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1BKU
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BU of 1bku by Molmil
EFFECTS OF GLYCOSYLATION ON THE STRUCTURE AND DYNAMICS OF EEL CALCITONIN, NMR, 10 STRUCTURES
Descriptor: CALCITONIN
Authors:Hashimoto, Y, Nishikido, J, Toma, K, Yamamoto, K, Haneda, K, Inazu, T, Valentine, K, Opella, S.J.
Deposit date:1998-07-13
Release date:1999-01-13
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Effects of glycosylation on the structure and dynamics of eel calcitonin in micelles and lipid bilayers determined by nuclear magnetic resonance spectroscopy.
Biochemistry, 38, 1999
1BYV
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BU of 1byv by Molmil
GLYCOSYLATED EEL CALCITONIN
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEIN (CALCITONIN)
Authors:Hashimoto, Y, Toma, K, Nishikido, J, Yamamoto, K, Haneda, K, Inazu, T, Valentine, K.G, Opella, S.J.
Deposit date:1998-10-16
Release date:1998-10-28
Last modified:2020-07-29
Method:SOLUTION NMR
Cite:Effects of glycosylation on the structure and dynamics of eel calcitonin in micelles and lipid bilayers determined by nuclear magnetic resonance spectroscopy.
Biochemistry, 38, 1999
1BZB
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BU of 1bzb by Molmil
GLYCOSYLATED EEL CALCITONIN
Descriptor: PROTEIN (CALCITONIN), alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Hashimoto, Y, Toma, K, Nishikido, J, Yamamoto, K, Haneda, K, Inazu, T, Valentine, K, Opella, S.J.
Deposit date:1998-10-27
Release date:1998-11-11
Last modified:2020-07-29
Method:SOLUTION NMR
Cite:Effects of glycosylation on the structure and dynamics of eel calcitonin in micelles and lipid bilayers determined by nuclear magnetic resonance spectroscopy.
Biochemistry, 38, 1999
1FB9
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BU of 1fb9 by Molmil
EFFECTS OF S-SULFONATION ON THE SOLUTION STRUCTURE OF SALMON CALCITONIN
Descriptor: CALCITONIN ANALOGUE
Authors:Wu, H, Mao, J, Wang, Y, Dou, H.
Deposit date:2000-07-14
Release date:2003-07-01
Last modified:2018-06-27
Method:SOLUTION NMR
Cite:Solution structure and biological activity of recombinant salmon calcitonin S-sulfonated analog
Biochem.Biophys.Res.Commun., 306, 2003
2G48
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BU of 2g48 by Molmil
crystal structure of human insulin-degrading enzyme in complex with amylin
Descriptor: 1,4-DIETHYLENE DIOXIDE, Insulin-degrading enzyme, Islet amyloid polypeptide
Authors:Shen, Y, Tang, W.-J.
Deposit date:2006-02-21
Release date:2006-10-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Nature, 443, 2006
2KB8
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BU of 2kb8 by Molmil
The dynamic alpha-helix structure of micelle-bound human amylin.
Descriptor: Islet amyloid polypeptide
Authors:Patil, S.M, Xu, S, Sheftic, S.R, Alexandrescu, A.T.
Deposit date:2008-11-21
Release date:2009-02-24
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Dynamic alpha-helix structure of micelle-bound human amylin.
J.Biol.Chem., 284, 2009
2KJ7
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BU of 2kj7 by Molmil
Three-Dimensional NMR Structure of Rat Islet Amyloid Polypeptide in DPC micelles
Descriptor: Islet amyloid polypeptide
Authors:Nanga, R, Brender, J.R, Xu, J, Hartman, K, Subramanian, V, Ramamoorthy, A.
Deposit date:2009-05-22
Release date:2009-06-23
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Three-dimensional structure and orientation of rat islet amyloid polypeptide protein in a membrane environment by solution NMR spectroscopy.
J.Am.Chem.Soc., 131, 2009
2L7S
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BU of 2l7s by Molmil
Determination of the three-dimensional structure of adrenomedullin, a first step towards the analysis of its interactions with receptors and small molecules
Descriptor: Adrenomedullin
Authors:Jimenez-Barbero, J, Perez-Castells, J, Nieto, L.
Deposit date:2010-12-21
Release date:2011-09-28
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure of micelle-bound adrenomedullin: a first step toward the analysis of its interactions with receptors and small molecules.
Biopolymers, 97, 2012
2L86
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BU of 2l86 by Molmil
Solution NMR structure of human amylin in SDS micelles at pH 7.3
Descriptor: Islet amyloid polypeptide
Authors:Nanga, R, Brender, J.R, Vivekanandan, S, Ramamoorthy, A.
Deposit date:2011-01-04
Release date:2011-07-13
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment.
Biochim.Biophys.Acta, 1808, 2011
3G7V
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Islet Amyloid Polypeptide (IAPP or Amylin) fused to Maltose Binding Protein
Descriptor: GLYCEROL, Maltose-binding periplasmic protein, Islet amyloid polypeptide fusion protein, ...
Authors:Wiltzius, J.J.W, Sawaya, M.R, Eisenberg, D.
Deposit date:2009-02-10
Release date:2009-06-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process
Protein Sci., 18, 2009
3G7W
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BU of 3g7w by Molmil
Islet Amyloid Polypeptide (IAPP or Amylin) Residues 1 to 22 fused to Maltose Binding Protein
Descriptor: GLYCEROL, Maltose-binding periplasmic protein, Islet amyloid polypeptide fusion protein, ...
Authors:Wiltzius, J.J.W, Sawaya, M.R, Eisenberg, D.
Deposit date:2009-02-11
Release date:2009-06-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process
Protein Sci., 18, 2009
3HGZ
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BU of 3hgz by Molmil
Crystal structure of human insulin-degrading enzyme in complex with amylin
Descriptor: Insulin-degrading enzyme, Islet amyloid polypeptide, ZINC ION
Authors:Guo, Q, Bian, Y, Tang, W.J.
Deposit date:2009-05-14
Release date:2009-12-08
Last modified:2021-10-13
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme.
J.Mol.Biol., 395, 2010
5II0
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BU of 5ii0 by Molmil
Crystal structure of the human calcitonin receptor ectodomain in complex with a truncated salmon calcitonin analogue
Descriptor: Calcitonin, Calcitonin receptor, SODIUM ION, ...
Authors:Johansson, E, Reedtz-Runge, S.
Deposit date:2016-03-01
Release date:2016-05-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.097 Å)
Cite:Type II Turn of Receptor-bound Salmon Calcitonin Revealed by X-ray Crystallography.
J.Biol.Chem., 291, 2016
5K5G
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BU of 5k5g by Molmil
Structure of human islet amyloid polypeptide in complex with an engineered binding protein
Descriptor: HI18, Islet amyloid polypeptide
Authors:Mirecka, E.A, Feuerstein, S, Gremer, L, Schroeder, G.F, Stoldt, M, Willbold, D, Hoyer, W.
Deposit date:2016-05-23
Release date:2016-10-26
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:beta-Hairpin of Islet Amyloid Polypeptide Bound to an Aggregation Inhibitor.
Sci Rep, 6, 2016
5MGQ
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BU of 5mgq by Molmil
Solution structure of oxidized and amidated human IAPP (1-37), the diabetes II peptide.
Descriptor: Islet amyloid polypeptide
Authors:Rodriguez Camargo, D.C, Tripsianes, K, Reif, B.
Deposit date:2016-11-21
Release date:2017-03-29
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes.
Sci Rep, 7, 2017
6NIY
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BU of 6niy by Molmil
A high-resolution cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex
Descriptor: Calcitonin, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:dal Maso, E, Glukhova, A, Zhu, Y, Garcia-Nafria, J, Tate, C.G, Atanasio, S, Reynolds, C.A, Ramirez-Aportela, E, Carazo, J.-M, Hick, C.A, Furness, S.G.B, Hay, D.L, Liang, Y.-L, Miller, L.J, Christopoulos, A, Wang, M.-W, Wootten, D, Sexton, P.M.
Deposit date:2019-01-02
Release date:2019-01-23
Last modified:2020-04-08
Method:ELECTRON MICROSCOPY (3.34 Å)
Cite:The Molecular Control of Calcitonin Receptor Signaling.
Acs Pharmacol Transl Sci, 2, 2019
6PFO
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BU of 6pfo by Molmil
Crystal structure of N-glycosylated human calcitonin receptor extracellular domain in complex with salmon calcitonin (16-32)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Calcitonin, Maltodextrin-binding protein,Calcitonin receptor, ...
Authors:Lee, S, Pioszak, A.A.
Deposit date:2019-06-21
Release date:2020-02-12
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Calcitonin Receptor N-Glycosylation Enhances Peptide Hormone Affinity by Controlling Receptor Dynamics.
J.Mol.Biol., 432, 2020
6UCJ
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BU of 6ucj by Molmil
proIAPP in DPC Micelles - Two-Conformer Ensemble Refinement, Open Conformer
Descriptor: Islet amyloid polypeptide
Authors:DeLisle, C.F, Malooley, A.L, Banerjee, I, Lorieau, J.L.
Deposit date:2019-09-16
Release date:2020-02-26
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Pro-islet amyloid polypeptide in micelles contains a helical prohormone segment.
Febs J., 287, 2020
6UCK
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BU of 6uck by Molmil
proIAPP in DPC Micelles - Two-Conformer Ensemble Refinement, Bent Conformer
Descriptor: Islet amyloid polypeptide
Authors:DeLisle, C.F, Malooley, A.L, Banerjee, I, Lorieau, J.L.
Deposit date:2019-09-16
Release date:2020-02-26
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Pro-islet amyloid polypeptide in micelles contains a helical prohormone segment.
Febs J., 287, 2020
6UUN
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BU of 6uun by Molmil
CryoEM Structure of the active Adrenomedullin 1 receptor G protein complex with adrenomedullin peptide
Descriptor: ADM, Calcitonin gene-related peptide type 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R.
Deposit date:2019-10-30
Release date:2020-03-25
Last modified:2020-04-29
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.
Acs Pharmacol Transl Sci, 3, 2020
6UUS
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BU of 6uus by Molmil
CryoEM Structure of the active Adrenomedullin 2 receptor G protein complex with adrenomedullin peptide
Descriptor: ADM, Calcitonin gene-related peptide type 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R.
Deposit date:2019-10-31
Release date:2020-04-01
Last modified:2020-04-29
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.
Acs Pharmacol Transl Sci, 3, 2020
6VW2
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BU of 6vw2 by Molmil
Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils
Descriptor: Islet amyloid polypeptide (SUMO-tagged)
Authors:Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2020-02-18
Release date:2020-06-10
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils.
Nat.Struct.Mol.Biol., 27, 2020
6Y1A
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BU of 6y1a by Molmil
Amyloid fibril structure of islet amyloid polypeptide
Descriptor: AMINO GROUP, Islet amyloid polypeptide
Authors:Roeder, C, Kupreichyk, T, Gremer, L, Schaefer, L.U, Pothula, K.R, Ravelli, R.B.G, Willbold, D, Hoyer, W, Schroder, G.F.
Deposit date:2020-02-11
Release date:2020-03-04
Last modified:2020-07-22
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-beta fibrils.
Nat.Struct.Mol.Biol., 27, 2020
6ZRF
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amyloid structure of amylin (IAPP - islet amyloid polypeptide)
Descriptor: Islet amyloid polypeptide
Authors:Gallardo, R.U, Iadanza, M.G, Ranson, N.A, Radford, S.E.
Deposit date:2020-07-13
Release date:2020-09-30
Last modified:2020-11-18
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Fibril structures of diabetes-related amylin variants reveal a basis for surface-templated assembly.
Nat.Struct.Mol.Biol., 27, 2020
6ZRQ
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two-protofilament amyloid structure of S20G variant of human amylin (IAPP - islet amyloid polypeptide)
Descriptor: Islet amyloid polypeptide
Authors:Gallardo, R.U, Iadanza, M.G, Ranson, N.A, Radford, S.E.
Deposit date:2020-07-14
Release date:2020-09-30
Last modified:2020-11-18
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Fibril structures of diabetes-related amylin variants reveal a basis for surface-templated assembly.
Nat.Struct.Mol.Biol., 27, 2020

 

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