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8IAH
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BU of 8iah by Molmil
Structure of mammalian spectrin-actin junctional complex of membrane skeleton, State I, Global map
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ...
Authors:Li, N, Chen, S, Gao, N.
Deposit date:2023-02-08
Release date:2023-05-03
Last modified:2023-05-10
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis of membrane skeleton organization in red blood cells.
Cell, 186, 2023
8IAI
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BU of 8iai by Molmil
Structure of mammalian spectrin-actin junctional complex of membrane skeleton, State II, Global map
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ...
Authors:Li, N, Chen, S, Gao, N.
Deposit date:2023-02-08
Release date:2023-05-03
Last modified:2023-05-10
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural basis of membrane skeleton organization in red blood cells.
Cell, 186, 2023
7SXA
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BU of 7sxa by Molmil
T-Plastin-F-actin complex, pre-bundling intermediate state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ...
Authors:Mei, L, Reynolds, M.J, Alushin, G.M.
Deposit date:2021-11-22
Release date:2022-08-31
Last modified:2022-09-21
Method:ELECTRON MICROSCOPY (6.87 Å)
Cite:Structural mechanism for bidirectional actin cross-linking by T-plastin.
Proc.Natl.Acad.Sci.USA, 119, 2022
7SX8
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BU of 7sx8 by Molmil
T-Plastin-F-actin complex, parallel bundled state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ...
Authors:Mei, L, Reynolds, M.J, Alushin, G.M.
Deposit date:2021-11-22
Release date:2022-08-31
Last modified:2022-09-21
Method:ELECTRON MICROSCOPY (9 Å)
Cite:Structural mechanism for bidirectional actin cross-linking by T-plastin.
Proc.Natl.Acad.Sci.USA, 119, 2022
7SX9
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BU of 7sx9 by Molmil
T-Plastin-F-actin complex, anti-parallel bundled state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ...
Authors:Mei, L, Reynolds, M.J, Alushin, G.M.
Deposit date:2021-11-22
Release date:2022-08-31
Last modified:2022-09-21
Method:ELECTRON MICROSCOPY (10 Å)
Cite:Structural mechanism for bidirectional actin cross-linking by T-plastin.
Proc.Natl.Acad.Sci.USA, 119, 2022
7SQC
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BU of 7sqc by Molmil
Ciliary C1 central pair apparatus isolated from Chlamydomonas reinhardtii
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CPC1, Calmodulin, ...
Authors:Gui, M, Wang, X, Dutcher, S.K, Brown, A, Zhang, R.
Deposit date:2021-11-05
Release date:2022-04-13
Last modified:2022-06-08
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Ciliary central apparatus structure reveals mechanisms of microtubule patterning.
Nat.Struct.Mol.Biol., 29, 2022
7SJ9
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BU of 7sj9 by Molmil
13pf E254A microtubule from recombinant human tubulin decorated with EB3
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Microtubule-associated protein RP/EB family member 3, ...
Authors:LaFrance, B.J, Greber, B.J, Zhang, R, McCollum, C, Nogales, E.
Deposit date:2021-10-16
Release date:2022-01-19
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural transitions in the GTP cap visualized by cryo-electron microscopy of catalytically inactive microtubules.
Proc.Natl.Acad.Sci.USA, 119, 2022
7R94
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BU of 7r94 by Molmil
T-Plastin-F-actin complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ...
Authors:Mei, L, Alushin, G.M.
Deposit date:2021-06-28
Release date:2022-07-06
Last modified:2022-09-21
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural mechanism for bidirectional actin cross-linking by T-plastin.
Proc.Natl.Acad.Sci.USA, 119, 2022
7N6G
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BU of 7n6g by Molmil
C1 of central pair
Descriptor: CPC1, Calmodulin, DPY30, ...
Authors:Han, L, Zhang, K.
Deposit date:2021-06-08
Release date:2022-05-18
Last modified:2022-06-01
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of an active central apparatus.
Nat.Struct.Mol.Biol., 29, 2022
7ANK
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BU of 7ank by Molmil
Crystal structure of sarcomeric protein FATZ-1 (d91-FATZ-1 construct) in complex with half dimer of alpha-actinin-2
Descriptor: Alpha-actinin-2, Myozenin-1
Authors:Sponga, A, Arolas, J.L, Rodriguez Chamorro, A, Mlynek, G, Hollerl, E, Schreiner, C, Pedron, M, Kostan, J, Ribeiro, E.A, Djinovic-Carugo, K.
Deposit date:2020-10-12
Release date:2021-06-30
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.204 Å)
Cite:Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with alpha-actinin.
Sci Adv, 7, 2021
6ZSH
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BU of 6zsh by Molmil
The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members
Descriptor: EH domain-binding protein 1
Authors:Rai, A, Bleimling, N, Vetter, I.R, Goody, R.S.
Deposit date:2020-07-15
Release date:2020-09-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members.
Nat Commun, 11, 2020
6M5G
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BU of 6m5g by Molmil
F-actin-Utrophin complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ...
Authors:Kumari, A, Ragunath, V.K, Sirajuddin, M.
Deposit date:2020-03-10
Release date:2020-05-20
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural insights into actin filament recognition by commonly used cellular actin markers.
Embo J., 39, 2020
6VEC
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BU of 6vec by Molmil
Cryo-EM structure of F-actin/Plastin2-ABD2 complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ...
Authors:Zheng, W, Kudryashov, D.S, Egelman, E.H.
Deposit date:2019-12-31
Release date:2020-12-09
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Osteogenesis imperfecta mutations in plastin 3 lead to impaired calcium regulation of actin bundling.
Bone Res, 8, 2020
6SWT
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BU of 6swt by Molmil
Affimer9 co-crystalised with the CH domains of alpha actinin 2.
Descriptor: Affimer 9, Alpha-actinin-2
Authors:Peckham, M, Trinh, C.H, Rogers, B.
Deposit date:2019-09-23
Release date:2020-10-07
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Nanoscale Pattern Extraction from Relative Positions of Sparse 3D Localizations.
Nano Lett., 21, 2021
6SL3
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BU of 6sl3 by Molmil
ALPHA-ACTININ FROM ENTAMOEBA HISTOLYTICA in orthorhombic space group
Descriptor: CALCIUM ION, Calponin homology domain protein putative
Authors:Pinotsis, N, Khan, M.B, Djinovic-Carugo, K.
Deposit date:2019-08-18
Release date:2020-08-26
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Calcium modulates the domain flexibility and function of an alpha-actinin similar to the ancestral alpha-actinin.
Proc.Natl.Acad.Sci.USA, 117, 2020
6SL2
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BU of 6sl2 by Molmil
ALPHA-ACTININ FROM ENTAMOEBA HISTOLYTICA
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Calponin homology domain protein putative, ...
Authors:Pinotsis, N, Khan, M.B, Djinovic-Carugo, K.
Deposit date:2019-08-18
Release date:2020-08-26
Last modified:2020-11-04
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Calcium modulates the domain flexibility and function of an alpha-actinin similar to the ancestral alpha-actinin.
Proc.Natl.Acad.Sci.USA, 117, 2020
6SL7
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BU of 6sl7 by Molmil
The Delta Calcium mutant of ALPHA-ACTININ FROM ENTAMOEBA HISTOLYTICA
Descriptor: Calponin homology domain protein putative
Authors:Pinotsis, N, Lopez Arolas, A, Djinovic-Carugo, K.
Deposit date:2019-08-18
Release date:2020-08-26
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Calcium modulates the domain flexibility and function of an alpha-actinin similar to the ancestral alpha-actinin.
Proc.Natl.Acad.Sci.USA, 117, 2020
6OA6
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BU of 6oa6 by Molmil
CRYSTAL STRUCTURE OF THE ACTIN-BINDING DOMAIN OF HUMAN ALPHA-ACTININ-4
Descriptor: Alpha-actinin-4, GLYCEROL
Authors:Birrane, G, Feng, D.
Deposit date:2019-03-15
Release date:2020-03-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis.
J. Am. Soc. Nephrol., 31, 2020
6O31
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BU of 6o31 by Molmil
CRYSTAL STRUCTURE OF THE ACTIN-BINDING DOMAIN OF HUMAN ALPHA-ACTININ-4
Descriptor: Alpha-actinin-4
Authors:Birrane, G, Feng, D.
Deposit date:2019-02-25
Release date:2020-02-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis.
J. Am. Soc. Nephrol., 31, 2020
6NF1
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BU of 6nf1 by Molmil
Vav1 inhibited by an allosteric inhibitor: Vav1 inhibitors block GEF activity
Descriptor: (2S)-3-[(3S)-1-(ethylsulfonyl)piperidin-3-yl]-2-{[3-(4-methylphenyl)imidazo[1,2-a]pyrazin-8-yl]amino}propan-1-ol, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Proto-oncogene vav, ...
Authors:Knapp, M.S, Elling, R.A, Ornelas, E.
Deposit date:2018-12-18
Release date:2019-12-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Allosteric Inhibitors of VAV1 Block Guanine Nucleotide Exchange Activity
To Be Published
6MIB
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BU of 6mib by Molmil
Crystal structure of the ILK ATP-binding deficient mutant (L207W)/alpha-parvin core complex
Descriptor: Alpha-parvin, Integrin-linked protein kinase
Authors:Fukuda, K, Qin, J.
Deposit date:2018-09-19
Release date:2018-11-07
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Non-catalytic signaling by pseudokinase ILK for regulating cell adhesion.
Nat Commun, 9, 2018
6ICI
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BU of 6ici by Molmil
Crystal structure of human MICAL3
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, [F-actin]-monooxygenase MICAL3
Authors:Hwang, K.Y, Kim, J.S.
Deposit date:2018-09-06
Release date:2020-03-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and kinetic insights into flavin-containing monooxygenase and calponin-homology domains in human MICAL3.
Iucrj, 7, 2020
6D8C
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BU of 6d8c by Molmil
Cryo-EM structure of FLNaABD E254K bound to phalloidin-stabilized F-actin
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ...
Authors:Iwamoto, D.V, Huehn, A.R, Simon, B, Huet-Calderwood, C, Baldassarre, M, Sindelar, C.V, Calderwood, D.A.
Deposit date:2018-04-26
Release date:2018-09-19
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Structural basis of the filamin A actin-binding domain interaction with F-actin.
Nat. Struct. Mol. Biol., 25, 2018
6ANU
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BU of 6anu by Molmil
Cryo-EM structure of F-actin complexed with the beta-III-spectrin actin-binding domain
Descriptor: Actin, cytoplasmic 1, Spectrin beta chain, ...
Authors:Wang, F, Orlova, A, Avery, A.W, Hays, T.S, Egelman, E.H.
Deposit date:2017-08-14
Release date:2017-11-22
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (7 Å)
Cite:Structural basis for high-affinity actin binding revealed by a beta-III-spectrin SCA5 missense mutation.
Nat Commun, 8, 2017
5NL7
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BU of 5nl7 by Molmil
The crystal structure of the Actin Binding Domain (ABD) of alpha actinin from Entamoeba histolytica
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Calponin homology domain protein putative
Authors:Pinotsis, N, Djinovic-Carugo, K, Khan, M.B.
Deposit date:2017-04-04
Release date:2018-05-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Calcium modulates the domain flexibility and function of an alpha-actinin similar to the ancestral alpha-actinin.
Proc.Natl.Acad.Sci.USA, 117, 2020

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