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8USU	Crystal Structure of L-galactose 1-dehydrogenase of Myrciaria dubia in complex with NAD Descriptor: L-galactose dehydrogenase isoform X1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE Authors: Santillan, J.A.V, Cabrejos, D.A.L, Pereira, H.M, Gomez, J.C.C, Garratt, R.C. Deposit date: 2023-10-30 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (2.97 Å) Cite: Structural insights into the Smirnoff-Wheeler pathway for vitamin C production in the Amazon fruit Camu-Camu. J.Exp.Bot., 2024
8RB6	Structure of Aldo-Keto Reductase 1C3 (AKR1C3) in complex with an inhibitor M689, with the 3-hydroxy-benzoisoxazole moiety. Resolution 2.0A Descriptor: 1,2-ETHANEDIOL, 4-[[4-(3-hydroxyphenyl)phenyl]amino]-1,2-benzoxazol-3-ol, Aldo-keto reductase family 1 member C3, ... Authors: Frydenvang, K, Mirza, O.A. Deposit date: 2023-12-03 Release date: 2024-03-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer. Eur.J.Med.Chem., 268, 2024
8IKU	Aldo-keto reductase KmAKR - W297H Descriptor: NADPH-dependent alpha-keto amide reductase Authors: Xu, S.Y, Zhou, L, Xu, Y, Wang, Y.J, Zheng, Y.G. Deposit date: 2023-03-01 Release date: 2024-03-06 Method: X-RAY DIFFRACTION (2.13 Å) Cite: Aldo-keto reductase KmAKR - W297H from Kluyveromyces marxianus To Be Published
8CNF	Human Aldose Reductase Mutant L300G in Complex with a Ligand with an IDD Structure ({5-fluoro-2-[(3-nitrobenzyl)carbamoyl]phenoxy}acetic acid) Descriptor: Aldo-keto reductase family 1 member B1, CITRIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Klee, L.-S, Heine, A, Klebe, G. Deposit date: 2023-02-22 Release date: 2024-03-06 Method: X-RAY DIFFRACTION (0.95 Å) Cite: Human Aldose Reductase Mutant L300G in Complex with a Ligand with an IDD Structure ({5-fluoro-2-[(3-nitrobenzyl)carbamoyl]phenoxy}acetic acid) To Be Published
8CNP	Human Aldose Reductase Mutant L300G in Complex with a Ligand with an IDD Structure (3-({[2-(carboxymethoxy)-4-fluorobenzoyl]amino}methyl)benzoic acid) Descriptor: 3-({[2-(carboxymethoxy)-4-fluorobenzoyl]amino}methyl)benzoic acid, Aldo-keto reductase family 1 member B1, CITRIC ACID, ... Authors: Klee, L.-S, Heine, A, Klebe, G. Deposit date: 2023-02-24 Release date: 2024-03-06 Method: X-RAY DIFFRACTION (0.94 Å) Cite: Human Aldose Reductase Mutant L300G in Complex with a Ligand with an IDD Structure (3-({[2-(carboxymethoxy)-4-fluorobenzoyl]amino}methyl)benzoic acid) To Be Published
8HW0	the structure of AKR6D1 Descriptor: GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NADPH-dependent aldo/keto reductase AKR6D1 Authors: Chen, M, Yang, H. Deposit date: 2022-12-28 Release date: 2024-01-17 Method: X-RAY DIFFRACTION (1.5 Å) Cite: structure of AKR6D1 To Be Published
8HNQ	The structure of a alcohol dehydrogenase AKR13B2 with NADP Descriptor: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Chen, M, Yang, H, Lu, F. Deposit date: 2022-12-08 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (2 Å) Cite: The structure of AKR13B2 To Be Published
8FH6	Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And Two AT-001 Descriptor: (8-oxo-7-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-7,8-dihydropyrazino[2,3-d]pyridazin-5-yl)acetic acid, 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member B1, ... Authors: Arenas, R, Wilson, D.K. Deposit date: 2022-12-13 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (1.952 Å) Cite: Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And Two AT-001 To Be Published
8FH9	Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And AT-007 Descriptor: (4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid, 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member B1, ... Authors: Arenas, R, Wilson, D.K. Deposit date: 2022-12-13 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And AT-007 To Be Published
8FH8	Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And AT-003 Soaked In Hydrogen Peroxide Descriptor: 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member B1, HYDROGEN PEROXIDE, ... Authors: Arenas, R, Wilson, D.K. Deposit date: 2022-12-13 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And AT-003 Soaked In Hydrogen Peroxide To Be Published
8FH5	Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And AT-001 Descriptor: (8-oxo-7-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-7,8-dihydropyrazino[2,3-d]pyridazin-5-yl)acetic acid, Aldo-keto reductase family 1 member B1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Arenas, R, Wilson, D.K. Deposit date: 2022-12-13 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (1.62 Å) Cite: Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And AT-001 To Be Published
8FH7	Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And AT-003 Descriptor: 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member B1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Arenas, R, Wilson, D.K. Deposit date: 2022-12-13 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And AT-003 To Be Published
8BJL	Human Aldose Reductase in Complex with a Ligand with a Fluoro-Indol-Acetic-Acid Structure (Schl44172) Descriptor: 2-(6-fluoranylindol-1-yl)ethanoic acid, CITRIC ACID, DI(HYDROXYETHYL)ETHER, ... Authors: Hubert, L.-S, Heine, A, Klebe, G. Deposit date: 2022-11-04 Release date: 2023-11-15 Method: X-RAY DIFFRACTION (0.97 Å) Cite: Human Aldose Reductase in Complex with a Ligand with a Fluoro-Indol-Acetic-Acid Structure (Schl44172) To Be Published
8B66	Human Aldose Reductase Mutant A299G in Complex with a Ligand with an IDD Structure (3-({[2-(carboxymethoxy)-4-fluorobenzoyl]amino}methyl)benzoic acid) Descriptor: 3-({[2-(carboxymethoxy)-4-fluorobenzoyl]amino}methyl)benzoic acid, Aldo-keto reductase family 1 member B1, CITRIC ACID, ... Authors: Hubert, L.-S, Heine, A, Klebe, G. Deposit date: 2022-09-26 Release date: 2023-10-11 Method: X-RAY DIFFRACTION (0.95 Å) Cite: Human Aldose Reductase Mutant A299G in Complex with a Ligand with an IDD Structure (3-({[2-(carboxymethoxy)-4-fluorobenzoyl]amino}methyl)benzoic acid) To Be Published
8B3N	Human Aldose Reductase Mutant A299G/L300G in Complex with a Ligand with an IDD Structure (3-({[2-(carboxymethoxy)-4-fluorobenzoyl]amino}methyl)benzoic acid) Descriptor: 3-({[2-(carboxymethoxy)-4-fluorobenzoyl]amino}methyl)benzoic acid, Aldo-keto reductase family 1 member B1, CITRIC ACID, ... Authors: Hubert, L.-S, Heine, A, Klebe, G. Deposit date: 2022-09-16 Release date: 2023-09-27 Method: X-RAY DIFFRACTION (1.03 Å) Cite: Human Aldose Reductase Mutant A299G/L300G in Complex with a Ligand with an IDD Structure (3-({[2-(carboxymethoxy)-4-fluorobenzoyl]amino}methyl)benzoic acid) To Be Published
8B3R	Human Aldose Reductase Mutant A299G/L300G in Complex with a Ligand with an IDD Structure ({5-fluoro-2-[(3-nitrobenzyl)carbamoyl]phenoxy}acetic acid) Descriptor: Aldo-keto reductase family 1 member B1, CITRIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Hubert, L.-S, Heine, A, Klebe, G. Deposit date: 2022-09-16 Release date: 2023-09-27 Method: X-RAY DIFFRACTION (0.96 Å) Cite: Human Aldose Reductase Mutant A299G/L300G in Complex with a Ligand with an IDD Structure ({5-fluoro-2-[(3-nitrobenzyl)carbamoyl]phenoxy}acetic acid) To Be Published
8B34	Structure of Human Aldose Reductase Mutant A299G with a Citrate Molecule Bound in the Anion Binding Pocket Descriptor: Aldo-keto reductase family 1 member B1, CITRIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Hubert, L.-S, Heine, A, Klebe, G. Deposit date: 2022-09-15 Release date: 2023-09-27 Method: X-RAY DIFFRACTION (0.97 Å) Cite: Structure of Human Aldose Reductase Mutant A299G with a Citrate Molecule Bound in the Anion Binding Pocket To Be Published
8I0C	Crystal structure of Aldo-keto reductase 1C3 complexed with compound S0703 Descriptor: 1-[4-[3,5-bis(chloranyl)phenyl]-3-fluoranyl-phenyl]cyclopropane-1-carboxylic acid, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Jiang, J, He, S, Liu, Y, Fang, P, Sun, H. Deposit date: 2023-01-10 Release date: 2023-09-20 Method: X-RAY DIFFRACTION (2.33 Å) Cite: Development of Biaryl-Containing Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment. J.Med.Chem., 66, 2023
8AUU	Human Aldose Reductase Mutant A299G in Complex with a Ligand with an IDD Structure ({5-fluoro-2-[(3-nitrobenzyl)carbamoyl]phenoxy}acetic acid) Descriptor: Aldo-keto reductase family 1 member B1, CITRIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Hubert, L.-S, Heine, A, Klebe, G. Deposit date: 2022-08-25 Release date: 2023-09-06 Method: X-RAY DIFFRACTION (0.95 Å) Cite: Human Aldose Reductase Mutant A299G in Complex with a Ligand with an IDD Structure ({5-fluoro-2-[(3-nitrobenzyl)carbamoyl]phenoxy}acetic acid) To Be Published
8K1I	Crystal structure of arabinose dehydrogenase from Candida auris Descriptor: NADP-dependent oxidoreductase domain-containing protein Authors: Zhang, J, Bai, X, He, S.R, Zhao, Z.D. Deposit date: 2023-07-11 Release date: 2023-08-30 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal structure of arabinose dehydrogenase from Candida auris To Be Published
8AQP	Structure of Human Aldose Reductase Mutant A299G/L300A with a Citrate Molecule Bound in the Anion Binding Pocket Descriptor: Aldo-keto reductase family 1 member B1, CITRIC ACID, DI(HYDROXYETHYL)ETHER, ... Authors: Hubert, L.-S, Heine, A, Klebe, G. Deposit date: 2022-08-13 Release date: 2023-08-23 Method: X-RAY DIFFRACTION (0.96 Å) Cite: Structure of Human Aldose Reductase Mutant A299G/L300A with a Citrate Molecule Bound in the Anion Binding Pocket To Be Published
8AQG	Structure of Human Aldose Reductase Mutant A299G/L300G with a Citrate Molecule Bound in the Anion Binding Pocket Descriptor: Aldo-keto reductase family 1 member B1, CITRIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Hubert, L.-S, Heine, A, Klebe, G. Deposit date: 2022-08-12 Release date: 2023-08-23 Method: X-RAY DIFFRACTION (0.95 Å) Cite: Structure of Human Aldose Reductase Mutant A299/L300G with a Citrate Molecule Bound in the Anion Binding Pocket To Be Published
8AE9	Human Aldose Reductase in Complex with a Hydroxyphenyl-Thiophen-Acid Inhibitor (Schl32357) Descriptor: 5-(5-(3-hydroxyphenyl)thiophen-2-yl)pentanoic acid, Aldose reductase, DIMETHYL SULFOXIDE, ... Authors: Hubert, L.-S, Heine, A, Klebe, G, Reul, S. Deposit date: 2022-07-12 Release date: 2023-08-16 Method: X-RAY DIFFRACTION (0.95 Å) Cite: Human Aldose Reductase in Complex with a Hydroxyphenyl-Thiophen-Acid Inhibitor (Schl32357) To Be Published
8A4N	Structure of Human Aldose Reductase Mutant L300G with a Citrate Molecule Bound in the Anion Binding Pocket Descriptor: Aldo-keto reductase family 1 member B1, CITRIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Hubert, L.-S, Heine, A, Klebe, G. Deposit date: 2022-06-13 Release date: 2023-07-05 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (0.93 Å) Cite: Structure of Human Aldose Reductase Mutant L300G with a Citrate Molecule Bound in the Anion Binding Pocket To Be Published
8GLV	96-nm repeat unit of doublet microtubules from Chlamydomonas reinhardtii flagella Descriptor: 28 kDa inner dynein arm light chain, axonemal, AAA+ ATPase domain-containing protein, ... Authors: Walton, T, Brown, A. Deposit date: 2023-03-23 Release date: 2023-05-31 Last modified: 2023-06-28 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Axonemal structures reveal mechanoregulatory and disease mechanisms. Nature, 618, 2023

 

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