1BDG
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HEXOKINASE FROM SCHISTOSOMA MANSONI COMPLEXED WITH GLUCOSE
Descriptor:HEXOKINASE, ALPHA-D-GLUCOSE, SULFATE ION
Authors:Mulichak, A.M., Garavito, R.M.
Deposit date:1998-05-08
Release date:1999-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The structure of mammalian hexokinase-1.
Nat.Struct.Biol., 5, 1998
1BG3
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RAT BRAIN HEXOKINASE TYPE I COMPLEX WITH GLUCOSE AND INHIBITOR GLUCOSE-6-PHOSPHATE
Descriptor:HEXOKINASE, BETA-D-GLUCOSE, ALPHA-D-GLUCOSE-6-PHOSPHATE, ...
Authors:Mulichak, A.M., Garavito, R.M.
Deposit date:1998-06-04
Release date:1999-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The structure of mammalian hexokinase-1.
Nat.Struct.Biol., 5, 1998
1CZA
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MUTANT MONOMER OF RECOMBINANT HUMAN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE, GLUCOSE-6-PHOSPHATE, AND ADP
Descriptor:HEXOKINASE TYPE I, ALPHA-D-GLUCOSE, ALPHA-D-GLUCOSE-6-PHOSPHATE, ...
Authors:Aleshin, A.E., Liu, X., Kirby, C., Bourenkov, G.P., Bartunik, H.D., Fromm, H.J., Honzatko, R.B.
Deposit date:1999-09-01
Release date:2000-03-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation.
J.Mol.Biol., 296, 2000
1DGK
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MUTANT MONOMER OF RECOMBINANT HUMAN HEXOKINASE TYPE I WITH GLUCOSE AND ADP IN THE ACTIVE SITE
Descriptor:HEXOKINASE TYPE I, ALPHA-D-GLUCOSE, PHOSPHATE ION, ...
Authors:Aleshin, A.E., Liu, X., Kirby, C., Bourenkov, G.P., Bartunik, H.D., Fromm, H.J., Honzatko, R.B.
Deposit date:1999-11-24
Release date:2000-03-08
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation.
J.Mol.Biol., 296, 2000
1HKB
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CRYSTAL STRUCTURE OF RECOMBINANT HUMAN BRAIN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE AND GLUCOSE-6-PHOSPHATE
Descriptor:D-GLUCOSE 6-PHOSPHOTRANSFERASE, BETA-D-GLUCOSE, ALPHA-D-GLUCOSE-6-PHOSPHATE, ...
Authors:Aleshin, A.E., Zeng, C., Burenkov, G.P., Bartunik, H.D., Fromm, H.J., Honzatko, R.B.
Deposit date:1997-12-01
Release date:1998-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The mechanism of regulation of hexokinase: new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate.
Structure, 6, 1998
1HKC
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RECOMBINANT HUMAN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE AND PHOSPHATE
Descriptor:D-GLUCOSE 6-PHOSPHOTRANSFERASE, BETA-D-GLUCOSE, PHOSPHATE ION, ...
Authors:Aleshin, A.E., Honzatko, R.B.
Deposit date:1998-07-01
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Regulation of hexokinase I: crystal structure of recombinant human brain hexokinase complexed with glucose and phosphate.
J.Mol.Biol., 282, 1998
1HKG
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STRUCTURAL DYNAMICS OF YEAST HEXOKINASE DURING CATALYSIS
Descriptor:HEXOKINASE A
Authors:Bennett Jr., W.S., Steitz, T.A.
Deposit date:1980-12-22
Release date:1981-02-26
Last modified:2012-04-25
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural dynamics of yeast hexokinase during catalysis.
Philos.Trans.R.Soc.London,Ser.B, 293, 1981
1IG8
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CRYSTAL STRUCTURE OF YEAST HEXOKINASE PII WITH THE CORRECT AMINO ACID SEQUENCE
Descriptor:hexokinase PII, SULFATE ION
Authors:Kuser, P.R., Krauchenco, S., Antunes, O.A., Polikarpov, I.
Deposit date:2001-04-17
Release date:2001-05-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The high resolution crystal structure of yeast hexokinase PII with the correct primary sequence provides new insights into its mechanism of action.
J.Biol.Chem., 275, 2000
1QHA
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HUMAN HEXOKINASE TYPE I COMPLEXED WITH ATP ANALOGUE AMP-PNP
Descriptor:PROTEIN (HEXOKINASE), ALPHA-D-GLUCOSE, ALPHA-D-GLUCOSE-6-PHOSPHATE, ...
Authors:Rosano, C., Sabini, E., Deriu, D., Magnani, M., Bolognesi, M.
Deposit date:1999-05-11
Release date:1999-11-10
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Binding of non-catalytic ATP to human hexokinase I highlights the structural components for enzyme-membrane association control.
Structure Fold.Des., 7, 1999
2NZT
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CRYSTAL STRUCTURE OF HUMAN HEXOKINASE II
Descriptor:Hexokinase-2, ALPHA-D-GLUCOSE, BETA-D-GLUCOSE-6-PHOSPHATE, ...
Authors:Rabeh, W.M., Zhu, H., Nedyalkova, L., Tempel, W., Wasney, G., Landry, R., Vedadi, M., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2006-11-25
Release date:2006-12-05
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of human hexokinase II
To be Published
3B8A
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CRYSTAL STRUCTURE OF YEAST HEXOKINASE PI IN COMPLEX WITH GLUCOSE
Descriptor:Hexokinase-1, BETA-D-GLUCOSE, SULFATE ION
Authors:Kuser, P., Cupri, F., Bleicher, L., Polikarpov, I.
Deposit date:2007-10-31
Release date:2008-02-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Crystal structure of yeast hexokinase PI in complex with glucose: A classical "induced fit" example revised.
Proteins, 72, 2008
3F9M
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HUMAN PANCREATIC GLUCOKINASE IN COMPLEX WITH GLUCOSE AND ACTIVATOR SHOWING A MOBILE FLAP
Descriptor:Glucokinase, ALPHA-D-GLUCOSE, 2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDE
Authors:Petit, P., Gluais, L., Lagarde, A., Vuillard, L., Boutin, J.A., Ferry, G.
Deposit date:2008-11-14
Release date:2008-12-02
Last modified:2012-04-25
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The active conformation of human glucokinase is not altered by allosteric activators
Acta Crystallogr.,Sect.D, 67, 2011
3FGU
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CATALYTIC COMPLEX OF HUMAN GLUCOKINASE
Descriptor:Glucokinase, BETA-D-GLUCOSE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Petit, P., Lagarde, A., Boutin, J.A., Ferry, G., Vuillard, L.
Deposit date:2008-12-08
Release date:2009-12-15
Last modified:2012-04-25
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The active conformation of human glucokinase is not altered by allosteric activators
Acta Crystallogr.,Sect.D, 67, 2011
3HM8
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CRYSTAL STRUCTURE OF THE C-TERMINAL HEXOKINASE DOMAIN OF HUMAN HK3
Descriptor:Hexokinase-3, ALPHA-D-GLUCOSE, BETA-D-GLUCOSE-6-PHOSPHATE
Authors:Nedyalkova, L., Tong, Y., Rabeh, W., Tempel, W., Landry, R., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-05-28
Release date:2009-08-11
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the C-terminal Hexokinase domain of human HK3
To be Published
3ID8
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TERNARY COMPLEX OF HUMAN PANCREATIC GLUCOKINASE CRYSTALLIZED WITH ACTIVATOR, GLUCOSE AND AMP-PNP
Descriptor:Glucokinase, ALPHA-D-GLUCOSE, 2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDE, ...
Authors:Petit, P., Gluais, L., Lagarde, A., Boutin, J.A., Ferry, G., Vuillard, L.
Deposit date:2009-07-20
Release date:2010-07-28
Last modified:2012-04-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The active conformation of human glucokinase is not altered by allosteric activators
Acta Crystallogr.,Sect.D, 67, 2011
3IDH
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HUMAN PANCREATIC GLUCOKINASE IN COMPLEX WITH GLUCOSE
Descriptor:Glucokinase, ALPHA-D-GLUCOSE, POTASSIUM ION
Authors:Petit, P., Gluais, L., Lagarde, A., Boutin, J.A., Ferry, G., Vuillard, L.
Deposit date:2009-07-21
Release date:2010-07-28
Last modified:2012-04-25
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:The active conformation of human glucokinase is not altered by allosteric activators
Acta Crystallogr.,Sect.D, 67, 2011
3O08
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CRYSTAL STRUCTURE OF DIMERIC KLHXK1 IN CRYSTAL FORM I
Descriptor:Hexokinase, SULFATE ION, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID
Authors:Kuettner, E.B., Kettner, K., Keim, A., Kriegel, T.M., Strater, N.
Deposit date:2010-07-19
Release date:2010-10-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Hexokinase KlHxk1 of Kluyveromyces lactis: A MOLECULAR BASIS FOR UNDERSTANDING THE CONTROL OF YEAST HEXOKINASE FUNCTIONS VIA COVALENT MODIFICATION AND OLIGOMERIZATION.
J.Biol.Chem., 285, 2010
3O1B
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CRYSTAL STRUCTURE OF DIMERIC KLHXK1 IN CRYSTAL FORM II
Descriptor:Hexokinase
Authors:Kuettner, E.B., Kettner, K., Keim, A., Kriegel, T.M., Strater, N.
Deposit date:2010-07-21
Release date:2010-10-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of Hexokinase KlHxk1 of Kluyveromyces lactis: A MOLECULAR BASIS FOR UNDERSTANDING THE CONTROL OF YEAST HEXOKINASE FUNCTIONS VIA COVALENT MODIFICATION AND OLIGOMERIZATION.
J.Biol.Chem., 285, 2010
3O1W
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CRYSTAL STRUCTURE OF DIMERIC KLHXK1 IN CRYSTAL FORM III
Descriptor:Hexokinase, GLYCEROL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ...
Authors:Kuettner, E.B., Kettner, K., Keim, A., Kriegel, T.M., Strater, N.
Deposit date:2010-07-22
Release date:2010-10-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Crystal Structure of Hexokinase KlHxk1 of Kluyveromyces lactis: A MOLECULAR BASIS FOR UNDERSTANDING THE CONTROL OF YEAST HEXOKINASE FUNCTIONS VIA COVALENT MODIFICATION AND OLIGOMERIZATION.
J.Biol.Chem., 285, 2010
3O4W
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CRYSTAL STRUCTURE OF DIMERIC KLHXK1 IN CRYSTAL FORM IV
Descriptor:Hexokinase, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, GLYCEROL, ...
Authors:Kuettner, E.B., Kettner, K., Keim, A., Kriegel, T.M., Strater, N.
Deposit date:2010-07-27
Release date:2010-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Crystal Structure of Hexokinase KlHxk1 of Kluyveromyces lactis: A MOLECULAR BASIS FOR UNDERSTANDING THE CONTROL OF YEAST HEXOKINASE FUNCTIONS VIA COVALENT MODIFICATION AND OLIGOMERIZATION.
J.Biol.Chem., 285, 2010
3O5B
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CRYSTAL STRUCTURE OF DIMERIC KLHXK1 IN CRYSTAL FORM VII WITH GLUCOSE BOUND (OPEN STATE)
Descriptor:Hexokinase, BETA-D-GLUCOSE, SULFATE ION
Authors:Kuettner, E.B., Kettner, K., Keim, A., Kriegel, T.M., Strater, N.
Deposit date:2010-07-28
Release date:2010-10-13
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Crystal Structure of Hexokinase KlHxk1 of Kluyveromyces lactis: A MOLECULAR BASIS FOR UNDERSTANDING THE CONTROL OF YEAST HEXOKINASE FUNCTIONS VIA COVALENT MODIFICATION AND OLIGOMERIZATION.
J.Biol.Chem., 285, 2010
3O6W
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CRYSTAL STRUCTURE OF MONOMERIC KLHXK1 IN CRYSTAL FORM VIII (OPEN STATE)
Descriptor:Hexokinase, GLYCEROL, PHOSPHATE ION
Authors:Kuettner, E.B., Kettner, K., Keim, A., Kriegel, T.M., Strater, N.
Deposit date:2010-07-29
Release date:2010-10-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Crystal Structure of Hexokinase KlHxk1 of Kluyveromyces lactis: A MOLECULAR BASIS FOR UNDERSTANDING THE CONTROL OF YEAST HEXOKINASE FUNCTIONS VIA COVALENT MODIFICATION AND OLIGOMERIZATION.
J.Biol.Chem., 285, 2010
3O80
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CRYSTAL STRUCTURE OF MONOMERIC KLHXK1 IN CRYSTAL FORM IX (OPEN STATE)
Descriptor:Hexokinase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Kuettner, E.B., Kettner, K., Keim, A., Kriegel, T.M., Strater, N.
Deposit date:2010-08-02
Release date:2010-10-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Crystal Structure of Hexokinase KlHxk1 of Kluyveromyces lactis: A MOLECULAR BASIS FOR UNDERSTANDING THE CONTROL OF YEAST HEXOKINASE FUNCTIONS VIA COVALENT MODIFICATION AND OLIGOMERIZATION.
J.Biol.Chem., 285, 2010
3O8M
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CRYSTAL STRUCTURE OF MONOMERIC KLHXK1 IN CRYSTAL FORM XI WITH GLUCOSE BOUND (CLOSED STATE)
Descriptor:Hexokinase, ALPHA-D-GLUCOSE, BETA-D-GLUCOSE, ...
Authors:Kuettner, E.B., Kettner, K., Keim, A., Kriegel, T.M., Strater, N.
Deposit date:2010-08-03
Release date:2010-10-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Crystal Structure of Hexokinase KlHxk1 of Kluyveromyces lactis: A MOLECULAR BASIS FOR UNDERSTANDING THE CONTROL OF YEAST HEXOKINASE FUNCTIONS VIA COVALENT MODIFICATION AND OLIGOMERIZATION.
J.Biol.Chem., 285, 2010
3QIC
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THE STRUCTURE OF HUMAN GLUCOKINASE E339K MUTATION
Descriptor:Glucokinase, ALPHA-D-GLUCOSE, GLYCEROL
Authors:Liu, Q., Liu, S., Liu, J.
Deposit date:2011-01-27
Release date:2011-06-01
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of E339K mutated human glucokinase reveals changes in the ATP binding site.
Febs Lett., 585, 2011
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