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6Z1S
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BU of 6z1s by Molmil
Structure of Polyphenol Oxidase (mutant G292N) from Thermothelomyces thermophila
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Dimarogona, M, Nikolaivits, E, Valmas, A, Topakas, E.
Deposit date:2020-05-14
Release date:2021-03-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Considerations Regarding Activity Determinants of Fungal Polyphenol Oxidases Based on Mutational and Structural Studies.
Appl.Environ.Microbiol., 87, 2021
8HPI
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BU of 8hpi by Molmil
Crystal structure of Tyrosinase from Priestia megaterium
Descriptor: 1,2-ETHANEDIOL, Tyrosinase, ZINC ION
Authors:Huang, Y, Song, W.
Deposit date:2022-12-12
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Crystal structure of Tyrosinase from Priestia megaterium
To Be Published
6QXD
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BU of 6qxd by Molmil
Crystal Structure of tyrosinase from Bacillus megaterium with JKB inhibitor in the active site.
Descriptor: (2,4-dinitrophenyl)-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]methanone, COPPER (II) ION, Tyrosinase
Authors:Deri Zenaty, B, Gitto, R, Pazy, Y, Fishman, A.
Deposit date:2019-03-07
Release date:2019-06-19
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.317 Å)
Cite:Exploiting the 1-(4-fluorobenzyl)piperazine fragment for the development of novel tyrosinase inhibitors as anti-melanogenic agents: Design, synthesis, structural insights and biological profile.
Eur.J.Med.Chem., 178, 2019
6EI4
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BU of 6ei4 by Molmil
Crystal Structure of tyrosinase from Bacillus megaterium with B5N inhibitor in the active site
Descriptor: COPPER (II) ION, Tyrosinase, [4-[(4-fluorophenyl)methyl]piperazin-1-yl]-(2-methylphenyl)methanone
Authors:Deri, B, Gitto, R, Pazy Benhar, Y, Fishman, A.
Deposit date:2017-09-17
Release date:2018-04-25
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments.
J. Med. Chem., 61, 2018
4D87
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BU of 4d87 by Molmil
Crystal Structure of Tyrosinase from Bacillus megaterium in complex with SDS
Descriptor: COPPER (II) ION, DODECYL SULFATE, Tyrosinase
Authors:Adir, N, Goldfeder, M, Fishman, A.
Deposit date:2012-01-10
Release date:2012-06-20
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Changes in tyrosinase specificity by ionic liquids and sodium dodecyl sulfate.
Appl.Microbiol.Biotechnol., 97, 2013
5OAE
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BU of 5oae by Molmil
Crystal Structure of tyrosinase from Bacillus megaterium with SVF inhibitor in the active site
Descriptor: 1-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]ethanone, COPPER (II) ION, Tyrosinase
Authors:Deri, B, Gitto, R, Pazy Benhar, Y, Fishman, A.
Deposit date:2017-06-21
Release date:2018-04-25
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments.
J. Med. Chem., 61, 2018
5OR4
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BU of 5or4 by Molmil
Crystal structure of Aspergillus oryzae catechol oxidase in deoxy-form
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COPPER (II) ION, ...
Authors:Hakulinen, N, Penttinen, L, Rutanen, C, Rouvinen, J.
Deposit date:2017-08-15
Release date:2018-05-09
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.445 Å)
Cite:A new crystal form of Aspergillus oryzae catechol oxidase and evaluation of copper site structures in coupled binuclear copper enzymes.
PLoS ONE, 13, 2018
5OR3
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BU of 5or3 by Molmil
Crystal structure of Aspergillus oryzae catechol oxidase in met/deoxy-form
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Hakulinen, N, Penttinen, L, Rutanen, C, Rouvinen, J.
Deposit date:2017-08-15
Release date:2018-05-09
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.795 Å)
Cite:A new crystal form of Aspergillus oryzae catechol oxidase and evaluation of copper site structures in coupled binuclear copper enzymes.
PLoS ONE, 13, 2018
5I3A
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BU of 5i3a by Molmil
Crystal Structure of tyrosinase from Bacillus megaterium with configuration A of hydroquinone inhibitor in the active site
Descriptor: Tyrosinase, ZINC ION, benzene-1,4-diol
Authors:Kanteev, M, Deri, B, Adir, N, Fishman, A.
Deposit date:2016-02-10
Release date:2016-10-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The unravelling of the complex pattern of tyrosinase inhibition.
Sci Rep, 6, 2016
5I3B
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BU of 5i3b by Molmil
Crystal Structure of tyrosinase from Bacillus megaterium with configuration B of hydroquinone inhibitor in the active site
Descriptor: Tyrosinase, ZINC ION, benzene-1,4-diol
Authors:Kanteev, M, Deri, B, Adir, N, Fishman, A.
Deposit date:2016-02-10
Release date:2016-10-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The unravelling of the complex pattern of tyrosinase inhibition.
Sci Rep, 6, 2016
5I38
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BU of 5i38 by Molmil
Crystal Structure of tyrosinase from Bacillus megaterium with inhibitor kojic acid in the active site
Descriptor: 5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE, COPPER (II) ION, Tyrosinase
Authors:Kanteev, M, Goldfeder, M, Deri, B, Adir, N, Fishman, A.
Deposit date:2016-02-10
Release date:2016-10-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The unravelling of the complex pattern of tyrosinase inhibition.
Sci Rep, 6, 2016
4P6S
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BU of 4p6s by Molmil
Crystal Structure of tyrosinase from Bacillus megaterium with L-DOPA in the active site
Descriptor: 3,4-DIHYDROXYPHENYLALANINE, Tyrosinase, ZINC ION
Authors:Goldfeder, M, Kanteev, M, Adir, N, Fishman, A.
Deposit date:2014-03-25
Release date:2014-07-30
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Determination of tyrosinase substrate-binding modes reveals mechanistic differences between type-3 copper proteins.
Nat Commun, 5, 2014
4P6R
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BU of 4p6r by Molmil
Crystal Structure of tyrosinase from Bacillus megaterium with tyrosine in the active site
Descriptor: TYROSINE, Tyrosinase, ZINC ION
Authors:Goldfeder, M, Kanteev, M, Adir, N, Fishman, A.
Deposit date:2014-03-25
Release date:2014-07-30
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Determination of tyrosinase substrate-binding modes reveals mechanistic differences between type-3 copper proteins.
Nat Commun, 5, 2014
4P6T
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BU of 4p6t by Molmil
Crystal Structure of tyrosinase from Bacillus megaterium with p-tyrosol in the active site
Descriptor: 4-(2-hydroxyethyl)phenol, COPPER (II) ION, Tyrosinase
Authors:Goldfeder, M, Kanteev, M, Adir, N, Fishman, A.
Deposit date:2014-03-25
Release date:2014-07-30
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Determination of tyrosinase substrate-binding modes reveals mechanistic differences between type-3 copper proteins.
Nat Commun, 5, 2014
6GSG
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BU of 6gsg by Molmil
Crystal structure of Aspergillus oryzae catechol oxidase complexed with resorcinol
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, COPPER (II) ION, Catechol oxidase, ...
Authors:Penttinen, L, Hakulinen, N, Rouvinen, J.
Deposit date:2018-06-14
Release date:2018-09-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.192 Å)
Cite:Unraveling Substrate Specificity and Catalytic Promiscuity of Aspergillus oryzae Catechol Oxidase.
Chembiochem, 19, 2018
3NM8
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BU of 3nm8 by Molmil
Crystal structure of Tyrosinase from Bacillus megaterium
Descriptor: CHLORIDE ION, COPPER (II) ION, Tyrosinase, ...
Authors:Sendovski, M, Kanteev, M, Adir, N, Fishman, A.
Deposit date:2010-06-22
Release date:2010-11-17
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:First structures of an active bacterial tyrosinase reveal copper plasticity
J.Mol.Biol., 405, 2011
3NQ1
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BU of 3nq1 by Molmil
Crystal Structure of Tyrosinase from Bacillus megaterium in complex with inhibitor kojic acid
Descriptor: 5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE, COPPER (II) ION, Tyrosinase, ...
Authors:Sendovski, M, Kanteev, M, Adir, N, Fishman, A.
Deposit date:2010-06-29
Release date:2010-11-17
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:First structures of an active bacterial tyrosinase reveal copper plasticity.
J.Mol.Biol., 405, 2011
3NQ5
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BU of 3nq5 by Molmil
Crystal Structure of Tyrosinase from Bacillus megaterium R209H mutant
Descriptor: COPPER (II) ION, Tyrosinase, ZINC ION
Authors:Sendovski, M, Kanteev, M, Adir, N, Fishman, A.
Deposit date:2010-06-29
Release date:2010-11-17
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:First structures of an active bacterial tyrosinase reveal copper plasticity.
J.Mol.Biol., 405, 2011
3NQ0
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BU of 3nq0 by Molmil
Crystal Structure of Tyrosinase from Bacillus megaterium crystallized in the absence of Zinc
Descriptor: COPPER (II) ION, Tyrosinase
Authors:Sendovski, M, Kanteev, M, Adir, N, Fishman, A.
Deposit date:2010-06-29
Release date:2010-11-17
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:First structures of an active bacterial tyrosinase reveal copper plasticity.
J.Mol.Biol., 405, 2011
3NTM
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BU of 3ntm by Molmil
Crystal Structure of Tyrosinase from Bacillus megaterium crystallized in the absence of zinc, partial occupancy of CuB
Descriptor: COPPER (II) ION, Tyrosinase
Authors:Sendovski, M, Kanteev, M, Adir, N, Fishman, A.
Deposit date:2010-07-05
Release date:2010-11-17
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:First structures of an active bacterial tyrosinase reveal copper plasticity
J.Mol.Biol., 405, 2011
3NPY
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BU of 3npy by Molmil
Crystal Structure of Tyrosinase from Bacillus megaterium soaked in CuSO4
Descriptor: CHLORIDE ION, COPPER (II) ION, Tyrosinase, ...
Authors:Sendovski, M, Kanteev, M, Adir, N, Fishman, A.
Deposit date:2010-06-29
Release date:2010-11-17
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.192 Å)
Cite:First structures of an active bacterial tyrosinase reveal copper plasticity.
J.Mol.Biol., 405, 2011
4HD4
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BU of 4hd4 by Molmil
Crystal Structure of Tyrosinase from Bacillus megaterium V218F mutant
Descriptor: COPPER (II) ION, Tyrosinase
Authors:Goldfeder, M, Kanteev, M, Adir, N, Fishman, A.
Deposit date:2012-10-02
Release date:2013-01-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Influencing the monophenolase/diphenolase activity ratio in tyrosinase.
Biochim.Biophys.Acta, 1834, 2013
4HD7
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BU of 4hd7 by Molmil
Crystal Structure of Tyrosinase from Bacillus megaterium V218G mutant soaked in CuSO4
Descriptor: COPPER (II) ION, Tyrosinase
Authors:Goldfeder, M, Kanteev, M, Adir, N, Fishman, A.
Deposit date:2012-10-02
Release date:2013-01-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Influencing the monophenolase/diphenolase activity ratio in tyrosinase.
Biochim.Biophys.Acta, 1834, 2013
4HD6
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BU of 4hd6 by Molmil
Crystal Structure of Tyrosinase from Bacillus megaterium V218F mutant soaked in CuSO4
Descriptor: COPPER (II) ION, Tyrosinase
Authors:Goldfeder, M, Kanteev, M, Adir, N, Fishman, A.
Deposit date:2012-10-02
Release date:2013-01-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Influencing the monophenolase/diphenolase activity ratio in tyrosinase.
Biochim.Biophys.Acta, 1834, 2013
2Y9W
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BU of 2y9w by Molmil
Crystal structure of PPO3, a tyrosinase from Agaricus bisporus, in deoxy-form that contains additional unknown lectin-like subunit
Descriptor: COPPER (II) ION, DI(HYDROXYETHYL)ETHER, HOLMIUM ATOM, ...
Authors:Ismaya, W.T, Rozeboom, H.J, Weijn, A, Mes, J.J, Fusetti, F, Wichers, H.J, Dijkstra, B.W.
Deposit date:2011-02-17
Release date:2011-07-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of Agaricus Bisporus Mushroom Tyrosinase: Identity of the Tetramer Subunits and Interaction with Tropolone.
Biochemistry, 50, 2011

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