1A7X
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FKBP12-FK1012 COMPLEX
Descriptor:FKBP12, BENZYL-CARBAMIC ACID [8-DEETHYL-ASCOMYCIN-8-YL]ETHYL ESTER
Authors:Schultz, L.W., Clardy, J.
Deposit date:1998-03-18
Release date:1998-06-17
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Chemical inducers of dimerization: the atomic structure of FKBP12-FK1012A-FKBP12.
Bioorg.Med.Chem.Lett., 8, 1998
1BKF
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FK506 BINDING PROTEIN FKBP MUTANT R42K/H87V COMPLEX WITH IMMUNOSUPPRESSANT FK506
Descriptor:FK506 BINDING PROTEIN, 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN
Authors:Itoh, S., Decenzo, M.T., Livingston, D.J., Pearlman, D.A., Navia, M.A.
Deposit date:1995-10-18
Release date:1996-08-01
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Conformation of Fk506 in X-Ray Structures of its Complexes with Human Recombinant Fkbp12 Mutants
Bioorg.Med.Chem.Lett., 5, 1995
1BL4
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FKBP MUTANT F36V COMPLEXED WITH REMODELED SYNTHETIC LIGAND
Descriptor:PROTEIN (FK506 BINDING PROTEIN), {3-[3-(3,4-DIMETHOXY-PHENYL)-1-(1-{1-[2-(3,4,5-TRIMETHOXY-PHENYL)-BUTYRYL]-PIPERIDIN-2YL}-VINYLOXY)-PROPYL]-PHENOXY}-ACETIC ACID
Authors:Hatada, M.H., Clackson, T., Yang, W., Rozamus, L.W., Amara, J., Rollins, C.T., Stevenson, L.F., Magari, S.R., Wood, S.A., Courage, N.L., Lu, X., Cerasoli Junior, F., Gilman, M., Holt, D.
Deposit date:1998-07-23
Release date:1998-09-02
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity.
Proc.Natl.Acad.Sci.USA, 95, 1998
1C9H
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CRYSTAL STRUCTURE OF FKBP12.6 IN COMPLEX WITH RAPAMYCIN
Descriptor:FKBP12.6, RAPAMYCIN IMMUNOSUPPRESSANT DRUG
Authors:Deivanayagam, C.C.S., Carson, M., Thotakura, A., Narayana, S.V.L., Chodavarapu, C.S.
Deposit date:1999-08-02
Release date:2000-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of FKBP12.6 in complex with rapamycin.
Acta Crystallogr.,Sect.D, 56, 2000
1D6O
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NATIVE FKBP
Descriptor:PROTEIN (FK506-BINDING PROTEIN), AMMONIUM ION, SULFATE ION
Authors:Burkhard, P., Taylor, P., Walkinshaw, M.D.
Deposit date:1999-10-15
Release date:1999-10-21
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:X-ray structures of small ligand-FKBP complexes provide an estimate for hydrophobic interaction energies.
J.Mol.Biol., 295, 2000
1D7H
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FKBP COMPLEXED WITH DMSO
Descriptor:PROTEIN (FK506-BINDING PROTEIN), AMMONIUM ION, SULFATE ION, ...
Authors:Burkhard, P., Taylor, P., Walkinshaw, M.D.
Deposit date:1999-10-18
Release date:1999-10-21
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray structures of small ligand-FKBP complexes provide an estimate for hydrophobic interaction energies.
J.Mol.Biol., 295, 2000
1D7I
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FKBP COMPLEXED WITH METHYL METHYLSULFINYLMETHYL SULFIDE (DSS)
Descriptor:PROTEIN (FK506-BINDING PROTEIN), AMMONIUM ION, SULFATE ION, ...
Authors:Burkhard, P., Taylor, P., Walkinshaw, M.D.
Deposit date:1999-10-18
Release date:1999-10-21
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray structures of small ligand-FKBP complexes provide an estimate for hydrophobic interaction energies.
J.Mol.Biol., 295, 2000
1D7J
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FKBP COMPLEXED WITH 4-HYDROXY-2-BUTANONE
Descriptor:PROTEIN (FK506-BINDING PROTEIN), AMMONIUM ION, SULFATE ION, ...
Authors:Burkhard, P., Taylor, P., Walkinshaw, M.D.
Deposit date:1999-10-18
Release date:1999-10-21
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:X-ray structures of small ligand-FKBP complexes provide an estimate for hydrophobic interaction energies.
J.Mol.Biol., 295, 2000
1EYM
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FK506 BINDING PROTEIN MUTANT, HOMODIMERIC COMPLEX
Descriptor:FK506 BINDING PROTEIN
Authors:Rollins, C.T., Rivera, V.M., Woolfson, D.N., Keenan, T., Hatada, M., Adams, S.E., Andrade, L.J., Yaeger, D., van Schravendijk, M.R., Holt, D.A., Gilman, M., Clackson, T.
Deposit date:2000-05-07
Release date:2000-08-09
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:A ligand-reversible dimerization system for controlling protein-protein interactions.
Proc.Natl.Acad.Sci.USA, 97, 2000
1F40
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SOLUTION STRUCTURE OF FKBP12 COMPLEXED WITH GPI-1046, A NEUROTROPHIC LIGAND
Descriptor:FK506 BINDING PROTEIN (FKBP12), (2S)-[3-PYRIDYL-1-PROPYL]-1-[3,3-DIMETHYL-1,2-DIOXOPENTYL]-2-PYRROLIDINECARBOXYLATE
Authors:Sich, C., Improta, S., Cowley, D.J., Guenet, C., Merly, J.P., Teufel, M., Saudek, V.
Deposit date:2000-06-07
Release date:2000-11-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of a neurotrophic ligand bound to FKBP12 and its effects on protein dynamics.
Eur.J.Biochem., 267, 2000
1FAP
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THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-RAPAMYCIN COMPLEX INTERACTING WITH HUMAN FRAP
Descriptor:FK506-BINDING PROTEIN, FRAP, RAPAMYCIN IMMUNOSUPPRESSANT DRUG
Authors:Choi, J., Chen, J., Schreiber, S.L., Clardy, J.
Deposit date:1996-03-15
Release date:1997-07-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP.
Science, 273, 1996
1FKB
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ATOMIC STRUCTURE OF THE RAPAMYCIN HUMAN IMMUNOPHILIN FKBP-12 COMPLEX
Descriptor:FK506 BINDING PROTEIN, RAPAMYCIN IMMUNOSUPPRESSANT DRUG
Authors:Van Duyne, G.D., Standaert, R.F., Schreiber, S.L., Clardy, J.C.
Deposit date:1992-07-02
Release date:1993-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Atomic Structure of the Rapamycin Human Immunophilin Fkbp-12 Complex
J.Am.Chem.Soc., 113, 1991
1FKD
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FK-506 BINDING PROTEIN: THREE-DIMENSIONAL STRUCTURE OF THE COMPLEX WITH THE ANTAGONIST L-685,818
Descriptor:FK506 BINDING PROTEIN, 18-HYDROXYASCOMYCIN
Authors:Becker, J.W., Rotonda, J., Mckeever, B.M.
Deposit date:1992-12-02
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:FK-506-binding protein: three-dimensional structure of the complex with the antagonist L-685,818.
J.Biol.Chem., 268, 1993
1FKF
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ATOMIC STRUCTURE OF FKBP-FK506, AN IMMUNOPHILIN-IMMUNOSUPPRESSANT COMPLEX
Descriptor:FK506 BINDING PROTEIN, 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN
Authors:Vanduyne, G.D., Standaert, R.F., Karplus, P.A., Schreiber, S.L., Clardy, J.
Deposit date:1991-05-07
Release date:1991-07-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex.
Science, 252, 1991
1FKG
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DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12
Descriptor:FK506 BINDING PROTEIN, 1,3-DIPHENYL-1-PROPYL-1-(3,3-DIMETHYL-1,2-DIOXYPENTYL)-2-PIPERIDINE CARBOXYLATE
Authors:Holt, D.A., Luengo, J.I., Yamashita, D.S., Oh, H.-J., Konialian, A.L., Yen, H.-K., Rozamus, L.W., Brandt, M., Bossard, M.J., Levy, M.A., Eggleston, D.S., Stout, T.J., Liang, J., Schultz, L.W., Clardy, J.
Deposit date:1993-08-05
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS AND THE X-RAY CRYSTAL-STRUCTURES OF THEIR COMPLEXES WITH FKBP12.
J.Am.Chem.Soc., 115, 1993
1FKH
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DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12
Descriptor:FK506 BINDING PROTEIN, 1-CYCLOHEXYL-3-PHENYL-1-PROPYL-1-(3,3-DIMETHYL-1,2-DIOXYPENTYL)-2-PIPERIDINE CARBOXYLATE
Authors:Holt, D.A., Luengo, J.I., Yamashita, D.S., Oh, H.-J., Konialian, A.L., Yen, H.-K., Rozamus, L.W., Brandt, M., Bossard, M.J., Levy, M.A., Eggleston, D.S., Stout, T.J., Liang, J., Schultz, L.W., Clardy, J.
Deposit date:1993-08-05
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS AND THE X-RAY CRYSTAL-STRUCTURES OF THEIR COMPLEXES WITH FKBP12.
J.Am.Chem.Soc., 115, 1993
1FKI
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DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12
Descriptor:FK506 BINDING PROTEIN, (21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE
Authors:Holt, D.A., Luengo, J.I., Yamashita, D.S., Oh, H.-J., Konialian, A.L., Yen, H.-K., Rozamus, L.W., Brandt, M., Bossard, M.J., Levy, M.A., Eggleston, D.S., Stout, T.J., Liang, J., Schultz, L.W., Clardy, J.
Deposit date:1993-08-05
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS AND THE X-RAY CRYSTAL-STRUCTURES OF THEIR COMPLEXES WITH FKBP12.
J.Am.Chem.Soc., 115, 1993
1FKJ
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ATOMIC STRUCTURE OF FKBP12-FK506, AN IMMUNOPHILIN IMMUNOSUPPRESSANT COMPLEX
Descriptor:FK506 BINDING PROTEIN, 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN
Authors:Wilson, K.P., Sintchak, M.D., Thomson, J.A., Navia, M.A.
Deposit date:1995-08-18
Release date:1995-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Comparative X-ray structures of the major binding protein for the immunosuppressant FK506 (tacrolimus) in unliganded form and in complex with FK506 and rapamycin.
Acta Crystallogr.,Sect.D, 51, 1995
1FKK
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ATOMIC STRUCTURE OF FKBP12, AN IMMUNOPHILIN BINDING PROTEIN
Descriptor:FK506 BINDING PROTEIN, SULFATE ION
Authors:Wilson, K.P., Sintchak, M.D., Thomson, J.A., Navia, M.A.
Deposit date:1995-08-18
Release date:1995-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Comparative X-ray structures of the major binding protein for the immunosuppressant FK506 (tacrolimus) in unliganded form and in complex with FK506 and rapamycin.
Acta Crystallogr.,Sect.D, 51, 1995
1FKL
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ATOMIC STRUCTURE OF FKBP12-RAPAYMYCIN, AN IMMUNOPHILIN-IMMUNOSUPPRESSANT COMPLEX
Descriptor:FK506 BINDING PROTEIN, RAPAMYCIN IMMUNOSUPPRESSANT DRUG
Authors:Wilson, K.P., Sintchak, M.D., Thomson, J.A., Navia, M.A.
Deposit date:1995-08-18
Release date:1995-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Comparative X-ray structures of the major binding protein for the immunosuppressant FK506 (tacrolimus) in unliganded form and in complex with FK506 and rapamycin.
Acta Crystallogr.,Sect.D, 51, 1995
1FKR
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SOLUTION STRUCTURE OF FKBP, A ROTAMASE ENZYME AND RECEPTOR FOR FK506 AND RAPAMYCIN
Descriptor:FK506 AND RAPAMYCIN-BINDING PROTEIN
Authors:Michnick, S.W., Rosen, M.K., Wandless, T.J., Karplus, M., Schreiber, S.L.
Deposit date:1992-03-05
Release date:1994-01-31
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin.
Science, 252, 1991
1FKS
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SOLUTION STRUCTURE OF FKBP, A ROTAMASE ENZYME AND RECEPTOR FOR FK506 AND RAPAMYCIN
Descriptor:FK506 AND RAPAMYCIN-BINDING PROTEIN
Authors:Michnick, S.W., Rosen, M.K., Wandless, T.J., Karplus, M., Schreiber, S.L.
Deposit date:1992-03-05
Release date:1994-01-31
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin.
Science, 252, 1991
1FKT
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SOLUTION STRUCTURE OF FKBP, A ROTAMASE ENZYME AND RECEPTOR FOR FK506 AND RAPAMYCIN
Descriptor:FK506 AND RAPAMYCIN-BINDING PROTEIN
Authors:Michnick, S.W., Rosen, M.K., Wandless, T.J., Karplus, M., Schreiber, S.L.
Deposit date:1992-03-05
Release date:1994-01-31
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin.
Science, 252, 1991
1J4H
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CRYSTAL STRUCTURE ANALYSIS OF THE FKBP12 COMPLEXED WITH 000107 SMALL MOLECULE
Descriptor:FKBP12, 3-PHENYL-2-{[4-(TOLUENE-4-SULFONYL)-THIOMORPHOLINE-3-CARBONYL]-AMINO}-PROPIONIC ACID ETHYL ESTER
Authors:Li, P., Ding, Y., Wang, L., Wu, B., Shu, C., Li, S., Shen, B., Rao, Z.
Deposit date:2001-09-30
Release date:2003-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design and structure-based study of new potential FKBP12 inhibitors
Biophys.J., 85, 2003
1J4I
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CRYSTAL STRUCTURE ANALYSIS OF THE FKBP12 COMPLEXED WITH 000308 SMALL MOLECULE
Descriptor:FKBP12, 4-METHYL-2-{[4-(TOLUENE-4-SULFONYL)-THIOMORPHOLINE-3-CARBONYL]-AMINO}-PENTANOIC ACID
Authors:Li, P., Ding, Y., Wang, L., Wu, B., Shu, C., Li, S., Shen, B., Rao, Z.
Deposit date:2001-09-30
Release date:2003-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design and structure-based study of new potential FKBP12 inhibitors
Biophys.J., 85, 2003
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