1DG6
| CRYSTAL STRUCTURE OF APO2L/TRAIL | Descriptor: | APO2L/TNF-RELATED APOPOTIS INDUCING LIGAND (TRAIL), CHLORIDE ION, ZINC ION | Authors: | Hymowitz, S.G, O'ConnelL, M.P, Ultsch, M.H, de Vos, A.M, Kelley, R.F. | Deposit date: | 1999-11-23 | Release date: | 2000-01-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL. Biochemistry, 39, 2000
|
|
5UUI
| Crystal Structure of Spin-Labeled T77C TNFa | Descriptor: | S-[(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate, Tumor necrosis factor | Authors: | Horanyi, P.S, Dranow, D.M, Ceska, T. | Deposit date: | 2017-02-16 | Release date: | 2017-08-02 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Natural Conformational Sampling of Human TNF alpha Visualized by Double Electron-Electron Resonance. Biophys. J., 113, 2017
|
|
2TNF
| 1.4 A RESOLUTION STRUCTURE OF MOUSE TUMOR NECROSIS FACTOR, TOWARDS MODULATION OF ITS SELECTIVITY AND TRIMERISATION | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ISOPROPYL ALCOHOL, PROTEIN (TUMOR NECROSIS FACTOR ALPHA) | Authors: | Baeyens, K.J, De Bondt, H.L, Raeymaekers, A, Fiers, W, De Ranter, C.J. | Deposit date: | 1998-10-12 | Release date: | 1999-10-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | The structure of mouse tumour-necrosis factor at 1.4 A resolution: towards modulation of its selectivity and trimerization. Acta Crystallogr.,Sect.D, 55, 1999
|
|
6I50
| |
2Q8O
| |
3FC0
| 1.8 A crystal structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells | Descriptor: | ACETATE ION, GITR ligand | Authors: | Chattopadhyay, K, Ramagopal, U.A, Nathenson, S.G, Almo, S.C. | Deposit date: | 2008-11-20 | Release date: | 2008-12-30 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | 1.8 A structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells. Acta Crystallogr.,Sect.D, 65, 2009
|
|
1U5X
| Crystal structure of murine APRIL at pH 5.0 | Descriptor: | Tumor necrosis factor ligand superfamily member 13 | Authors: | Wallweber, H.J, Compaan, D.M, Starovasnik, M.A, Hymowitz, S.G. | Deposit date: | 2004-07-28 | Release date: | 2004-10-12 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The Crystal Structure of A Proliferation-inducing Ligand, APRIL. J.Mol.Biol., 343, 2004
|
|
4TSV
| |
2E7A
| |
6W9G
| Crystal Structure of the Fab fragment of humanized 5c8 antibody containing the fluorescent non-canonical amino acid L-(7-hydroxycoumarin-4-yl)ethylglycine in complex with CD40L at pH 6.8 | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 5c8* Fab (heavy chain), ... | Authors: | Henderson, J.N, Simmons, C.R, Mills, J.H. | Deposit date: | 2020-03-23 | Release date: | 2020-12-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Structural Insights into How Protein Environments Tune the Spectroscopic Properties of a Noncanonical Amino Acid Fluorophore. Biochemistry, 59, 2020
|
|
5M2J
| Complex between human TNF alpha and Llama VHH2 | Descriptor: | Anti-(ED-B) scFV, Tumor necrosis factor | Authors: | Cambillau, C, Spinelli, S, Desmyter, A, de Haard, H. | Deposit date: | 2016-10-13 | Release date: | 2017-08-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions. Front Immunol, 8, 2017
|
|
1XU1
| The crystal structure of APRIL bound to TACI | Descriptor: | NICKEL (II) ION, Tumor necrosis factor ligand superfamily member 13, Tumor necrosis factor receptor superfamily member 13B | Authors: | Hymowitz, S.G, Patel, D.R, Wallweber, H.J.A, Runyon, S, Yan, M, Yin, J, Shriver, S.K, Gordon, N.C, Pan, B, Skelton, N.J, Kelley, R.F, Starovasnik, M.A. | Deposit date: | 2004-10-25 | Release date: | 2004-11-09 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structures of APRIL-receptor complexes: Like BCMA, TACI employs only a single cysteine-rich domain for high-affinity ligand binding J.Biol.Chem., 280, 2005
|
|
1S55
| Mouse RANKL Structure at 1.9A Resolution | Descriptor: | CHLORIDE ION, Tumor necrosis factor ligand superfamily member 11 | Authors: | Teale, M.J, Feug, X, Chen, L, Bice, T, Meehan, E.J. | Deposit date: | 2004-01-19 | Release date: | 2005-07-05 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Murine RANKL Extra Cellular Domain Homotrimer Structure In Space Groups P212121 And H3 At 1.9 And 2.6 Respectively To be Published
|
|
7SGM
| Crystal structure of a Fab variant containing a fluorescent noncanonical amino acid with blocked excited state proton transfer and in complex with its antigen, CD40L | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5c8* Fab heavy chain, ... | Authors: | Henderson, J.N, Mills, J.H, Simmons, C.R. | Deposit date: | 2021-10-06 | Release date: | 2022-02-02 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Basis for Blocked Excited State Proton Transfer in a Fluorescent, Photoacidic Non-Canonical Amino Acid-Containing Antibody Fragment. J.Mol.Biol., 434, 2022
|
|
5L19
| Crystal Structure of a human FasL mutant | Descriptor: | SULFATE ION, Tumor necrosis factor ligand superfamily member 6, ZINC ION | Authors: | Liu, W, Bonanno, J.B, Almo, S.C. | Deposit date: | 2016-07-28 | Release date: | 2016-09-07 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structure of the Complex of Human FasL and Its Decoy Receptor DcR3. Structure, 24, 2016
|
|
1ALY
| |
1KXG
| The 2.0 Ang Resolution Structure of BLyS, B Lymphocyte Stimulator. | Descriptor: | 1,4-DIETHYLENE DIOXIDE, B lymphocyte stimulator, CITRIC ACID, ... | Authors: | Oren, D.A, Li, Y, Volovik, Y, Morris, T.S, Dharia, C, Das, K, Galperina, O, Gentz, R, Arnold, E. | Deposit date: | 2002-01-31 | Release date: | 2002-03-20 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis of BLyS receptor recognition. Nat.Struct.Biol., 9, 2002
|
|
6ZT0
| Crystal structure of the Eiger TNF domain/Grindelwald extracellular domain complex | Descriptor: | 1,2-ETHANEDIOL, Protein eiger, Protein grindelwald | Authors: | Palmerini, V, Cecatiello, V, Pasqualato, S, Mapelli, M. | Deposit date: | 2020-07-17 | Release date: | 2021-03-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions. Nat Commun, 12, 2021
|
|
5Y9J
| BAFF in complex with belimumab | Descriptor: | Tumor necrosis factor ligand superfamily member 13B, belibumab light chain, belimumab heavy chain | Authors: | Heo, Y.-S, Shin, W. | Deposit date: | 2017-08-25 | Release date: | 2018-02-21 | Last modified: | 2019-09-04 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | BAFF-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus. Nat Commun, 9, 2018
|
|
2RJL
| Crystal structure of human TL1A extracellular domain C95S/C135S mutant | Descriptor: | TNF superfamily ligand TL1A | Authors: | Zhan, C, Patskovsky, Y, Yan, Q, Shi, W, Toro, R, Bonanno, J, Nathenson, S.G, Almo, S.C. | Deposit date: | 2007-10-15 | Release date: | 2008-08-26 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Biochemical and structural characterization of the human TL1A ectodomain. Biochemistry, 48, 2009
|
|
2QDN
| |
7JRA
| |
2AZ5
| Crystal Structure of TNF-alpha with a small molecule inhibitor | Descriptor: | 6,7-DIMETHYL-3-[(METHYL{2-[METHYL({1-[3-(TRIFLUOROMETHYL)PHENYL]-1H-INDOL-3-YL}METHYL)AMINO]ETHYL}AMINO)METHYL]-4H-CHROMEN-4-ONE, Tumor necrosis factor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, ... | Authors: | He, M.M. | Deposit date: | 2005-09-09 | Release date: | 2005-11-29 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Small-molecule inhibition of TNF-alpha. Science, 310, 2005
|
|
3L9J
| Selection of a novel highly specific TNFalpha antagonist: Insight from the crystal structure of the antagonist-TNFalpha complex | Descriptor: | MAGNESIUM ION, TNFalpha, Tumor necrosis factor, ... | Authors: | Byla, P, Andersen, M.H, Thogersen, H.C, Gad, H.H, Hartmann, R. | Deposit date: | 2010-01-05 | Release date: | 2010-02-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Selection of a novel and highly specific TNF{alpha} antagonist: insight from the crystal structure of the antagonist-TNF{alpha} complex J.Biol.Chem., 285, 2010
|
|
2RE9
| Crystal structure of TL1A at 2.1 A | Descriptor: | GLYCEROL, MAGNESIUM ION, TNF superfamily ligand TL1A | Authors: | Jin, T.C, Guo, F, Kim, S, Howard, A.J, Zhang, Y.Z. | Deposit date: | 2007-09-25 | Release date: | 2007-10-09 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | X-ray crystal structure of TNF ligand family member TL1A at 2.1 A. Biochem.Biophys.Res.Commun., 364, 2007
|
|