1F9V
 
 | | CRYSTAL STRUCTURES OF MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE KINESIN MOTOR ATPASE | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KAR3, MAGNESIUM ION | | Authors: | Yun, M, Zhang, X, Park, C.G, Park, H.W, Endow, S.A. | | Deposit date: | 2000-07-11 | | Release date: | 2001-06-13 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | A structural pathway for activation of the kinesin motor ATPase.
EMBO J., 20, 2001
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1F9T
 | | CRYSTAL STRUCTURES OF KINESIN MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE MOTOR ATPASE | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KAR3, MAGNESIUM ION | | Authors: | Yun, M, Zhang, X, Park, C.-G, Park, H.-W, Endow, S.A. | | Deposit date: | 2000-07-11 | | Release date: | 2001-06-13 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | A structural pathway for activation of the kinesin motor ATPase.
EMBO J., 20, 2001
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2ZFI
 | | Crystal Structure of the Kif1A Motor Domain Before Mg Release | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF1A, Kinesin heavy chain isoform 5C, ... | | Authors: | Nitta, R, Okada, Y, Hirokawa, N. | | Deposit date: | 2008-01-07 | | Release date: | 2008-09-23 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Structural model for strain-dependent microtubule activation of Mg-ADP release from kinesin.
Nat.Struct.Mol.Biol., 15, 2008
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2VVG
 | | Crystal Structure of the G.intestinalis Kinesin 2 GiKIN2a Motor Domain | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-2, MAGNESIUM ION | | Authors: | Hoeng, J.C, Loewe, J, Dawson, S.C, Cande, W.Z, Sagolla, M.S, Mancuso, J.J. | | Deposit date: | 2008-06-08 | | Release date: | 2008-07-08 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | High-Resolution Crystal Structure and in Vivo Function of a Kinesin-2 Homologue in Giardia Intestinalis.
Mol.Biol.Cell, 19, 2008
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4A14
 | | HUMAN KIF7, A KINESIN INVOLVED IN HEDGEHOG SIGNALLING | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF7, MAGNESIUM ION | | Authors: | Klejnot, M, Kozielski, F. | | Deposit date: | 2011-09-14 | | Release date: | 2012-01-25 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural Insights Into Human Kif7, a Kinesin Involved in Hedgehog Signalling.
Acta Crystallogr.,Sect.D, 68, 2012
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1RY6
 | | Crystal Structure of Internal Kinesin Motor Domain | | Descriptor: | INTERNAL KINESIN, SULFATE ION | | Authors: | Shipley, K, Hekmat-Nejad, M, Turner, J, Moores, C, Anderson, R, Milligan, R, Sakowicz, R, Fletterick, R. | | Deposit date: | 2003-12-19 | | Release date: | 2004-04-13 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structure of a kinesin microtubule depolymerization machine.
Embo J., 23, 2004
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3ZCW
 | | Eg5 - New allosteric binding site | | Descriptor: | (2E)-2-(3-fluoranyl-4-methoxy-phenyl)imino-1-[[2-(trifluoromethyl)phenyl]methyl]-3H-benzimidazole-5-carboxylic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, ... | | Authors: | Ulaganathan, V, Talapatra, S.K, Kozielski, F, Pannifer, A.D. | | Deposit date: | 2012-11-23 | | Release date: | 2013-01-23 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.691 Å) | | Cite: | Structural Insights Into a Unique Inhibitor Binding Pocket in Kinesin Spindle Protein.
J.Am.Chem.Soc., 135, 2013
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1F9U
 | | CRYSTAL STRUCTURES OF MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE KINESIN MOTOR ATPASE | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KAR3, MAGNESIUM ION | | Authors: | Yun, M, Zhang, X, Park, C.G, Park, H.W, Endow, S.A. | | Deposit date: | 2000-07-11 | | Release date: | 2001-06-13 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | A structural pathway for activation of the kinesin motor ATPase.
EMBO J., 20, 2001
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3ZFD
 | | Crystal Structure of the Kif4 Motor Domain Complexed With Mg-AMPPNP | | Descriptor: | CHROMOSOME-ASSOCIATED KINESIN KIF4, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Chang, Q, Nitta, R, Inoue, S, Hirokawa, N. | | Deposit date: | 2012-12-11 | | Release date: | 2013-03-20 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | Structural Basis for the ATP-Induced Isomerization of Kinesin.
J.Mol.Biol., 425, 2013
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7LXR
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6TLE
 | | Human Eg5 motor domain mutant E344K | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, MAGNESIUM ION, ... | | Authors: | Garcia-Saez, I, Skoufias, D.A. | | Deposit date: | 2019-12-02 | | Release date: | 2021-06-30 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Human Eg5 motor domain mutant E344K
To Be Published
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7EOB
 | | Crystal structure of KIF1A Motor-Neck domain E239K mutant with ADP-Mg-AlFx | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Kinesin-like protein KIF1A, ... | | Authors: | Ogawa, T, Jiang, X, Hirokawa, N. | | Deposit date: | 2021-04-21 | | Release date: | 2021-12-29 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | A neuropathy-associated kinesin KIF1A mutation hyper-stabilizes the motor-neck interaction during the ATPase cycle.
Embo J., 41, 2022
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1BG2
 | | HUMAN UBIQUITOUS KINESIN MOTOR DOMAIN | | Descriptor: | ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, KINESIN, ... | | Authors: | Kull, F.J, Sablin, E.P, Lau, R, Fletterick, R.J, Vale, R.D. | | Deposit date: | 1998-06-04 | | Release date: | 1998-10-14 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of the kinesin motor domain reveals a structural similarity to myosin.
Nature, 380, 1996
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3ZFC
 | | Crystal Structure of the Kif4 Motor Domain Complexed With Mg-AMPPNP | | Descriptor: | CHROMOSOME-ASSOCIATED KINESIN KIF4, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Chang, Q, Nitta, R, Inoue, S, Hirokawa, N. | | Deposit date: | 2012-12-11 | | Release date: | 2013-03-20 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural Basis for the ATP-Induced Isomerization of Kinesin.
J.Mol.Biol., 425, 2013
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3B6U
 | | Crystal structure of the motor domain of human kinesin family member 3B in complex with ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF3B, MAGNESIUM ION, ... | | Authors: | Zhu, H, Shen, Y, Tempel, W, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | | Deposit date: | 2007-10-29 | | Release date: | 2007-11-13 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Motor domain of human kinesin family member 3B in complex with ADP.
To be Published
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8HFH
 | | CENP-E motor domain in complex with AMPPNP and Mg2+ | | Descriptor: | Centromere-associated protein E, IMIDAZOLE, MAGNESIUM ION, ... | | Authors: | Shibuya, A, Yokoyama, H. | | Deposit date: | 2022-11-10 | | Release date: | 2023-03-08 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of the motor domain of centromere-associated protein E in complex with a non-hydrolysable ATP analogue.
Febs Lett., 597, 2023
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6G6Y
 | | Eg5-inhibitor complex | | Descriptor: | (~{N}~{Z})-~{N}-[(5~{S})-4-ethanoyl-5-methyl-5-phenyl-1,3,4-thiadiazolidin-2-ylidene]ethanamide, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... | | Authors: | Talapatra, S.K, Kozielski, F, Tham, C.L. | | Deposit date: | 2018-04-03 | | Release date: | 2018-08-08 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors.
Eur J Med Chem, 156, 2018
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1X88
 | | Human Eg5 motor domain bound to Mg-ADP and monastrol | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ETHYL 4-(3-HYDROXYPHENYL)-6-METHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE, Kinesin-like protein KIF11, ... | | Authors: | Maliga, Z, Mitchison, T.J. | | Deposit date: | 2004-08-17 | | Release date: | 2005-11-15 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural Basis of Eg5 Inhibition by Monastrol
TO BE PUBLISHED
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2PG2
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1VFV
 | | Crystal Structure of the Kif1A Motor Domain Complexed With Mg-AMPPNP | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PROTEIN (Fusion protein consisting of Kinesin-like protein KIF1A, ... | | Authors: | Nitta, R, Kikkawa, M, Okada, Y, Hirokawa, N. | | Deposit date: | 2004-04-19 | | Release date: | 2004-08-10 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | KIF1A Alternately Uses Two Loops to Bind Microtubules
Science, 305, 2004
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5WDE
 | | Crystal structure of the KIFC3 motor domain in complex with ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIFC3, MAGNESIUM ION, ... | | Authors: | Shen, Y, Tempel, W, Landry, R, Arrowsmith, C.H, Edwards, A.M, Park, H, Structural Genomics Consortium (SGC) | | Deposit date: | 2017-07-05 | | Release date: | 2017-08-09 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein.
Sci Rep, 7, 2017
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2XT3
 | | HUMAN KIF7, A KINESIN INVOLVED IN HEDGEHOG SIGNALLING | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF7, MAGNESIUM ION | | Authors: | Klejnot, M, Kozielski, F. | | Deposit date: | 2010-10-04 | | Release date: | 2011-12-14 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.882 Å) | | Cite: | Structural Insights Into Human Kif7, a Kinesin Involved in Hedgehog Signalling.
Acta Crystallogr.,Sect.D, 68, 2012
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2X7C
 | | Crystal structure of human kinesin Eg5 in complex with (S)-enastron | | Descriptor: | (S)-4-(3-HYDROXYPHENYL)-2-THIOXO-1,2,3,4,7,8-HEXAHYDROQUINAZOLIN-5(6H)-ONE, ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, ... | | Authors: | Kaan, H.Y.K, Ulaganathan, V, Rath, O, Laggner, C, Prokopcova, H, Dallinger, D, Kappe, C.O, Kozielski, F. | | Deposit date: | 2010-02-26 | | Release date: | 2010-07-14 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
J.Med.Chem., 53, 2010
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1Q0B
 | | Crystal structure of the motor protein KSP in complex with ADP and monastrol | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ETHYL 4-(3-HYDROXYPHENYL)-6-METHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE, Kinesin-like protein KIF11, ... | | Authors: | Yan, Y, Sardana, V, Xu, B, Halczenko, W, Homnick, C, Buser, C.A, Hartman, G.D, Huber, H.E, Kuo, L.C. | | Deposit date: | 2003-07-15 | | Release date: | 2004-01-13 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Inhibition of a mitotic motor protein: where, how, and conformational consequences
J.Mol.Biol., 335, 2004
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3DC4
 | | Crystal structure of the Drosophila kinesin family member NOD in complex with ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein Nod, MAGNESIUM ION | | Authors: | Cochran, J.C, Mulko, N.K, Kull, F.J. | | Deposit date: | 2008-06-03 | | Release date: | 2009-02-10 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | ATPase cycle of the nonmotile kinesin NOD allows microtubule end tracking and drives chromosome movement.
Cell(Cambridge,Mass.), 136, 2009
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