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4W8I
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Crystal structure of LpSPL/Lpp2128, Legionella pneumophila sphingosine-1 phosphate lyase
Descriptor: Probable sphingosine-1-phosphate lyase
Authors:Stogios, P.J, Daniels, C, Skarina, T, Cuff, M, Di Leo, R, Savchenko, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2014-08-24
Release date:2014-11-05
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy.
Proc.Natl.Acad.Sci.USA, 113, 2016
5K1R
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BU of 5k1r by Molmil
Structure of Burkholderia pseudomallei K96243 sphingosine-1-phosphate lyase Bpss2021
Descriptor: Burkholderia pseudomallei sphingosine-1-phosphate lyase Bpss2021, PYRIDOXAL-5'-PHOSPHATE
Authors:Mclean, C.J, Campopiano, D.J, Marles-Wright, J.
Deposit date:2016-05-18
Release date:2016-11-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.104 Å)
Cite:Characterization of homologous sphingosine-1-phosphate lyase isoforms in the bacterial pathogen Burkholderia pseudomallei.
J. Lipid Res., 58, 2017
5O5C
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BU of 5o5c by Molmil
The crystal structure of DfoJ, the desferrioxamine biosynthetic pathway lysine decarboxylase from the fire blight disease pathogen Erwinia amylovora
Descriptor: PYRIDOXAL-5'-PHOSPHATE, Putative decarboxylase involved in desferrioxamine biosynthesis
Authors:Salomone-Stagni, M, Bartho, J.D, Polsinelli, I, Bellini, D, Walsh, M.A, Demitri, N, Benini, S.
Deposit date:2017-06-01
Release date:2018-02-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A complete structural characterization of the desferrioxamine E biosynthetic pathway from the fire blight pathogen Erwinia amylovora.
J. Struct. Biol., 202, 2018
4E1O
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BU of 4e1o by Molmil
Human histidine decarboxylase complex with Histidine methyl ester (HME)
Descriptor: HISTIDINE-METHYL-ESTER, Histidine decarboxylase, PYRIDOXAL-5'-PHOSPHATE
Authors:Komori, H, Nitta, Y, Ueno, H, Higuchi, Y.
Deposit date:2012-03-06
Release date:2012-07-18
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural study reveals that Ser-354 determines substrate specificity on human histidine decarboxylase
J.Biol.Chem., 287, 2012
2JIS
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BU of 2jis by Molmil
Human cysteine sulfinic acid decarboxylase (CSAD) in complex with PLP.
Descriptor: CYSTEINE SULFINIC ACID DECARBOXYLASE, NITRATE ION, PYRIDOXAL-5'-PHOSPHATE
Authors:Collins, R, Moche, M, Arrowsmith, C, Berglund, H, Busam, R, Dahlgren, L.G, Edwards, A, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Johansson, I, Kallas, A, Karlberg, T, Kotenyova, T, Lehtio, L, Nordlund, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Stenmark, P, Sundstrom, M, Thorsell, A.G, Tresaugues, L, van den Berg, S, Weigelt, J, Welin, M, Holmberg-Schiavone, L, Structural Genomics Consortium (SGC)
Deposit date:2007-06-30
Release date:2007-08-28
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The Crystal Structure of Human Cysteine Sulfinic Acid Decarboxylase (Csad)
To be Published
1XEY
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BU of 1xey by Molmil
Crystal structure of the complex of Escherichia coli GADA with glutarate at 2.05 A resolution
Descriptor: ACETATE ION, GLUTARIC ACID, Glutamate decarboxylase alpha, ...
Authors:Dutyshev, D.I, Darii, E.L, Fomenkova, N.P, Pechik, I.V, Polyakov, K.M, Nikonov, S.V, Andreeva, N.S, Sukhareva, B.S.
Deposit date:2004-09-13
Release date:2004-10-05
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure of Escherichia coli glutamate decarboxylase (GADalpha) in complex with glutarate at 2.05 angstroms resolution.
Acta Crystallogr.,Sect.D, 61, 2005
3F9T
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Crystal structure of L-tyrosine decarboxylase MfnA (EC 4.1.1.25) (NP_247014.1) from METHANOCOCCUS JANNASCHII at 2.11 A resolution
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, L-tyrosine decarboxylase MfnA, PYRIDOXAL-5'-PHOSPHATE
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2008-11-14
Release date:2008-11-25
Last modified:2023-02-01
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Crystal structure of L-tyrosine decarboxylase MfnA (EC 4.1.1.25) (NP_247014.1) from METHANOCOCCUS JANNASCHII at 2.11 A resolution
To be published
6ZEK
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BU of 6zek by Molmil
Crystal structure of mouse CSAD
Descriptor: CHLORIDE ION, COBALT (II) ION, Cysteine sulfinic acid decarboxylase, ...
Authors:Mahootchi, E, Raasakka, A, Haavik, J, Kursula, P.
Deposit date:2020-06-16
Release date:2021-04-28
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and substrate specificity determinants of the taurine biosynthetic enzyme cysteine sulphinic acid decarboxylase.
J.Struct.Biol., 213, 2021
8AYF
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BU of 8ayf by Molmil
Crystal structure of human Sphingosine-1-phosphate lyase 1
Descriptor: ACETATE ION, GLYCEROL, Sphingosine-1-phosphate lyase 1
Authors:Giardina, G, Catalano, F, Pampalone, G, Cellini, B.
Deposit date:2022-09-02
Release date:2023-09-13
Last modified:2024-01-03
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Dual species sphingosine-1-phosphate lyase inhibitors to combine antifungal and anti-inflammatory activities in cystic fibrosis: a feasibility study.
Sci Rep, 13, 2023
7A0A
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BU of 7a0a by Molmil
Crystal structure of mouse CSAD in apo form
Descriptor: Cysteine sulfinic acid decarboxylase, SODIUM ION, SULFATE ION
Authors:Mahootchi, E, Raasakka, A, Haavik, J, Kursula, P.
Deposit date:2020-08-07
Release date:2021-08-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The structure of cysteine sulphinic acid decarboxylase reveals structural determinants for substrate specificity of pyridoxal phosphate-dependent decarboxylases
To be published
8CMX
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BU of 8cmx by Molmil
Structure of sphingosine-1-phosphate lyase (SPL) from Aspergillus fumigatus
Descriptor: Sphinganine-1-phosphate aldolase BST1, putative
Authors:Catalano, F, Pampalone, G.
Deposit date:2023-02-21
Release date:2024-01-03
Method:X-RAY DIFFRACTION (3.46 Å)
Cite:Dual species sphingosine-1-phosphate lyase inhibitors to combine antifungal and anti-inflammatory activities in cystic fibrosis: a feasibility study.
Sci Rep, 13, 2023
8OR9
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BU of 8or9 by Molmil
Human holo aromatic L-amino acid decarboxylase (AADC) native structure at physiological pH
Descriptor: Dopa decarboxylase (Aromatic L-amino acid decarboxylase), PYRIDOXAL-5'-PHOSPHATE, TETRAETHYLENE GLYCOL
Authors:Bisello, G, Perduca, M, Bertoldi, M.
Deposit date:2023-04-13
Release date:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Human aromatic amino acid decarboxylase is an asymmetric and flexible enzyme: Implication in aromatic amino acid decarboxylase deficiency.
Protein Sci., 32, 2023
8ORA
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BU of 8ora by Molmil
Human holo aromatic L-amino acid decarboxylase (AADC) external aldimine with L-Dopa methylester
Descriptor: Dopa decarboxylase (Aromatic L-amino acid decarboxylase), PYRIDOXAL-5'-PHOSPHATE, TETRAETHYLENE GLYCOL, ...
Authors:Bisello, G, Perduca, M, Bertoldi, M.
Deposit date:2023-04-13
Release date:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Human aromatic amino acid decarboxylase is an asymmetric and flexible enzyme: Implication in aromatic amino acid decarboxylase deficiency.
Protein Sci., 32, 2023
1JS3
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Crystal structure of dopa decarboxylase in complex with the inhibitor carbidopa
Descriptor: CARBIDOPA, DOPA decarboxylase, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Burkhard, P, Dominici, P, Borri-Voltattorni, C, Jansonius, J.N, Malashkevich, V.N.
Deposit date:2001-08-16
Release date:2001-10-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase.
Nat.Struct.Biol., 8, 2001
1PMM
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BU of 1pmm by Molmil
Crystal structure of Escherichia coli GadB (low pH)
Descriptor: ACETIC ACID, Glutamate decarboxylase beta, PYRIDOXAL-5'-PHOSPHATE
Authors:Capitani, G, De Biase, D, Aurizi, C, Gut, H, Bossa, F, Grutter, M.G.
Deposit date:2003-06-11
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure and functional analysis of escherichia coli glutamate decarboxylase
Embo J., 22, 2003
1PMO
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BU of 1pmo by Molmil
Crystal structure of Escherichia coli GadB (neutral pH)
Descriptor: (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Glutamate decarboxylase beta
Authors:Capitani, G, De Biase, D, Aurizi, C, Gut, H, Bossa, F, Grutter, M.G.
Deposit date:2003-06-11
Release date:2004-02-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure and functional analysis of escherichia coli glutamate decarboxylase
Embo J., 22, 2003
1JS6
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BU of 1js6 by Molmil
Crystal Structure of DOPA decarboxylase
Descriptor: DOPA decarboxylase, PYRIDOXAL-5'-PHOSPHATE
Authors:Burkhard, P, Dominici, P, Borri-Voltattorni, C, Jansonius, J.N, Malashkevich, V.N.
Deposit date:2001-08-16
Release date:2001-10-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase.
Nat.Struct.Biol., 8, 2001
4OBV
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BU of 4obv by Molmil
Ruminococcus gnavus tryptophan decarboxylase RUMGNA_01526 (alpha-FMT)
Descriptor: Pyridoxal-dependent decarboxylase domain protein, alpha-(fluoromethyl)-D-tryptophan, {5-hydroxy-4-[(1E)-4-(1H-indol-3-yl)-3-oxobut-1-en-1-yl]-6-methylpyridin-3-yl}methyl dihydrogen phosphate
Authors:Fraser, J.S, Van Benschoten, A.H.
Deposit date:2014-01-07
Release date:2014-10-29
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Discovery and Characterization of Gut Microbiota Decarboxylases that Can Produce the Neurotransmitter Tryptamine.
Cell Host Microbe, 16, 2014
5EUE
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BU of 5eue by Molmil
S1P Lyase Bacterial Surrogate bound to N-(2-((4-methoxy-2,5-dimethylbenzyl)amino)-1-phenylethyl)-5-methylisoxazole-3-carboxamide
Descriptor: PHOSPHATE ION, Putative sphingosine-1-phosphate lyase, ~{N}-[(1~{S})-2-[(4-methoxy-2,5-dimethyl-phenyl)methylamino]-1-phenyl-ethyl]-5-methyl-1,2-oxazole-3-carboxamide
Authors:Argiriadi, M.A, Banach, D, Radziejewska, E, Marchie, S, DiMauro, J, Dinges, J, Dominguez, E, Hutchins, C, Judge, R.A, Queeney, K, Wallace, G, Harris, C.M.
Deposit date:2015-11-18
Release date:2016-03-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:Creation of a S1P Lyase bacterial surrogate for structure-based drug design.
Bioorg.Med.Chem.Lett., 26, 2016
5EUD
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BU of 5eud by Molmil
S1P Lyase Bacterial Surrogate bound to N-(1-(4-(3-hydroxyprop-1-yn-1-yl)phenyl)-2-((4-methoxy-2,5-dimethylbenzyl)amino)ethyl)-5-methylisoxazole-3-carboxamide
Descriptor: PHOSPHATE ION, Putative sphingosine-1-phosphate lyase, ~{N}-[(1~{S})-2-[(4-methoxy-2,5-dimethyl-phenyl)methylamino]-1-[4-(3-oxidanylprop-1-ynyl)phenyl]ethyl]-5-methyl-1,2-oxazole-3-carboxamide
Authors:Argiriadi, M.A, Banach, D, Radziejewska, E, Marchie, S, DiMauro, J, Dinges, J, Dominguez, E, Hutchins, C, Judge, R.A, Queeney, K, Wallace, G, Harris, C.M.
Deposit date:2015-11-18
Release date:2016-03-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Creation of a S1P Lyase bacterial surrogate for structure-based drug design.
Bioorg.Med.Chem.Lett., 26, 2016
4OBU
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BU of 4obu by Molmil
Ruminococcus gnavus tryptophan decarboxylase RUMGNA_01526 (apo)
Descriptor: PYRIDOXAL-5'-PHOSPHATE, Pyridoxal-dependent decarboxylase domain protein
Authors:Van Benschoten, A.H, Fraser, J.S.
Deposit date:2014-01-07
Release date:2014-10-29
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.804 Å)
Cite:Discovery and Characterization of Gut Microbiota Decarboxylases that Can Produce the Neurotransmitter Tryptamine.
Cell Host Microbe, 16, 2014
3RBL
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BU of 3rbl by Molmil
Crystal structure of Human aromatic L-amino acid decarboxylase (AADC) in the apo form
Descriptor: CHLORIDE ION, aromatic L-amino acid decarboxylase
Authors:Giardina, G, Montioli, R, Gianni, S, Cellini, B, Paiardini, A, Borri Voltattorni, C, Cutruzzola, F.
Deposit date:2011-03-29
Release date:2011-10-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases.
Proc.Natl.Acad.Sci.USA, 108, 2011
3RCH
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BU of 3rch by Molmil
Crystal structure of Human aromatic L-amino acid decarboxylase (AADC) in the open conformation with LLP and PLP bound to Chain-A and Chain-B respectively
Descriptor: PYRIDOXAL-5'-PHOSPHATE, aromatic L-amino acid decarboxylase
Authors:Giardina, G, Montioli, R, Gianni, S, Cellini, B, Paiardini, A, Borri Voltattorni, C, Cutruzzola, F.
Deposit date:2011-03-31
Release date:2011-10-19
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases.
Proc.Natl.Acad.Sci.USA, 108, 2011
5GP4
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BU of 5gp4 by Molmil
Lactobacillus brevis CGMCC 1306 Glutamate decarboxylase
Descriptor: Glutamate decarboxylase, PYRIDOXAL-5'-PHOSPHATE
Authors:Mei, L, Huang, J.
Deposit date:2016-07-31
Release date:2017-08-02
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Lactobacillus brevis CGMCC 1306 glutamate decarboxylase: Crystal structure and functional analysis.
Biochem. Biophys. Res. Commun., 503, 2018
2OKK
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BU of 2okk by Molmil
The X-ray crystal structure of the 65kDa isoform of Glutamic Acid Decarboxylase (GAD65)
Descriptor: GAMMA-AMINO-BUTANOIC ACID, GLYCEROL, Glutamate decarboxylase 2
Authors:Buckle, A.M, Fenalti, G, Law, R.H.P, Whisstock, J.C.
Deposit date:2007-01-17
Release date:2007-03-27
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop.
Nat.Struct.Mol.Biol., 14, 2007

 

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