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5E6X
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BU of 5e6x by Molmil
Re-refinement of the Crystal Structure of the Plexin-Semaphorin-Integrin Domain/Hybrid Domain/I-EGF1 Segment from the Human Integrin b2 Subunit
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Integrin beta-2
Authors:Springer, T.A, Sen, M.
Deposit date:2015-10-10
Release date:2016-03-02
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Leukocyte integrin alpha L beta 2 headpiece structures: The alpha I domain, the pocket for the internal ligand, and concerted movements of its loops.
Proc.Natl.Acad.Sci.USA, 113, 2016
2P26
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BU of 2p26 by Molmil
Structure of the PHE2 and PHE3 fragments of the integrin beta2 subunit
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Integrin beta-2
Authors:Shi, M, Foo, S.Y, Tan, S.M, Mitchell, E.P, Law, S.K.A, Lescar, J.
Deposit date:2007-03-06
Release date:2007-08-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A structural hypothesis for the transition between bent and extended conformations of the leukocyte beta2 integrins
J.Biol.Chem., 282, 2007
4WK0
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BU of 4wk0 by Molmil
Metal Ion and Ligand Binding of Integrin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ARG-GLY-ASP, ...
Authors:Xia, W, Springer, T.A.
Deposit date:2014-10-01
Release date:2014-12-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Metal ion and ligand binding of integrin alpha 5 beta 1.
Proc.Natl.Acad.Sci.USA, 111, 2014
5E6V
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BU of 5e6v by Molmil
Re-refinement of the Crystal Structure of the Plexin-Semaphorin-Integrin Domain/Hybrid Domain/I-EGF1 Segment from the Human Integrin b2 Subunit
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Integrin beta-2
Authors:Sen, M, Springer, T.A.
Deposit date:2015-10-10
Release date:2016-03-02
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Leukocyte integrin alpha L beta 2 headpiece structures: The alpha I domain, the pocket for the internal ligand, and concerted movements of its loops.
Proc.Natl.Acad.Sci.USA, 113, 2016
4WJK
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BU of 4wjk by Molmil
Metal Ion and Ligand Binding of Integrin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Xia, W, Springer, T.A.
Deposit date:2014-09-30
Release date:2014-12-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Metal ion and ligand binding of integrin alpha 5 beta 1.
Proc.Natl.Acad.Sci.USA, 111, 2014
7UDH
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BU of 7udh by Molmil
Integrin alaphIIBbeta3 complex with BMS4-3
Descriptor: (4-{[(5S)-3-(piperidin-4-yl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperazin-1-yl)acetic acid, 10E5 Fab heavy chain, 10E5 Fab light chain, ...
Authors:Lin, F.-Y, Zhu, J, Zhu, J, Springer, T.A.
Deposit date:2022-03-19
Release date:2022-08-17
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.99998844 Å)
Cite:A general chemical principle for creating closure-stabilizing integrin inhibitors.
Cell, 185, 2022
7UBR
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BU of 7ubr by Molmil
Integrin alaphIIBbeta3 complex with GR144053
Descriptor: 10E5 Fab heavy chain, 10E5 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lin, F.-Y, Zhu, J, Zhu, J, Springer, T.A.
Deposit date:2022-03-15
Release date:2022-08-17
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.04992747 Å)
Cite:A general chemical principle for creating closure-stabilizing integrin inhibitors.
Cell, 185, 2022
6BXJ
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BU of 6bxj by Molmil
Structure of a single-chain beta3 integrin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Chimera protein of Integrin beta-3 and Integrin alpha-L, MAGNESIUM ION
Authors:Thinn, A.M.M, Wang, Z, Zhou, D, Zhao, Y, Curtis, B.R, Zhu, J.
Deposit date:2017-12-18
Release date:2018-10-03
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.092 Å)
Cite:Autonomous conformational regulation of beta3integrin and the conformation-dependent property of HPA-1a alloantibodies.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5E6S
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BU of 5e6s by Molmil
Structures of leukocyte integrin aLB2: The aI domain, the headpiece, and the pocket for the internal ligand
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Integrin alpha-L, ...
Authors:Springer, T.A, Sen, M.
Deposit date:2015-10-10
Release date:2016-03-02
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Leukocyte integrin alpha L beta 2 headpiece structures: The alpha I domain, the pocket for the internal ligand, and concerted movements of its loops.
Proc.Natl.Acad.Sci.USA, 113, 2016
3T3P
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BU of 3t3p by Molmil
A Novel High Affinity Integrin alphaIIbbeta3 Receptor Antagonist That Unexpectedly Displaces Mg2+ from the beta3 MIDAS
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Zhu, J, Zhu, J, Springer, T.A.
Deposit date:2011-07-25
Release date:2012-03-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-Guided Design of a High-Affinity Platelet Integrin alphaIIbbeta3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS
Sci Transl Med, 4, 2012
7TMZ
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BU of 7tmz by Molmil
Integrin alaphIIBbeta3 complex with BMS compound 4
Descriptor: (4-{[(5S)-3-{4-[(E)-imino(4-methylpiperazin-1-yl)methyl]phenyl}-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperazin-1-yl)acetic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhu, J, Lin, F.-Y, Zhu, J, Springer, T.A.
Deposit date:2022-01-20
Release date:2022-08-17
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.20002 Å)
Cite:A general chemical principle for creating closure-stabilizing integrin inhibitors.
Cell, 185, 2022
3NIG
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BU of 3nig by Molmil
The Closed Headpiece of Integrin IIb 3 and its Complex with an IIb 3 -Specific Antagonist That Does Not Induce Opening
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Zhu, J.H, Zhu, J.Q, Springer, T.A.
Deposit date:2010-06-15
Release date:2010-12-22
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Closed headpiece of integrin {alpha}IIb{beta}3 and its complex with an {alpha}IIb{beta}3-specific antagonist that does not induce opening.
Blood, 116, 2010
5FFG
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BU of 5ffg by Molmil
Crystal structure of integrin alpha V beta 6 head
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Dong, X, Springer, T.A.
Deposit date:2015-12-18
Release date:2017-01-25
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Force interacts with macromolecular structure in activation of TGF-beta.
Nature, 542, 2017
7U9V
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BU of 7u9v by Molmil
Integrin alaphIIBbeta3 complex with BMS4-1
Descriptor: (4-{[(5S)-3-(4-carbamimidoylphenyl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperazin-1-yl)acetic acid, 10E5 Fab heavy chain, 10E5 light chain, ...
Authors:Zhu, J, Lin, F.-Y, Zhu, J, Springer, T.A.
Deposit date:2022-03-11
Release date:2022-08-17
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.25492167 Å)
Cite:A general chemical principle for creating closure-stabilizing integrin inhibitors.
Cell, 185, 2022
3NID
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BU of 3nid by Molmil
The Closed Headpiece of Integrin alphaIIB beta3 and its Complex with an alpahIIB beta3 -Specific Antagonist That Does Not Induce Opening
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Zhu, J.H, Zhu, J.Q, Springer, T.A.
Deposit date:2010-06-15
Release date:2010-12-22
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Closed headpiece of integrin {alpha}IIb{beta}3 and its complex with an {alpha}IIb{beta}3-specific antagonist that does not induce opening.
Blood, 116, 2010
7L8P
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BU of 7l8p by Molmil
Integrin alphaIIbbeta3 in complex with sibrafiban
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Lin, F.-Y, Springer, T.A.
Deposit date:2020-12-31
Release date:2022-06-15
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.34995365 Å)
Cite:A general chemical principle for creating closure-stabilizing integrin inhibitors.
Cell, 185, 2022
7UCY
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BU of 7ucy by Molmil
Integrin alaphIIBbeta3 complex with gantofiban
Descriptor: (4-{[(5R)-3-(4-carbamimidoylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}piperazin-1-yl)acetic acid, 10E5 Fab heavy chain, 10E5 Fab light chain, ...
Authors:Lin, F.-Y, Zhu, J, Zhu, J, Springer, T.A.
Deposit date:2022-03-17
Release date:2022-08-17
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.34996319 Å)
Cite:A general chemical principle for creating closure-stabilizing integrin inhibitors.
Cell, 185, 2022
3ZE2
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BU of 3ze2 by Molmil
Integrin alphaIIB beta3 headpiece and RGD peptide complex
Descriptor: 10E5 FAB HEAVY CHAIN, 10E5 FAB LIGHT CHAIN, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhu, J.H, Zhu, J.Q, Springer, T.A.
Deposit date:2012-12-03
Release date:2013-06-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Complete Integrin Headpiece Opening in Eight Steps.
J.Cell Biol., 201, 2013
7UKT
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BU of 7ukt by Molmil
Integrin alaphIIBbeta3 complex with BMS4.2
Descriptor: (1-{[(5S)-3-(4-carbamimidoylphenyl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperidin-4-yl)acetic acid, 10E5 Fab heavy chain, 10E5 Fab light chain, ...
Authors:Lin, F.-Y, Zhu, J, Zhu, J, Springer, T.A.
Deposit date:2022-04-01
Release date:2022-08-17
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.36994433 Å)
Cite:A general chemical principle for creating closure-stabilizing integrin inhibitors.
Cell, 185, 2022
6BXB
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BU of 6bxb by Molmil
Crystal structure of an extended b3 integrin P33
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Chimera protein of Integrin beta-3 and Integrin alpha-L, ...
Authors:Zhou, D, Zhu, J.
Deposit date:2017-12-18
Release date:2018-08-01
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structure of an extended beta3integrin.
Blood, 132, 2018
2VDR
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BU of 2vdr by Molmil
Integrin AlphaIIbBeta3 Headpiece Bound to a chimeric Fibrinogen Gamma chain peptide, LGGAKQRGDV
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, FIBRINOGEN, ...
Authors:Springer, T.A, Zhu, J, Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
3NIF
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BU of 3nif by Molmil
The Closed Headpiece of Integrin IIb 3 and its Complex with an IIb 3 -Specific Antagonist That Does Not Induce Opening
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-ethyl-7-piperazin-1-yl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one, ...
Authors:Zhu, J.H, Zhu, J.Q, Springer, T.A.
Deposit date:2010-06-15
Release date:2010-12-22
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Closed headpiece of integrin {alpha}IIb{beta}3 and its complex with an {alpha}IIb{beta}3-specific antagonist that does not induce opening.
Blood, 116, 2010
7UJK
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BU of 7ujk by Molmil
Integrin alaphIIBbeta3 complex with lamifiban
Descriptor: 10E5 Fab heavy chain, 10E5 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lin, F.-Y, Zhu, J, Zhu, J, Springer, T.A.
Deposit date:2022-03-30
Release date:2022-08-17
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.43265581 Å)
Cite:A general chemical principle for creating closure-stabilizing integrin inhibitors.
Cell, 185, 2022
3ZDY
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BU of 3zdy by Molmil
Integrin alphaIIB beta3 headpiece and RGD peptide complex
Descriptor: 10E5 FAB HEAVY CHAIN, 10E5 FAB LIGHT CHAIN, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhu, J.H, Zhu, J.Q, Springer, T.A.
Deposit date:2012-12-03
Release date:2013-06-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Complete Integrin Headpiece Opening in Eight Steps.
J.Cell Biol., 201, 2013
3ZDX
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BU of 3zdx by Molmil
Integrin alphaIIB beta3 headpiece and RGD peptide complex
Descriptor: 10E5 FAB, HEAVY CHAIN, LIGHT CHAIN, ...
Authors:Zhu, J.H, Zhu, J.Q, Springer, T.A.
Deposit date:2012-12-03
Release date:2013-06-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Complete Integrin Headpiece Opening in Eight Steps.
J.Cell Biol., 201, 2013

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