1CJG
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NMR STRUCTURE OF LAC REPRESSOR HP62-DNA COMPLEX
Descriptor:DNA (5'-D(*GP*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*TP*C)-3'), PROTEIN (LAC REPRESSOR)
Authors:Spronk, C.A.E.M., Bonvin, A.M.J.J., Radha, P.K., Melacini, G., Boelens, R., Kaptein, R.
Deposit date:1999-04-14
Release date:2000-01-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The solution structure of Lac repressor headpiece 62 complexed to a symmetrical lac operator.
Structure Fold.Des., 7, 1999
1L1M
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SOLUTION STRUCTURE OF A DIMER OF LAC REPRESSOR DNA-BINDING DOMAIN COMPLEXED TO ITS NATURAL OPERATOR O1
Descriptor:5'-D(*GP*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*GP*GP*AP*TP*AP*AP*CP*AP*AP*TP*TP*T)-3', 5'-D(*AP*AP*AP*TP*TP*GP*TP*TP*AP*TP*CP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*TP*C)-3', Lactose operon repressor
Authors:Kalodimos, C.G., Bonvin, A.M.J.J., Salinas, R.K., Wechselberger, R., Boelens, R., Kaptein, R.
Deposit date:2002-02-19
Release date:2002-06-26
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Plasticity in protein-DNA recognition: lac repressor interacts with its natural operator 01 through alternative conformations of its DNA-binding domain.
EMBO J., 21, 2002
1LCC
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STRUCTURE OF THE COMPLEX OF LAC REPRESSOR HEADPIECE AND AN 11 BASE-PAIR HALF-OPERATOR DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND RESTRAINED MOLECULAR DYNAMICS
Descriptor:DNA (5'-D(*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*T)-3'), Lac Repressor, ...
Authors:Chuprina, V.P., Rullmann, J.A.C., Lamerichs, R.M.J.N., Van Boom, J.H., Boelens, R., Kaptein, R.
Deposit date:1993-03-25
Release date:1994-01-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the complex of lac repressor headpiece and an 11 base-pair half-operator determined by nuclear magnetic resonance spectroscopy and restrained molecular dynamics.
J.Mol.Biol., 234, 1993
1LCD
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STRUCTURE OF THE COMPLEX OF LAC REPRESSOR HEADPIECE AND AN 11 BASE-PAIR HALF-OPERATOR DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND RESTRAINED MOLECULAR DYNAMICS
Descriptor:DNA (5'-D(*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*T)-3'), Lac Repressor, ...
Authors:Chuprina, V.P., Rullmann, J.A.C., Lamerichs, R.M.J.N., Van Boom, J.H., Boelens, R., Kaptein, R.
Deposit date:1993-03-25
Release date:1994-01-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the complex of lac repressor headpiece and an 11 base-pair half-operator determined by nuclear magnetic resonance spectroscopy and restrained molecular dynamics.
J.Mol.Biol., 234, 1993
1LQC
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LAC REPRESSOR HEADPIECE (RESIDUES 1-56), NMR, 32 STRUCTURES
Descriptor:LAC REPRESSOR
Authors:Slijper, M., Bonvin, A.M.J.J., Boelens, R., Kaptein, R.
Deposit date:1996-08-13
Release date:1997-02-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Refined structure of lac repressor headpiece (1-56) determined by relaxation matrix calculations from 2D and 3D NOE data: change of tertiary structure upon binding to the lac operator.
J.Mol.Biol., 259, 1996
1OSL
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SOLUTION STRUCTURE OF A DIMERIC LACTOSE DNA-BINDING DOMAIN COMPLEXED TO A NONSPECIFIC DNA SEQUENCE
Descriptor:5'-D(*CP*GP*AP*TP*AP*AP*GP*AP*TP*AP*TP*CP*TP*TP*AP*TP*CP*G)-3', Lactose operon repressor
Authors:Kalodimos, C.G., Bonvin, A.M.J.J., Boelens, R., Kaptein, R.
Deposit date:2003-03-20
Release date:2004-05-04
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and flexibility adaptation in nonspecific and specific protein-DNA complexes.
Science, 305, 2004
1PRU
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PURINE REPRESSOR DNA-BINDING DOMAIN DNA BINDING
Descriptor:PURINE REPRESSOR
Authors:Nagadoi, A., Morikawa, S., Nakamura, H., Enari, M., Kobayashi, K., Yamamoto, H., Sampei, G., Mizobuchi, K., Schumacher, M.A., Brennan, R.G., Nishimura, Y.
Deposit date:1995-05-08
Release date:1996-03-08
Last modified:2012-02-22
Method:SOLUTION NMR
Cite:Structural comparison of the free and DNA-bound forms of the purine repressor DNA-binding domain.
Structure, 3, 1995
1PRV
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PURINE REPRESSOR DNA-BINDING DOMAIN DNA BINDING
Descriptor:PURINE REPRESSOR
Authors:Nagadoi, A., Morikawa, S., Nakamura, H., Enari, M., Kobayashi, K., Yamamoto, H., Sampei, G., Mizobuchi, K., Schumacher, M.A., Brennan, R.G., Nishimura, Y.
Deposit date:1995-05-08
Release date:1996-03-08
Last modified:2012-02-22
Method:SOLUTION NMR
Cite:Structural comparison of the free and DNA-bound forms of the purine repressor DNA-binding domain.
Structure, 3, 1995
1UXC
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FRUCTOSE REPRESSOR DNA-BINDING DOMAIN, NMR, MINIMIZED STRUCTURE
Descriptor:FRUCTOSE REPRESSOR
Authors:Penin, F., Geourjon, C., Montserret, R., Bockmann, A., Lesage, A., Yang, Y., Bonod-Bidaud, C., Cortay, J.C., Negre, D., Cozzone, A.J., Deleage, G.
Deposit date:1996-12-26
Release date:1997-04-21
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Three-dimensional structure of the DNA-binding domain of the fructose repressor from Escherichia coli by 1H and 15N NMR.
J.Mol.Biol., 270, 1997
1UXD
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FRUCTOSE REPRESSOR DNA-BINDING DOMAIN, NMR, 34 STRUCTURES
Descriptor:FRUCTOSE REPRESSOR
Authors:Penin, F., Geourjon, C., Montserret, R., Bockmann, A., Lesage, A., Yang, Y., Bonod-Bidaud, C., Cortay, J.C., Negre, D., Cozzone, A.J., Deleage, G.
Deposit date:1996-12-26
Release date:1997-04-01
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Three-dimensional structure of the DNA-binding domain of the fructose repressor from Escherichia coli by 1H and 15N NMR.
J.Mol.Biol., 270, 1997
2BJC
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NMR STRUCTURE OF A PROTEIN-DNA COMPLEX OF AN ALTERED SPECIFICITY MUTANT OF THE LAC REPRESSOR HEADPIECE THAT MIMICS THE GAL REPRESSOR
Descriptor:LACTOSE OPERON REPRESSOR, 5'-D(*GP*AP*AP*TP*TP*GP*TP*AP*AP*GP *CP*GP*CP*TP*TP*AP*CP*AP*AP*TP*TP*C)-3'
Authors:Salinas, R.K., Folkers, G.E., Bonvin, A.M.J.J., Das, D., Boelens, R., Kaptein, R.
Deposit date:2005-02-01
Release date:2005-10-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Altered Specificity in DNA Binding by the Lac Repressor: A Mutant Lac Headpiece that Mimics the Gal Repressor
Chembiochem, 6, 2005
2KEI
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REFINED SOLUTION STRUCTURE OF A DIMER OF LAC REPRESSOR DNA-BINDING DOMAIN COMPLEXED TO ITS NATURAL OPERATOR O1
Descriptor:Lactose operon repressor, DNA (5'-D(*GP*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*GP*GP*AP*TP*AP*AP*CP*AP*AP*TP*TP*T)-3'), DNA (5'-D(P*AP*AP*AP*TP*TP*GP*TP*TP*AP*TP*CP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*TP*C)-3')
Authors:Romanuka, J., Folkers, G., Biris, N., Tishchenko, E., Wienk, H., Kaptein, R., Boelens, R.
Deposit date:2009-01-30
Release date:2009-05-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Specificity and affinity of Lac repressor for the auxiliary operators O2 and O3 are explained by the structures of their protein-DNA complexes.
J.Mol.Biol., 390, 2009
2KEJ
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SOLUTION STRUCTURE OF A DIMER OF LAC REPRESSOR DNA-BINDING DOMAIN COMPLEXED TO ITS NATURAL OPERATOR O2
Descriptor:Lactose operon repressor, DNA (5'-D(*GP*AP*AP*AP*TP*GP*TP*GP*AP*GP*CP*GP*AP*GP*TP*AP*AP*CP*AP*AP*CP*CP*G)-3'), DNA (5'-D(P*CP*GP*GP*TP*TP*GP*TP*TP*AP*CP*TP*CP*GP*CP*TP*CP*AP*CP*AP*TP*TP*TP*C)-3')
Authors:Romanuka, J., Folkers, G., Biris, N., Tishchenko, E., Wienk, H., Kaptein, R., Boelens, R.
Deposit date:2009-01-30
Release date:2009-05-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Specificity and affinity of Lac repressor for the auxiliary operators O2 and O3 are explained by the structures of their protein-DNA complexes.
J.Mol.Biol., 390, 2009
2KEK
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SOLUTION STRUCTURE OF A DIMER OF LAC REPRESSOR DNA-BINDING DOMAIN COMPLEXED TO ITS NATURAL OPERATOR O3
Descriptor:Lactose operon repressor, DNA (5'-D(*CP*GP*GP*CP*AP*GP*TP*GP*AP*GP*CP*GP*CP*AP*AP*CP*GP*CP*AP*AP*TP*TP*C)-3'), DNA (5'-D(P*GP*AP*AP*TP*TP*GP*CP*GP*TP*TP*GP*CP*GP*CP*TP*CP*AP*CP*TP*GP*CP*CP*G)-3')
Authors:Romanuka, J., Folkers, G., Biris, N., Tishchenko, E., Wienk, H., Kaptein, R., Boelens, R.
Deposit date:2009-01-30
Release date:2009-05-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Specificity and affinity of Lac repressor for the auxiliary operators O2 and O3 are explained by the structures of their protein-DNA complexes.
J.Mol.Biol., 390, 2009
2LCV
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STRUCTURE OF THE CYTIDINE REPRESSOR DNA-BINDING DOMAIN; AN ALTERNATE CALCULATION
Descriptor:HTH-type transcriptional repressor CytR
Authors:Moody, C.L., Tretyachenko-Ladokhina, V., Senear, D.F., Cocco, M.J.
Deposit date:2011-05-10
Release date:2011-06-29
Last modified:2016-04-27
Method:SOLUTION NMR
Cite:Multiple Conformations of the Cytidine Repressor DNA-Binding Domain Coalesce to One upon Recognition of a Specific DNA Surface.
Biochemistry, 50, 2011
1BDH
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PURINE REPRESSOR MUTANT-HYPOXANTHINE-PALINDROMIC OPERATOR COMPLEX
Descriptor:DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), PROTEIN (PURINE REPRESSOR), HYPOXANTHINE
Authors:Glasfeld, A., Schumacher, M.A., Choi, K.Y., Zalkin, H., Brennan, R.G.
Deposit date:1996-07-25
Release date:1997-04-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A Positively Charged Residue Bound in the Minor Groove Does not Alter the Bending of a DNA Duplex
J.Am.Chem.Soc., 118, 1996
1BDI
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PURINE REPRESSOR MUTANT-HYPOXANTHINE-PALINDROMIC OPERATOR COMPLEX
Descriptor:DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), PROTEIN (PURINE REPRESSOR), HYPOXANTHINE
Authors:Glasfeld, A., Schumacher, M.A., Choi, K.Y., Zalkin, H., Brennan, R.G.
Deposit date:1996-07-25
Release date:1997-04-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:A Positively Charged Residue Bound in the Minor Groove Does not Alter the Bending of a DNA Duplex
J.Am.Chem.Soc., 118, 1996
1EFA
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CRYSTAL STRUCTURE OF THE LAC REPRESSOR DIMER BOUND TO OPERATOR AND THE ANTI-INDUCER ONPF
Descriptor:DNA (5'-D(*GP*AP*AP*T*TP*GP*TP*GP*AP*GP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*T)-3'), LAC REPRESSOR, ORTHONITROPHENYL-BETA-D-FUCOPYRANOSIDE
Authors:Bell, C.E., Lewis, M.
Deposit date:2000-02-07
Release date:2000-03-06
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A closer view of the conformation of the Lac repressor bound to operator.
Nat.Struct.Biol., 7, 2000
1JFS
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PURINE REPRESSOR MUTANT-HYPOXANTHINE-PURF OPERATOR COMPLEX
Descriptor:5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T)-3', PURINE NUCLEOTIDE SYNTHESIS REPRESSOR, HYPOXANTHINE
Authors:Huffman, J.L., Lu, F., Zalkin, H., Brennan, R.G.
Deposit date:2001-06-21
Release date:2002-02-08
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Role of residue 147 in the gene regulatory function of the Escherichia coli purine repressor.
Biochemistry, 41, 2002
1JFT
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PURINE REPRESSOR MUTANT-HYPOXANTHINE-PURF OPERATOR COMPLEX
Descriptor:5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T)-3', PURINE NUCLEOTIDE SYNTHESIS REPRESSOR, PHOSPHATE ION, ...
Authors:Huffman, J.L., Lu, F., Zalkin, H., Brennan, R.G.
Deposit date:2001-06-21
Release date:2002-02-08
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Role of residue 147 in the gene regulatory function of the Escherichia coli purine repressor.
Biochemistry, 41, 2002
1JH9
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PURINE REPRESSOR MUTANT-HYPOXANTHINE-PURF OPERATOR COMPLEX
Descriptor:5'-D(*AP*AP*CP*GP*AP*AP*AP*AP*CP*GP*TP*TP*TP*TP*CP*GP*T)-3', PURINE NUCLEOTIDE SYNTHESIS REPRESSOR, PHOSPHATE ION, ...
Authors:Huffman, J.L., Lu, F., Zalkin, H., Brennan, R.G.
Deposit date:2001-06-27
Release date:2002-02-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Role of residue 147 in the gene regulatory function of the Escherichia coli purine repressor.
Biochemistry, 41, 2002
1JWL
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STRUCTURE OF THE DIMERIC LAC REPRESSOR/OPERATOR O1/ONPF COMPLEX
Descriptor:5'-D(*AP*GP*AP*AP*T*TP*GP*TP*GP*AP*GP*CP*GP*GP*AP*TP*AP*AP*CP*AP*AP*TP*T)-3', 5'-D(*TP*AP*AP*TP*TP*GP*TP*TP*AP*TP*CP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*TP*C)-3', Lactose Operon Repressor, ...
Authors:Bell, C.E., Lewis, M.
Deposit date:2001-09-04
Release date:2001-10-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (4 Å)
Cite:Crystallographic analysis of Lac repressor bound to natural operator O1.
J.Mol.Biol., 312, 2001
1JYE
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STRUCTURE OF A DIMERIC LAC REPRESSOR WITH C-TERMINAL DELETION AND K84L SUBSTITUTION
Descriptor:Lactose Operon Repressor, GLYCEROL
Authors:Bell, C.E., Barry, J., Matthews, K.S., Lewis, M.
Deposit date:2001-09-12
Release date:2001-10-18
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of a variant of lac repressor with increased thermostability and decreased affinity for operator.
J.Mol.Biol., 313, 2001
1JYF
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STRUCTURE OF THE DIMERIC LAC REPRESSOR WITH AN 11-RESIDUE C-TERMINAL DELETION.
Descriptor:Lactose Operon Repressor, GLYCEROL
Authors:Bell, C.E., Barry, J., Matthews, K.S., Lewis, M.
Deposit date:2001-09-12
Release date:2001-10-18
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of a variant of lac repressor with increased thermostability and decreased affinity for operator.
J.Mol.Biol., 313, 2001
1LBG
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LACTOSE OPERON REPRESSOR BOUND TO 21-BASE PAIR SYMMETRIC OPERATOR DNA, ALPHA CARBONS ONLY
Descriptor:DNA (5'-D(*GP*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*T)-3'), PROTEIN (LACTOSE OPERON REPRESSOR)
Authors:Lewis, M., Chang, G., Horton, N.C., Kercher, M.A., Pace, H.C., Lu, P.
Deposit date:1996-01-03
Release date:1996-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (4.8 Å)
Cite:Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.
Science, 271, 1996
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