1F0J
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CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B
Descriptor:PHOSPHODIESTERASE 4B, ZINC ION, MAGNESIUM ION, ...
Authors:Xu, R.X., Hassell, A.M., Vanderwall, D., Lambert, M.H., Holmes, W.D., Luther, M.A., Rocque, W.J., Milburn, M.V., Zhao, Y., Ke, H., Nolte, R.T.
Deposit date:2000-05-16
Release date:2000-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity.
Science, 288, 2000
1MKD
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CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN AND ZARDAVERINE COMPLEX
Descriptor:Phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Lee, M.E., Markowitz, J., Lee, J.-O., Lee, H.
Deposit date:2002-08-29
Release date:2003-03-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of phosphodiesterase 4D and inhibitor complex
FEBS LETT., 530, 2002
1OYN
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CRYSTAL STRUCTURE OF PDE4D2 IN COMPLEX WITH (R,S)-ROLIPRAM
Descriptor:cAMP-specific phosphodiesterase PDE4D2, ZINC ION, ROLIPRAM
Authors:Huai, Q., Wang, H., Sun, Y., Kim, H.Y., Liu, Y., Ke, H.
Deposit date:2003-04-05
Release date:2003-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity
Structure, 11, 2003
1PTW
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THE CRYSTAL STRUCTURE OF AMP-BOUND PDE4 SUGGESTS A MECHANISM FOR PHOSPHODIESTERASE CATALYSIS
Descriptor:cAMP-specific phosphodiesterase PDE4D2, ZINC ION, ADENOSINE MONOPHOSPHATE
Authors:Huai, Q., Colicelli, J., Ke, H.
Deposit date:2003-06-23
Release date:2003-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structure of AMP-bound PDE4 suggests a mechanism for phosphodiesterase catalysis
Biochemistry, 42, 2003
1Q9M
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THREE DIMENSIONAL STRUCTURES OF PDE4D IN COMPLEX WITH ROLIPRAMS AND IMPLICATION ON INHIBITOR SELECTIVITY
Descriptor:cAMP-specific phosphodiesterase PDE4D2, ZINC ION, ROLIPRAM
Authors:Huai, Q., Wang, H., Sun, Y., Kim, H.Y., Liu, Y., Ke, H.
Deposit date:2003-08-25
Release date:2003-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Three dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity
Structure, 11, 2003
1RKP
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CRYSTAL STRUCTURE OF PDE5A1-IBMX
Descriptor:cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ...
Authors:Huai, Q., Liu, Y., Francis, S.H., Corbin, J.D., Ke, H.
Deposit date:2003-11-22
Release date:2004-03-30
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor IBMX suggest a conformation determinant of inhibitor selectivity
J.Biol.Chem., 279, 2004
1RO6
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CRYSTAL STRUCTURE OF PDE4B2B COMPLEXED WITH ROLIPRAM (R & S)
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MANGANESE (II) ION, ...
Authors:Xu, R.X., Rocque, W.J., Lambert, M.H., Vanderwall, D.E., Nolte, R.T.
Deposit date:2003-12-01
Release date:2004-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.
J.Mol.Biol., 337, 2004
1RO9
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CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH 8-BR-AMP
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, 8-BROMO-ADENOSINE-5'-MONOPHOSPHATE
Authors:Xu, R.X., Rocque, W.J., Lambert, M.H., Vanderwall, D.E., Nolte, R.T.
Deposit date:2003-12-01
Release date:2004-12-07
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.
J.Mol.Biol., 337, 2004
1ROR
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CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH AMP
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, ADENOSINE MONOPHOSPHATE
Authors:Xu, R.X., Rocque, W.J., Lambert, M.H., Vanderwall, D.E., Nolte, R.T.
Deposit date:2003-12-02
Release date:2004-12-07
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.
J.Mol.Biol., 337, 2004
1SO2
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CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B IN COMPLEX WITH A DIHYDROPYRIDAZINE INHIBITOR
Descriptor:cGMP-inhibited 3',5'-cyclic phosphodiesterase B, MAGNESIUM ION, 1-DEOXY-1-[(2-HYDROXYETHYL)(NONANOYL)AMINO]HEXITOL, ...
Authors:Scapin, G., Patel, S.B., Chung, C., Varnerin, J.P., Edmondson, S.D., Mastracchio, A., Parmee, E.R., Becker, J.W., Singh, S.B., Van Der Ploeg, L.H., Tota, M.R.
Deposit date:2004-03-12
Release date:2004-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of Human Phosphodiesterase 3B: Atomic Basis for Substrate and Inhibitor Specificity
Biochemistry, 43, 2004
1SOJ
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CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B IN COMPLEX WITH IBMX
Descriptor:cGMP-inhibited 3',5'-cyclic phosphodiesterase B, MAGNESIUM ION, 3-ISOBUTYL-1-METHYLXANTHINE
Authors:Scapin, G., Patel, S.B., Chung, C., Varnerin, J.P., Edmondson, S.D., Mastracchio, A., Parmee, E.R., Becker, J.W., Singh, S.B., Van Der Ploeg, L.H., Tota, M.R.
Deposit date:2004-03-15
Release date:2004-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structure of Human Phosphodiesterase 3B: Atomic Basis for Substrate and Inhibitor Specificity
Biochemistry, 43, 2004
1T9R
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CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 5A
Descriptor:cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, PHOSPHATE ION, ...
Authors:Zhang, K.Y.J., Card, G.L., Suzuki, Y., Artis, D.R., Fong, D., Gillette, S., Hsieh, D., Neiman, J., West, B.L., Zhang, C., Milburn, M.V., Kim, S.-H., Schlessinger, J., Bollag, G.
Deposit date:2004-05-18
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases
Mol.Cell, 15, 2004
1T9S
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CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 5A IN COMPLEX WITH GMP
Descriptor:cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ...
Authors:Zhang, K.Y.J., Card, G.L., Suzuki, Y., Artis, D.R., Fong, D., Gillette, S., Hsieh, D., Neiman, J., West, B.L., Zhang, C., Milburn, M.V., Kim, S.-H., Schlessinger, J., Bollag, G.
Deposit date:2004-05-18
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases
Mol.Cell, 15, 2004
1TAZ
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CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 1B
Descriptor:Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, ZINC ION, MAGNESIUM ION
Authors:Zhang, K.Y.J., Card, G.L., Suzuki, Y., Artis, D.R., Fong, D., Gillette, S., Hsieh, D., Neiman, J., West, B.L., Zhang, C., Milburn, M.V., Kim, S.-H., Schlessinger, J., Bollag, G.
Deposit date:2004-05-19
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases
Mol.Cell, 15, 2004
1TB5
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CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH AMP
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MAGNESIUM ION, ...
Authors:Zhang, K.Y.J., Card, G.L., Suzuki, Y., Artis, D.R., Fong, D., Gillette, S., Hsieh, D., Neiman, J., West, B.L., Zhang, C., Milburn, M.V., Kim, S.-H., Schlessinger, J., Bollag, G.
Deposit date:2004-05-19
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases
Mol.Cell, 15, 2004
1TB7
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CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH AMP
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Zhang, K.Y.J., Card, G.L., Suzuki, Y., Artis, D.R., Fong, D., Gillette, S., Hsieh, D., Neiman, J., West, B.L., Zhang, C., Milburn, M.V., Kim, S.-H., Schlessinger, J., Bollag, G.
Deposit date:2004-05-19
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases
Mol.Cell, 15, 2004
1TBB
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CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH ROLIPRAM
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Zhang, K.Y.J., Card, G.L., Suzuki, Y., Artis, D.R., Fong, D., Gillette, S., Hsieh, D., Neiman, J., West, B.L., Zhang, C., Milburn, M.V., Kim, S.-H., Schlessinger, J., Bollag, G.
Deposit date:2004-05-19
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases
Mol.Cell, 15, 2004
1TBF
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CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 5A IN COMPLEX WITH SILDENAFIL
Descriptor:cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ...
Authors:Zhang, K.Y.J., Card, G.L., Suzuki, Y., Artis, D.R., Fong, D., Gillette, S., Hsieh, D., Neiman, J., West, B.L., Zhang, C., Milburn, M.V., Kim, S.-H., Schlessinger, J., Bollag, G.
Deposit date:2004-05-20
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases
Mol.Cell, 15, 2004
1UDT
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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 5 COMPLEXED WITH SILDENAFIL(VIAGRA)
Descriptor:cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ...
Authors:Sung, B.-J., Lee, J.I., Heo, Y.-S., Kim, J.H., Moon, J., Yoon, J.M., Hyun, Y.-L., Kim, E., Eum, S.J., Lee, T.G., Cho, J.M., Park, S.-Y., Lee, J.-O., Jeon, Y.H., Hwang, K.Y., Ro, S.
Deposit date:2003-05-06
Release date:2004-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules
Nature, 425, 2003
1UDU
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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 5 COMPLEXED WITH TADALAFIL(CIALIS)
Descriptor:cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ...
Authors:Sung, B.-J., Lee, J.I., Heo, Y.-S., Kim, J.H., Moon, J., Yoon, J.M., Hyun, Y.-L., Kim, E., Eum, S.J., Lee, T.G., Cho, J.M., Park, S.-Y., Lee, J.-O., Jeon, Y.H., Hwang, K.Y., Ro, S.
Deposit date:2003-05-06
Release date:2004-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules
Nature, 425, 2003
1UHO
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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 5 COMPLEXED WITH VARDENAFIL(LEVITRA)
Descriptor:cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ...
Authors:Sung, B.-J., Lee, J.I., Heo, Y.-S., Kim, J.H., Moon, J., Yoon, J.M., Hyun, Y.-L., Kim, E., Eum, S.J., Lee, T.G., Cho, J.M., Park, S.-Y., Lee, J.-O., Jeon, Y.H., Hwang, K.Y., Ro, S.
Deposit date:2003-07-09
Release date:2004-07-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules
Nature, 425, 2003
1XLX
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CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH CILOMILAST
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MAGNESIUM ION, ...
Authors:Card, G.L., England, B.P., Suzuki, Y., Fong, D., Powell, B., Lee, B., Luu, C., Tabrizizad, M., Gillette, S., Ibrahim, P.N., Artis, D.R., Bollag, G., Milburn, M.V., Kim, S.-H., Schlessinger, J., Zhang, K.Y.J.
Deposit date:2004-09-30
Release date:2004-12-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases.
Structure, 12, 2004
1XLZ
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CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH FILAMINAST
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MAGNESIUM ION, ...
Authors:Card, G.L., England, B.P., Suzuki, Y., Fong, D., Powell, B., Lee, B., Luu, C., Tabrizizad, M., Gillette, S., Ibrahim, P.N., Artis, D.R., Bollag, G., Milburn, M.V., Kim, S.-H., Schlessinger, J., Zhang, K.Y.J.
Deposit date:2004-09-30
Release date:2004-12-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases.
STRUCTURE, 12, 2004
1XM4
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CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH PICLAMILAST
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MAGNESIUM ION, ...
Authors:Card, G.L., England, B.P., Suzuki, Y., Fong, D., Powell, B., Lee, B., Luu, C., Tabrizizad, M., Gillette, S., Ibrahim, P.N., Artis, D.R., Bollag, G., Milburn, M.V., Kim, S.-H., Schlessinger, J., Zhang, K.Y.J.
Deposit date:2004-10-01
Release date:2004-12-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases.
STRUCTURE, 12, 2004
1XM6
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CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH (R)-MESOPRAM
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MAGNESIUM ION, ...
Authors:Card, G.L., England, B.P., Suzuki, Y., Fong, D., Powell, B., Lee, B., Luu, C., Tabrizizad, M., Gillette, S., Ibrahim, P.N., Artis, D.R., Bollag, G., Milburn, M.V., Kim, S.-H., Schlessinger, J., Zhang, K.Y.J.
Deposit date:2004-10-01
Release date:2004-12-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases.
STRUCTURE, 12, 2004
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