally Active Inhibitors of Protein Kinase B (Akt).
J.Med.Chem., 53, 2010
2XH5
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STRUCTURE OF 4-(4-TERT-BUTYLBENZYL)-1-(7H-PYRROLO(2,3-D)PYRIMIDIN-4- YL)PIPERIDIN-4-AMINE BOUND TO PKB
Descriptor:RAC-BETA SERINE/THREONINE-PROTEIN KINASE, GLYCOGEN SYNTHASE KINASE-3 BETA, 4-(4-tert-butylbenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium
Authors:Davies, T.G., McHardy, T., Caldwell, J.J., Cheung, K.M., Hunter, L.J., Taylor, K., Rowlands, M., Ruddle, R., Henley, A., Brandon, A.D., Valenti, M., Fazal, L., Seavers, L., Raynaud, F.I., Eccles, S.A., Aherne, G.W., Garrett, M.D., Collins, I.
Deposit date:2010-06-09
Release date:2010-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Discovery of 4-Amino-1-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Piperidine-4-Carboxamides as Selective, Orally Active Inhibitors of Protein Kinase B (Akt).
J.Med.Chem., 53, 2010
3A8W
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CRYSTAL STRUCTURE OF PKCIOTA KINASE DOMAIN
Descriptor:Protein kinase C iota type, ADENOSINE-5'-TRIPHOSPHATE, SULFATE ION
Authors:Takimura, T., Kamata, K.
Deposit date:2009-10-11
Release date:2010-05-05
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of the PKC-iota kinase domain in its ATP-bound and apo forms reveal defined structures of residues 533-551 in the C-terminal tail and their roles in ATP binding
Acta Crystallogr.,Sect.D, 66, 2010
3A8X
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CRYSTAL STRUCTURE OF PKCIOTA KINASE DOMAIN
Descriptor:Protein kinase C iota type, SULFATE ION
Authors:Takimura, T., Kamata, K.
Deposit date:2009-10-11
Release date:2010-05-05
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of the PKC-iota kinase domain in its ATP-bound and apo forms reveal defined structures of residues 533-551 in the C-terminal tail and their roles in ATP binding
Acta Crystallogr.,Sect.D, 66, 2010
3CQU
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CRYSTAL STRUCTURE OF AKT-1 COMPLEXED WITH SUBSTRATE PEPTIDE AND INHIBITOR
Descriptor:RAC-alpha serine/threonine-protein kinase, Glycogen synthase kinase-3 beta, N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Authors:Pandit, J.
Deposit date:2008-04-03
Release date:2008-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Synthesis and structure based optimization of novel Akt inhibitors
Bioorg.Med.Chem.Lett., 18, 2008
3CQW
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CRYSTAL STRUCTURE OF AKT-1 COMPLEXED WITH SUBSTRATE PEPTIDE AND INHIBITOR
Descriptor:RAC-alpha serine/threonine-protein kinase, Glycogen synthase kinase-3 beta, MANGANESE (II) ION, ...
Authors:Pandit, J.
Deposit date:2008-04-03
Release date:2008-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Synthesis and structure based optimization of novel Akt inhibitors
Bioorg.Med.Chem.Lett., 18, 2008
3D0E
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CRYSTAL STRUCTURE OF HUMAN AKT2 IN COMPLEX WITH GSK690693
Descriptor:RAC-beta serine/threonine-protein kinase, 4-{2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-piperidin-3-ylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl}-2-methylbut-3-yn-2-ol
Authors:Concha, N.O., Smallwood, A.
Deposit date:2008-05-01
Release date:2008-10-21
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.
J.Med.Chem., 51, 2008
3E87
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CRYSTAL STRUCTURES OF THE KINASE DOMAIN OF AKT2 IN COMPLEX WITH ATP-COMPETITIVE INHIBITORS
Descriptor:RAC-beta serine/threonine-protein kinase, Glycogen synthase kinase-3 beta peptide, N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide
Authors:Concha, N.O., Elkins, P.A., Smallwood, A., Ward, P.
Deposit date:2008-08-19
Release date:2008-10-14
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Aminofurazans as potent inhibitors of AKT kinase
Bioorg.Med.Chem.Lett., 19, 2009
3E88
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CRYSTAL STRUCTURES OF THE KINASE DOMAIN OF AKT2 IN COMPLEX WITH ATP-COMPETITIVE INHIBITORS
Descriptor:RAC-beta serine/threonine-protein kinase, Glycogen synthase kinase-3 beta peptide, 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-6-{[(2R)-2-amino-3-phenylpropyl]oxy}-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol
Authors:Concha, N.O., Elkins, P.A., Smallwood, A., Ward, P.
Deposit date:2008-08-19
Release date:2008-10-14
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Aminofurazans as potent inhibitors of AKT kinase
Bioorg.Med.Chem.Lett., 19, 2009
3E8D
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CRYSTAL STRUCTURES OF THE KINASE DOMAIN OF AKT2 IN COMPLEX WITH ATP-COMPETITIVE INHIBITORS
Descriptor:RAC-beta serine/threonine-protein kinase, Glycogen synthase kinase-3 beta peptide, 4-[2-(4-amino-2,5-dihydro-1,2,5-oxadiazol-3-yl)-6-{[(1S)-3-amino-1-phenylpropyl]oxy}-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol
Authors:Concha, N.O., Elkins, P.A., Smallwood, A., Ward, P.
Deposit date:2008-08-19
Release date:2008-10-14
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Aminofurazans as potent inhibitors of AKT kinase
Bioorg.Med.Chem.Lett., 19, 2009
3HDM
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CRYSTAL STRUCTURE OF SERUM AND GLUCOCORTICOID-REGULATED KINASE 1 IN COMPLEX WITH COMPOUND 1
Descriptor:Serine/threonine-protein kinase Sgk1, 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid
Authors:Zhao, B., Hammond, M.
Deposit date:2009-05-07
Release date:2009-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Design and synthesis of orally bioavailable serum and glucocorticoid-regulated kinase 1 (SGK1) inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
3HDN
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CRYSTAL STRUCTURE OF SERUM AND GLUCOCORTICOID-REGULATED KINASE 1 IN COMPLEX WITH COMPOUND 2
Descriptor:Serine/threonine-protein kinase Sgk1, [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid
Authors:Zhao, B., Hammond, M.
Deposit date:2009-05-07
Release date:2009-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Design and synthesis of orally bioavailable serum and glucocorticoid-regulated kinase 1 (SGK1) inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
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