1K47
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CRYSTAL STRUCTURE OF THE STREPTOCOCCUS PNEUMONIAE PHOSPHOMEVALONATE KINASE (PMK)
Descriptor:phosphomevalonate kinase
Authors:Romanowski, M.J., Bonanno, J.B., Burley, S.K., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2001-10-05
Release date:2002-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Crystal structure of the Streptococcus pneumoniae phosphomevalonate kinase, a member of the GHMP kinase superfamily.
Proteins, 47, 2002
2V2Q
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ISPE IN COMPLEX WITH LIGAND
Descriptor:4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE, BROMIDE ION, GLYCEROL, ...
Authors:Alphey, M.S., Hunter, W.N.
Deposit date:2007-06-06
Release date:2007-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Synthesis and Characterization of Cytidine Derivatives that Inhibit the Kinase Ispe of the Non-Mevalonate Pathway for Isoprenoid Biosynthesis.
Chemmedchem, 3, 2008
2V2V
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ISPE IN COMPLEX WITH LIGAND
Descriptor:4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL KINASE, SULFATE ION, GLYCEROL, ...
Authors:Alphey, M.S., Hunter, W.N.
Deposit date:2007-06-07
Release date:2007-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Synthesis and Characterization of Cytidine Derivatives that Inhibit the Kinase Ispe of the Non-Mevalonate Pathway for Isoprenoid Biosynthesis.
Chemmedchem, 3, 2008
2V2Z
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ISPE IN COMPLEX WITH ADP AND CDPME
Descriptor:4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL KINASE, 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Sgraja, T., Alphey, M.S., Hunter, W.N.
Deposit date:2007-06-08
Release date:2007-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Characterization of Aquifex Aeolicus 4-Diphosphocytidyl-2C-Methyl-D-Erythritol Kinase -Ligand Recognition in a Template for Antimicrobial Drug Discovery.
FEBS J., 275, 2008
2V34
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ISPE IN COMPLEX WITH CYTIDINE AND LIGAND
Descriptor:4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL KINASE, 4-AMINO-1-BETA-D-RIBOFURANOSYL-2(1H)-PYRIMIDINONE, CHLORIDE ION, ...
Authors:Sgraja, T., Alphey, M.S., Hunter, W.N.
Deposit date:2007-06-11
Release date:2007-06-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Characterization of Aquifex Aeolicus 4-Diphosphocytidyl-2C-Methyl-D-Erythritol Kinase -Ligand Recognition in a Template for Antimicrobial Drug Discovery.
FEBS J., 275, 2008
2V8P
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ISPE IN COMPLEX WITH ADP AND CDP
Descriptor:4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE, CYTIDINE-5'-DIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Sgraja, T., Alphey, M.S., Hunter, W.N.
Deposit date:2007-08-13
Release date:2007-08-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Characterization of Aquifex Aeolicus 4-Diphosphocytidyl-2C-Methyl-D-Erythritol Kinase -Ligand Recognition in a Template for Antimicrobial Drug Discovery.
FEBS J., 275, 2008
2VF3
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AQUIFEX AEOLICUS ISPE IN COMPLEX WITH LIGAND
Descriptor:4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL KINASE, ethyl {3-[4-amino-5-{3-[(cyclopropylsulfonyl)amino]prop-1-yn-1-yl}-2-oxopyrimidin-1(2H)-yl]oxetan-3-yl}acetate, PYROPHOSPHATE 2-, ...
Authors:Alphey, M.S., Hunter, W.N.
Deposit date:2007-10-30
Release date:2008-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Inhibitors of the Kinase Ispe: Structure-Activity Relationships and Co-Crystal Structure Analysis.
Org.Biomol.Chem., 6, 2008
3GON
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STREPTOCOCCUS PNEUMONIAE PHOSPHOMEVALONATE KINASE IN COMPLEX WITH PHOSPHOMEVALONATE AND AMPPNP
Descriptor:Phosphomevalonate kinase, (3R)-3-HYDROXY-3-METHYL-5-(PHOSPHONOOXY)PENTANOIC ACID, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Andreassi, J.L., Bilder, P.W., Vetting, M.W., Roderick, S.L., Leyh, T.S.
Deposit date:2009-03-19
Release date:2009-07-21
Last modified:2013-03-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the ternary complex of phosphomevalonate kinase: the enzyme and its family
Biochemistry, 48, 2009
5WAS
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CORYNEBACTERIUM GLUTAMICUM HYDROLYZED HOMOSERINE KINASE
Descriptor:Homoserine kinase, PHOSPHATE ION
Authors:Petit, C., Ronning, D.R.
Deposit date:2017-06-27
Release date:2018-02-07
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (1.799 Å)
Cite:Reduction of Feedback Inhibition in Homoserine Kinase (ThrB) ofCorynebacterium glutamicumEnhances l-Threonine Biosynthesis.
ACS Omega, 3, 2018
5WAT
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CORYNEBACTERIUM GLUTAMICUM FULL LENGTH HOMOSERINE KINASE
Descriptor:Homoserine kinase, PHOSPHATE ION, HEXAETHYLENE GLYCOL, ...
Authors:Petit, C., Ronning, D.R.
Deposit date:2017-06-27
Release date:2018-02-07
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (2.141 Å)
Cite:Reduction of Feedback Inhibition in Homoserine Kinase (ThrB) ofCorynebacterium glutamicumEnhances l-Threonine Biosynthesis.
ACS Omega, 3, 2018
6CYZ
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MYCOBACTERIAL HOMOSERINE KINASE THRB IN COMPLEX WITH AMPPNP
Descriptor:Homoserine kinase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, CHLORIDE ION
Authors:Li, J., Korotkov, K.V.
Deposit date:2018-04-07
Release date:2018-04-18
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Mycobacterial homoserine kinase ThrB
To Be Published
1FI4
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THE X-RAY CRYSTAL STRUCTURE OF MEVALONATE 5-DIPHOSPHATE DECARBOXYLASE AT 2.3 ANGSTROM RESOLUTION.
Descriptor:MEVALONATE 5-DIPHOSPHATE DECARBOXYLASE
Authors:Bonanno, J.B., Edo, C., Eswar, N., Pieper, U., Romanowski, M.J., Ilyin, V., Gerchman, S.E., Kycia, H., Studier, F.W., Sali, A., Burley, S.K., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2000-08-03
Release date:2001-03-21
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structural genomics of enzymes involved in sterol/isoprenoid biosynthesis.
Proc.Natl.Acad.Sci.USA, 98, 2001
1FWK
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CRYSTAL STRUCTURE OF HOMOSERINE KINASE COMPLEXED WITH ADP
Descriptor:HOMOSERINE KINASE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Zhou, T., Daugherty, M., Grishin, N.V., Osterman, A.L., Zhang, H.
Deposit date:2000-09-22
Release date:2000-12-20
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily.
Structure Fold.Des., 8, 2000
1FWL
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CRYSTAL STRUCTURE OF HOMOSERINE KINASE
Descriptor:HOMOSERINE KINASE
Authors:Zhou, T., Daugherty, M., Grishin, N.V., Osterman, A.L., Zhang, H.
Deposit date:2000-09-22
Release date:2000-12-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily.
Structure Fold.Des., 8, 2000
1H72
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CRYSTAL STRUCTURE OF HOMOSERINE KINASE COMPLEXED WITH HSE
Descriptor:HOMOSERINE KINASE, L-HOMOSERINE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Krishna, S.S., Zhou, T., Daugherty, M., Osterman, A.L., Zhang, H.
Deposit date:2001-07-02
Release date:2001-09-13
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for the Catalysis and Substrate Specificity of Homoserine Kinase
Biochemistry, 40, 2001
1H73
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CRYSTAL STRUCTURE OF HOMOSERINE KINASE COMPLEXED WITH THREONINE
Descriptor:HOMOSERINE KINASE, THREONINE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Krishna, S.S., Zhou, T., Daugherty, M., Osterman, A.L., Zhang, H.
Deposit date:2001-07-02
Release date:2001-09-13
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for the Catalysis and Substrate Specificity of Homoserine Kinase
Biochemistry, 40, 2001
1H74
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CRYSTAL STRUCTURE OF HOMOSERINE KINASE COMPLEXED WITH ILE
Descriptor:HOMOSERINE KINASE, ISOLEUCINE, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Krishna, S.S., Zhou, T., Daugherty, M., Osterman, A.L., Zhang, H.
Deposit date:2001-07-02
Release date:2001-11-28
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis for the Catalysis and Substrate Specificity of Homoserine Kinase
Biochemistry, 40, 2001
1KKH
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CRYSTAL STRUCTURE OF THE METHANOCOCCUS JANNASCHII MEVALONATE KINASE
Descriptor:Mevalonate Kinase, 1,4-DIETHYLENE DIOXIDE
Authors:Yang, D., Shipman, L.W., Roessner, C.A., Scott, A.I., Sacchettini, J.C.
Deposit date:2001-12-08
Release date:2002-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the Methanococcus jannaschii mevalonate kinase, a member of the GHMP kinase superfamily.
J.Biol.Chem., 277, 2002
1KVK
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THE STRUCTURE OF BINARY COMPLEX BETWEEN A MAMMALIAN MEVALONATE KINASE AND ATP: INSIGHTS INTO THE REACTION MECHANISM AND HUMAN INHERITED DISEASE
Descriptor:mevalonate kinase, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Fu, Z., Wang, M., Potter, D., Mizioko, H.M., Kim, J.J.
Deposit date:2002-01-26
Release date:2002-03-27
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Structure of a Binary complex between a Mammalian Mevalonate Kinase and ATP: Insights into the Reaction Mechanism and Human Inherited Disease
J.Biol.Chem., 277, 2002
1OJ4
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TERNARY COMPLEX OF 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE
Descriptor:4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE, 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Miallau, L., Alphey, M.S., Hunter, W.N.
Deposit date:2003-06-30
Release date:2003-07-31
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Biosynthesis of Isoprenoids: Crystal Structure of 4-Diphosphocytidyl-2C-Methyl-D-Erythritol Kinase
Proc.Natl.Acad.Sci.USA, 100, 2003
1PIE
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CRYSTAL STRUCTURE OF LACTOCOCCUS LACTIS GALACTOKINASE COMPLEXED WITH GALACTOSE
Descriptor:Galactokinase, ALPHA D-GALACTOSE, PHOSPHATE ION
Authors:Thoden, J.B., Holden, H.M.
Deposit date:2003-05-30
Release date:2003-09-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular Structure of Galactokinase
J.Biol.Chem., 278, 2003
1S4E
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PYROCOCCUS FURIOSUS GALACTOKINASE IN COMPLEX WITH GALACTOSE, ADP AND MAGNESIUM
Descriptor:Galactokinase, ALPHA D-GALACTOSE, MAGNESIUM ION, ...
Authors:Hartley, A., Glynn, S.E., Barynin, V., Baker, P.J., Sedelnikova, S.E., Verhees, C., de Geus, D., van der Oost, J., Timson, D.J., Reece, R.J., Rice, D.W.
Deposit date:2004-01-16
Release date:2004-04-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Substrate specificity and mechanism from the structure of Pyrococcus furiosus galactokinase
J.Mol.Biol., 337, 2004
1UEK
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CRYSTAL STRUCTURE OF 4-(CYTIDINE 5'-DIPHOSPHO)-2C-METHYL-D-ERYTHRITOL KINASE
Descriptor:4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol kinase
Authors:Wada, T., Kuramitsu, S., Yokoyama, S., Tame, J.R.H., Park, S.Y., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2003-05-17
Release date:2003-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of 4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase, an Enzyme in the Non-mevalonate Pathway of Isoprenoid Synthesis.
J.Biol.Chem., 278, 2003
1VIS
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CRYSTAL STRUCTURE OF MEVALONATE KINASE
Descriptor:Mevalonate kinase, 1,4-DIETHYLENE DIOXIDE
Authors:Structural GenomiX
Deposit date:2003-12-01
Release date:2003-12-30
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Structural analysis of a set of proteins resulting from a bacterial genomics project
Proteins, 60, 2005
1WUU
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CRYSTAL STRUCTURE OF HUMAN GALACTOKINASE COMPLEXED WITH MGAMPPNP AND GALACTOSE
Descriptor:Galactokinase, ALPHA D-GALACTOSE, MAGNESIUM ION, ...
Authors:Thoden, J.B., Timson, D.J., Reece, R.J., Holden, H.M.
Deposit date:2004-12-08
Release date:2004-12-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular Structure of Human Galactokinase: IMPLICATIONS FOR TYPE II GALACTOSEMIA
J.Biol.Chem., 280, 2005