1LTU
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CRYSTAL STRUCTURE OF CHROMOBACTERIUM VIOLACEUM, APO (NO IRON BOUND) STRUCTURE
Descriptor:PHENYLALANINE-4-HYDROXYLASE (E.C.1.14.16.1)
Authors:Erlandsen, H., Kim, J.Y., Patch, M.G., Han, A., Volner, A., Abu-Omar, M.M., Stevens, R.C.
Deposit date:2002-05-20
Release date:2002-07-17
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structural comparison of bacterial and human iron-dependent phenylalanine hydroxylases: similar fold, different stability and reaction rates.
J.Mol.Biol., 320, 2002
1LTV
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CRYSTAL STRUCTURE OF CHROMOBACTERIUM VIOLACEUM PHENYLALANINE HYDROXYLASE, STRUCTURE WITH BOUND OXIDIZED FE(III)
Descriptor:PHENYLALANINE-4-HYDROXYLASE (E.C.1.14.16.1)
Authors:Erlandsen, H., Kim, J.Y., Patch, M.G., Han, A., Volner, A., Abu-Omar, M.M., Stevens, R.C.
Deposit date:2002-05-20
Release date:2002-07-17
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural comparison of bacterial and human iron-dependent phenylalanine hydroxylases: similar fold, different stability and reaction rates.
J.Mol.Biol., 320, 2002
1LTZ
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CRYSTAL STRUCTURE OF CHROMOBACTERIUM VIOLACEUM PHENYLALANINE HYDROXYLASE, STRUCTURE HAS BOUND IRON (III) AND OXIDIZED COFACTOR 7,8-DIHYDROBIOPTERIN
Descriptor:PHENYLALANINE-4-HYDROXYLASE (E.C.1.14.16.1)
Authors:Erlandsen, H., Kim, J.Y., Patch, M.G., Han, A., Volner, A., Abu-Omar, M.M., Stevens, R.C.
Deposit date:2002-05-21
Release date:2002-07-17
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural comparison of bacterial and human iron-dependent phenylalanine hydroxylases: similar fold, different stability and reaction rates.
J.Mol.Biol., 320, 2002
1TOH
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TYROSINE HYDROXYLASE CATALYTIC AND TETRAMERIZATION DOMAINS FROM RAT
Descriptor:TYROSINE HYDROXYLASE
Authors:Goodwill, K.E., Sabatier, C., Stevens, R.C.
Deposit date:1997-06-04
Release date:1998-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of tyrosine hydroxylase at 2.3 A and its implications for inherited neurodegenerative diseases.
Nat.Struct.Biol., 4, 1997
2PAH
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TETRAMERIC HUMAN PHENYLALANINE HYDROXYLASE
Descriptor:PROTEIN (PHENYLALANINE HYDROXYLASE) (1.14.16.1)
Authors:Stevens, R.C., Fusetti, F., Erlandsen, H.
Deposit date:1998-05-26
Release date:1999-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of tetrameric human phenylalanine hydroxylase and its implications for phenylketonuria.
J.Biol.Chem., 273, 1998
2TOH
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TYROSINE HYDROXYLASE CATALYTIC AND TETRAMERIZATION DOMAINS FROM RAT
Descriptor:TYROSINE 3-MONOOXYGENASE, 7,8-DIHYDROBIOPTERIN
Authors:Goodwill, K.E., Sabatier, C., Stevens, R.C.
Deposit date:1998-08-26
Release date:1999-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 A resolution: self-hydroxylation of Phe300 and the pterin-binding site.
Biochemistry, 37, 1998
2V27
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STRUCTURE OF THE COLD ACTIVE PHENYLALANINE HYDROXYLASE FROM COLWELLIA PSYCHRERYTHRAEA 34H
Descriptor:PHENYLALANINE HYDROXYLASE (E.C.1.14.16.1)
Authors:Leiros, H.-K.S., Pey, A.L., Innselset, M., Moe, E., Leiros, I., Steen, I.H., Martinez, A.
Deposit date:2007-06-03
Release date:2007-06-19
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of Phenylalanine Hydroxylase from Colwellia Psychrerythraea 34H, a Monomeric Cold Active Enzyme with Local Flexibility Around the Active Site and High Overall Stability.
J.Biol.Chem., 282, 2007
2V28
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APO STRUCTURE OF THE COLD ACTIVE PHENYLALANINE HYDROXYLASE FROM COLWELLIA PSYCHRERYTHRAEA 34H
Descriptor:PHENYLALANINE-4-HYDROXYLASE (E.C.1.14.16.1)
Authors:Leiros, H.-K.S., Pey, A.L., Innselset, M., Moe, E., Leiros, I., Steen, I.H., Martinez, A.
Deposit date:2007-06-04
Release date:2007-06-19
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of Phenylalanine Hydroxylase from Colwellia Psychrerythraea 34H, a Monomeric Cold Active Enzyme with Local Flexibility Around the Active Site and High Overall Stability.
J.Biol.Chem., 282, 2007
2XSN
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CRYSTAL STRUCTURE OF HUMAN TYROSINE HYDROXYLASE CATALYTIC DOMAIN
Descriptor:TYROSINE 3-MONOOXYGENASE (E.C.1.14.16.2)
Authors:Muniz, J.R.C., Cooper, C.D.O., Yue, W.W., Krysztofinska, E., Von Delft, F., Knapp, S., Gileadi, O., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Kavanagh, K.L., Oppermann, U.
Deposit date:2010-10-29
Release date:2010-11-17
Last modified:2012-12-05
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Crystal Structure of Human Tyrosine Hydroxylase Catalytic Domain
To be Published
3TCY
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CRYSTALLOGRAPHIC STRUCTURE OF PHENYLALANINE HYDROXYLASE FROM CHROMOBACTERIUM VIOLACEUM (CPAH) BOUND TO PHENYLALANINE IN A SITE DISTAL TO THE ACTIVE SITE
Descriptor:Phenylalanine-4-hydroxylase (E.C.1.14.16.1)
Authors:Ronau, J.A., Abu-Omar, M.M., Das, C.
Deposit date:2011-08-09
Release date:2012-08-22
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:An additional substrate binding site in a bacterial phenylalanine hydroxylase.
Eur.Biophys.J., 42, 2013
3TK2
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CRYSTALLOGRAPHIC STRUCTURE OF PHENYLALANINE HYDROXYLASE FROM CHROMOBACTERIUM VIOLACEUM COCRYSTALLIZED WITH PHENYLALANINE IN A SITE DISTAL TO THE ACTIVE SITE
Descriptor:Phenylalanine-4-hydroxylase (E.C.1.14.16.1)
Authors:Ronau, J.A., Abu-Omar, M.M., Das, C.
Deposit date:2011-08-25
Release date:2012-09-05
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:An additional substrate binding site in a bacterial phenylalanine hydroxylase.
Eur.Biophys.J., 42, 2013
3TK4
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CRYSTAL STRUCTURE OF PHENYLALANINE HYDROXYLASE FROM CHROMOBACTERIUM VIOLACEUM BOUND TO COBALT
Descriptor:Phenylalanine-4-hydroxylase (E.C.1.14.16.1)
Authors:Ronau, J.A., Abu-Omar, M.M., Das, C.
Deposit date:2011-08-25
Release date:2012-09-05
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:An additional substrate binding site in a bacterial phenylalanine hydroxylase.
Eur.Biophys.J., 42, 2013
4BPT
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STRUCTURAL AND THERMODYNAMIC INSIGHT INTO PHENYLALANINE HYDROXYLASE FROM THE HUMAN PATHOGEN LEGIONELLA PNEUMOPHILA
Descriptor:PHENYLALANINE-4-HYDROXYLASE (PAH) (PHE-4-MONOOXYGENASE) (E.C.1.14.16.1)
Authors:Leiros, H.-K.S., Flydal, M.I., Martinez, A.
Deposit date:2013-05-28
Release date:2013-08-21
Last modified:2014-01-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and Thermodynamic Insight Into Phenylalanine Hydroxylase from the Human Pathogen Legionella Pneumophila.
FEBS Open Bio, 3, 2013
4ESM
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CRYSTALLOGRAPHIC STRUCTURE OF PHENYLALANINE HYDROXYLASE FROM CHROMOBACTERIUM VIOLACEUM Y155A MUTATION
Descriptor:Phenylalanine-4-hydroxylase (E.C.1.14.16.1)
Authors:Ronau, J.A., Paul, L.P., Corn, I.R., Wagner, K.T., Abu-Omar, M.M., Das, C.
Deposit date:2012-04-23
Release date:2013-05-08
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:An additional substrate binding site in a bacterial phenylalanine hydroxylase.
Eur.Biophys.J., 42, 2013
4ETL
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CRYSTALLOGRAPHIC STRUCTURE OF PHENYLALANINE HYDROXYLASE FROM CHROMOBACTERIUM VIOLACEUM F258A MUTATION
Descriptor:Phenylalanine-4-hydroxylase (E.C.1.14.16.1)
Authors:Ronau, J.A., Paul, L.P., Corn, I.R., Wagner, K.T., Abu-Omar, M.M., Das, C.
Deposit date:2012-04-24
Release date:2013-05-08
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:An additional substrate binding site in a bacterial phenylalanine hydroxylase.
Eur.Biophys.J., 42, 2013
4JPX
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CRYSTAL STRUCTURE OF PHENYLALANINE HYDROXYLASE S203P MUTANT FROM CHROMOBACTERIUM VIOLACEUM
Descriptor:Phenylalanine-4-hydroxylase (E.C.1.14.16.1)
Authors:Ronau, J.A., Abu-Omar, M.M., Das, C.
Deposit date:2013-03-19
Release date:2013-08-07
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:An additional substrate binding site in a bacterial phenylalanine hydroxylase.
Eur.Biophys.J., 42, 2013
4JPY
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IRON AND PHENYLALANINE BOUND CRYSTAL STRUCTURE OF PHENYLALANINE HYDROXYLASE FROM CHROMOBACTERIUM VIOLACEUM
Descriptor:Phenylalanine-4-hydroxylase (E.C.1.14.16.1)
Authors:Ronau, J.A., Abu-Omar, M.M., Das, C.
Deposit date:2013-03-19
Release date:2013-08-07
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:An additional substrate binding site in a bacterial phenylalanine hydroxylase.
Eur.Biophys.J., 42, 2013
4Q3W
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CRYSTAL STRUCTURE OF C. VIOLACEUM PHENYLALANINE HYDROXYLASE D139E MUTATION
Descriptor:Phenylalanine-4-hydroxylase (E.C.1.14.16.1)
Authors:Ronau, J.A., Abu-Omar, M.M., Das, C.
Deposit date:2014-04-12
Release date:2015-02-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:A conserved acidic residue in phenylalanine hydroxylase contributes to cofactor affinity and catalysis.
Biochemistry, 53, 2014
4Q3X
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CRYSTAL STRUCTURE OF C. VIOLACEUM PHENYLALANINE HYDROXYLASE D139N MUTATION
Descriptor:Phenylalanine-4-hydroxylase (E.C.1.14.16.1)
Authors:Ronau, J.A., Abu-Omar, M.M., Das, C.
Deposit date:2014-04-12
Release date:2015-02-18
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:A conserved acidic residue in phenylalanine hydroxylase contributes to cofactor affinity and catalysis.
Biochemistry, 53, 2014
4Q3Y
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CRYSTAL STRUCTURE OF C. VIOLACEUM PHENYLALANINE HYDROXYLASE D139A MUTATION
Descriptor:Phenylalanine-4-hydroxylase (E.C.1.14.16.1)
Authors:Ronau, J.A., Abu-Omar, M.M., Das, C.
Deposit date:2014-04-12
Release date:2015-02-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:A conserved acidic residue in phenylalanine hydroxylase contributes to cofactor affinity and catalysis.
Biochemistry, 53, 2014
4Q3Z
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CRYSTAL STRUCTURE OF C. VIOLACEUM PHENYLALANINE HYDROXYLASE D139K MUTATION
Descriptor:Phenylalanine-4-hydroxylase (E.C.1.14.16.1)
Authors:Ronau, J.A., Abu-Omar, M.M., Das, C.
Deposit date:2014-04-12
Release date:2015-02-18
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:A conserved acidic residue in phenylalanine hydroxylase contributes to cofactor affinity and catalysis.
Biochemistry, 53, 2014
4V06
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CRYSTAL STRUCTURE OF HUMAN TRYPTOPHAN HYDROXYLASE 2 (TPH2), CATALYTIC DOMAIN
Descriptor:TRYPTOPHAN 5-HYDROXYLASE 2 (E.C.1.14.16.4)
Authors:Kopec, J., Oberholzer, A., Fitzpatrick, F., Newman, J., Tallant, C., Kiyani, W., Shrestha, L., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2014-09-11
Release date:2014-10-15
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Crystal Structure of Human Tryptophane Hydroxylase 2 (Tph2), Catalytic Domain
To be Published
5L01
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TRYPTOPHAN 5-HYDROXYLASE IN COMPLEX WITH INHIBITOR (3~{S})-8-[2-AZANYL-6-[(1~{R})-1-(4-CHLORANYL-2-PHENYL-PHENYL)-2,2,2-TRIS(FLUORANYL)ETHOXY]PYRIMIDIN-4-YL]-2,8-DIAZASPIRO[4.5]DECANE-3-CARBOXYLIC ACID
Descriptor:Tryptophan 5-hydroxylase 1 (E.C.1.14.16.4)
Authors:Stein, A.J., Goldberg, D.R., De Lombaert, S., Holt, M.C.
Deposit date:2016-07-26
Release date:2017-01-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Optimization of spirocyclic proline tryptophan hydroxylase-1 inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
5DEN
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THE FIRST STRUCTURE OF A FULL-LENGTH MAMMALIAN PHENYLALANINE HYDROXYLASE REVEALS THE ARCHITECTURE OF AN AUTO-INHIBITED TETRAMER
Descriptor:Phenylalanine-4-hydroxylase (E.C.1.14.16.1)
Authors:Arturo, E.C., Loll, P.J., Jaffe, E.K.
Deposit date:2015-08-25
Release date:2016-02-17
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer.
Proc.Natl.Acad.Sci.USA, 113, 2016
5EGQ
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STRUCTURE OF TETRAMERIC RAT PHENYLALANINE HYDROXYLASE MUTANT R270K, RESIDUES 25-453
Descriptor:Phenylalanine-4-hydroxylase (E.C.1.14.16.1)
Authors:Taylor, A.B., Khan, C.A., Fitzpatrick, P.F.
Deposit date:2015-10-27
Release date:2016-05-18
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Domain Movements upon Activation of Phenylalanine Hydroxylase Characterized by Crystallography and Chromatography-Coupled Small-Angle X-ray Scattering.
J.Am.Chem.Soc., 138, 2016
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