1AIQ
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CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE R126E MUTANT
Descriptor:THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID
Authors:Strop, P., Montfort, W.R.
Deposit date:1997-04-23
Release date:1997-11-12
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of a marginally active thymidylate synthase mutant, Arg 126-->Glu.
Protein Sci., 6, 1997
1AJM
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CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE R126E MUTANT
Descriptor:THYMIDYLATE SYNTHASE
Authors:Strop, P., Montfort, W.R.
Deposit date:1997-05-06
Release date:1997-11-12
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of a marginally active thymidylate synthase mutant, Arg 126-->Glu.
Protein Sci., 6, 1997
1AN5
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E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH CB3717
Descriptor:THYMIDYLATE SYNTHASE, PHOSPHATE ION, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID
Authors:Stout, T.J., Sage, C.R., Stroud, R.M.
Deposit date:1997-06-26
Release date:1998-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The additivity of substrate fragments in enzyme-ligand binding.
Structure, 6, 1998
1AOB
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E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH DDURD
Descriptor:THYMIDYLATE SYNTHASE, PHOSPHATE ION, 2'-5'DIDEOXYURIDINE, ...
Authors:Stout, T.J., Sage, C.R., Stroud, R.M.
Deposit date:1997-06-30
Release date:1998-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The additivity of substrate fragments in enzyme-ligand binding.
Structure, 6, 1998
1AXW
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E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH METHOTREXATE (MTX) AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)
Descriptor:THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, METHOTREXATE
Authors:Stout, T.J., Sage, C.R., Stroud, R.M.
Deposit date:1997-10-23
Release date:1998-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of Thymidylate Synthase Inhibitors Using Flexible Docking and an Empirically Tuned Scoring Function
To be Published
1B02
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CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE A FROM BACILLUS SUBTILIS
Descriptor:PROTEIN (THYMIDYLATE SYNTHASE), 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID
Authors:Fox, K.M., Maley, F., Garibian, A., Changchien, L., Vanroey, P.
Deposit date:1998-11-16
Release date:1999-03-29
Last modified:2014-01-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of thymidylate synthase A from Bacillus subtilis.
Protein Sci., 8, 1999
1B49
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DCMP HYDROXYMETHYLASE FROM T4 (PHOSPHATE-BOUND)
Descriptor:PROTEIN (DEOXYCYTIDYLATE HYDROXYMETHYLASE), PHOSPHATE ION
Authors:Song, H.K., Sohn, S.H., Suh, S.W.
Deposit date:1999-01-06
Release date:1999-01-13
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of deoxycytidylate hydroxymethylase from bacteriophage T4, a component of the deoxyribonucleoside triphosphate-synthesizing complex.
EMBO J., 18, 1999
1B5D
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DCMP HYDROXYMETHYLASE FROM T4 (INTACT)
Descriptor:PROTEIN (DEOXYCYTIDYLATE HYDROXYMETHYLASE), 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE
Authors:Song, H.K., Sohn, S.H., Suh, S.W.
Deposit date:1999-01-06
Release date:1999-01-13
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of deoxycytidylate hydroxymethylase from bacteriophage T4, a component of the deoxyribonucleoside triphosphate-synthesizing complex.
EMBO J., 18, 1999
1B5E
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DCMP HYDROXYMETHYLASE FROM T4
Descriptor:PROTEIN (DEOXYCYTIDYLATE HYDROXYMETHYLASE), 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE
Authors:Song, H.K., Sohn, S.H., Suh, S.W.
Deposit date:1999-01-06
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of deoxycytidylate hydroxymethylase from bacteriophage T4, a component of the deoxyribonucleoside triphosphate-synthesizing complex.
EMBO J., 18, 1999
1BDU
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E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH DURD
Descriptor:THYMIDYLATE SYNTHASE, PHOSPHATE ION, 2'-DEOXYURIDINE
Authors:Stout, T.J., Sage, C.R., Stroud, R.M.
Deposit date:1997-06-27
Release date:1998-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The additivity of substrate fragments in enzyme-ligand binding.
Structure, 6, 1998
1BID
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E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH DUMP
Descriptor:THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE
Authors:Stout, T.J., Sage, C.R., Stroud, R.M.
Deposit date:1997-06-27
Release date:1998-07-01
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The additivity of substrate fragments in enzyme-ligand binding.
Structure, 6, 1998
1BJG
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D221(169)N MUTANT DOES NOT PROMOTE OPENING OF THE COFACTOR IMIDAZOLIDINE RING
Descriptor:THYMIDYLATE SYNTHASE, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, 5,10-METHYLENE-6-HYDROFOLIC ACID
Authors:Sage, C.R., Michelitsch, M.D., Finer-Moore, J., Stroud, R.M.
Deposit date:1998-06-25
Release date:1998-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine.
Biochemistry, 37, 1998
1BKO
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THERMOSTABLE THYMIDYLATE SYNTHASE A FROM BACILLUS SUBTILIS
Descriptor:THYMIDYLATE SYNTHASE A
Authors:Stout, T.J., Schellenberger, U., Santi, D.V., Stroud, R.M.
Deposit date:1998-07-09
Release date:1999-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal structures of a unique thermal-stable thymidylate synthase from Bacillus subtilis.
Biochemistry, 37, 1998
1BKP
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THERMOSTABLE THYMIDYLATE SYNTHASE A FROM BACILLUS SUBTILIS
Descriptor:THYMIDYLATE SYNTHASE A
Authors:Stout, T.J., Schellenberger, U., Santi, D.V., Stroud, R.M.
Deposit date:1998-07-09
Release date:1999-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structures of a unique thermal-stable thymidylate synthase from Bacillus subtilis.
Biochemistry, 37, 1998
1BO7
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THYMIDYLATE SYNTHASE R179T MUTANT
Descriptor:PROTEIN (THYMIDYLATE SYNTHASE), URIDINE-5'-MONOPHOSPHATE
Authors:Morse, R., Finer-Moore, J., Stroud, R.M.
Deposit date:1998-08-10
Release date:1998-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry, 39, 2000
1BO8
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THYMIDYLATE SYNTHASE R178T MUTANT
Descriptor:PROTEIN (THYMIDYLATE SYNTHASE), POTASSIUM ION, URIDINE-5'-MONOPHOSPHATE
Authors:Morse, R., Finer-Moore, J., Stroud, R.M.
Deposit date:1998-08-10
Release date:1998-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry, 39, 2000
1BP0
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THYMIDYLATE SYNTHASE R23I MUTANT
Descriptor:PROTEIN (THYMIDYLATE SYNTHASE), POTASSIUM ION, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE
Authors:Morse, R., Finer-Moore, J., Stroud, R.M.
Deposit date:1998-08-11
Release date:2000-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry, 39, 2000
1BP6
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THYMIDYLATE SYNTHASE R23I, R179T DOUBLE MUTANT
Descriptor:PROTEIN (THYMIDYLATE SYNTHASE), POTASSIUM ION, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE
Authors:Morse, R.J., Finer-Moore, J.S., Stroud, R.M.
Deposit date:1998-08-13
Release date:1998-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry, 39, 2000
1BPJ
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THYMIDYLATE SYNTHASE R178T, R179T DOUBLE MUTANT
Descriptor:PROTEIN (THYMIDYLATE SYNTHASE), POTASSIUM ION, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE
Authors:Morse, R.J., Finer-Moore, J.S., Stroud, R.M.
Deposit date:1998-08-11
Release date:1998-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry, 39, 2000
1BQ1
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E. COLI THYMIDYLATE SYNTHASE MUTANT N177A IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)
Descriptor:THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID
Authors:Reyes, C.L., Sage, C.R., Rutenber, E.E., Finer-Moore, J.S., Stroud, R.M.
Deposit date:1998-08-20
Release date:1999-05-18
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Inactivity of N229A thymidylate synthase due to water-mediated effects: isolating a late stage in methyl transfer.
J.Mol.Biol., 284, 1998
1BQ2
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E. COLI THYMIDYLATE SYNTHASE MUTANT N177A
Descriptor:THYMIDYLATE SYNTHASE, PHOSPHATE ION
Authors:Reyes, C.L., Sage, C.R., Rutenber, E.E., Finer-Moore, J.S., Stroud, R.M.
Deposit date:1998-08-20
Release date:1999-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Inactivity of N229A thymidylate synthase due to water-mediated effects: isolating a late stage in methyl transfer.
J.Mol.Biol., 284, 1998
1BSF
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THERMOSTABLE THYMIDYLATE SYNTHASE A FROM BACILLUS SUBTILIS
Descriptor:THYMIDYLATE SYNTHASE A
Authors:Stout, T.J., Schellenberger, U., Santi, D.V., Stroud, R.M.
Deposit date:1998-07-10
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of a unique thermal-stable thymidylate synthase from Bacillus subtilis.
Biochemistry, 37, 1998
1BSP
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THERMOSTABLE THYMIDYLATE SYNTHASE A FROM BACILLUS SUBTILIS
Descriptor:THYMIDYLATE SYNTHASE A, PHOSPHATE ION
Authors:Stout, T.J., Schellenberger, U., Santi, D.V., Stroud, R.M.
Deposit date:1998-07-09
Release date:1999-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of a unique thermal-stable thymidylate synthase from Bacillus subtilis.
Biochemistry, 37, 1998
1CI7
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TERNARY COMPLEX OF THYMIDYLATE SYNTHASE FROM PNEUMOCYSTIS CARINII
Descriptor:PROTEIN (THYMIDYLATE SYNTHASE), 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID
Authors:Anderson, A.C., O'Neil, R.H., Delano, W.L., Stroud, R.M.
Deposit date:1999-04-08
Release date:2000-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The structural mechanism for half-the-sites reactivity in an enzyme, thymidylate synthase, involves a relay of changes between subunits.
Biochemistry, 38, 1999
1DDU
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E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH CB3717 AND 2',5'-DIDEOXYURIDINE (DDURD)
Descriptor:THYMIDYLATE SYNTHASE, PHOSPHATE ION, 2'-5'DIDEOXYURIDINE, ...
Authors:Stout, T.J., Sage, C.R., Stroud, R.M.
Deposit date:1997-06-26
Release date:1998-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The additivity of substrate fragments in enzyme-ligand binding.
Structure, 6, 1998
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