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1PDG
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BU of 1pdg by Molmil
CRYSTAL STRUCTURE OF HUMAN PLATELET-DERIVED GROWTH FACTOR BB
Descriptor: PLATELET-DERIVED GROWTH FACTOR BB
Authors:Oefner, C, Darcy, A.D, Winkler, F.K, Eggimann, B, Hosnag, M.
Deposit date:1992-07-14
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of human platelet-derived growth factor BB.
EMBO J., 11, 1992
1FZV
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THE CRYSTAL STRUCTURE OF HUMAN PLACENTA GROWTH FACTOR-1 (PLGF-1), AN ANGIOGENIC PROTEIN AT 2.0A RESOLUTION
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, PLACENTA GROWTH FACTOR
Authors:Iyer, S, Leonidas, D.D, Swaminathan, G.J, Maglione, D, Battisti, M, Tucci, M, Persico, M.G, Acharya, K.R.
Deposit date:2000-10-04
Release date:2001-05-09
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution.
J.Biol.Chem., 276, 2001
1RV6
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Crystal Structure of PlGF in Complex with Domain 2 of VEGFR1
Descriptor: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FLT1 protein, placenta growth factor (PlGF)
Authors:Christinger, H.W, Fuh, G, de Vos, A.M, Wiesmann, C.
Deposit date:2003-12-12
Release date:2004-01-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1.
J.Biol.Chem., 279, 2004
1WQ8
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Crystal structure of Vammin, a VEGF-F from a snake venom
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Vascular endothelial growth factor toxin
Authors:Suto, K, Yamazaki, Y, Morita, T, Mizuno, H.
Deposit date:2004-09-23
Release date:2004-12-07
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of novel vascular endothelial growth factors (VEGF) from snake venoms: insight into selective VEGF binding to kinase insert domain-containing receptor but not to fms-like tyrosine kinase-1.
J.Biol.Chem., 280, 2005
1WQ9
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Crystal structure of VR-1, a VEGF-F from a snake venom
Descriptor: Vascular endothelial growth factor
Authors:Suto, K, Yamazaki, Y, Morita, T, Mizuno, H.
Deposit date:2004-09-24
Release date:2004-12-07
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of novel vascular endothelial growth factors (VEGF) from snake venoms: insight into selective VEGF binding to kinase insert domain-containing receptor but not to fms-like tyrosine kinase-1.
J.Biol.Chem., 280, 2005
2C7W
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Crystal Structure of human vascular endothelial growth factor-B: Identification of amino acids important for angiogeninc activity
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, VASCULAR ENDOTHELIAL GROWTH FACTOR B PRECURSOR
Authors:Iyer, S, Scotney, P.D, Nash, A.D, Acharya, K.R.
Deposit date:2005-11-29
Release date:2007-01-30
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Crystal Structure of Human Vascular Endothelial Growth Factor-B: Identification of Amino Acids Important for Receptor Binding
J.Mol.Biol., 359, 2006
2GNN
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BU of 2gnn by Molmil
Crystal Structure of the Orf Virus NZ2 Variant of VEGF-E
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, BENZAMIDINE, ...
Authors:Prota, A.E, Pieren, M, Wagner, A, Kostrewa, D, Winkler, F.K, Ballmer-Hofer, K.
Deposit date:2006-04-10
Release date:2006-05-09
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the Orf virus NZ2 variant of vascular endothelial growth factor-E. Implications for receptor specificity.
J.Biol.Chem., 281, 2006
2VWE
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Crystal Structure of Vascular Endothelial Growth Factor-B in Complex with a Neutralizing Antibody Fab Fragment
Descriptor: ANTI-VEGF-B MONOCLONAL ANTIBODY, VASCULAR ENDOTHELIAL GROWTH FACTOR B
Authors:Leonard, P, Scotney, P.D, Jabeen, T, Iyer, S, Fabri, L.J, Nash, A.D, Acharya, K.R.
Deposit date:2008-06-23
Release date:2008-11-04
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal Structure of Vascular Endothelial Growth Factor-B in Complex with a Neutralising Antibody Fab Fragment.
J.Mol.Biol., 384, 2008
2X1X
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CRYSTAL STRUCTURE OF VEGF-C IN COMPLEX WITH DOMAINS 2 AND 3 OF VEGFR2 IN A TETRAGONAL CRYSTAL FORM
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MERCURY (II) ION, ...
Authors:Leppanen, V.-M, Prota, A.E, Jeltsch, M, Anisimov, A, Kalkkinen, N, Strandin, T, Lankinen, H, Goldman, A, Ballmer-Hofer, K, Alitalo, K.
Deposit date:2010-01-08
Release date:2010-02-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Determinants of Growth Factor Binding and Specificity by Vegf Receptor 2.
Proc.Natl.Acad.Sci.USA, 107, 2010
2X1W
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Crystal Structure of VEGF-C in Complex with Domains 2 and 3 of VEGFR2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CESIUM ION, ...
Authors:Leppanen, V.M, Prota, A.E, Jeltsch, M, Anisimov, A, Kalkkinen, N, Strandin, T, Lankinen, H, Goldman, A, Ballmer-Hofer, K, Alitalo, K.
Deposit date:2010-01-08
Release date:2010-03-09
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Determinants of Growth Factor Binding and Specificity by Vegf Receptor 2.
Proc.Natl.Acad.Sci.USA, 107, 2010
2XAC
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Structural Insights into the Binding of VEGF-B by VEGFR-1D2: Recognition and Specificity
Descriptor: GLYCEROL, VASCULAR ENDOTHELIAL GROWTH FACTOR B, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1
Authors:Iyer, S, Darley, P, Acharya, K.R.
Deposit date:2010-03-30
Release date:2010-05-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structural Insights Into the Binding of Vegf-B by Vegfr-1D2: Recognition and Specificity
J.Biol.Chem., 285, 2010
3MJG
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BU of 3mjg by Molmil
The structure of a platelet derived growth factor receptor complex
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-type platelet-derived growth factor receptor, ...
Authors:Shim, A.H.R, He, X.
Deposit date:2010-04-12
Release date:2010-06-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex.
Proc.Natl.Acad.Sci.USA, 107, 2010
3MJK
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Structure of a growth factor precursor
Descriptor: Platelet-derived growth factor subunit A
Authors:Liu, H, He, X.
Deposit date:2010-04-12
Release date:2010-06-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex.
Proc.Natl.Acad.Sci.USA, 107, 2010
2XV7
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BU of 2xv7 by Molmil
Crystal structure of vascular endothelial growth factor D
Descriptor: VASCULAR ENDOTHELIAL GROWTH FACTOR D, alpha-D-mannopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Leppanen, V.-M, Jeltsch, M, Anisimov, A, Tvorogov, D, Aho, K, Kalkkinen, N, Toivanen, P, Yla-Herttuala, S, Ballmer-Hofer, K, Alitalo, K.
Deposit date:2010-10-23
Release date:2011-01-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Determinants of Vascular Endothelial Growth Factor-D - Receptor Binding and Specificity.
Blood, 117, 2011
3V6B
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BU of 3v6b by Molmil
VEGFR-2/VEGF-E complex structure
Descriptor: VEGF-E, Vascular endothelial growth factor receptor 2
Authors:Brozzo, M.S, Leppanen, V.-M, Winkler, F.K, Kisko, K, Ballmer-Hofer, K.
Deposit date:2011-12-19
Release date:2012-01-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.205 Å)
Cite:Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization.
Blood, 119, 2012
4HQX
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BU of 4hqx by Molmil
CRYSTAL STRUCTURE OF HUMAN PDGF-BB IN COMPLEX WITH A Modified nucleotide aptamer (SOMAmer SL4)
Descriptor: MAGNESIUM ION, Platelet-derived growth factor subunit B, SODIUM ION, ...
Authors:Davies, D.R, Edwards, T.E, Janjic, N, Gelinas, A.D, Zhang, C, Jarvis, T.C.
Deposit date:2012-10-26
Release date:2012-11-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets.
Proc.Natl.Acad.Sci.USA, 109, 2012
4HQU
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BU of 4hqu by Molmil
Crystal structure of human PDGF-BB in complex with a modified nucleotide aptamer (SOMAmer SL5)
Descriptor: MAGNESIUM ION, Platelet-derived growth factor subunit B, SODIUM ION, ...
Authors:Davies, D.R, Edwards, T.E, Janjic, N, Gelinas, A.D, Zhang, C, Jarvis, T.C.
Deposit date:2012-10-26
Release date:2012-11-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets.
Proc.Natl.Acad.Sci.USA, 109, 2012
4BSK
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BU of 4bsk by Molmil
Crystal structure of VEGF-C in complex with VEGFR-3 domains D1-2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, VASCULAR ENDOTHELIAL GROWTH FACTOR C, ...
Authors:Leppanen, V.M, Tvorogov, D, Kisko, K, Prota, A.E, Jeltsch, M, Anisimov, A, Markovic-Mueller, S, Stuttfeld, E, Goldie, K.N, Ballmer-Hofer, K, Alitalo, K.
Deposit date:2013-06-10
Release date:2013-07-31
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (4.201 Å)
Cite:Structural and Mechanistic Insights Into Vegfr-3 Ligand Binding and Activation
Proc.Natl.Acad.Sci.USA, 110, 2013
4QCI
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PDGF-B blocking antibody bound to PDGF-BB
Descriptor: Platelet-derived growth factor subunit B, anti-PDGF-BB antibody - Light Chain, anti-PDGF-BB antibody - Heavy chain
Authors:Kuai, J, Mosyak, L, Tam, M, LaVallie, E, Pullen, N, Carven, G.
Deposit date:2014-05-12
Release date:2015-03-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Characterization of Binding Mode of Action of a Blocking Anti-Platelet-Derived Growth Factor (PDGF)-B Monoclonal Antibody, MOR8457, Reveals Conformational Flexibility and Avidity Needed for PDGF-BB To Bind PDGF Receptor-beta.
Biochemistry, 54, 2015
6T9E
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Crystal structure of a bispecific DutaFab in complex with human PDGF
Descriptor: DutaFab mat VH chain, DutaFab mat VL chain, Platelet-derived growth factor subunit B
Authors:Kimbung, R, Logan, D.T, Beckmann, R, Jensen, K, Speck, J, Fenn, S, Kettenberger, H.
Deposit date:2019-10-28
Release date:2020-12-16
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.989 Å)
Cite:DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously.
Nat Commun, 12, 2021

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