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8I6Y
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BU of 8i6y by Molmil
Crystal structure of Arabidopsis thaliana LOX1
Descriptor: FE (III) ION, Linoleate 9S-lipoxygenase 1
Authors:Liu, X, Liu, L.
Deposit date:2023-01-30
Release date:2024-02-07
Method:X-RAY DIFFRACTION (3.26 Å)
Cite:UV-B light signal mediates stomatal closure by activating the 9-lipoxygenase pathway
To Be Published
8GHE
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BU of 8ghe by Molmil
The structure of h12-LOX in tetrameric form bound to endogenous inhibitor oleoyl-CoA
Descriptor: FE (II) ION, Polyunsaturated fatty acid lipoxygenase ALOX12, S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name)
Authors:Black, K.A, Mobbs, J.I, Venugopal, H, Thal, D.M, Glukhova, A.
Deposit date:2023-03-09
Release date:2023-08-09
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (2.05 Å)
Cite:Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors.
Blood, 142, 2023
8GHD
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BU of 8ghd by Molmil
The structure of h12-LOX in hexameric form bound to inhibitor ML355 and arachidonic acid
Descriptor: ARACHIDONIC ACID, FE (II) ION, N-(1,3-benzothiazol-2-yl)-4-{[(2-hydroxy-3-methoxyphenyl)methyl]amino}benzene-1-sulfonamide, ...
Authors:Black, K.A, Mobbs, J.I, Venugopal, H, Thal, D.M, Glukhova, A.
Deposit date:2023-03-09
Release date:2023-08-09
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors.
Blood, 142, 2023
8GHC
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BU of 8ghc by Molmil
The structure of h12-LOX in dimeric form
Descriptor: FE (II) ION, Polyunsaturated fatty acid lipoxygenase ALOX12
Authors:Black, K.A, Mobbs, J.I, Venugopal, H, Thal, D.M, Glukhova, A.
Deposit date:2023-03-09
Release date:2023-08-09
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors.
Blood, 142, 2023
8GHB
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BU of 8ghb by Molmil
The structure of h12-LOX in monomeric form
Descriptor: FE (II) ION, Polyunsaturated fatty acid lipoxygenase ALOX12
Authors:Black, K.A, Mobbs, J.I, Venugopal, H, Thal, D.M, Glukhova, A.
Deposit date:2023-03-09
Release date:2023-08-09
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors.
Blood, 142, 2023
7TTL
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BU of 7ttl by Molmil
Stable-5-LOX elongated Ha2 (4 copies ASU)
Descriptor: Arachidonate 5-lipoxygenase, FE (II) ION
Authors:Gilbert, N.C, Newcomer, M.E.
Deposit date:2022-02-01
Release date:2022-08-31
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Helical remodeling augments 5-lipoxygenase activity in the synthesis of proinflammatory mediators.
J.Biol.Chem., 298, 2022
7TTK
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BU of 7ttk by Molmil
Stable-5-LOX
Descriptor: Arachidonate 5-lipoxygenase, FE (II) ION
Authors:Gilbert, N.C, Newcomer, M.E.
Deposit date:2022-02-01
Release date:2023-02-15
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Stable-5-LOX "closed"
To Be Published
7TTJ
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BU of 7ttj by Molmil
Stable-5-LOX elongated Ha2
Descriptor: Arachidonate 5-lipoxygenase, FE (II) ION
Authors:Gilbert, N.C, Newcomer, M.E.
Deposit date:2022-02-01
Release date:2022-08-31
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Helical remodeling augments 5-lipoxygenase activity in the synthesis of proinflammatory mediators.
J.Biol.Chem., 298, 2022
7SOJ
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BU of 7soj by Molmil
Structure of V750A Soybean Lipoxygenase at 277K
Descriptor: FE (III) ION, Lipoxygenase
Authors:Gee, C.L, Offenbacher, A.R, Hu, S.
Deposit date:2021-10-31
Release date:2022-11-02
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Temporal and spatial resolution of distal protein motions that activate hydrogen tunneling in soybean lipoxygenase.
Proc.Natl.Acad.Sci.USA, 120, 2023
7SOI
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BU of 7soi by Molmil
Structure of I552A Soybean Lipoxygenase at 277K
Descriptor: FE (III) ION, Lipoxygenase, SODIUM ION
Authors:Gee, C.L, Offenbacher, A.R, Hu, S.
Deposit date:2021-10-31
Release date:2022-11-09
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Temporal and spatial resolution of distal protein motions that activate hydrogen tunneling in soybean lipoxygenase.
Proc.Natl.Acad.Sci.USA, 120, 2023
7LAF
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BU of 7laf by Molmil
15-lipoxygenase-2 loop mutant bound to imidazole-based inhibitor
Descriptor: 3-{[(4-methylphenyl)methyl]sulfanyl}-1-phenyl-1H-1,2,4-triazole, MANGANESE (II) ION, Polyunsaturated fatty acid lipoxygenase ALOX15B
Authors:Newcomer, M.E, Gilbert, N.C, Neau, D.B.
Deposit date:2021-01-06
Release date:2022-01-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
Bioorg.Med.Chem., 46, 2021
6NS6
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BU of 6ns6 by Molmil
Crystal structure of fungal lipoxygenase from Fusarium graminearum. P21 crystal form.
Descriptor: FE (II) ION, lipoxygenase
Authors:Pakhomova, S, Boeglin, W.E, Neau, D.B, Bartlett, S.G, Brash, A.R, Newcomer, M.E.
Deposit date:2019-01-24
Release date:2019-03-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere.
Protein Sci., 28, 2019
6NS5
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BU of 6ns5 by Molmil
Crystal structure of fungal lipoxygenase from Fusarium graminearum. Second C2 crystal form.
Descriptor: FE (II) ION, lipoxygenase
Authors:Pakhomova, S, Boeglin, W.E, Neau, D.B, Bartlett, S.G, Brash, A.R, Newcomer, M.E.
Deposit date:2019-01-24
Release date:2019-03-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere.
Protein Sci., 28, 2019
6NS4
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BU of 6ns4 by Molmil
Crystal structure of fungal lipoxygenase from Fusarium graminearum. C2 crystal form.
Descriptor: ACETATE ION, FE (II) ION, GLYCEROL, ...
Authors:Pakhomova, S, Boeglin, W.E, Neau, D.B, Bartlett, S.G, Brash, A.R, Newcomer, M.E.
Deposit date:2019-01-24
Release date:2019-03-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere.
Protein Sci., 28, 2019
6NS3
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BU of 6ns3 by Molmil
Crystal structure of fungal lipoxygenase from Fusarium graminearum. I222 crystal form.
Descriptor: FE (II) ION, lipoxygenase
Authors:Pakhomova, S, Boeglin, W.E, Neau, D.B, Bartlett, S.G, Brash, A.R, Newcomer, M.E.
Deposit date:2019-01-24
Release date:2019-03-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere.
Protein Sci., 28, 2019
6NS2
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BU of 6ns2 by Molmil
Crystal structure of fungal lipoxygenase from Fusarium graminearum. P212121 crystal form.
Descriptor: FE (II) ION, lipoxygenase
Authors:Pakhomova, S, Boeglin, W.E, Neau, D.B, Bartlett, S.G, Brash, A.R, Newcomer, M.E.
Deposit date:2019-01-24
Release date:2019-03-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere.
Protein Sci., 28, 2019
6NCF
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BU of 6ncf by Molmil
The structure of Stable-5-Lipoxygenase bound to AKBA
Descriptor: (3alpha,8alpha,17alpha,18alpha)-3-(acetyloxy)-11-oxours-12-en-23-oic acid, Arachidonate 5-lipoxygenase, FE (II) ION
Authors:Newcomer, M.E, Gilbert, N.C, Neau, D.B.
Deposit date:2018-12-11
Release date:2020-05-13
Last modified:2020-07-08
Method:X-RAY DIFFRACTION (2.871 Å)
Cite:Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products.
Nat.Chem.Biol., 16, 2020
6N2W
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BU of 6n2w by Molmil
The structure of Stable-5-Lipoxygenase bound to NDGA
Descriptor: 4-[(2R,3S)-3-[(3,4-DIHYDROXYPHENYL)METHYL]-2-METHYLBUTYL]BENZENE-1,2-DIOL, Arachidonate 5-lipoxygenase, FE (II) ION
Authors:Newcomer, M.E, Gilbert, N.C, Neau, D.B.
Deposit date:2018-11-14
Release date:2020-05-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products.
Nat.Chem.Biol., 16, 2020
5TR0
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BU of 5tr0 by Molmil
Lipoxygenase-1 (soybean) L754A mutant at 293K
Descriptor: FE (II) ION, Seed linoleate 13S-lipoxygenase-1
Authors:Poss, E.M, Fraser, J.S.
Deposit date:2016-10-24
Release date:2017-11-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The "Undoing" of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network.
J.Am.Chem.Soc., 141, 2019
5TQP
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BU of 5tqp by Molmil
LIPOXYGENASE-1 (SOYBEAN) I553G MUTANT AT 300K
Descriptor: FE (III) ION, Seed linoleate 13S-lipoxygenase-1
Authors:Poss, E.M, Fraser, J.S.
Deposit date:2016-10-24
Release date:2017-11-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Hydrogen-Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron Tunneling.
ACS Cent Sci, 3, 2017
5TQO
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BU of 5tqo by Molmil
Lipoxygenase-1 (soybean) L546A/L754A mutant at 300K
Descriptor: FE (III) ION, Seed linoleate 13S-lipoxygenase-1
Authors:Poss, E.M, Fraser, J.S, Gee, C.
Deposit date:2016-10-24
Release date:2017-11-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The "Undoing" of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network.
J.Am.Chem.Soc., 141, 2019
5TQN
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BU of 5tqn by Molmil
Lipoxygenase-1 (soybean) L546A mutant at 293K
Descriptor: FE (II) ION, Seed linoleate 13S-lipoxygenase-1
Authors:Poss, E.M, Fraser, J.S, Gee, C.
Deposit date:2016-10-24
Release date:2017-11-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The "Undoing" of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network.
J.Am.Chem.Soc., 141, 2019
5T5V
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BU of 5t5v by Molmil
LIPOXYGENASE-1 (SOYBEAN) AT 293K
Descriptor: FE (III) ION, Seed linoleate 13S-lipoxygenase-1
Authors:Poss, E.M, Fraser, J.S.
Deposit date:2016-08-31
Release date:2017-09-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Hydrogen-Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron Tunneling.
ACS Cent Sci, 3, 2017
5MEG
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BU of 5meg by Molmil
Manganese-substituted Cyanothece lipoxygenase 2 (Mn-CspLOX2)
Descriptor: Arachidonate 15-lipoxygenase, CHLORIDE ION, ETHANOL, ...
Authors:Newie, J, Neumann, P, Werner, M, Mata, R.A, Ficner, R, Feussner, I.
Deposit date:2016-11-14
Release date:2017-05-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Lipoxygenase 2 from Cyanothece sp. controls dioxygen insertion by steric shielding and substrate fixation.
Sci Rep, 7, 2017
5MEF
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BU of 5mef by Molmil
Cyanothece lipoxygenase 2 (CspLOX2) variant - L304F
Descriptor: Arachidonate 15-lipoxygenase, CHLORIDE ION, FE (III) ION, ...
Authors:Newie, J, Neumann, P, Werner, M, Mata, R.A, Ficner, R, Feussner, I.
Deposit date:2016-11-14
Release date:2017-05-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.357 Å)
Cite:Lipoxygenase 2 from Cyanothece sp. controls dioxygen insertion by steric shielding and substrate fixation.
Sci Rep, 7, 2017

 

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