PDB: 45 resultsInfo pagesStatus searchChemie searchBIRD

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4RBX	Crystal structure of human alpha-defensin 5, HD5 (Glu21Arg mutant) Descriptor: Defensin-5, SULFATE ION Authors: Pazgier, M, Gohain, N, Tolbert, W.D. Deposit date: 2014-09-13 Release date: 2015-07-29 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.1 Å) Cite: Design of a potent antibiotic peptide based on the active region of human defensin 5. J.Med.Chem., 58, 2015
1ZMI	Crystal structure of human alpha_defensin-2 (variant GLY16->D-ALA), P 32 2 1 space group ) Descriptor: GLYCEROL, Neutrophil defensin 2, SULFATE ION Authors: Lubkowski, J, Prahl, A, Lu, W. Deposit date: 2005-05-10 Release date: 2005-08-16 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.15 Å) Cite: Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids. J.Biol.Chem., 280, 2005
1ZMK	Crystal structure of human alpha-defensin-2 (variant Gly16-> D-ALA), P 42 21 2 space group Descriptor: CHLORIDE ION, GLYCEROL, Neutrophil defensin 2 Authors: Lubkowski, J, Prahl, A, Lu, W. Deposit date: 2005-05-10 Release date: 2005-08-16 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids. J.Biol.Chem., 280, 2005
3HJ2	Crystal structure of covalent dimer of HNP1 Descriptor: HUMAN NEUTROPHIL PEPTIDE 1 Authors: Lubkowski, J, Pazgier, M, Lu, W. Deposit date: 2009-05-20 Release date: 2009-10-20 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.4 Å) Cite: What Dictates the Multifaced Functions of the Human alpha-Defensin HNP1? To be Published
1ZMH	Crystal structure of human neutrophil peptide 2, HNP-2 (variant Gly16-> D-Ala) Descriptor: GLYCEROL, HEXAETHYLENE GLYCOL, Neutrophil defensin 2, ... Authors: Lubkowski, J, Prahl, A, Lu, W. Deposit date: 2005-05-10 Release date: 2005-08-16 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids. J.Biol.Chem., 280, 2005
4RBW	Crystal structure of human alpha-defensin 5, HD5 (Thr7Arg Glu21Arg mutant) Descriptor: CHLORIDE ION, Defensin-5, SULFATE ION Authors: Pazgier, M, Gohain, N, Tolbert, W.D. Deposit date: 2014-09-13 Release date: 2015-07-29 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Design of a potent antibiotic peptide based on the active region of human defensin 5. J.Med.Chem., 58, 2015
3LO6	Crystal structure of human alpha-defensin 1 (W26Aba mutant) Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Neutrophil defensin 1 Authors: Pazgier, M, Lu, W. Deposit date: 2010-02-03 Release date: 2010-03-09 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Trp-26 imparts functional versatility to human alpha-defensin HNP1. J.Biol.Chem., 285, 2010
3LO9	Crystal structure of human alpha-defensin 1 (W26Ahp mutant) Descriptor: Neutrophil defensin 1 Authors: Pazgier, M, Lu, W. Deposit date: 2010-02-03 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Trp-26 imparts functional versatility to human alpha-defensin HNP1. J.Biol.Chem., 285, 2010
3GNY	Crystal structure of human alpha-defensin 1 (HNP1) Descriptor: CHLORIDE ION, GLYCEROL, Neutrophil defensin 1 Authors: Pazgier, M, Lu, W.-Y. Deposit date: 2009-03-18 Release date: 2009-07-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Through the looking glass, mechanistic insights from enantiomeric human defensins. J.Biol.Chem., 284, 2009
3LO2	Crystal structure of human alpha-defensin 1 (Y21A mutant) Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Neutrophil defensin 1, SULFATE ION, ... Authors: Pazgier, M, Lu, W. Deposit date: 2010-02-03 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Trp-26 imparts functional versatility to human alpha-defensin HNP1. J.Biol.Chem., 285, 2010
3LOE	Crystal structure of human alpha-defensin 1 (F28A mutant) Descriptor: GLYCEROL, Neutrophil defensin 1, SULFATE ION Authors: Pazgier, M, Lu, W. Deposit date: 2010-02-03 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Trp-26 imparts functional versatility to human alpha-defensin HNP1. J.Biol.Chem., 285, 2010
1ZMM	Crystal structure of human alpha-defensin-4 Descriptor: Neutrophil defensin 4 Authors: Lubkowski, J, Szyk, A, Lu, W. Deposit date: 2005-05-10 Release date: 2006-05-30 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal structures of human {alpha}-defensins HNP4, HD5, and HD6. Protein Sci., 15, 2006
2PM1	Derivative of human alpha-defensin 1 (HNP1) Descriptor: Neutrophil defensin 1 (HNP-1) (HP-1) (HP1) (Defensin, alpha 1) Authors: Lubkowski, J, Pazgier, M, Lu, W. Deposit date: 2007-04-20 Release date: 2007-05-29 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Derivative of human alpha-defensin 1 (HNP1) To be Published
3LO1	Crystal structure of human alpha-defensin 1 (Y16A mutant) Descriptor: 2-(2-METHOXYETHOXY)ETHANOL, AZIDE ION, Neutrophil defensin 1 Authors: Pazgier, M, Lu, W. Deposit date: 2010-02-03 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Trp-26 imparts functional versatility to human alpha-defensin HNP1. J.Biol.Chem., 285, 2010
3LVX	Crystal structure of human alpha-defensin 1 (I6A mutant) Descriptor: GLYCEROL, Neutrophil defensin 1, SULFATE ION Authors: Pazgier, M, Lu, W. Deposit date: 2010-02-22 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Trp-26 imparts functional versatility to human alpha-defensin HNP1. J.Biol.Chem., 285, 2010
3H6C	Crystal structure of human alpha-defensin 1 (Mutant Gln22Ala) Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Neutrophil defensin 1 Authors: Pazgier, M, Lu, W. Deposit date: 2009-04-23 Release date: 2010-03-09 Last modified: 2021-10-27 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Trp-26 imparts functional versatility to human alpha-defensin HNP1. J.Biol.Chem., 285, 2010
3I5W	Crystal structure of human alpha-defensin 5 (mutant R13H) Descriptor: CHLORIDE ION, CITRATE ANION, Defensin-5 Authors: Pazgier, M, Lu, W. Deposit date: 2009-07-06 Release date: 2009-07-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Selective arginines are important for the antibacterial activity and host cell interaction of human alpha-defensin 5 Febs Lett., 583, 2009
1ZMP	Crystal structure of human defensin-5 Descriptor: CHLORIDE ION, Defensin 5, GLYCEROL, ... Authors: Lubkowski, J, Szyk, A, Lu, W. Deposit date: 2005-05-10 Release date: 2006-05-30 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Crystal structures of human {alpha}-defensins HNP4, HD5, and HD6. Protein Sci., 15, 2006
3HJD	X-ray structure of monomeric variant of HNP1 Descriptor: Human neutrophil peptide 1 Authors: Lubkowski, J, Pazgier, M, Lu, W. Deposit date: 2009-05-21 Release date: 2009-10-13 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.65 Å) Cite: What Dictates the Multifaced Functions of the Human alpha-Defensin HNP? To be Published
6DMM	Crystal structure of the G23A mutant of human alpha defensin HNP4. Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Neutrophil defensin 4, SULFATE ION Authors: Gohain, N, Tolbert, W.D, Pazgier, M. Deposit date: 2018-06-05 Release date: 2019-01-30 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.67 Å) Cite: Systematic mutational analysis of human neutrophil alpha-defensin HNP4. Biochim Biophys Acta Biomembr, 1861, 2019
7YOA	High-resolution crystal structure of the mouse alpha-defensin cryptdin 14 Descriptor: Alpha-defensin 14, SULFATE ION Authors: Yang, Y, Lu, W. Deposit date: 2022-08-01 Release date: 2022-11-30 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.67 Å) Cite: Mouse alpha-Defensins: Structural and Functional Analysis of the 17 Cryptdin Isoforms Identified from a Single Jejunal Crypt. Infect.Immun., 91, 2023
4E82	Crystal structure of monomeric variant of human alpha-defensin 5, HD5 (Glu21EMe mutant) Descriptor: Defensin-5 Authors: Pazgier, M. Deposit date: 2012-03-19 Release date: 2012-05-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Functional determinants of human enteric {alpha}-defensin HD5: crucial role for hydrophobicity at dimer interface. J.Biol.Chem., 287, 2012
4LBF	Crystal structure of HUMAN ALPHA-DEFENSIN 1 (HNP1) I20A/L25A mutant Descriptor: GLYCEROL, Neutrophil defensin 1 Authors: Tolbert, W.D, Wu, X, Pazgier, M. Deposit date: 2013-06-20 Release date: 2013-11-27 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Single, Double and Quadruple Alanine Substitutions at Oligomeric Interfaces Identify Hydrophobicity as the Key Determinant of Human Neutrophil Alpha Defensin HNP1 Function. Plos One, 8, 2013
6DMQ	Crystal structure of the T27A mutant of human alpha defensin HNP4. Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Neutrophil defensin 4 Authors: Gohain, N, Tolbert, W.D, Pazgier, M. Deposit date: 2018-06-05 Release date: 2019-01-30 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Systematic mutational analysis of human neutrophil alpha-defensin HNP4. Biochim Biophys Acta Biomembr, 1861, 2019
4LBB	Crystal structure of human alpha-defensin 1 (HNP1) I20A mutant Descriptor: CHLORIDE ION, Neutrophil defensin 1 Authors: Tolbert, W.D, Wu, X, Pazgier, M. Deposit date: 2013-06-20 Release date: 2013-11-27 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.719 Å) Cite: Single, Double and Quadruple Alanine Substitutions at Oligomeric Interfaces Identify Hydrophobicity as the Key Determinant of Human Neutrophil Alpha Defensin HNP1 Function. Plos One, 8, 2013

 

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