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3TMS	PLASTIC ADAPTATION TOWARD MUTATIONS IN PROTEINS: STRUCTURAL COMPARISON OF THYMIDYLATE SYNTHASES Descriptor: PHOSPHATE ION, THYMIDYLATE SYNTHASE Authors: Perry, K.M, Stroud, R.M. Deposit date: 1991-09-19 Release date: 1991-10-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases. Proteins, 8, 1990
2TSC	STRUCTURE, MULTIPLE SITE BINDING, AND SEGMENTAL ACCOMODATION IN THYMIDYLATE SYNTHASE ON BINDING D/UMP AND AN ANTI-FOLATE Descriptor: 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE Authors: Montfort, W.R, Stroud, R.M. Deposit date: 1991-07-03 Release date: 1991-10-15 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate. Biochemistry, 29, 1990
4TMS	PLASTIC ADAPTATION TOWARD MUTATIONS IN PROTEINS: STRUCTURAL COMPARISON OF THYMIDYLATE SYNTHASES Descriptor: PHOSPHATE ION, THYMIDYLATE SYNTHASE Authors: Finer-Moore, J, Stroud, R. Deposit date: 1992-01-07 Release date: 1992-01-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases. Proteins, 8, 1990
2TDD	STRUCTURES OF THYMIDYLATE SYNTHASE WITH A C-TERMINAL DELETION: ROLE OF THE C-TERMINUS IN ALIGNMENT OF D/UMP AND CH2H4FOLATE Descriptor: 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, 5-HYDROXYMETHYLENE-6-HYDROFOLIC ACID, THYMIDYLATE SYNTHASE Authors: Perry, K.M, Carreras, C.W, Chang, L.C, Santi, D.V, Stroud, R.M. Deposit date: 1993-04-05 Release date: 1993-07-15 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate. Biochemistry, 32, 1993
1TDC	STRUCTURES OF THYMIDYLATE SYNTHASE WITH A C-TERMINAL DELETION: ROLE OF THE C-TERMINUS IN ALIGNMENT OF D/UMP AND CH2H4FOLATE Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE Authors: Perry, K.M, Carreras, C.W, Chang, L.C, Santi, D.V, Stroud, R.M. Deposit date: 1993-02-15 Release date: 1993-07-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate. Biochemistry, 32, 1993
1TDB	STRUCTURES OF THYMIDYLATE SYNTHASE WITH A C-TERMINAL DELETION: ROLE OF THE C-TERMINUS IN ALIGNMENT OF D/UMP AND CH2H4FOLATE Descriptor: 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE Authors: Perry, K.M, Carreras, C.W, Chang, L.C, Santi, D.V, Stroud, R.M. Deposit date: 1993-02-15 Release date: 1993-07-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate. Biochemistry, 32, 1993
1TDA	STRUCTURES OF THYMIDYLATE SYNTHASE WITH A C-TERMINAL DELETION: ROLE OF THE C-TERMINUS IN ALIGNMENT OF D/UMP AND CH2H4FOLATE Descriptor: PHOSPHATE ION, THYMIDYLATE SYNTHASE Authors: Perry, K.M, Carreras, C.W, Chang, L.C, Santi, D.V, Stroud, R.M. Deposit date: 1993-02-15 Release date: 1993-07-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (3.09 Å) Cite: Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate. Biochemistry, 32, 1993
1THY	REFINED STRUCTURES OF SUBSTRATE-BOUND AND PHOSPHATE-BOUND THYMIDYLATE SYNTHASE FROM LACTOBACILLUS CASEI Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE Authors: Finer-Moore, J, Stroud, R. Deposit date: 1993-04-02 Release date: 1993-10-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei. J.Mol.Biol., 232, 1993
2BBQ	STRUCTURAL BASIS FOR RECOGNITION OF POLYGLUTAMYL FOLATES BY THYMIDYLATE SYNTHASE Descriptor: 10-PARPARGYL-5,8-DIDEAZAFOLATE-4-GLUTAMIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE Authors: Kamb, A, Finer-Moore, J, Stroud, R.M. Deposit date: 1992-09-16 Release date: 1994-01-31 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for recognition of polyglutamyl folates by thymidylate synthase. Biochemistry, 31, 1992
1TIS	CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE FROM T4 PHAGE Descriptor: PHOSPHATE ION, THYMIDYLATE SYNTHASE Authors: Finer-Moore, J, Stroud, R. Deposit date: 1994-01-24 Release date: 1994-04-30 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal structure of thymidylate synthase from T4 phage: component of a deoxynucleoside triphosphate-synthesizing complex. Biochemistry, 33, 1994
1TYS	WATER-MEDIATED SUBSTRATE(SLASH)PRODUCT DISCRIMINATION: THE PRODUCT COMPLEX OF THYMIDYLATE SYNTHASE AT 1.83 ANGSTROMS Descriptor: DIHYDROFOLIC ACID, THYMIDINE-5'-PHOSPHATE, THYMIDYLATE SYNTHASE Authors: Fauman, E, Rutenber, E, Stroud, R. Deposit date: 1993-05-07 Release date: 1994-06-22 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Water-mediated substrate/product discrimination: the product complex of thymidylate synthase at 1.83 A. Biochemistry, 33, 1994
1TLC	THYMIDYLATE SYNTHASE COMPLEXED WITH DGMP AND FOLATE ANALOG 1843U89 Descriptor: 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN-9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID, THYMIDYLATE SYNTHASE Authors: Weichsel, A, Montfort, W.R, Ciesla, J, Maley, F. Deposit date: 1995-03-07 Release date: 1995-06-03 Last modified: 2018-04-18 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89. Proc.Natl.Acad.Sci.USA, 92, 1995
1LCB	LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DTMP AND H2FOLATE Descriptor: DIHYDROFOLIC ACID, THYMIDINE-5'-PHOSPHATE, THYMIDYLATE SYNTHASE Authors: Birdsall, D.L, Finer-Moore, J, Stroud, R.M. Deposit date: 1995-06-22 Release date: 1995-10-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei. J.Mol.Biol., 232, 1993
1LCE	LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DUMP AND CH2THF Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5,10-METHYLENE-6-HYDROFOLIC ACID, THYMIDYLATE SYNTHASE Authors: Birdsall, D.L, Finer-Moore, J, Stroud, R.M. Deposit date: 1995-06-22 Release date: 1995-10-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei. J.Mol.Biol., 232, 1993
1LCA	LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DUMP AND CB3717 Descriptor: 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE Authors: Birdsall, D.L, Finer-Moore, J, Stroud, R.M. Deposit date: 1995-06-22 Release date: 1995-10-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei. J.Mol.Biol., 232, 1993
1SYN	E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH BW1843U89 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN-9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID, THYMIDYLATE SYNTHASE Authors: Stout, T.J, Stroud, R.M. Deposit date: 1995-09-19 Release date: 1996-01-29 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2 Å) Cite: The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition. Structure, 4, 1996
1TSD	THYMIDYLATE SYNTHASE COMPLEX WITH 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) AND FOLATE ANALOG 1843U89 Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, BETA-MERCAPTOETHANOL, S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN-9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID, ... Authors: Weichsel, A, Montfort, W.R. Deposit date: 1995-08-15 Release date: 1996-01-29 Last modified: 2018-04-18 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Ligand-induced distortion of an active site in thymidylate synthase upon binding anticancer drug 1843U89. Nat.Struct.Biol., 2, 1995
1TSX	THYMIDYLATE SYNTHASE R179E MUTANT Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE Authors: Finer-Moore, J, Stroud, R.M. Deposit date: 1995-12-05 Release date: 1996-03-08 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase. Protein Eng., 9, 1996
1TSZ	THYMIDYLATE SYNTHASE R179K MUTANT Descriptor: PHOSPHATE ION, THYMIDYLATE SYNTHASE Authors: Finer-Moore, J, Stroud, R.M. Deposit date: 1995-12-05 Release date: 1996-03-08 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase. Protein Eng., 9, 1996
1TSW	THYMIDYLATE SYNTHASE R179A MUTANT Descriptor: PHOSPHATE ION, THYMIDYLATE SYNTHASE Authors: Finer-Moore, J, Stroud, R.M. Deposit date: 1995-12-05 Release date: 1996-03-08 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase. Protein Eng., 9, 1996
1TSV	THYMIDYLATE SYNTHASE R179A MUTANT Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE Authors: Finer-Moore, J, Stroud, R.M. Deposit date: 1995-12-05 Release date: 1996-03-08 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase. Protein Eng., 9, 1996
1TSY	THYMIDYLATE SYNTHASE R179K MUTANT Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE Authors: Finer-Moore, J, Stroud, R.M. Deposit date: 1995-12-05 Release date: 1996-03-08 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase. Protein Eng., 9, 1996
1NJE	THYMIDYLATE SYNTHASE WITH 2'-DEOXYCYTIDINE 5'-MONOPHOSPHATE (DCMP) Descriptor: 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE Authors: Finer-Moore, J, Stroud, R.M. Deposit date: 1996-01-23 Release date: 1996-07-11 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase. Biochemistry, 35, 1996
1NJD	THYMIDYLATE SYNTHASE, MUTATION, N229D WITH 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE Authors: Finer-Moore, J, Stroud, R.M. Deposit date: 1996-01-23 Release date: 1996-07-11 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase. Biochemistry, 35, 1996
1NJC	THYMIDYLATE SYNTHASE, MUTATION, N229D WITH 2'-DEOXYCYTIDINE 5'-MONOPHOSPHATE (DCMP) Descriptor: 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE Authors: Finer-Moore, J, Stroud, R.M. Deposit date: 1996-01-23 Release date: 1996-07-11 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase. Biochemistry, 35, 1996

 

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